P01295 (GRP_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gastrin-releasing peptide
Short name=GRP

Alternative name(s):
Proventricular peptide

Cleaved into the following chain:

1. Neuromedin-C
   Alternative name(s):
   GRP-10

Gene names

Name:

GRP

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	27 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GRP stimulates gastrin release as well as other gastrointestinal hormones.
Subcellular location	Secreted.
Sequence similarities	Belongs to the bombesin/neuromedin-B/ranatensin family.

Ontologies

Keywords
Cellular component	Secreted
PTM	Amidation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 27	27	Gastrin-releasing peptide		PRO_0000223263
	Peptide	18 – 27	10	Neuromedin-C		PRO_0000003045
Amino acid modifications
	Modified residue	27	1	Methionine amide Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P01295 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 3C121D0118D551C7	FASTA	27	2,842
	10 20 APLQPGGSPA LTKIYPRGSH WAVGHLM

References

[1]	"Characterization of an avian gastric (proventricular) peptide having sequence homology with the porcine gastrin-releasing peptide and the amphibian peptides bombesin and alytesin." McDonald T.J., Joernvall H., Ghatei M., Bloom S.R., Mutt V. FEBS Lett. 122:45-48(1980) [PubMed: 7215543] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Isolation, sequence and biosynthetic significance of a novel fragment of gastrin-releasing peptide from chicken proventriculus." Campbell B.J., Young J., Dimaline R., Dockray G.J. Biochim. Biophys. Acta 1048:66-71(1990) [PubMed: 2297533] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00597429.
PIR	RHCHA. A01563.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000004456; ENSGALP00000004447; ENSGALG00000002821.
Family and domain databases
InterPro	IPR000874. Bombesin. [Graphical view]
Pfam	PF02044. Bombesin. 1 hit. [Graphical view]
PROSITE	PS00257. BOMBESIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRP_CHICK

Accession

Primary (citable) accession number: P01295

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program