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P01258

- CALC_HUMAN

UniProt

P01258 - CALC_HUMAN

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Protein
Calcitonin
Gene
CALCA, CALC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.

GO - Molecular functioni

  1. calcitonin receptor binding Source: UniProtKB
  2. identical protein binding Source: IntAct
  3. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. activation of protein kinase activity Source: UniProtKB
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  3. aging Source: Ensembl
  4. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
  5. embryo implantation Source: UniProtKB
  6. feeding behavior Source: Ensembl
  7. inflammatory response Source: Ensembl
  8. monocyte chemotaxis Source: BHF-UCL
  9. negative regulation of bone resorption Source: UniProtKB
  10. negative regulation of neurological system process Source: Ensembl
  11. negative regulation of ossification Source: Ensembl
  12. negative regulation of smooth muscle contraction Source: Ensembl
  13. negative regulation of transcription, DNA-templated Source: UniProtKB
  14. neuropeptide signaling pathway Source: Ensembl
  15. positive regulation of adenylate cyclase activity Source: UniProtKB
  16. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  17. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  18. positive regulation of ossification Source: Ensembl
  19. regulation of heart rate Source: Ensembl
  20. regulation of inflammatory response Source: Ensembl
  21. response to heat Source: Ensembl
  22. response to pain Source: Ensembl
  23. vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.
REACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Cleaved into the following 2 chains:
Alternative name(s):
Calcitonin carboxyl-terminal peptide
Short name:
CCP
PDN-21
Gene namesi
Name:CALCA
Synonyms:CALC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1437. CALCA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB
  4. neuronal cell body Source: Ensembl
  5. nucleus Source: Ensembl
  6. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 8257
PRO_0000004050Add
BLAST
Peptidei85 – 11632Calcitonin1 Publication
PRO_0000004051Add
BLAST
Peptidei121 – 14121Katacalcin
PRO_0000004052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 911 Publication
Modified residuei116 – 1161Proline amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiP01258.
PRIDEiP01258.

Expressioni

Gene expression databases

ArrayExpressiP01258.
BgeeiP01258.
CleanExiHS_CALCA.
GenevestigatoriP01258.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1018474,EBI-1018474
ATP2B2Q018142EBI-1018474,EBI-1174243
ATP2B4P236342EBI-1018474,EBI-1174388

Protein-protein interaction databases

BioGridi107247. 4 interactions.
IntActiP01258. 3 interactions.
MINTiMINT-2799962.
STRINGi9606.ENSP00000331746.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi88 – 10518
Helixi109 – 1113

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JXZNMR-A85-116[»]
ProteinModelPortaliP01258.
SMRiP01258. Positions 85-116.

Miscellaneous databases

EvolutionaryTraceiP01258.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000038203.
HOVERGENiHBG031362.
KOiK12332.
OMAiTENEHEL.
PhylomeDBiP01258.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P01258-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL    50
LAALVQNYVQ MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF 100
NKFHTFPQTA IGVGAPGKKR DMSSDLERDH RPHVSMPQNA N 141
Length:141
Mass (Da):15,466
Last modified:February 8, 2011 - v2
Checksum:iC3688905D0EB2502
GO
Isoform 2 (identifier: P01258-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-141: VSMPQNAN → NHCPEESL

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:141
Mass (Da):15,534
Checksum:i1810E64810E31144
GO
Isoform 3 (identifier: P06881-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P06881.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,898
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21G → R.1 Publication
Corresponds to variant rs34587547 [ dbSNP | Ensembl ].
VAR_025271
Natural varianti57 – 571N → D.10 Publications
Corresponds to variant rs5239 [ dbSNP | Ensembl ].
VAR_014592
Natural varianti67 – 671E → K.1 Publication
Corresponds to variant rs34164367 [ dbSNP | Ensembl ].
VAR_025272
Natural varianti76 – 761S → R.1 Publication
Corresponds to variant rs5241 [ dbSNP | Ensembl ].
VAR_014593
Natural varianti123 – 1231S → T.1 Publication
Corresponds to variant rs34414857 [ dbSNP | Ensembl ].
VAR_025273
Natural varianti138 – 1381Q → P.1 Publication
Corresponds to variant rs13306224 [ dbSNP | Ensembl ].
VAR_025274

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei134 – 1418VSMPQNAN → NHCPEESL in isoform 2.
VSP_000709

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921M → I in AAA51913. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00356 mRNA. Translation: CAA25103.1.
M12666, M12664, M12665 Genomic DNA. Translation: AAA51913.1.
M26095 mRNA. Translation: AAA35501.1.
X03662 mRNA. Translation: CAA27299.1.
M64486 mRNA. Translation: AAA58403.1.
DQ080435 Genomic DNA. Translation: AAY68212.1.
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68468.1.
BC069684 mRNA. Translation: AAH69684.1.
BC069704 mRNA. Translation: AAH69704.1.
BC069760 mRNA. Translation: AAH69760.1.
BC069778 mRNA. Translation: AAH69778.1.
BC093753 mRNA. Translation: AAH93753.1.
BC101599 mRNA. Translation: AAI01600.1.
BC143562 mRNA. Translation: AAI43563.1.
K03513 mRNA. Translation: AAA52124.1.
X02330 mRNA. Translation: CAA26189.1.
CCDSiCCDS7819.1. [P01258-1]
PIRiA41716.
S07643. TCHU.
RefSeqiNP_001029124.1. NM_001033952.2.
NP_001732.1. NM_001741.2.
UniGeneiHs.37058.

Genome annotation databases

EnsembliENST00000331587; ENSP00000331746; ENSG00000110680. [P01258-1]
ENST00000359642; ENSP00000352663; ENSG00000110680. [P01258-2]
ENST00000396372; ENSP00000379657; ENSG00000110680. [P01258-1]
ENST00000469608; ENSP00000420618; ENSG00000110680. [P01258-2]
ENST00000570903; ENSP00000460716; ENSG00000262933.
ENST00000571711; ENSP00000459971; ENSG00000262933.
ENST00000574146; ENSP00000459562; ENSG00000262933.
GeneIDi796.
KEGGihsa:796.
UCSCiuc001mlv.1. human. [P01258-1]

Polymorphism databases

DMDMi322510018.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Calcitonin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00356 mRNA. Translation: CAA25103.1 .
M12666 , M12664 , M12665 Genomic DNA. Translation: AAA51913.1 .
M26095 mRNA. Translation: AAA35501.1 .
X03662 mRNA. Translation: CAA27299.1 .
M64486 mRNA. Translation: AAA58403.1 .
DQ080435 Genomic DNA. Translation: AAY68212.1 .
AC090835 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68468.1 .
BC069684 mRNA. Translation: AAH69684.1 .
BC069704 mRNA. Translation: AAH69704.1 .
BC069760 mRNA. Translation: AAH69760.1 .
BC069778 mRNA. Translation: AAH69778.1 .
BC093753 mRNA. Translation: AAH93753.1 .
BC101599 mRNA. Translation: AAI01600.1 .
BC143562 mRNA. Translation: AAI43563.1 .
K03513 mRNA. Translation: AAA52124.1 .
X02330 mRNA. Translation: CAA26189.1 .
CCDSi CCDS7819.1. [P01258-1 ]
PIRi A41716.
S07643. TCHU.
RefSeqi NP_001029124.1. NM_001033952.2.
NP_001732.1. NM_001741.2.
UniGenei Hs.37058.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JXZ NMR - A 85-116 [» ]
ProteinModelPortali P01258.
SMRi P01258. Positions 85-116.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107247. 4 interactions.
IntActi P01258. 3 interactions.
MINTi MINT-2799962.
STRINGi 9606.ENSP00000331746.

Polymorphism databases

DMDMi 322510018.

Proteomic databases

MaxQBi P01258.
PRIDEi P01258.

Protocols and materials databases

DNASUi 796.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331587 ; ENSP00000331746 ; ENSG00000110680 . [P01258-1 ]
ENST00000359642 ; ENSP00000352663 ; ENSG00000110680 . [P01258-2 ]
ENST00000396372 ; ENSP00000379657 ; ENSG00000110680 . [P01258-1 ]
ENST00000469608 ; ENSP00000420618 ; ENSG00000110680 . [P01258-2 ]
ENST00000570903 ; ENSP00000460716 ; ENSG00000262933 .
ENST00000571711 ; ENSP00000459971 ; ENSG00000262933 .
ENST00000574146 ; ENSP00000459562 ; ENSG00000262933 .
GeneIDi 796.
KEGGi hsa:796.
UCSCi uc001mlv.1. human. [P01258-1 ]

Organism-specific databases

CTDi 796.
GeneCardsi GC11M014945.
HGNCi HGNC:1437. CALCA.
MIMi 114130. gene.
neXtProti NX_P01258.
PharmGKBi PA26029.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000038203.
HOVERGENi HBG031362.
KOi K12332.
OMAi TENEHEL.
PhylomeDBi P01258.
TreeFami TF333069.

Enzyme and pathway databases

Reactomei REACT_18290. Calcitonin-like ligand receptors.
REACT_19327. G alpha (s) signalling events.
REACT_75925. Amyloids.

Miscellaneous databases

EvolutionaryTracei P01258.
GeneWikii Calcitonin.
GenomeRNAii 796.
NextBioi 3234.
PROi P01258.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01258.
Bgeei P01258.
CleanExi HS_CALCA.
Genevestigatori P01258.

Family and domain databases

InterProi IPR021118. Calcitonin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view ]
PANTHERi PTHR10505. PTHR10505. 1 hit.
Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view ]
PRINTSi PR00270. CALCITONINA.
SMARTi SM00113. CALCITONIN. 1 hit.
[Graphical view ]
PROSITEi PS00258. CALCITONIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-57.
  2. "Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression."
    Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.
    Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-57.
  3. "Expression and function of the human calcitonin/alpha-CGRP gene in health and disease."
    Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.
    Biochem. Soc. Symp. 52:91-105(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-57.
  4. "Ectopic synthesis of high-Mr calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing."
    Riley J.H., Edbrooke M.R., Craig R.K.
    FEBS Lett. 198:71-79(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-57.
  5. "A novel calcitonin carboxyl-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene."
    Minvielle S., Giscard-Dartevelle S., Cohen R., Taboulet J., Labye F., Jullienne A., Rivaille P., Milhaud G., Moukhtar M.S., Lasmoles F.
    J. Biol. Chem. 266:24627-24631(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ASP-57.
    Tissue: Thyroid carcinoma.
  6. NIEHS SNPs program
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-2; ASP-57; LYS-67; ARG-76; THR-123 AND PRO-138.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-57.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-57.
    Tissue: Placenta.
  10. "Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide."
    Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.
    Biochem. Biophys. Res. Commun. 123:648-655(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 48-83 (ISOFORM 1), VARIANT ASP-57.
  11. "Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma."
    Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.
    EMBO J. 4:715-724(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-141 (ISOFORM 1), VARIANT ASP-57.
  12. "Human calcitonin. Structure of calcitonin M and D."
    Neher R., Riniker B., Rittel W., Zuber H.
    Helv. Chim. Acta 51:1900-1905(1968) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 85-116, AMIDATION AT PRO-116.
  13. "A 1H NMR study of human calcitonin in solution."
    Motta A., Temussi P.A., Wunsch E., Bovermann G.
    Biochemistry 30:2364-2371(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF CALCITONIN.
  14. Cited for: CHARACTERIZATION OF KATACALCIN.
  15. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Entry informationi

Entry nameiCALC_HUMAN
AccessioniPrimary (citable) accession number: P01258
Secondary accession number(s): B7ZL39
, Q13935, Q13937, Q52LX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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