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Protein

Somatoliberin

Gene

GHRH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.

Miscellaneous

The carboxyl-amidated somatoliberin is twice as active as that having a free carboxyl end.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Somatoliberin
Alternative name(s):
Growth hormone-releasing factor
Short name:
GRF
Growth hormone-releasing hormone
Short name:
GHRH
Gene namesi
Name:GHRH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001489211 – 44SomatoliberinAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44Leucine amide1 Publication1

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiP01287.
PRIDEiP01287.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021037.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Phylogenomic databases

eggNOGiENOG410J1XI. Eukaryota.
ENOG410ZCJQ. LUCA.
HOVERGENiHBG017807.
OrthoDBiEOG091G11MO.

Family and domain databases

InterProiView protein in InterPro
IPR000532. Glucagon_GIP_secretin_VIP.
PfamiView protein in Pfam
PF00123. Hormone_2. 1 hit.
SMARTiView protein in SMART
SM00070. GLUCA. 1 hit.
PROSITEiView protein in PROSITE
PS00260. GLUCAGON. 1 hit.

Sequencei

Sequence statusi: Complete.

P01287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
YADAIFTNSY RKVLGQLSAR KLLQDIMSRQ QGERNQEQGA RVRL
Length:44
Mass (Da):5,110
Last modified:July 21, 1986 - v1
Checksum:i1271DC7059F4802E
GO

Sequence databases

PIRiA01553. RHPG.
UniGeneiSsc.71374.

Similar proteinsi

Entry informationi

Entry nameiSLIB_PIG
AccessioniPrimary (citable) accession number: P01287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families