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Protein

VIP peptides

Gene

VIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.1 Publication
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.1 Publication

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • neuropeptide hormone activity Source: ProtInc

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antifungal humoral response Source: UniProtKB
  • body fluid secretion Source: ProtInc
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • innate immune response Source: UniProtKB
  • mRNA stabilization Source: AgBase
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: BHF-UCL
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of protein catabolic process Source: BHF-UCL
  • prolactin secretion Source: AgBase
  • regulation of protein localization Source: BHF-UCL
  • response to yeast Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146469-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
SIGNORiP01282.

Names & Taxonomyi

Protein namesi
Recommended name:
VIP peptides
Cleaved into the following 3 chains:
Alternative name(s):
Peptide histidine valine 42
Alternative name(s):
Peptide histidine methioninamide 27
Alternative name(s):
Vasoactive intestinal polypeptide
Gene namesi
Name:VIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:12693. VIP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7432.
OpenTargetsiENSG00000146469.
PharmGKBiPA37312.

Chemistry databases

ChEMBLiCHEMBL5737.

Polymorphism and mutation databases

BioMutaiVIP.
DMDMi138574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000001145721 – 79Add BLAST59
PeptideiPRO_000001145881 – 122Intestinal peptide PHV-42Add BLAST42
PeptideiPRO_000001145981 – 107Intestinal peptide PHM-27Add BLAST27
PeptideiPRO_0000011460125 – 152Vasoactive intestinal peptideAdd BLAST28
PropeptideiPRO_0000011461156 – 170Add BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineBy similarity1
Modified residuei107Methionine amide1 Publication1
Modified residuei152Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP01282.
PeptideAtlasiP01282.
PRIDEiP01282.

PTM databases

iPTMnetiP01282.
PhosphoSitePlusiP01282.

Expressioni

Gene expression databases

BgeeiENSG00000146469.
CleanExiHS_VIP.
ExpressionAtlasiP01282. baseline and differential.
GenevisibleiP01282. HS.

Organism-specific databases

HPAiCAB018649.
HPA017324.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-751454,EBI-2871277
FAPQ128842EBI-751454,EBI-4319803
SGTAO437653EBI-751454,EBI-347996
VIPR1P322412EBI-6656819,EBI-3917984

GO - Molecular functioni

  • hormone activity Source: BHF-UCL
  • neuropeptide hormone activity Source: ProtInc

Protein-protein interaction databases

BioGridi113273. 8 interactors.
IntActiP01282. 8 interactors.
MINTiMINT-1473277.
STRINGi9606.ENSP00000356213.

Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi128 – 152Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RRHNMR-A125-153[»]
2RRINMR-A125-153[»]
ProteinModelPortaliP01282.
SMRiP01282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01282.

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01282.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG091G0KH7.
PhylomeDBiP01282.
TreeFamiTF332804.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTRNKAQLL VLLTLLSVLF SQTSAWPLYR APSALRLGDR IPFEGANEPD
60 70 80 90 100
QVSLKEDIDM LQNALAENDT PYYDVSRNAR HADGVFTSDF SKLLGQLSAK
110 120 130 140 150
KYLESLMGKR VSSNISEDPV PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI
160 170
LNGKRSSEGE SPDFPEELEK
Length:170
Mass (Da):19,169
Last modified:July 21, 1986 - v1
Checksum:i93EC0177F89508FD
GO
Isoform 2 (identifier: P01282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-113: Missing.

Show »
Length:169
Mass (Da):19,082
Checksum:iF325BDFEF47132C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96 – 97QL → PP in AAA61286 (PubMed:3748844).Curated2
Sequence conflicti116S → L in AAA61288 (PubMed:3025882).Curated1
Sequence conflicti136R → G in AAA61288 (PubMed:3025882).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023256113Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00157
, L00154, L00155, L00156 Genomic DNA. Translation: AAA61289.1.
M11553
, M11549, M11550, M11551, M11552 Genomic DNA. Translation: AAA61284.1.
M36634 mRNA. Translation: AAA61287.1.
M14623
, M14619, M14620, M14621, M14622 Genomic DNA. Translation: AAA61288.1.
M33027 Genomic DNA. Translation: AAA69515.1.
AL133356 Genomic DNA. Translation: CAI21764.1.
AL133356 Genomic DNA. Translation: CAI21765.1.
BC009794 mRNA. Translation: AAH09794.1.
M36610
, M36606, M36607, M36608, M36609 Genomic DNA. Translation: AAA61286.1.
M54930 mRNA. Translation: AAA63268.1.
M32162, M31645 Genomic DNA. Translation: AAA61285.1.
CCDSiCCDS5240.1. [P01282-1]
CCDS5241.1. [P01282-2]
PIRiA23296. VRHU.
RefSeqiNP_003372.1. NM_003381.3. [P01282-1]
NP_919416.1. NM_194435.2. [P01282-2]
UniGeneiHs.53973.

Genome annotation databases

EnsembliENST00000367243; ENSP00000356212; ENSG00000146469. [P01282-2]
ENST00000367244; ENSP00000356213; ENSG00000146469. [P01282-1]
GeneIDi7432.
KEGGihsa:7432.
UCSCiuc003qpe.6. human. [P01282-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Vasoactive intestinal peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00157
, L00154, L00155, L00156 Genomic DNA. Translation: AAA61289.1.
M11553
, M11549, M11550, M11551, M11552 Genomic DNA. Translation: AAA61284.1.
M36634 mRNA. Translation: AAA61287.1.
M14623
, M14619, M14620, M14621, M14622 Genomic DNA. Translation: AAA61288.1.
M33027 Genomic DNA. Translation: AAA69515.1.
AL133356 Genomic DNA. Translation: CAI21764.1.
AL133356 Genomic DNA. Translation: CAI21765.1.
BC009794 mRNA. Translation: AAH09794.1.
M36610
, M36606, M36607, M36608, M36609 Genomic DNA. Translation: AAA61286.1.
M54930 mRNA. Translation: AAA63268.1.
M32162, M31645 Genomic DNA. Translation: AAA61285.1.
CCDSiCCDS5240.1. [P01282-1]
CCDS5241.1. [P01282-2]
PIRiA23296. VRHU.
RefSeqiNP_003372.1. NM_003381.3. [P01282-1]
NP_919416.1. NM_194435.2. [P01282-2]
UniGeneiHs.53973.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RRHNMR-A125-153[»]
2RRINMR-A125-153[»]
ProteinModelPortaliP01282.
SMRiP01282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113273. 8 interactors.
IntActiP01282. 8 interactors.
MINTiMINT-1473277.
STRINGi9606.ENSP00000356213.

Chemistry databases

ChEMBLiCHEMBL5737.

PTM databases

iPTMnetiP01282.
PhosphoSitePlusiP01282.

Polymorphism and mutation databases

BioMutaiVIP.
DMDMi138574.

Proteomic databases

PaxDbiP01282.
PeptideAtlasiP01282.
PRIDEiP01282.

Protocols and materials databases

DNASUi7432.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367243; ENSP00000356212; ENSG00000146469. [P01282-2]
ENST00000367244; ENSP00000356213; ENSG00000146469. [P01282-1]
GeneIDi7432.
KEGGihsa:7432.
UCSCiuc003qpe.6. human. [P01282-1]

Organism-specific databases

CTDi7432.
DisGeNETi7432.
GeneCardsiVIP.
HGNCiHGNC:12693. VIP.
HPAiCAB018649.
HPA017324.
MIMi192320. gene.
neXtProtiNX_P01282.
OpenTargetsiENSG00000146469.
PharmGKBiPA37312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW68. Eukaryota.
ENOG4111JKK. LUCA.
GeneTreeiENSGT00530000063592.
HOGENOMiHOG000253943.
HOVERGENiHBG018069.
InParanoidiP01282.
KOiK05264.
OMAiFSHTLAW.
OrthoDBiEOG091G0KH7.
PhylomeDBiP01282.
TreeFamiTF332804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146469-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
SIGNORiP01282.

Miscellaneous databases

EvolutionaryTraceiP01282.
GeneWikiiVasoactive_intestinal_peptide.
GenomeRNAii7432.
PROiP01282.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146469.
CleanExiHS_VIP.
ExpressionAtlasiP01282. baseline and differential.
GenevisibleiP01282. HS.

Family and domain databases

InterProiIPR000532. Glucagon_GIP_secretin_VIP.
IPR015523. VIP.
[Graphical view]
PANTHERiPTHR11213:SF5. PTHR11213:SF5. 1 hit.
PfamiPF00123. Hormone_2. 2 hits.
[Graphical view]
SMARTiSM00070. GLUCA. 2 hits.
[Graphical view]
PROSITEiPS00260. GLUCAGON. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIP_HUMAN
AccessioniPrimary (citable) accession number: P01282
Secondary accession number(s): Q5TCY8, Q5TCY9, Q96QK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.