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Protein

VIP peptides

Gene

VIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.1 Publication
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.1 Publication

GO - Molecular functioni

  1. hormone activity Source: BHF-UCL
  2. neuropeptide hormone activity Source: ProtInc

GO - Biological processi

  1. body fluid secretion Source: ProtInc
  2. G-protein coupled receptor signaling pathway Source: ProtInc
  3. learning or memory Source: Ensembl
  4. mRNA stabilization Source: AgBase
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of potassium ion transport Source: Ensembl
  7. negative regulation of smooth muscle cell proliferation Source: Ensembl
  8. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  9. positive regulation of cell proliferation Source: ProtInc
  10. positive regulation of endothelial cell proliferation Source: Ensembl
  11. positive regulation of penile erection Source: Ensembl
  12. positive regulation of protein catabolic process Source: BHF-UCL
  13. positive regulation of vasodilation Source: Ensembl
  14. prolactin secretion Source: AgBase
  15. regulation of protein localization Source: BHF-UCL
  16. regulation of sensory perception of pain Source: Ensembl
  17. regulation of signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Alternative name(s):
Peptide histidine valine 42
Alternative name(s):
Peptide histidine methioninamide 27
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:VIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12693. VIP.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37312.

Polymorphism and mutation databases

BioMutaiVIP.
DMDMi138574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 7959PRO_0000011457Add
BLAST
Peptidei81 – 12242Intestinal peptide PHV-42PRO_0000011458Add
BLAST
Peptidei81 – 10727Intestinal peptide PHM-27PRO_0000011459Add
BLAST
Peptidei125 – 15228Vasoactive intestinal peptidePRO_0000011460Add
BLAST
Propeptidei156 – 17015PRO_0000011461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071Methionine amide1 Publication
Modified residuei152 – 1521Asparagine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01282.
PRIDEiP01282.

PTM databases

PhosphoSiteiP01282.

Expressioni

Gene expression databases

BgeeiP01282.
CleanExiHS_VIP.
GenevestigatoriP01282.

Organism-specific databases

HPAiCAB018649.
HPA017324.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-751454,EBI-2871277
FAPQ128842EBI-751454,EBI-4319803
SGTAO437653EBI-751454,EBI-347996
VIPR1P322412EBI-6656819,EBI-3917984

Protein-protein interaction databases

BioGridi113273. 4 interactions.
IntActiP01282. 7 interactions.
MINTiMINT-1473277.
STRINGi9606.ENSP00000356213.

Structurei

Secondary structure

1
170
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi128 – 15225Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RRHNMR-A125-153[»]
2RRINMR-A125-153[»]
ProteinModelPortaliP01282.
SMRiP01282. Positions 81-109, 125-153.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01282.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44083.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01282.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG7QVM4H.
PhylomeDBiP01282.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD
60 70 80 90 100
QVSLKEDIDM LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK
110 120 130 140 150
KYLESLMGKR VSSNISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGE SPDFPEELEK
Length:170
Mass (Da):19,169
Last modified:July 21, 1986 - v1
Checksum:i93EC0177F89508FD
GO
Isoform 2 (identifier: P01282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: Missing.

Show »
Length:169
Mass (Da):19,082
Checksum:iF325BDFEF47132C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 972QL → PP in AAA61286 (PubMed:3748844).Curated
Sequence conflicti116 – 1161S → L in AAA61288 (PubMed:3025882).Curated
Sequence conflicti136 – 1361R → G in AAA61288 (PubMed:3025882).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 1131Missing in isoform 2. 1 PublicationVSP_023256

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00157
, L00154, L00155, L00156 Genomic DNA. Translation: AAA61289.1.
M11553
, M11549, M11550, M11551, M11552 Genomic DNA. Translation: AAA61284.1.
M36634 mRNA. Translation: AAA61287.1.
M14623
, M14619, M14620, M14621, M14622 Genomic DNA. Translation: AAA61288.1.
M33027 Genomic DNA. Translation: AAA69515.1.
AL133356 Genomic DNA. Translation: CAI21764.1.
AL133356 Genomic DNA. Translation: CAI21765.1.
BC009794 mRNA. Translation: AAH09794.1.
M36610
, M36606, M36607, M36608, M36609 Genomic DNA. Translation: AAA61286.1.
M54930 mRNA. Translation: AAA63268.1.
M32162, M31645 Genomic DNA. Translation: AAA61285.1.
CCDSiCCDS5240.1. [P01282-1]
CCDS5241.1. [P01282-2]
PIRiA23296. VRHU.
RefSeqiNP_003372.1. NM_003381.3. [P01282-1]
NP_919416.1. NM_194435.2. [P01282-2]
UniGeneiHs.53973.

Genome annotation databases

EnsembliENST00000367243; ENSP00000356212; ENSG00000146469. [P01282-2]
ENST00000367244; ENSP00000356213; ENSG00000146469. [P01282-1]
GeneIDi7432.
KEGGihsa:7432.
UCSCiuc003qpe.4. human. [P01282-1]
uc003qpf.4. human. [P01282-2]

Polymorphism and mutation databases

BioMutaiVIP.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Vasoactive intestinal peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00157
, L00154, L00155, L00156 Genomic DNA. Translation: AAA61289.1.
M11553
, M11549, M11550, M11551, M11552 Genomic DNA. Translation: AAA61284.1.
M36634 mRNA. Translation: AAA61287.1.
M14623
, M14619, M14620, M14621, M14622 Genomic DNA. Translation: AAA61288.1.
M33027 Genomic DNA. Translation: AAA69515.1.
AL133356 Genomic DNA. Translation: CAI21764.1.
AL133356 Genomic DNA. Translation: CAI21765.1.
BC009794 mRNA. Translation: AAH09794.1.
M36610
, M36606, M36607, M36608, M36609 Genomic DNA. Translation: AAA61286.1.
M54930 mRNA. Translation: AAA63268.1.
M32162, M31645 Genomic DNA. Translation: AAA61285.1.
CCDSiCCDS5240.1. [P01282-1]
CCDS5241.1. [P01282-2]
PIRiA23296. VRHU.
RefSeqiNP_003372.1. NM_003381.3. [P01282-1]
NP_919416.1. NM_194435.2. [P01282-2]
UniGeneiHs.53973.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RRHNMR-A125-153[»]
2RRINMR-A125-153[»]
ProteinModelPortaliP01282.
SMRiP01282. Positions 81-109, 125-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113273. 4 interactions.
IntActiP01282. 7 interactions.
MINTiMINT-1473277.
STRINGi9606.ENSP00000356213.

Chemistry

ChEMBLiCHEMBL5737.

PTM databases

PhosphoSiteiP01282.

Polymorphism and mutation databases

BioMutaiVIP.
DMDMi138574.

Proteomic databases

PaxDbiP01282.
PRIDEiP01282.

Protocols and materials databases

DNASUi7432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367243; ENSP00000356212; ENSG00000146469. [P01282-2]
ENST00000367244; ENSP00000356213; ENSG00000146469. [P01282-1]
GeneIDi7432.
KEGGihsa:7432.
UCSCiuc003qpe.4. human. [P01282-1]
uc003qpf.4. human. [P01282-2]

Organism-specific databases

CTDi7432.
GeneCardsiGC06P153164.
HGNCiHGNC:12693. VIP.
HPAiCAB018649.
HPA017324.
MIMi192320. gene.
neXtProtiNX_P01282.
PharmGKBiPA37312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44083.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01282.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG7QVM4H.
PhylomeDBiP01282.
TreeFamiTF332804.

Enzyme and pathway databases

ReactomeiREACT_19327. G alpha (s) signalling events.

Miscellaneous databases

EvolutionaryTraceiP01282.
GeneWikiiVasoactive_intestinal_peptide.
GenomeRNAii7432.
NextBioi29108.
PROiP01282.
SOURCEiSearch...

Gene expression databases

BgeeiP01282.
CleanExiHS_VIP.
GenevestigatoriP01282.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27."
    Itoh N., Obata K., Yanaihara N., Okamoto H.
    Nature 304:547-549(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure of the human vasoactive intestinal polypeptide gene."
    Tsukada T., Horovitch S.J., Montminy M.R., Mandel G., Goodman R.H.
    DNA 4:293-300(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Vasoactive intestinal peptide: expression of the prohormone in bacterial cells."
    Delamarter J.F., Buell G.N., Kawashima E., Polak J.M., Bloom S.R.
    Peptides 6 Suppl. 1:95-102(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Structure and expression of the gene encoding the vasoactive intestinal peptide precursor."
    Linder S., Barkhem T., Norberg A., Persson H., Schalling M., Hoekfelt T., Magnusson G.
    Proc. Natl. Acad. Sci. U.S.A. 84:605-609(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter."
    Yamagami T., Ohsawa K., Nishizawa M., Inoue C., Gotoh E., Yanaihara N., Yamamoto H., Okamoto H.
    Ann. N. Y. Acad. Sci. 527:87-102(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Prostate.
  8. "Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor."
    Gozes I., Bodener M., Shani Y., Fridkin M.
    Peptides 7:1-6(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-170, AMIDATION AT MET-107 AND ASN-152.
  9. "Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene."
    Bloom S.R., Delamarter J.F., Kawashima E., Christofides N.D., Buell G., Polak J.M.
    Lancet 2:1163-1165(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-170 (ISOFORM 1).
    Tissue: Pancreatic carcinoma.
  10. "Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level."
    Gozes I., Giladi E., Shani Y.
    J. Neurochem. 48:1136-1141(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-155.
  11. "Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide."
    Yiangou Y., di Marzo V., Spokes R.A., Panico M., Morris H.R., Bloom S.R.
    J. Biol. Chem. 262:14010-14013(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 81-122.
  12. "Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma."
    Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Matsuo H., Eto T.
    Biochem. Biophys. Res. Commun. 185:134-141(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 127-152.
    Tissue: Pheochromocytoma.
  13. "Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor."
    Ma J.N., Currier E.A., Essex A., Feddock M., Spalding T.A., Nash N.R., Brann M.R., Burstein E.S.
    Biochem. Pharmacol. 67:1279-1284(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (PHM-27).
  14. "Structural determination of the vasoactive intestinal peptide by two-dimensional H-NMR spectroscopy."
    Theriault Y., Boulanger Y., St Pierre S.
    Biopolymers 31:459-464(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF VIP.

Entry informationi

Entry nameiVIP_HUMAN
AccessioniPrimary (citable) accession number: P01282
Secondary accession number(s): Q5TCY8, Q5TCY9, Q96QK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 29, 2015
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.