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P01263 (CALC1_ONCKE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length136 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Subcellular location

Secreted.

Pharmaceutical use

Available under the names Calcimar (Rhone-Poulenc Rorer), Miacalcin (Novartis) or Forcaltonin (Unigene). Used for the treatment of Paget's disease and hypercalcemia in malignancy.

Sequence similarities

Belongs to the calcitonin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525
Propeptide26 – 8055
PRO_0000004077
Peptide83 – 11432Calcitonin-1
PRO_0000004078
Propeptide119 – 13618
PRO_0000004079

Amino acid modifications

Modified residue1141Proline amide
Disulfide bond83 ↔ 89

Secondary structure

... 136
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01263 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: BDD8867AE113B2A8

FASTA13615,179
        10         20         30         40         50         60 
MVMMKLSALL IAYFLVICQM YSSHAAPART GLESMTDQVT LTDYEARRLL NAIVKEFVQM 

        70         80         90        100        110        120 
TSEELEQQAN EGNSLDRPMS KRCSNLSTCV LGKLSQELHK LQTYPRTNTG SGTPGKKRSL 

       130 
PESNRYASYG DSYDGI 

« Hide

References

[1]"The structure of procalcitonin of the salmon as deduced from its cDNA sequence."
Poeschl E., Lindley I., Hofer E., Seifert J.M., Brunowsky W., Besemer J.
FEBS Lett. 226:96-100(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Amino acid sequence of salmon ultimobranchial calcitonin."
Niall H.D., Keutmann H.T., Copp D.H., Potts J.T. Jr.
Proc. Natl. Acad. Sci. U.S.A. 64:771-778(1969) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 85-116.
[3]"Synthesis of salmon calcitonin, a high activity hypocalcemic hormone."
Guttmann S., Pless J., Huguenin R.L., Sandrin E., Bossert H., Zehnder K.
Helv. Chim. Acta 52:1789-1795(1969) [PubMed] [Europe PMC] [Abstract]
Cited for: SYNTHESIS OF CALCITONIN.
[4]"Two-dimensional NMR and structure determination of salmon calcitonin in methanol."
Meadows R.P., Nikonowicz E.P., Jones C.R., Bastian J.W., Gorenstein D.G.
Biochemistry 30:1247-1254(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF CALCITONIN.
[5]"Solution structure of salmon calcitonin."
Meyer J.-P., Pelton J.T., Hoflack J., Saudek V.
Biopolymers 31:233-241(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF CALCITONIN.
[6]"Solution conformation of salmon calcitonin in sodium dodecyl sulfate micelles as determined by two-dimensional NMR and distance geometry calculations."
Motta A., Pastore A., Goud N.A., Castiglione Morelli M.A.
Biochemistry 30:10444-10450(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF CALCITONIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00765 mRNA. Translation: CAA68734.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLGNMR-A83-114[»]
2GLHNMR-A83-114[»]
ProteinModelPortalP01263.
SMRP01263. Positions 83-114.
ModBaseSearch...
MobiDBSearch...

Chemistry

DrugBankDB00017. Salmon Calcitonin.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031362.

Family and domain databases

InterProIPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERPTHR10505. PTHR10505. 1 hit.
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00270. CALCITONINA.
SMARTSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01263.

Entry information

Entry nameCALC1_ONCKE
AccessionPrimary (citable) accession number: P01263
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references