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Protein

Calcitonin gene-related peptide 1

Gene

Calca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name:
CGRP-I
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2254 Calca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5735

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000000406526 – 80Add BLAST55
PeptideiPRO_000000406683 – 119Calcitonin gene-related peptide 1Add BLAST37
PropeptideiPRO_0000004067125 – 1284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 89By similarity
Modified residuei119Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Interactioni

GO - Molecular functioni

Chemistry databases

BindingDBiP01256

Structurei

3D structure databases

SMRiP01256
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG031362

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR015476 Calcitonin_gene-rel_peptide
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00817 CALCITONINB
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Calcitonin-gene related peptide I (identifier: P01256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAA TLSEEEARLL
60 70 80 90 100
LAALVQNYMQ MKVRELEQEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR
110 120
SGGVVKDNFV PTNVGSEAFG RRRRDLQA
Length:128
Mass (Da):13,948
Last modified:April 1, 1988 - v1
Checksum:i75D14869C17078D3
GO
Isoform Calcitonin (identifier: P01257-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01257.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:136
Mass (Da):15,103
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40Missing in AAB59682 (PubMed:6283379).Curated1
Sequence conflicti40Missing in CAA24541 (PubMed:6283379).Curated1
Sequence conflicti40Missing in AAA40847 (PubMed:2994212).Curated1
Sequence conflicti51Missing in AAB59682 (PubMed:6283379).Curated1
Sequence conflicti51Missing in CAA24541 (PubMed:6283379).Curated1
Sequence conflicti51Missing in AAA40847 (PubMed:2994212).Curated1
Sequence conflicti70Q → EEQ in AAB59682 (PubMed:6283379).Curated1
Sequence conflicti70Q → EEQ in CAA24541 (PubMed:6283379).Curated1
Sequence conflicti70Q → EEQ in AAA40847 (PubMed:2994212).Curated1
Sequence conflicti99S → R in AAA40847 (PubMed:2994212).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29188, L00109, L00110 Genomic DNA Translation: AAB59682.1
V01231 mRNA Translation: CAA24541.1
M11597 mRNA Translation: AAA40847.1
PIRiA01524 TCRTR
B44173
RefSeqiNP_001029127.1, NM_001033955.1
NP_001029128.1, NM_001033956.1
UniGeneiRn.90085

Genome annotation databases

GeneIDi24241
KEGGirno:24241

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALCA_RAT
AccessioniPrimary (citable) accession number: P01256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome