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P01269

- PTHY_PIG

UniProt

P01269 - PTHY_PIG

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Protein

Parathyroid hormone

Gene
PTH
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells By similarity.

GO - Molecular functioni

  1. peptide hormone receptor binding Source: UniProtKB
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. positive regulation of bone mineralization Source: Ensembl
  4. positive regulation of cAMP biosynthetic process Source: Ensembl
  5. positive regulation of glucose import Source: UniProtKB
  6. positive regulation of glycogen biosynthetic process Source: UniProtKB
  7. positive regulation of signal transduction Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_221020. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:PTH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Propeptidei26 – 316PRO_0000023253
Chaini32 – 11584Parathyroid hormonePRO_0000023254Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain) By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014236.

Structurei

3D structure databases

ProteinModelPortaliP01269.
SMRiP01269. Positions 32-70.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6919Important for receptor binding By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41709.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
KOiK05261.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541. PTHR10541. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01269-1 [UniParc]FASTAAdd to Basket

« Hide

MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE    50
RVEWLRKKLQ DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE 100
ADKAAVDVLI KAKPQ 115
Length:115
Mass (Da):12,852
Last modified:January 1, 1988 - v1
Checksum:i9FE8BCDE614BAC16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05722 mRNA. Translation: CAA29193.1.
PIRiB26806. PTPG.
RefSeqiNP_999566.1. NM_214401.1.
UniGeneiSsc.668.

Genome annotation databases

GeneIDi399502.
KEGGissc:399502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X05722 mRNA. Translation: CAA29193.1 .
PIRi B26806. PTPG.
RefSeqi NP_999566.1. NM_214401.1.
UniGenei Ssc.668.

3D structure databases

ProteinModelPortali P01269.
SMRi P01269. Positions 32-70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000014236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399502.
KEGGi ssc:399502.

Organism-specific databases

CTDi 5741.

Phylogenomic databases

eggNOGi NOG41709.
HOGENOMi HOG000033707.
HOVERGENi HBG008319.
KOi K05261.

Enzyme and pathway databases

Reactomei REACT_221020. Class B/2 (Secretin family receptors).

Family and domain databases

InterProi IPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view ]
PANTHERi PTHR10541. PTHR10541. 1 hit.
Pfami PF01279. Parathyroid. 1 hit.
[Graphical view ]
PIRSFi PIRSF001832. PTH. 1 hit.
SMARTi SM00087. PTH. 1 hit.
[Graphical view ]
PROSITEi PS00335. PARATHYROID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat."
    Schmelzer H.-J., Gross G., Widera G., Mayer H.
    Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence."
    Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V.
    Biochemistry 14:3631-3635(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-115.
  3. Cited for: PROTEIN SEQUENCE OF 32-115.

Entry informationi

Entry nameiPTHY_PIG
AccessioniPrimary (citable) accession number: P01269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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