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Protein

Calcitonin

Gene

CALCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.

GO - Molecular functioni

  • calcitonin receptor binding Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-419812. Calcitonin-like ligand receptors.
R-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Cleaved into the following 2 chains:
Alternative name(s):
Calcitonin carboxyl-terminal peptide
Short name:
CCP
PDN-21
Gene namesi
Name:CALCA
Synonyms:CALC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1437. CALCA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • nucleus Source: Ensembl
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi796.
PharmGKBiPA26029.

Polymorphism and mutation databases

BioMutaiCYP2R1.
DMDMi322510018.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000405026 – 82Add BLAST57
PeptideiPRO_000000405185 – 116Calcitonin1 PublicationAdd BLAST32
PeptideiPRO_0000004052121 – 141KatacalcinAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Disulfide bondi85 ↔ 911 Publication
Modified residuei116Proline amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01258.
PeptideAtlasiP01258.
PRIDEiP01258.

PTM databases

iPTMnetiP01258.
PhosphoSitePlusiP01258.

Expressioni

Gene expression databases

BgeeiENSG00000110680.
CleanExiHS_CALCA.
ExpressionAtlasiP01258. baseline and differential.
GenevisibleiP01258. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1018474,EBI-1018474
ATP2B2Q018142EBI-1018474,EBI-1174243
ATP2B4P236342EBI-1018474,EBI-1174388

GO - Molecular functioni

  • calcitonin receptor binding Source: UniProtKB
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi107247. 4 interactors.
IntActiP01258. 3 interactors.
MINTiMINT-2799962.
STRINGi9606.ENSP00000331746.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi88 – 105Combined sources18
Helixi109 – 111Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JXZNMR-A85-116[»]
ProteinModelPortaliP01258.
SMRiP01258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01258.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP01258.
KOiK12332.
OrthoDBiEOG091G0RF5.
PhylomeDBiP01258.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01258-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL
60 70 80 90 100
LAALVQNYVQ MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF
110 120 130 140
NKFHTFPQTA IGVGAPGKKR DMSSDLERDH RPHVSMPQNA N
Length:141
Mass (Da):15,466
Last modified:February 8, 2011 - v2
Checksum:iC3688905D0EB2502
GO
Isoform 2 (identifier: P01258-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-141: VSMPQNAN → NHCPEESL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:141
Mass (Da):15,534
Checksum:i1810E64810E31144
GO
Isoform 3 (identifier: P06881-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P06881.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,898
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92M → I in AAA51913 (PubMed:3872459).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0252712G → R.1 PublicationCorresponds to variant rs34587547dbSNPEnsembl.1
Natural variantiVAR_01459257N → D.10 PublicationsCorresponds to variant rs5239dbSNPEnsembl.1
Natural variantiVAR_02527267E → K.1 PublicationCorresponds to variant rs34164367dbSNPEnsembl.1
Natural variantiVAR_01459376S → R.1 PublicationCorresponds to variant rs5241dbSNPEnsembl.1
Natural variantiVAR_025273123S → T.1 PublicationCorresponds to variant rs34414857dbSNPEnsembl.1
Natural variantiVAR_025274138Q → P.1 PublicationCorresponds to variant rs13306224dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000709134 – 141VSMPQNAN → NHCPEESL in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00356 mRNA. Translation: CAA25103.1.
M12666, M12664, M12665 Genomic DNA. Translation: AAA51913.1.
M26095 mRNA. Translation: AAA35501.1.
X03662 mRNA. Translation: CAA27299.1.
M64486 mRNA. Translation: AAA58403.1.
DQ080435 Genomic DNA. Translation: AAY68212.1.
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68468.1.
BC069684 mRNA. Translation: AAH69684.1.
BC069704 mRNA. Translation: AAH69704.1.
BC069760 mRNA. Translation: AAH69760.1.
BC069778 mRNA. Translation: AAH69778.1.
BC093753 mRNA. Translation: AAH93753.1.
BC101599 mRNA. Translation: AAI01600.1.
BC143562 mRNA. Translation: AAI43563.1.
K03513 mRNA. Translation: AAA52124.1.
X02330 mRNA. Translation: CAA26189.1.
CCDSiCCDS7819.1. [P01258-1]
PIRiA41716.
S07643. TCHU.
RefSeqiNP_001029124.1. NM_001033952.2.
NP_001732.1. NM_001741.2.
XP_016873772.1. XM_017018283.1.
XP_016873773.1. XM_017018284.1.
UniGeneiHs.37058.

Genome annotation databases

EnsembliENST00000331587; ENSP00000331746; ENSG00000110680.
ENST00000396372; ENSP00000379657; ENSG00000110680.
ENST00000469608; ENSP00000420618; ENSG00000110680.
GeneIDi796.
KEGGihsa:796.
UCSCiuc001mlv.2. human. [P01258-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Calcitonin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00356 mRNA. Translation: CAA25103.1.
M12666, M12664, M12665 Genomic DNA. Translation: AAA51913.1.
M26095 mRNA. Translation: AAA35501.1.
X03662 mRNA. Translation: CAA27299.1.
M64486 mRNA. Translation: AAA58403.1.
DQ080435 Genomic DNA. Translation: AAY68212.1.
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68468.1.
BC069684 mRNA. Translation: AAH69684.1.
BC069704 mRNA. Translation: AAH69704.1.
BC069760 mRNA. Translation: AAH69760.1.
BC069778 mRNA. Translation: AAH69778.1.
BC093753 mRNA. Translation: AAH93753.1.
BC101599 mRNA. Translation: AAI01600.1.
BC143562 mRNA. Translation: AAI43563.1.
K03513 mRNA. Translation: AAA52124.1.
X02330 mRNA. Translation: CAA26189.1.
CCDSiCCDS7819.1. [P01258-1]
PIRiA41716.
S07643. TCHU.
RefSeqiNP_001029124.1. NM_001033952.2.
NP_001732.1. NM_001741.2.
XP_016873772.1. XM_017018283.1.
XP_016873773.1. XM_017018284.1.
UniGeneiHs.37058.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JXZNMR-A85-116[»]
ProteinModelPortaliP01258.
SMRiP01258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107247. 4 interactors.
IntActiP01258. 3 interactors.
MINTiMINT-2799962.
STRINGi9606.ENSP00000331746.

PTM databases

iPTMnetiP01258.
PhosphoSitePlusiP01258.

Polymorphism and mutation databases

BioMutaiCYP2R1.
DMDMi322510018.

Proteomic databases

PaxDbiP01258.
PeptideAtlasiP01258.
PRIDEiP01258.

Protocols and materials databases

DNASUi796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331587; ENSP00000331746; ENSG00000110680.
ENST00000396372; ENSP00000379657; ENSG00000110680.
ENST00000469608; ENSP00000420618; ENSG00000110680.
GeneIDi796.
KEGGihsa:796.
UCSCiuc001mlv.2. human. [P01258-1]

Organism-specific databases

CTDi796.
DisGeNETi796.
GeneCardsiCALCA.
HGNCiHGNC:1437. CALCA.
MIMi114130. gene.
neXtProtiNX_P01258.
PharmGKBiPA26029.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP01258.
KOiK12332.
OrthoDBiEOG091G0RF5.
PhylomeDBiP01258.
TreeFamiTF333069.

Enzyme and pathway databases

ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-419812. Calcitonin-like ligand receptors.
R-HSA-977225. Amyloid fiber formation.

Miscellaneous databases

EvolutionaryTraceiP01258.
GeneWikiiCalcitonin.
GenomeRNAii796.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110680.
CleanExiHS_CALCA.
ExpressionAtlasiP01258. baseline and differential.
GenevisibleiP01258. HS.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALC_HUMAN
AccessioniPrimary (citable) accession number: P01258
Secondary accession number(s): B7ZL39
, Q13935, Q13937, Q52LX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.