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P01258 (CALC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcitonin

Cleaved into the following 2 chains:

  1. Calcitonin
  2. Katacalcin
    Alternative name(s):
    Calcitonin carboxyl-terminal peptide
    Short name=CCP
    PDN-21
Gene names
Name:CALCA
Synonyms:CALC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Katacalcin is a potent plasma calcium-lowering peptide.

Subcellular location

Secreted.

Sequence similarities

Belongs to the calcitonin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of protein kinase activity

Inferred from direct assay PubMed 17983652. Source: UniProtKB

adenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

detection of temperature stimulus involved in sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

embryo implantation

Inferred from direct assay PubMed 17983652. Source: UniProtKB

feeding behavior

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

monocyte chemotaxis

Inferred from direct assay PubMed 15248232. Source: BHF-UCL

negative regulation of bone resorption

Inferred from direct assay PubMed 17241109. Source: UniProtKB

negative regulation of neurological system process

Inferred from electronic annotation. Source: Ensembl

negative regulation of ossification

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 11014233. Source: UniProtKB

neuropeptide signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of adenylate cyclase activity

Inferred from direct assay PubMed 11014233PubMed 8078488. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay PubMed 17983652. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from direct assay PubMed 8078488. Source: UniProtKB

positive regulation of ossification

Inferred from electronic annotation. Source: Ensembl

regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

response to heat

Inferred from electronic annotation. Source: Ensembl

response to pain

Inferred from electronic annotation. Source: Ensembl

vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay PubMed 18057382. Source: UniProtKB

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcitonin receptor binding

Inferred from physical interaction PubMed 8078488PubMed 8940110. Source: UniProtKB

identical protein binding

Inferred from physical interaction PubMed 23395606. Source: IntAct

protein binding

Inferred from physical interaction PubMed 17689535. Source: IntAct

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P01258-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P01258-2)

The sequence of this isoform differs from the canonical sequence as follows:
     134-141: VSMPQNAN → NHCPEESL
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 3 (identifier: P06881-1)

The sequence of this isoform can be found in the external entry P06881.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 8257
PRO_0000004050
Peptide85 – 11632Calcitonin Ref.12
PRO_0000004051
Peptide121 – 14121Katacalcin
PRO_0000004052

Amino acid modifications

Modified residue1161Proline amide Ref.12
Disulfide bond85 ↔ 91 Ref.12

Natural variations

Alternative sequence134 – 1418VSMPQNAN → NHCPEESL in isoform 2.
VSP_000709
Natural variant21G → R. Ref.6
Corresponds to variant rs34587547 [ dbSNP | Ensembl ].
VAR_025271
Natural variant571N → D. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.8 Ref.9 Ref.10 Ref.11
Corresponds to variant rs5239 [ dbSNP | Ensembl ].
VAR_014592
Natural variant671E → K. Ref.6
Corresponds to variant rs34164367 [ dbSNP | Ensembl ].
VAR_025272
Natural variant761S → R. Ref.6
Corresponds to variant rs5241 [ dbSNP | Ensembl ].
VAR_014593
Natural variant1231S → T. Ref.6
Corresponds to variant rs34414857 [ dbSNP | Ensembl ].
VAR_025273
Natural variant1381Q → P. Ref.6
Corresponds to variant rs13306224 [ dbSNP | Ensembl ].
VAR_025274

Experimental info

Sequence conflict921M → I in AAA51913. Ref.2

Secondary structure

..... 141
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: C3688905D0EB2502

FASTA14115,466
        10         20         30         40         50         60 
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQNYVQ 

        70         80         90        100        110        120 
MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF NKFHTFPQTA IGVGAPGKKR 

       130        140 
DMSSDLERDH RPHVSMPQNA N 

« Hide

Isoform 2 [UniParc].

Checksum: 1810E64810E31144
Show »

FASTA14115,534
Isoform 3 [UniParc].

See P06881.

References

« Hide 'large scale' references
[1]"The complete sequence of human preprocalcitonin."
le Moullec J.-M., Jullienne A., Chenais J., Lasmoles F., Guliana J.M., Milhaud G., Moukhtar M.S.
FEBS Lett. 167:93-97(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-57.
[2]"Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression."
Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.
Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-57.
[3]"Expression and function of the human calcitonin/alpha-CGRP gene in health and disease."
Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.
Biochem. Soc. Symp. 52:91-105(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-57.
[4]"Ectopic synthesis of high-Mr calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing."
Riley J.H., Edbrooke M.R., Craig R.K.
FEBS Lett. 198:71-79(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-57.
[5]"A novel calcitonin carboxyl-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene."
Minvielle S., Giscard-Dartevelle S., Cohen R., Taboulet J., Labye F., Jullienne A., Rivaille P., Milhaud G., Moukhtar M.S., Lasmoles F.
J. Biol. Chem. 266:24627-24631(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ASP-57.
Tissue: Thyroid carcinoma.
[6]NIEHS SNPs program
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-2; ASP-57; LYS-67; ARG-76; THR-123 AND PRO-138.
[7]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-57.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-57.
Tissue: Placenta.
[10]"Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide."
Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.
Biochem. Biophys. Res. Commun. 123:648-655(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-83 (ISOFORM 1), VARIANT ASP-57.
[11]"Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma."
Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.
EMBO J. 4:715-724(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-141 (ISOFORM 1), VARIANT ASP-57.
[12]"Human calcitonin. Structure of calcitonin M and D."
Neher R., Riniker B., Rittel W., Zuber H.
Helv. Chim. Acta 51:1900-1905(1968) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 85-116, AMIDATION AT PRO-116.
[13]"A 1H NMR study of human calcitonin in solution."
Motta A., Temussi P.A., Wunsch E., Bovermann G.
Biochemistry 30:2364-2371(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF CALCITONIN.
[14]"Katacalcin: a new plasma calcium-lowering hormone."
Hillyard C.J., Myers C., Abeyasekera G., Stevvensvenson J.C., Craig R.K., MacIntyre I.
Lancet 1:846-848(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF KATACALCIN.
[15]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+Additional computationally mapped references.

Web resources

NIEHS-SNPs
Wikipedia

Calcitonin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00356 mRNA. Translation: CAA25103.1.
M12666, M12664, M12665 Genomic DNA. Translation: AAA51913.1.
M26095 mRNA. Translation: AAA35501.1.
X03662 mRNA. Translation: CAA27299.1.
M64486 mRNA. Translation: AAA58403.1.
DQ080435 Genomic DNA. Translation: AAY68212.1.
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68468.1.
BC069684 mRNA. Translation: AAH69684.1.
BC069704 mRNA. Translation: AAH69704.1.
BC069760 mRNA. Translation: AAH69760.1.
BC069778 mRNA. Translation: AAH69778.1.
BC093753 mRNA. Translation: AAH93753.1.
BC101599 mRNA. Translation: AAI01600.1.
BC143562 mRNA. Translation: AAI43563.1.
K03513 mRNA. Translation: AAA52124.1.
X02330 mRNA. Translation: CAA26189.1.
CCDSCCDS7819.1. [P01258-1]
PIRA41716.
TCHU. S07643.
RefSeqNP_001029124.1. NM_001033952.2.
NP_001732.1. NM_001741.2.
UniGeneHs.37058.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JXZNMR-A85-116[»]
ProteinModelPortalP01258.
SMRP01258. Positions 85-116.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107247. 4 interactions.
IntActP01258. 3 interactions.
MINTMINT-2799962.
STRING9606.ENSP00000331746.

Polymorphism databases

DMDM322510018.

Proteomic databases

MaxQBP01258.
PRIDEP01258.

Protocols and materials databases

DNASU796.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331587; ENSP00000331746; ENSG00000110680. [P01258-1]
ENST00000359642; ENSP00000352663; ENSG00000110680. [P01258-2]
ENST00000396372; ENSP00000379657; ENSG00000110680. [P01258-1]
ENST00000469608; ENSP00000420618; ENSG00000110680. [P01258-2]
ENST00000570903; ENSP00000460716; ENSG00000262933.
ENST00000571711; ENSP00000459971; ENSG00000262933.
ENST00000574146; ENSP00000459562; ENSG00000262933.
GeneID796.
KEGGhsa:796.
UCSCuc001mlv.1. human. [P01258-1]

Organism-specific databases

CTD796.
GeneCardsGC11M014945.
HGNCHGNC:1437. CALCA.
MIM114130. gene.
neXtProtNX_P01258.
PharmGKBPA26029.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000038203.
HOVERGENHBG031362.
KOK12332.
OMATENEHEL.
PhylomeDBP01258.
TreeFamTF333069.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

ArrayExpressP01258.
BgeeP01258.
CleanExHS_CALCA.
GenevestigatorP01258.

Family and domain databases

InterProIPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERPTHR10505. PTHR10505. 1 hit.
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00270. CALCITONINA.
SMARTSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01258.
GeneWikiCalcitonin.
GenomeRNAi796.
NextBio3234.
PROP01258.
SOURCESearch...

Entry information

Entry nameCALC_HUMAN
AccessionPrimary (citable) accession number: P01258
Secondary accession number(s): B7ZL39 expand/collapse secondary AC list , Q13935, Q13937, Q52LX7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM