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P01269

- PTHY_PIG

UniProt

P01269 - PTHY_PIG

Protein

Parathyroid hormone

Gene

PTH

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells By similarity.By similarity

    GO - Molecular functioni

    1. peptide hormone receptor binding Source: UniProtKB
    2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. positive regulation of bone mineralization Source: Ensembl
    4. positive regulation of cAMP biosynthetic process Source: Ensembl
    5. positive regulation of glucose import Source: UniProtKB
    6. positive regulation of glycogen biosynthetic process Source: UniProtKB
    7. positive regulation of signal transduction Source: Ensembl
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_221020. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone
    Short name:
    PTH
    Alternative name(s):
    Parathyrin
    Gene namesi
    Name:PTH
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Propeptidei26 – 3161 PublicationPRO_0000023253
    Chaini32 – 11584Parathyroid hormonePRO_0000023254Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Interactioni

    Subunit structurei

    Interacts with PTH1R (via N-terminal extracellular domain).By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000014236.

    Structurei

    3D structure databases

    ProteinModelPortaliP01269.
    SMRiP01269. Positions 32-70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 6919Important for receptor bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parathyroid hormone family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41709.
    HOGENOMiHOG000033707.
    HOVERGENiHBG008319.
    KOiK05261.

    Family and domain databases

    InterProiIPR003625. PTH.
    IPR001415. PTH/PTH-rel.
    [Graphical view]
    PANTHERiPTHR10541. PTHR10541. 1 hit.
    PfamiPF01279. Parathyroid. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001832. PTH. 1 hit.
    SMARTiSM00087. PTH. 1 hit.
    [Graphical view]
    PROSITEiPS00335. PARATHYROID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01269-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE    50
    RVEWLRKKLQ DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE 100
    ADKAAVDVLI KAKPQ 115
    Length:115
    Mass (Da):12,852
    Last modified:January 1, 1988 - v1
    Checksum:i9FE8BCDE614BAC16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05722 mRNA. Translation: CAA29193.1.
    PIRiB26806. PTPG.
    RefSeqiNP_999566.1. NM_214401.1.
    UniGeneiSsc.668.

    Genome annotation databases

    GeneIDi399502.
    KEGGissc:399502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05722 mRNA. Translation: CAA29193.1 .
    PIRi B26806. PTPG.
    RefSeqi NP_999566.1. NM_214401.1.
    UniGenei Ssc.668.

    3D structure databases

    ProteinModelPortali P01269.
    SMRi P01269. Positions 32-70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000014236.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399502.
    KEGGi ssc:399502.

    Organism-specific databases

    CTDi 5741.

    Phylogenomic databases

    eggNOGi NOG41709.
    HOGENOMi HOG000033707.
    HOVERGENi HBG008319.
    KOi K05261.

    Enzyme and pathway databases

    Reactomei REACT_221020. Class B/2 (Secretin family receptors).

    Family and domain databases

    InterProi IPR003625. PTH.
    IPR001415. PTH/PTH-rel.
    [Graphical view ]
    PANTHERi PTHR10541. PTHR10541. 1 hit.
    Pfami PF01279. Parathyroid. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001832. PTH. 1 hit.
    SMARTi SM00087. PTH. 1 hit.
    [Graphical view ]
    PROSITEi PS00335. PARATHYROID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat."
      Schmelzer H.-J., Gross G., Widera G., Mayer H.
      Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence."
      Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V.
      Biochemistry 14:3631-3635(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-115.
    3. Cited for: PROTEIN SEQUENCE OF 32-115.

    Entry informationi

    Entry nameiPTHY_PIG
    AccessioniPrimary (citable) accession number: P01269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3