P01269 (PTHY_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Parathyroid hormone
Short name=PTH

Alternative name(s):
Parathyrin

Gene names

Name:

PTH

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells By similarity.
Subunit structure	Interacts with PTH1R (via N-terminal extracellular domain) By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the parathyroid hormone family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Cleavage on pair of basic residues
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of glucose import Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of glycogen biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of signal transduction Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara peptide hormone receptor binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Ref.2
	Propeptide	26 – 31	6			PRO_0000023253
	Chain	32 – 115	84	Parathyroid hormone		PRO_0000023254
Regions
	Region	51 – 69	19	Important for receptor binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01269 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 9FE8BCDE614BAC16	FASTA	115	12,852
	10 20 30 40 50 60 MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE RVEWLRKKLQ 70 80 90 100 110 DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE ADKAAVDVLI KAKPQ

References

[1]	"Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat." Schmelzer H.-J., Gross G., Widera G., Mayer H. Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence." Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V. Biochemistry 14:3631-3635(1975) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-115.
[3]	"The amino acid sequence of porcine parathyroid hormone." Sauer R.T., Niall H.D., Hogan M.L., Keutmann H.T., O'Riordan J.L.H., Potts J.T. Jr. Biochemistry 13:1994-1999(1974) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 32-115.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X05722 mRNA. Translation: CAA29193.1.
PIR	PTPG. B26806.
RefSeq	NP_999566.1. NM_214401.1.
UniGene	Ssc.668.
3D structure databases
ProteinModelPortal	P01269.
SMR	P01269. Positions 32-70.
ModBase	Search...
Protein-protein interaction databases
STRING	9823.ENSSSCP00000014236.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	399502.
KEGG	ssc:399502.
Organism-specific databases
CTD	5741.
Phylogenomic databases
eggNOG	NOG41709.
HOGENOM	HOG000033707.
HOVERGEN	HBG008319.
KO	K05261.
OrthoDB	EOG4GHZQM.
Family and domain databases
InterPro	IPR003625. PTH. IPR001415. PTH/PTH-rel. [Graphical view]
PANTHER	PTHR10541. PTHR10541. 1 hit.
Pfam	PF01279. Parathyroid. 1 hit. [Graphical view]
PIRSF	PIRSF001832. PTH. 1 hit.
SMART	SM00087. PTH. 1 hit. [Graphical view]
PROSITE	PS00335. PARATHYROID. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTHY_PIG

Accession

Primary (citable) accession number: P01269

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program