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Protein

Calcitonin gene-related peptide 1

Gene

Calca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

GO - Molecular functioni

  • calcitonin receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • inflammatory response Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of smooth muscle contraction Source: RGD
  • regulation of heart contraction Source: RGD
  • vasodilation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name:
CGRP-I
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2254. Calca.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5735.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000000406526 – 80Add BLAST55
PeptideiPRO_000000406683 – 119Calcitonin gene-related peptide 1Add BLAST37
PropeptideiPRO_0000004067125 – 1284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 89By similarity
Modified residuei119Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Gene expression databases

BgeeiENSRNOG00000011130.

Interactioni

GO - Molecular functioni

  • calcitonin receptor binding Source: RGD
  • neuropeptide hormone activity Source: RGD

Protein-protein interaction databases

MINTiMINT-1504942.

Chemistry databases

BindingDBiP01256.

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG031362.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin-gene related peptide I (identifier: P01256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAA TLSEEEARLL
60 70 80 90 100
LAALVQNYMQ MKVRELEQEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR
110 120
SGGVVKDNFV PTNVGSEAFG RRRRDLQA
Length:128
Mass (Da):13,948
Last modified:April 1, 1988 - v1
Checksum:i75D14869C17078D3
GO
Isoform Calcitonin (identifier: P01257-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01257.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:136
Mass (Da):15,103
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40Missing in AAB59682 (PubMed:6283379).Curated1
Sequence conflicti40Missing in CAA24541 (PubMed:6283379).Curated1
Sequence conflicti40Missing in AAA40847 (PubMed:2994212).Curated1
Sequence conflicti51Missing in AAB59682 (PubMed:6283379).Curated1
Sequence conflicti51Missing in CAA24541 (PubMed:6283379).Curated1
Sequence conflicti51Missing in AAA40847 (PubMed:2994212).Curated1
Sequence conflicti70Q → EEQ in AAB59682 (PubMed:6283379).Curated1
Sequence conflicti70Q → EEQ in CAA24541 (PubMed:6283379).Curated1
Sequence conflicti70Q → EEQ in AAA40847 (PubMed:2994212).Curated1
Sequence conflicti99S → R in AAA40847 (PubMed:2994212).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29188, L00109, L00110 Genomic DNA. Translation: AAB59682.1.
V01231 mRNA. Translation: CAA24541.1.
M11597 mRNA. Translation: AAA40847.1.
PIRiA01524. TCRTR.
B44173.
RefSeqiNP_001029127.1. NM_001033955.1.
NP_001029128.1. NM_001033956.1.
UniGeneiRn.90085.

Genome annotation databases

GeneIDi24241.
KEGGirno:24241.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29188, L00109, L00110 Genomic DNA. Translation: AAB59682.1.
V01231 mRNA. Translation: CAA24541.1.
M11597 mRNA. Translation: AAA40847.1.
PIRiA01524. TCRTR.
B44173.
RefSeqiNP_001029127.1. NM_001033955.1.
NP_001029128.1. NM_001033956.1.
UniGeneiRn.90085.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1504942.

Chemistry databases

BindingDBiP01256.
ChEMBLiCHEMBL5735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24241.
KEGGirno:24241.

Organism-specific databases

CTDi796.
RGDi2254. Calca.

Phylogenomic databases

HOVERGENiHBG031362.

Gene expression databases

BgeeiENSRNOG00000011130.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALCA_RAT
AccessioniPrimary (citable) accession number: P01256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.