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P01269 (PTHY_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathyroid hormone

Short name=PTH
Alternative name(s):
Parathyrin
Gene names
Name:PTH
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells By similarity.

Subunit structure

Interacts with PTH1R (via N-terminal extracellular domain) By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the parathyroid hormone family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.2
Propeptide26 – 316
PRO_0000023253
Chain32 – 11584Parathyroid hormone
PRO_0000023254

Regions

Region51 – 6919Important for receptor binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P01269 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 9FE8BCDE614BAC16

FASTA11512,852
        10         20         30         40         50         60 
MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE RVEWLRKKLQ 

        70         80         90        100        110 
DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE ADKAAVDVLI KAKPQ 

« Hide

References

[1]"Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat."
Schmelzer H.-J., Gross G., Widera G., Mayer H.
Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence."
Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V.
Biochemistry 14:3631-3635(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-115.
[3]"The amino acid sequence of porcine parathyroid hormone."
Sauer R.T., Niall H.D., Hogan M.L., Keutmann H.T., O'Riordan J.L.H., Potts J.T. Jr.
Biochemistry 13:1994-1999(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-115.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05722 mRNA. Translation: CAA29193.1.
PIRPTPG. B26806.
RefSeqNP_999566.1. NM_214401.1.
UniGeneSsc.668.

3D structure databases

ProteinModelPortalP01269.
SMRP01269. Positions 32-70.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000014236.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID399502.
KEGGssc:399502.

Organism-specific databases

CTD5741.

Phylogenomic databases

eggNOGNOG41709.
HOGENOMHOG000033707.
HOVERGENHBG008319.
KOK05261.

Family and domain databases

InterProIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERPTHR10541. PTHR10541. 1 hit.
PfamPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFPIRSF001832. PTH. 1 hit.
SMARTSM00087. PTH. 1 hit.
[Graphical view]
PROSITEPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePTHY_PIG
AccessionPrimary (citable) accession number: P01269
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families