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P01244 (SOMA_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene names
Name:Gh1
Synonyms:Gh
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Subcellular location

Secreted.

Sequence similarities

Belongs to the somatotropin/prolactin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 216190Somatotropin
PRO_0000032998

Sites

Metal binding451Zinc By similarity
Metal binding1981Zinc By similarity

Amino acid modifications

Disulfide bond78 ↔ 189 Ref.3
Disulfide bond206 ↔ 214 Ref.3

Experimental info

Sequence conflict271F → L Ref.2
Sequence conflict271F → L Ref.4

Sequences

Sequence LengthMass (Da)Tools
P01244 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: CABF49DC0B2A226C

FASTA21624,656
        10         20         30         40         50         60 
MAADSQTPWL LTFSLLCLLW PQEAGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA 

        70         80         90        100        110        120 
YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL LRFSLLLIQS WLGPVQFLSR 

       130        140        150        160        170        180 
IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRIG QILKQTYDKF DANMRSDDAL 

       190        200        210 
LKNYGLLSCF KKDLHKAETY LRVMKCRRFA ESSCAF

« Hide

References

[1]"DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element."
Page G.S., Smith S., Goodman H.M.
Nucleic Acids Res. 9:2087-2104(1981) [PubMed: 6272224] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone."
Seeburg P.H., Shine J., Martial J.A., Baxter J.D., Goodman H.M.
Nature 270:486-494(1977) [PubMed: 339105] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Primary structure and evolution of rat growth hormone gene."
Barta A., Richards R.I., Baxter J.D., Shine J.
Proc. Natl. Acad. Sci. U.S.A. 78:4867-4871(1981) [PubMed: 6946433] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISULFIDE BONDS.
Tissue: Liver.
[4]"Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA."
Rohn W.M., Weigent D.A.
Neuroimmunomodulation 2:108-114(1995) [PubMed: 8521139] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		V01238 Genomic DNA. Translation: CAA24548.1.
V01237 mRNA. Translation: CAA24547.1.
V01239 Genomic DNA. Translation: CAA24549.1.
U62779 mRNA. Translation: AAB04025.1.
IPIIPI00211692.
PIRSTRT. A93725.
RefSeqNP_001030020.2. NM_001034848.2.
UniGeneRn.146351.

3D structure databases

ProteinModelPortalP01244.
SMRP01244. Positions 27-215.
ModBaseSearch...

Protein-protein interaction databases

STRINGP01244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015818; ENSRNOP00000015818; ENSRNOG00000011207.
GeneID24391.
KEGGrno:24391.
UCSCNM_001034848. rat.

Organism-specific databases

CTD2688.
RGD2686. Gh1.

Phylogenomic databases

eggNOGroNOG15682.
GeneTreeENSGT00390000006494.
HOVERGENHBG011318.
InParanoidP01244.
OrthoDBEOG42FSJN.
PhylomeDBP01244.

Gene expression databases

ArrayExpressP01244.
GenevestigatorP01244.
GermOnlineENSRNOG00000011207. Rattus norvegicus.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
Gene3DG3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
KOK05438.
PANTHERPTHR11417. Somatotropin. 1 hit.
PfamPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSPR00836. SOMATOTROPIN.
SUPFAMSSF47266. 4_helix_cytokine. 1 hit.
PROSITEPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603177.

Entry information

Entry nameSOMA_RAT
AccessionPrimary (citable) accession number: P01244
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 16, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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