P01260 (CALC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcitonin

Gene names

Name:	CALCA
Synonyms:	CALC

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	32 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Subcellular location	Secreted.
Sequence similarities	Belongs to the calcitonin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hormone
PTM	Amidation Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	activation of protein kinase activity Inferred from electronic annotation. Source: Compara adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara detection of temperature stimulus involved in sensory perception of pain Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Inferred from electronic annotation. Source: Compara embryo implantation Inferred from electronic annotation. Source: Compara feeding behavior Inferred from electronic annotation. Source: Compara inflammatory response Inferred from electronic annotation. Source: Compara monocyte chemotaxis Inferred from electronic annotation. Source: Compara negative regulation of bone resorption Inferred from electronic annotation. Source: Compara negative regulation of neurological system process Inferred from electronic annotation. Source: Compara negative regulation of ossification Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of adenylate cyclase activity Inferred from electronic annotation. Source: Compara positive regulation of ossification Inferred from electronic annotation. Source: Compara regulation of heart rate Inferred from electronic annotation. Source: Compara response to heat Inferred from electronic annotation. Source: Compara response to pain Inferred from electronic annotation. Source: Compara vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 32	32	Calcitonin		PRO_0000044665
Amino acid modifications
	Modified residue	32	1	Proline amide Ref.1
	Disulfide bond	1 ↔ 7		Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P01260 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: EDEA2A3ADFFE4909	FASTA	32	3,596
	10 20 30 CSNLSTCVLS AYWKDLNNYH RFSGMGFGPE TP

References

[1]	"Amino acid sequence of bovine thyrocalcitonin." Brewer H.B. Jr., Ronan R. Proc. Natl. Acad. Sci. U.S.A. 63:940-947(1969) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00697397.
PIR	TCBO. A38048.
UniGene	Bt.14302.
3D structure databases
ProteinModelPortal	P01260.
ModBase	Search...
Proteomic databases
PRIDE	P01260.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG050784.
Family and domain databases
InterPro	IPR018360. Calcitonin_CS. IPR001693. Calcitonin_peptide-like. IPR021116. Procalcitonin/adrenomedullin. IPR021118. Procalcitonin_A-typ. [Graphical view]
Pfam	PF00214. Calc_CGRP_IAPP. 1 hit. [Graphical view]
PRINTS	PR00270. CALCITONINA.
SMART	SM00113. CALCITONIN. 1 hit. [Graphical view]
PROSITE	PS00258. CALCITONIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CALC_BOVIN

Accession

Primary (citable) accession number: P01260

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program