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Protein

Parathyroid hormone

Gene

PTH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-373080. Class B/2 (Secretin family receptors).
R-SSC-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:PTH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Propeptidei26 – 3161 PublicationPRO_0000023253
Chaini32 – 11584Parathyroid hormonePRO_0000023254Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01269.

Expressioni

Gene expression databases

GenevisibleiP01269. SS.

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014236.

Structurei

3D structure databases

ProteinModelPortaliP01269.
SMRiP01269. Positions 32-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6919Important for receptor bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP01269.
KOiK05261.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE
60 70 80 90 100
RVEWLRKKLQ DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE
110
ADKAAVDVLI KAKPQ
Length:115
Mass (Da):12,852
Last modified:January 1, 1988 - v1
Checksum:i9FE8BCDE614BAC16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05722 mRNA. Translation: CAA29193.1.
PIRiB26806. PTPG.
RefSeqiNP_999566.1. NM_214401.1.
UniGeneiSsc.668.

Genome annotation databases

GeneIDi399502.
KEGGissc:399502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05722 mRNA. Translation: CAA29193.1.
PIRiB26806. PTPG.
RefSeqiNP_999566.1. NM_214401.1.
UniGeneiSsc.668.

3D structure databases

ProteinModelPortaliP01269.
SMRiP01269. Positions 32-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014236.

Proteomic databases

PaxDbiP01269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399502.
KEGGissc:399502.

Organism-specific databases

CTDi5741.

Phylogenomic databases

eggNOGiENOG410J02X. Eukaryota.
ENOG410ZH2H. LUCA.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP01269.
KOiK05261.

Enzyme and pathway databases

ReactomeiR-SSC-373080. Class B/2 (Secretin family receptors).
R-SSC-418555. G alpha (s) signalling events.

Gene expression databases

GenevisibleiP01269. SS.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat."
    Schmelzer H.-J., Gross G., Widera G., Mayer H.
    Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence."
    Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V.
    Biochemistry 14:3631-3635(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-115.
  3. Cited for: PROTEIN SEQUENCE OF 32-115.

Entry informationi

Entry nameiPTHY_PIG
AccessioniPrimary (citable) accession number: P01269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.