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Protein

Somatotropin

Gene

Gh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451ZincBy similarity
Metal bindingi198 – 1981ZincBy similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to alkaline pH Source: RGD
  • cellular response to insulin stimulus Source: Ensembl
  • female pregnancy Source: RGD
  • lung alveolus development Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuroblast proliferation Source: RGD
  • positive regulation of cell differentiation Source: RGD
  • positive regulation of growth Source: RGD
  • positive regulation of multicellular organism growth Source: Ensembl
  • positive regulation of neurogenesis Source: RGD
  • positive regulation of steroid hormone biosynthetic process Source: BHF-UCL
  • response to cytokine Source: RGD
  • response to food Source: Ensembl
  • response to light stimulus Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1170546. Prolactin receptor signaling.
R-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-RNO-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:Gh1
Synonyms:Gh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2686. Gh1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • extracellular region Source: Reactome
  • extracellular space Source: RGD
  • mitochondrion Source: RGD
  • nucleus Source: RGD
  • plasma membrane Source: Ensembl
  • secretory granule Source: RGD
  • trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 216190SomatotropinPRO_0000032998Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 1891 Publication
Modified residuei131 – 1311PhosphoserineBy similarity
Disulfide bondi206 ↔ 2141 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01244.
PRIDEiP01244.

Expressioni

Gene expression databases

ExpressionAtlasiP01244. baseline.
GenevisibleiP01244. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

BioGridi246561. 1 interaction.
STRINGi10116.ENSRNOP00000015818.

Structurei

3D structure databases

ProteinModelPortaliP01244.
SMRiP01244. Positions 27-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP01244.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG7F7W9X.
PhylomeDBiP01244.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADSQTPWL LTFSLLCLLW PQEAGAFPAM PLSSLFANAV LRAQHLHQLA
60 70 80 90 100
ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL
110 120 130 140 150
LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ
160 170 180 190 200
ELEDGSPRIG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY
210
LRVMKCRRFA ESSCAF
Length:216
Mass (Da):24,656
Last modified:July 21, 1986 - v1
Checksum:iCABF49DC0B2A226C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271F → L (PubMed:339105).Curated
Sequence conflicti27 – 271F → L (PubMed:8521139).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01238 Genomic DNA. Translation: CAA24548.1.
V01237 mRNA. Translation: CAA24547.1.
V01239 Genomic DNA. Translation: CAA24549.1.
U62779 mRNA. Translation: AAB04025.1.
PIRiA93725. STRT.
RefSeqiNP_001030020.2. NM_001034848.2.
UniGeneiRn.146351.

Genome annotation databases

EnsembliENSRNOT00000015818; ENSRNOP00000015818; ENSRNOG00000011207.
GeneIDi24391.
KEGGirno:24391.
UCSCiRGD:2686. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01238 Genomic DNA. Translation: CAA24548.1.
V01237 mRNA. Translation: CAA24547.1.
V01239 Genomic DNA. Translation: CAA24549.1.
U62779 mRNA. Translation: AAB04025.1.
PIRiA93725. STRT.
RefSeqiNP_001030020.2. NM_001034848.2.
UniGeneiRn.146351.

3D structure databases

ProteinModelPortaliP01244.
SMRiP01244. Positions 27-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246561. 1 interaction.
STRINGi10116.ENSRNOP00000015818.

Proteomic databases

PaxDbiP01244.
PRIDEiP01244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015818; ENSRNOP00000015818; ENSRNOG00000011207.
GeneIDi24391.
KEGGirno:24391.
UCSCiRGD:2686. rat.

Organism-specific databases

CTDi2688.
RGDi2686. Gh1.

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP01244.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG7F7W9X.
PhylomeDBiP01244.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-RNO-1170546. Prolactin receptor signaling.
R-RNO-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-RNO-982772. Growth hormone receptor signaling.

Miscellaneous databases

NextBioi603177.
PROiP01244.

Gene expression databases

ExpressionAtlasiP01244. baseline.
GenevisibleiP01244. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element."
    Page G.S., Smith S., Goodman H.M.
    Nucleic Acids Res. 9:2087-2104(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone."
    Seeburg P.H., Shine J., Martial J.A., Baxter J.D., Goodman H.M.
    Nature 270:486-494(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Primary structure and evolution of rat growth hormone gene."
    Barta A., Richards R.I., Baxter J.D., Shine J.
    Proc. Natl. Acad. Sci. U.S.A. 78:4867-4871(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISULFIDE BONDS.
    Tissue: Liver.
  4. "Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA."
    Rohn W.M., Weigent D.A.
    Neuroimmunomodulation 2:108-114(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiSOMA_RAT
AccessioniPrimary (citable) accession number: P01244
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: December 9, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.