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Protein

VIP peptides

Gene

Vip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHI also causes vasodilation.By similarity

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • receptor binding Source: RGD

GO - Biological processi

  • learning or memory Source: RGD
  • mRNA stabilization Source: AgBase
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of potassium ion transport Source: RGD
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of protein catabolic process Source: BHF-UCL
  • positive regulation of vasodilation Source: RGD
  • prolactin secretion Source: AgBase
  • regulation of protein localization Source: BHF-UCL
  • regulation of sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Alternative name(s):
Peptide histidine isoleucinamide 27
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:Vip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621647. Vip.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
PropeptideiPRO_000001147122 – 79Add BLAST58
PeptideiPRO_000001147281 – 122Intestinal peptide PHV-42By similarityAdd BLAST42
PeptideiPRO_000001147381 – 107Intestinal peptide PHI-27Add BLAST27
PeptideiPRO_0000011474125 – 152Vasoactive intestinal peptideAdd BLAST28
PropeptideiPRO_0000011475156 – 170Add BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Modified residuei76PhosphoserineCombined sources1
Modified residuei107Isoleucine amide1 Publication1
Glycosylationi133N-linked (GlcNAc...)Sequence analysis1
Modified residuei152Asparagine amide2 Publications1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01283.
PRIDEiP01283.

PTM databases

iPTMnetiP01283.
PhosphoSitePlusiP01283.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018808.
ExpressionAtlasiP01283. baseline and differential.
GenevisibleiP01283. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025477.

Chemistry databases

BindingDBiP01283.

Structurei

3D structure databases

ProteinModelPortaliP01283.
SMRiP01283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01283.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG091G0KH7.
PhylomeDBiP01283.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRSKPQFL AILTLFSVLF SQSLAWPLYG PPSSVRLDDR LQFEGAGDPD
60 70 80 90 100
QVSLKADSDI LQNALAENDT PYYDVSRNAR HADGVFTSDY SRLLGQISAK
110 120 130 140 150
KYLESLIGKR ISSSISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGD SPDFLEELEK
Length:170
Mass (Da):19,079
Last modified:October 1, 1993 - v2
Checksum:i202AEE82EBBD190B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02341 mRNA. Translation: CAA26200.1.
PIRiA60053. VRRT.
RefSeqiNP_446443.1. NM_053991.1.
UniGeneiRn.18675.

Genome annotation databases

EnsembliENSRNOT00000025477; ENSRNOP00000025477; ENSRNOG00000018808.
ENSRNOT00000092879; ENSRNOP00000076039; ENSRNOG00000018808.
GeneIDi117064.
KEGGirno:117064.
UCSCiRGD:621647. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02341 mRNA. Translation: CAA26200.1.
PIRiA60053. VRRT.
RefSeqiNP_446443.1. NM_053991.1.
UniGeneiRn.18675.

3D structure databases

ProteinModelPortaliP01283.
SMRiP01283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025477.

Chemistry databases

BindingDBiP01283.

PTM databases

iPTMnetiP01283.
PhosphoSitePlusiP01283.

Proteomic databases

PaxDbiP01283.
PRIDEiP01283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025477; ENSRNOP00000025477; ENSRNOG00000018808.
ENSRNOT00000092879; ENSRNOP00000076039; ENSRNOG00000018808.
GeneIDi117064.
KEGGirno:117064.
UCSCiRGD:621647. rat.

Organism-specific databases

CTDi7432.
RGDi621647. Vip.

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01283.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG091G0KH7.
PhylomeDBiP01283.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP01283.

Gene expression databases

BgeeiENSRNOG00000018808.
ExpressionAtlasiP01283. baseline and differential.
GenevisibleiP01283. RN.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIP_RAT
AccessioniPrimary (citable) accession number: P01283
Secondary accession number(s): Q9QUN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.