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Protein

Parathyroid hormone

Gene

PTH

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_306060. G alpha (s) signalling events.
REACT_314545. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Alternative name(s):
Parathyrin
Gene namesi
Name:PTH
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Propeptidei26 – 3161 PublicationPRO_0000023253
Chaini32 – 11584Parathyroid hormonePRO_0000023254Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Gene expression databases

GenevisibleiP01269. SS.

Interactioni

Subunit structurei

Interacts with PTH1R (via N-terminal extracellular domain).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014236.

Structurei

3D structure databases

ProteinModelPortaliP01269.
SMRiP01269. Positions 32-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6919Important for receptor bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41709.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP01269.
KOiK05261.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSAKDTVKV MVVMLAICFL ARSDGKPIKK RSVSEIQLMH NLGKHLSSLE
60 70 80 90 100
RVEWLRKKLQ DVHNFVALGA SIVHRDGGSQ RPRKKEDNVL VESHQKSLGE
110
ADKAAVDVLI KAKPQ
Length:115
Mass (Da):12,852
Last modified:January 1, 1988 - v1
Checksum:i9FE8BCDE614BAC16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05722 mRNA. Translation: CAA29193.1.
PIRiB26806. PTPG.
RefSeqiNP_999566.1. NM_214401.1.
UniGeneiSsc.668.

Genome annotation databases

GeneIDi399502.
KEGGissc:399502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05722 mRNA. Translation: CAA29193.1.
PIRiB26806. PTPG.
RefSeqiNP_999566.1. NM_214401.1.
UniGeneiSsc.668.

3D structure databases

ProteinModelPortaliP01269.
SMRiP01269. Positions 32-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399502.
KEGGissc:399502.

Organism-specific databases

CTDi5741.

Phylogenomic databases

eggNOGiNOG41709.
HOGENOMiHOG000033707.
HOVERGENiHBG008319.
InParanoidiP01269.
KOiK05261.

Enzyme and pathway databases

ReactomeiREACT_306060. G alpha (s) signalling events.
REACT_314545. Class B/2 (Secretin family receptors).

Gene expression databases

GenevisibleiP01269. SS.

Family and domain databases

InterProiIPR003625. PTH.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR10541:SF2. PTHR10541:SF2. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
PIRSFiPIRSF001832. PTH. 1 hit.
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of a full-length cDNA clone encoding preproparathyroid hormone from pig and rat."
    Schmelzer H.-J., Gross G., Widera G., Mayer H.
    Nucleic Acids Res. 15:6740-6740(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Porcine proparathyroid hormone. Identification, biosynthesis, and partial amino acid sequence."
    Chu L.L.H., Huang W.-Y., Littledike E.T., Hamilton J.W., Cohn D.V.
    Biochemistry 14:3631-3635(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-115.
  3. Cited for: PROTEIN SEQUENCE OF 32-115.

Entry informationi

Entry nameiPTHY_PIG
AccessioniPrimary (citable) accession number: P01269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: June 24, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.