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Protein

Somatotropin

Gene

Gh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45ZincBy similarity1
Metal bindingi198ZincBy similarity1

GO - Molecular functioni

  • growth hormone receptor binding Source: Ensembl
  • hormone activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • animal organ development Source: RGD
  • cellular response to alkaline pH Source: RGD
  • cellular response to insulin stimulus Source: Ensembl
  • cellular response to thyroid hormone stimulus Source: RGD
  • female pregnancy Source: RGD
  • lung alveolus development Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuroblast proliferation Source: RGD
  • positive regulation of growth Source: RGD
  • positive regulation of multicellular organism growth Source: Ensembl
  • positive regulation of neurogenesis Source: RGD
  • positive regulation of steroid hormone biosynthetic process Source: BHF-UCL
  • response to cytokine Source: RGD
  • response to estradiol Source: RGD
  • response to food Source: Ensembl
  • response to light stimulus Source: RGD
  • response to peptide hormone Source: RGD

Keywordsi

Molecular functionHormone
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1170546. Prolactin receptor signaling.
R-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-RNO-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:Gh1
Synonyms:Gh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2686. Gh1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000003299827 – 216SomatotropinAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 1891 Publication
Modified residuei131PhosphoserineBy similarity1
Disulfide bondi206 ↔ 2141 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01244.
PRIDEiP01244.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011207.
ExpressionAtlasiP01244. baseline.
GenevisibleiP01244. RN.

Interactioni

GO - Molecular functioni

  • growth hormone receptor binding Source: Ensembl
  • hormone activity Source: RGD

Protein-protein interaction databases

BioGridi246561. 1 interactor.
STRINGi10116.ENSRNOP00000015818.

Structurei

3D structure databases

ProteinModelPortaliP01244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP01244.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG091G0KPU.
PhylomeDBiP01244.
TreeFamiTF332592.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR034975. Somatotropin.
IPR001400. Somatotropin/Prolactin.
IPR018116. Somatotropin_CS.
PANTHERiPTHR11417. PTHR11417. 1 hit.
PTHR11417:SF2. PTHR11417:SF2. 1 hit.
PfamiView protein in Pfam
PF00103. Hormone_1. 1 hit.
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADSQTPWL LTFSLLCLLW PQEAGAFPAM PLSSLFANAV LRAQHLHQLA
60 70 80 90 100
ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL
110 120 130 140 150
LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ
160 170 180 190 200
ELEDGSPRIG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY
210
LRVMKCRRFA ESSCAF
Length:216
Mass (Da):24,656
Last modified:July 21, 1986 - v1
Checksum:iCABF49DC0B2A226C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27F → L (PubMed:339105).Curated1
Sequence conflicti27F → L (PubMed:8521139).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01238 Genomic DNA. Translation: CAA24548.1.
V01237 mRNA. Translation: CAA24547.1.
V01239 Genomic DNA. Translation: CAA24549.1.
U62779 mRNA. Translation: AAB04025.1.
PIRiA93725. STRT.
RefSeqiNP_001030020.2. NM_001034848.2.
UniGeneiRn.146351.

Genome annotation databases

EnsembliENSRNOT00000015818; ENSRNOP00000015818; ENSRNOG00000011207.
GeneIDi24391.
KEGGirno:24391.
UCSCiRGD:2686. rat.

Similar proteinsi

Entry informationi

Entry nameiSOMA_RAT
AccessioniPrimary (citable) accession number: P01244
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families