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Protein

Calcitonin-1

Gene
N/A
Organism
Oncorhynchus keta (Chum salmon) (Salmo keta)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

GO - Molecular functioni

  • calcitonin receptor binding Source: UniProtKB

GO - Biological processi

  • activation of adenylate cyclase activity Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  • sperm capacitation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin-1
OrganismiOncorhynchus keta (Chum salmon) (Salmo keta)
Taxonomic identifieri8018 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the names Calcimar (Rhone-Poulenc Rorer), Miacalcin (Novartis) or Forcaltonin (Unigene). Used for the treatment of Paget's disease and hypercalcemia in malignancy.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000000407726 – 80Add BLAST55
PeptideiPRO_000000407883 – 114Calcitonin-1Add BLAST32
PropeptideiPRO_0000004079119 – 136Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 89
Modified residuei114Proline amide1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Interactioni

GO - Molecular functioni

  • calcitonin receptor binding Source: UniProtKB

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi86 – 110Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GLGNMR-A83-114[»]
2GLHNMR-A83-114[»]
ProteinModelPortaliP01263.
SMRiP01263.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01263.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG031362.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMMKLSALL IAYFLVICQM YSSHAAPART GLESMTDQVT LTDYEARRLL
60 70 80 90 100
NAIVKEFVQM TSEELEQQAN EGNSLDRPMS KRCSNLSTCV LGKLSQELHK
110 120 130
LQTYPRTNTG SGTPGKKRSL PESNRYASYG DSYDGI
Length:136
Mass (Da):15,179
Last modified:August 1, 1988 - v1
Checksum:iBDD8867AE113B2A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00765 mRNA. Translation: CAA68734.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00765 mRNA. Translation: CAA68734.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GLGNMR-A83-114[»]
2GLHNMR-A83-114[»]
ProteinModelPortaliP01263.
SMRiP01263.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031362.

Miscellaneous databases

EvolutionaryTraceiP01263.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALC1_ONCKE
AccessioniPrimary (citable) accession number: P01263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Pharmaceutical

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.