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Protein

VIP peptides

Gene

Vip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHI also causes vasodilation.By similarity

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • receptor binding Source: RGD

GO - Biological processi

  • antibacterial humoral response Source: Ensembl
  • antifungal humoral response Source: Ensembl
  • defense response to Gram-negative bacterium Source: Ensembl
  • defense response to Gram-positive bacterium Source: Ensembl
  • innate immune response Source: Ensembl
  • learning or memory Source: RGD
  • mRNA stabilization Source: AgBase
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of potassium ion transport Source: RGD
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of protein catabolic process Source: BHF-UCL
  • positive regulation of vasodilation Source: RGD
  • prolactin secretion Source: AgBase
  • regulation of protein localization Source: BHF-UCL
  • regulation of sensory perception of pain Source: RGD
  • response to yeast Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Alternative name(s):
Peptide histidine isoleucinamide 27
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:Vip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621647. Vip.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Propeptidei22 – 7958PRO_0000011471Add
BLAST
Peptidei81 – 12242Intestinal peptide PHV-42By similarityPRO_0000011472Add
BLAST
Peptidei81 – 10727Intestinal peptide PHI-27PRO_0000011473Add
BLAST
Peptidei125 – 15228Vasoactive intestinal peptidePRO_0000011474Add
BLAST
Propeptidei156 – 17015PRO_0000011475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Modified residuei76 – 761PhosphoserineCombined sources
Modified residuei107 – 1071Isoleucine amide1 Publication
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence analysis
Modified residuei152 – 1521Asparagine amide2 Publications

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01283.
PRIDEiP01283.

PTM databases

iPTMnetiP01283.

Expressioni

Gene expression databases

ExpressionAtlasiP01283. baseline and differential.
GenevisibleiP01283. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025477.

Chemistry

BindingDBiP01283.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01283.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG7QVM4H.
PhylomeDBiP01283.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRSKPQFL AILTLFSVLF SQSLAWPLYG PPSSVRLDDR LQFEGAGDPD
60 70 80 90 100
QVSLKADSDI LQNALAENDT PYYDVSRNAR HADGVFTSDY SRLLGQISAK
110 120 130 140 150
KYLESLIGKR ISSSISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGD SPDFLEELEK
Length:170
Mass (Da):19,079
Last modified:October 1, 1993 - v2
Checksum:i202AEE82EBBD190B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02341 mRNA. Translation: CAA26200.1.
PIRiA60053. VRRT.
RefSeqiNP_446443.1. NM_053991.1.
UniGeneiRn.18675.

Genome annotation databases

EnsembliENSRNOT00000025477; ENSRNOP00000025477; ENSRNOG00000018808.
GeneIDi117064.
KEGGirno:117064.
UCSCiRGD:621647. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02341 mRNA. Translation: CAA26200.1.
PIRiA60053. VRRT.
RefSeqiNP_446443.1. NM_053991.1.
UniGeneiRn.18675.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025477.

Chemistry

BindingDBiP01283.

PTM databases

iPTMnetiP01283.

Proteomic databases

PaxDbiP01283.
PRIDEiP01283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025477; ENSRNOP00000025477; ENSRNOG00000018808.
GeneIDi117064.
KEGGirno:117064.
UCSCiRGD:621647. rat.

Organism-specific databases

CTDi7432.
RGDi621647. Vip.

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01283.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG7QVM4H.
PhylomeDBiP01283.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi619934.
PROiP01283.

Gene expression databases

ExpressionAtlasiP01283. baseline and differential.
GenevisibleiP01283. RN.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat."
    Nishizawa M., Hayakawa Y., Yanaihara N., Okamoto H.
    FEBS Lett. 183:55-59(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-170, AMIDATION AT ILE-107 AND ASN-152.
    Tissue: Brain cortex.
  3. "Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse."
    Lamperti E.D., Rosen K.M., Villa-Komaroff L.
    Brain Res. Mol. Brain Res. 9:217-231(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 78-155.
  4. "Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells."
    Goetzl E.J., Sreedharan S.P., Turck C.W.
    J. Biol. Chem. 263:9083-9086(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 134-152, AMIDATION AT ASN-152.
  5. "Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells."
    Wershil B.K., Turck C.W., Sreedharan S.P., Yang J., An S., Galli S.J., Goetzl E.J.
    Cell. Immunol. 151:369-378(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 134-152.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVIP_RAT
AccessioniPrimary (citable) accession number: P01283
Secondary accession number(s): Q9QUN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1993
Last modified: February 17, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.