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Protein

Calcitonin

Gene

Calca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

GO - Molecular functioni

  • calcitonin receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2254. Calca.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • cytosol Source: Ensembl
  • extracellular space Source: MGI
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
  • terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Propeptidei26 – 8257PRO_0000004062Add
BLAST
Peptidei85 – 11632CalcitoninPRO_0000004063Add
BLAST
Propeptidei121 – 13616PRO_0000004064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineCombined sources
Disulfide bondi85 ↔ 911 Publication
Glycosylationi87 – 871N-linked (GlcNAc...)Curated
Modified residuei116 – 1161Proline amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01257.
PRIDEiP01257.

PTM databases

iPTMnetiP01257.
PhosphoSiteiP01257.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011130.
ExpressionAtlasiP01257. baseline and differential.
GenevisibleiP01257. RN.

Interactioni

GO - Molecular functioni

  • calcitonin receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014948.

Structurei

3D structure databases

ProteinModelPortaliP01257.
SMRiP01257. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP01257.
OrthoDBiEOG091G0RF5.
PhylomeDBiP01257.
TreeFamiTF333069.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin (identifier: P01257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAT LSEEEARLLA
60 70 80 90 100
ALVQNYMQMK VRELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL
110 120 130
NKFHTFPQTS IGVGAPGKKR DMAKDLETNH HPYFGN
Length:136
Mass (Da):15,103
Last modified:November 1, 1988 - v1
Checksum:iA197358A802222F7
GO
Isoform Calcitonin-gene related peptide I (identifier: P01256-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01256.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,948
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01230 mRNA. Translation: CAA24540.1.
V01228 mRNA. Translation: CAA24538.1.
V01229 mRNA. Translation: CAA24539.1.
M26137 mRNA. Translation: AAA40849.1.
M31027, L00109, L00110 Genomic DNA. Translation: AAB59681.1.
PIRiA94259. TCRT.
RefSeqiNP_059034.1. NM_017338.2. [P01257-1]
XP_008757898.1. XM_008759676.1. [P01257-1]
UniGeneiRn.90085.

Genome annotation databases

EnsembliENSRNOT00000014948; ENSRNOP00000014948; ENSRNOG00000011130. [P01257-1]
GeneIDi24241.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01230 mRNA. Translation: CAA24540.1.
V01228 mRNA. Translation: CAA24538.1.
V01229 mRNA. Translation: CAA24539.1.
M26137 mRNA. Translation: AAA40849.1.
M31027, L00109, L00110 Genomic DNA. Translation: AAB59681.1.
PIRiA94259. TCRT.
RefSeqiNP_059034.1. NM_017338.2. [P01257-1]
XP_008757898.1. XM_008759676.1. [P01257-1]
UniGeneiRn.90085.

3D structure databases

ProteinModelPortaliP01257.
SMRiP01257. Positions 85-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014948.

PTM databases

iPTMnetiP01257.
PhosphoSiteiP01257.

Proteomic databases

PaxDbiP01257.
PRIDEiP01257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014948; ENSRNOP00000014948; ENSRNOG00000011130. [P01257-1]
GeneIDi24241.

Organism-specific databases

CTDi796.
RGDi2254. Calca.

Phylogenomic databases

eggNOGiENOG410IX7S. Eukaryota.
ENOG4111KS6. LUCA.
GeneTreeiENSGT00390000010511.
HOGENOMiHOG000038203.
HOVERGENiHBG031362.
InParanoidiP01257.
OrthoDBiEOG091G0RF5.
PhylomeDBiP01257.
TreeFamiTF333069.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Gene expression databases

BgeeiENSRNOG00000011130.
ExpressionAtlasiP01257. baseline and differential.
GenevisibleiP01257. RN.

Family and domain databases

InterProiIPR021118. Calcitonin.
IPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00270. CALCITONINA.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALC_RAT
AccessioniPrimary (citable) accession number: P01257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.