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Protein

Calcitonin

Gene

Calca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events
R-RNO-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2254 Calca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000000406226 – 82Add BLAST57
PeptideiPRO_000000406385 – 116CalcitoninAdd BLAST32
PropeptideiPRO_0000004064121 – 136Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Disulfide bondi85 ↔ 911 Publication
Glycosylationi87N-linked (GlcNAc...) asparagineCurated1
Modified residuei116Proline amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01257
PRIDEiP01257

PTM databases

iPTMnetiP01257
PhosphoSitePlusiP01257

Expressioni

Gene expression databases

BgeeiENSRNOG00000011130
ExpressionAtlasiP01257 baseline and differential
GenevisibleiP01257 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014948

Structurei

3D structure databases

ProteinModelPortaliP01257
SMRiP01257
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX7S Eukaryota
ENOG4111KS6 LUCA
GeneTreeiENSGT00390000010511
HOGENOMiHOG000038203
HOVERGENiHBG031362
InParanoidiP01257
OrthoDBiEOG091G0RF5
PhylomeDBiP01257
TreeFamiTF333069

Family and domain databases

InterProiView protein in InterPro
IPR021118 Calcitonin
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00270 CALCITONINA
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin (identifier: P01257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAT LSEEEARLLA
60 70 80 90 100
ALVQNYMQMK VRELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL
110 120 130
NKFHTFPQTS IGVGAPGKKR DMAKDLETNH HPYFGN
Length:136
Mass (Da):15,103
Last modified:November 1, 1988 - v1
Checksum:iA197358A802222F7
GO
Isoform Calcitonin-gene related peptide I (identifier: P01256-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01256.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:128
Mass (Da):13,948
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01230 mRNA Translation: CAA24540.1
V01228 mRNA Translation: CAA24538.1
V01229 mRNA Translation: CAA24539.1
M26137 mRNA Translation: AAA40849.1
M31027, L00109, L00110 Genomic DNA Translation: AAB59681.1
PIRiA94259 TCRT
RefSeqiNP_059034.1, NM_017338.2 [P01257-1]
XP_008757898.1, XM_008759676.2 [P01257-1]
UniGeneiRn.90085

Genome annotation databases

EnsembliENSRNOT00000014948; ENSRNOP00000014948; ENSRNOG00000011130 [P01257-1]
GeneIDi24241

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALC_RAT
AccessioniPrimary (citable) accession number: P01257
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health