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P01282

- VIP_HUMAN

UniProt

P01282 - VIP_HUMAN

Protein

VIP peptides

Gene

VIP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.1 Publication
    PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.1 Publication

    GO - Molecular functioni

    1. hormone activity Source: BHF-UCL
    2. neuropeptide hormone activity Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. body fluid secretion Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. learning or memory Source: Ensembl
    4. negative regulation of apoptotic process Source: Ensembl
    5. negative regulation of potassium ion transport Source: Ensembl
    6. negative regulation of smooth muscle cell proliferation Source: Ensembl
    7. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
    8. positive regulation of cell proliferation Source: ProtInc
    9. positive regulation of endothelial cell proliferation Source: Ensembl
    10. positive regulation of penile erection Source: Ensembl
    11. positive regulation of protein catabolic process Source: BHF-UCL
    12. positive regulation of vasodilation Source: Ensembl
    13. regulation of protein localization Source: BHF-UCL
    14. regulation of sensory perception of pain Source: Ensembl
    15. regulation of signal transduction Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    VIP peptides
    Cleaved into the following 3 chains:
    Alternative name(s):
    Peptide histidine valine 42
    Alternative name(s):
    Peptide histidine methioninamide 27
    Alternative name(s):
    Vasoactive intestinal polypeptide
    Gene namesi
    Name:VIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:12693. VIP.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37312.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 7959PRO_0000011457Add
    BLAST
    Peptidei81 – 12242Intestinal peptide PHV-42PRO_0000011458Add
    BLAST
    Peptidei81 – 10727Intestinal peptide PHM-27PRO_0000011459Add
    BLAST
    Peptidei125 – 15228Vasoactive intestinal peptidePRO_0000011460Add
    BLAST
    Propeptidei156 – 17015PRO_0000011461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei107 – 1071Methionine amide1 Publication
    Modified residuei152 – 1521Asparagine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP01282.
    PRIDEiP01282.

    PTM databases

    PhosphoSiteiP01282.

    Expressioni

    Gene expression databases

    BgeeiP01282.
    CleanExiHS_VIP.
    GenevestigatoriP01282.

    Organism-specific databases

    HPAiCAB018649.
    HPA017324.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DPP4P274872EBI-751454,EBI-2871277
    FAPQ128842EBI-751454,EBI-4319803
    VIPR1P322412EBI-6656819,EBI-3917984

    Protein-protein interaction databases

    BioGridi113273. 3 interactions.
    IntActiP01282. 6 interactions.
    MINTiMINT-1473277.
    STRINGi9606.ENSP00000356213.

    Structurei

    Secondary structure

    1
    170
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi128 – 15225

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RRHNMR-A125-153[»]
    2RRINMR-A125-153[»]
    ProteinModelPortaliP01282.
    SMRiP01282. Positions 81-109, 125-153.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01282.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucagon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44083.
    HOGENOMiHOG000253943.
    HOVERGENiHBG018069.
    InParanoidiP01282.
    KOiK05264.
    OMAiFSHTLAW.
    OrthoDBiEOG7QVM4H.
    PhylomeDBiP01282.
    TreeFamiTF332804.

    Family and domain databases

    InterProiIPR000532. Glucagon_GIP_secretin_VIP.
    IPR015523. VIP.
    [Graphical view]
    PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
    PfamiPF00123. Hormone_2. 2 hits.
    [Graphical view]
    SMARTiSM00070. GLUCA. 2 hits.
    [Graphical view]
    PROSITEiPS00260. GLUCAGON. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P01282-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD    50
    QVSLKEDIDM LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK 100
    KYLESLMGKR VSSNISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI 150
    LNGKRSSEGE SPDFPEELEK 170
    Length:170
    Mass (Da):19,169
    Last modified:July 21, 1986 - v1
    Checksum:i93EC0177F89508FD
    GO
    Isoform 2 (identifier: P01282-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-113: Missing.

    Show »
    Length:169
    Mass (Da):19,082
    Checksum:iF325BDFEF47132C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 972QL → PP in AAA61286. (PubMed:3748844)Curated
    Sequence conflicti116 – 1161S → L in AAA61288. (PubMed:3025882)Curated
    Sequence conflicti136 – 1361R → G in AAA61288. (PubMed:3025882)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei113 – 1131Missing in isoform 2. 1 PublicationVSP_023256

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00157
    , L00154, L00155, L00156 Genomic DNA. Translation: AAA61289.1.
    M11553
    , M11549, M11550, M11551, M11552 Genomic DNA. Translation: AAA61284.1.
    M36634 mRNA. Translation: AAA61287.1.
    M14623
    , M14619, M14620, M14621, M14622 Genomic DNA. Translation: AAA61288.1.
    M33027 Genomic DNA. Translation: AAA69515.1.
    AL133356 Genomic DNA. Translation: CAI21764.1.
    AL133356 Genomic DNA. Translation: CAI21765.1.
    BC009794 mRNA. Translation: AAH09794.1.
    M36610
    , M36606, M36607, M36608, M36609 Genomic DNA. Translation: AAA61286.1.
    M54930 mRNA. Translation: AAA63268.1.
    M32162, M31645 Genomic DNA. Translation: AAA61285.1.
    CCDSiCCDS5240.1. [P01282-1]
    CCDS5241.1. [P01282-2]
    PIRiA23296. VRHU.
    RefSeqiNP_003372.1. NM_003381.3. [P01282-1]
    NP_919416.1. NM_194435.2. [P01282-2]
    UniGeneiHs.53973.

    Genome annotation databases

    EnsembliENST00000367243; ENSP00000356212; ENSG00000146469. [P01282-2]
    ENST00000367244; ENSP00000356213; ENSG00000146469. [P01282-1]
    GeneIDi7432.
    KEGGihsa:7432.
    UCSCiuc003qpe.4. human. [P01282-1]
    uc003qpf.4. human. [P01282-2]

    Polymorphism databases

    DMDMi138574.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Vasoactive intestinal peptide entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00157
    , L00154 , L00155 , L00156 Genomic DNA. Translation: AAA61289.1 .
    M11553
    , M11549 , M11550 , M11551 , M11552 Genomic DNA. Translation: AAA61284.1 .
    M36634 mRNA. Translation: AAA61287.1 .
    M14623
    , M14619 , M14620 , M14621 , M14622 Genomic DNA. Translation: AAA61288.1 .
    M33027 Genomic DNA. Translation: AAA69515.1 .
    AL133356 Genomic DNA. Translation: CAI21764.1 .
    AL133356 Genomic DNA. Translation: CAI21765.1 .
    BC009794 mRNA. Translation: AAH09794.1 .
    M36610
    , M36606 , M36607 , M36608 , M36609 Genomic DNA. Translation: AAA61286.1 .
    M54930 mRNA. Translation: AAA63268.1 .
    M32162 , M31645 Genomic DNA. Translation: AAA61285.1 .
    CCDSi CCDS5240.1. [P01282-1 ]
    CCDS5241.1. [P01282-2 ]
    PIRi A23296. VRHU.
    RefSeqi NP_003372.1. NM_003381.3. [P01282-1 ]
    NP_919416.1. NM_194435.2. [P01282-2 ]
    UniGenei Hs.53973.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RRH NMR - A 125-153 [» ]
    2RRI NMR - A 125-153 [» ]
    ProteinModelPortali P01282.
    SMRi P01282. Positions 81-109, 125-153.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113273. 3 interactions.
    IntActi P01282. 6 interactions.
    MINTi MINT-1473277.
    STRINGi 9606.ENSP00000356213.

    Chemistry

    BindingDBi P01282.
    ChEMBLi CHEMBL5737.

    PTM databases

    PhosphoSitei P01282.

    Polymorphism databases

    DMDMi 138574.

    Proteomic databases

    PaxDbi P01282.
    PRIDEi P01282.

    Protocols and materials databases

    DNASUi 7432.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367243 ; ENSP00000356212 ; ENSG00000146469 . [P01282-2 ]
    ENST00000367244 ; ENSP00000356213 ; ENSG00000146469 . [P01282-1 ]
    GeneIDi 7432.
    KEGGi hsa:7432.
    UCSCi uc003qpe.4. human. [P01282-1 ]
    uc003qpf.4. human. [P01282-2 ]

    Organism-specific databases

    CTDi 7432.
    GeneCardsi GC06P153164.
    HGNCi HGNC:12693. VIP.
    HPAi CAB018649.
    HPA017324.
    MIMi 192320. gene.
    neXtProti NX_P01282.
    PharmGKBi PA37312.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44083.
    HOGENOMi HOG000253943.
    HOVERGENi HBG018069.
    InParanoidi P01282.
    KOi K05264.
    OMAi FSHTLAW.
    OrthoDBi EOG7QVM4H.
    PhylomeDBi P01282.
    TreeFami TF332804.

    Enzyme and pathway databases

    Reactomei REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P01282.
    GeneWikii Vasoactive_intestinal_peptide.
    GenomeRNAii 7432.
    NextBioi 29108.
    PROi P01282.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01282.
    CleanExi HS_VIP.
    Genevestigatori P01282.

    Family and domain databases

    InterProi IPR000532. Glucagon_GIP_secretin_VIP.
    IPR015523. VIP.
    [Graphical view ]
    PANTHERi PTHR11213:SF5. PTHR11213:SF5. 1 hit.
    Pfami PF00123. Hormone_2. 2 hits.
    [Graphical view ]
    SMARTi SM00070. GLUCA. 2 hits.
    [Graphical view ]
    PROSITEi PS00260. GLUCAGON. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27."
      Itoh N., Obata K., Yanaihara N., Okamoto H.
      Nature 304:547-549(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure of the human vasoactive intestinal polypeptide gene."
      Tsukada T., Horovitch S.J., Montminy M.R., Mandel G., Goodman R.H.
      DNA 4:293-300(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Vasoactive intestinal peptide: expression of the prohormone in bacterial cells."
      Delamarter J.F., Buell G.N., Kawashima E., Polak J.M., Bloom S.R.
      Peptides 6 Suppl. 1:95-102(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Structure and expression of the gene encoding the vasoactive intestinal peptide precursor."
      Linder S., Barkhem T., Norberg A., Persson H., Schalling M., Hoekfelt T., Magnusson G.
      Proc. Natl. Acad. Sci. U.S.A. 84:605-609(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter."
      Yamagami T., Ohsawa K., Nishizawa M., Inoue C., Gotoh E., Yanaihara N., Yamamoto H., Okamoto H.
      Ann. N. Y. Acad. Sci. 527:87-102(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Prostate.
    8. "Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor."
      Gozes I., Bodener M., Shani Y., Fridkin M.
      Peptides 7:1-6(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-170, AMIDATION AT MET-107 AND ASN-152.
    9. "Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene."
      Bloom S.R., Delamarter J.F., Kawashima E., Christofides N.D., Buell G., Polak J.M.
      Lancet 2:1163-1165(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-170 (ISOFORM 1).
      Tissue: Pancreatic carcinoma.
    10. "Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level."
      Gozes I., Giladi E., Shani Y.
      J. Neurochem. 48:1136-1141(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-155.
    11. "Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide."
      Yiangou Y., di Marzo V., Spokes R.A., Panico M., Morris H.R., Bloom S.R.
      J. Biol. Chem. 262:14010-14013(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 81-122.
    12. "Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma."
      Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.
      Biochem. Biophys. Res. Commun. 185:134-141(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 127-152.
      Tissue: Pheochromocytoma.
    13. "Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor."
      Ma J.N., Currier E.A., Essex A., Feddock M., Spalding T.A., Nash N.R., Brann M.R., Burstein E.S.
      Biochem. Pharmacol. 67:1279-1284(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (PHM-27).
    14. "Structural determination of the vasoactive intestinal peptide by two-dimensional H-NMR spectroscopy."
      Theriault Y., Boulanger Y., St Pierre S.
      Biopolymers 31:459-464(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF VIP.

    Entry informationi

    Entry nameiVIP_HUMAN
    AccessioniPrimary (citable) accession number: P01282
    Secondary accession number(s): Q5TCY8, Q5TCY9, Q96QK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 152 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3