Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01243 (CSH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 156. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chorionic somatomammotropin hormone

Short name=Choriomammotropin
Alternative name(s):
Lactogen
Placental lactogen
Short name=PL
Gene names
Name:CSH1
AND
Name:CSH2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Ref.14

Subcellular location

Secreted.

Miscellaneous

The sequence of CSH1 is shown.

Sequence similarities

Belongs to the somatotropin/prolactin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.10 Ref.11
Chain27 – 217191Chorionic somatomammotropin hormone Ref.13
PRO_0000032958

Sites

Metal binding441Zinc
Metal binding2001Zinc

Amino acid modifications

Disulfide bond79 ↔ 191 Ref.13 Ref.14
Disulfide bond208 ↔ 215In monomeric form Ref.13 Ref.14
Disulfide bond208Interchain (with C-215); in dimeric form Ref.13 Ref.14
Disulfide bond215Interchain (with C-208); in dimeric form Ref.13 Ref.14

Natural variations

Natural variant31P → A in CSH2. Ref.8
Corresponds to variant rs1130686 [ dbSNP | Ensembl ].
VAR_007166
Natural variant104 – 1052IS → L in CSH2.
VAR_007167

Experimental info

Sequence conflict841I → T AA sequence Ref.11
Sequence conflict951Missing AA sequence Ref.11
Sequence conflict1161Missing AA sequence Ref.11
Sequence conflict134 – 1363SDD → BBS AA sequence Ref.11

Secondary structure

................... 217
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01243 [UniParc].

Last modified April 1, 1988. Version 2.
Checksum: 235B0DC7A713F431

FASTA21725,020
        10         20         30         40         50         60 
MAPGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFEET 

        70         80         90        100        110        120 
YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE LLRISLLLIE SWLEPVRFLR 

       130        140        150        160        170        180 
SMFANNLVYD TSDSDDYHLL KDLEEGIQTL MGRLEDGSRR TGQILKQTYS KFDTNSHNHD 

       190        200        210 
ALLKNYGLLY CFRKDMDKVE TFLRMVQCRS VEGSCGF 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements."
Selby M.J., Barta A., Baxter J.D., Bell G.I., Eberhardt N.L.
J. Biol. Chem. 259:13131-13138(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CSH1).
[2]"The human growth hormone gene locus: structure, evolution, and allelic variations."
Hirt H., Kimelman J., Birnbaum M.J., Chen E.Y., Seeburg P.H., Eberhardt N.L., Barta A.
DNA 6:59-70(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CSH2).
[3]"Two structurally different genes produce the same secreted human placental lactogen hormone."
Barrera-Saldana H.A., Seeburg P.H., Saunders G.F.
J. Biol. Chem. 258:3787-3793(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[4]"The human growth hormone locus: nucleotide sequence, biology, and evolution."
Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.
Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CSH1 AND CSH2).
[5]"The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone."
Seeburg P.H.
DNA 1:239-249(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[6]"Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes."
Sedman L., Padhukasahasram B., Kelgo P., Laan M.
Hum. Mutat. 29:1181-1193(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-3.
Tissue: Placenta and Uterus.
[9]"Construction and analysis of recombinant DNA for human chorionic somatomammotropin."
Shine J., Seeburg P.H., Martial J.A., Baxter J.D., Goodman H.M.
Nature 270:494-499(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 50-217.
[10]"Amino acid sequence of human chorionic somatomammotropin."
Li C.H., Dixon J.S., Chung D.
Arch. Biochem. Biophys. 155:95-110(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-217.
[11]"Amino-acid sequence of human placental lactogen."
Sherwood L.M., Handwerger S., McLaurin W.D., Lanner M.
Nature New Biol. 233:59-61(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-217.
[12]Erratum
Sherwood L.M., Handwerger S., McLaurin W.D., Lanner M.
Nature New Biol. 235:64-64(1972)
[13]"Identification of the interchain disulfide bonds of dimeric human placental lactogen."
Schneider A.B., Kowalski K., Russell J., Sherwood L.M.
J. Biol. Chem. 254:3782-3787(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERCHAIN DISULFIDE BONDS.
[14]"Crystal structure and site 1 binding energetics of human placental lactogen."
Walsh S.T., Kossiakoff A.A.
J. Mol. Biol. 358:773-784(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 27-217, FUNCTION, ZINC-BINDING SITES, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00573 mRNA. Translation: CAA23836.1.
J00289 Genomic DNA. Translation: AAA98747.1.
K02401 Genomic DNA. Translation: AAA52115.1.
M15894 Genomic DNA. Translation: AAA52116.1.
J03071 Genomic DNA. Translation: AAA52551.1.
J03071 Genomic DNA. Translation: AAA52553.1.
J00118 mRNA. Translation: AAA98621.1.
EU421716 Genomic DNA. Translation: ABZ88723.1.
BT006926 mRNA. Translation: AAP35572.1.
BC002717 mRNA. Translation: AAH02717.1.
BC005921 mRNA. Translation: AAH05921.1.
BC020756 mRNA. Translation: AAH20756.1.
BC022044 mRNA. Translation: AAH22044.1.
BC035965 mRNA. Translation: AAH35965.1.
BC062775 mRNA. Translation: AAH62775.1.
BC119748 mRNA. Translation: AAI19749.1.
PIRA26449.
LCHUC. C32435.
E32435.
RefSeqNP_001308.1. NM_001317.5.
NP_066271.1. NM_020991.3.
UniGeneHs.654390.
Hs.654515.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z7CX-ray2.00A27-217[»]
ProteinModelPortalP01243.
SMRP01243. Positions 29-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107829. 4 interactions.
107830. 6 interactions.
IntActP01243. 4 interactions.
MINTMINT-1190951.
STRING9606.ENSP00000333268.

Polymorphism databases

DMDM130299.

Proteomic databases

PRIDEP01243.

Protocols and materials databases

DNASU1442.
1443.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316193; ENSP00000316416; ENSG00000136488.
ENST00000392886; ENSP00000376623; ENSG00000213218.
GeneID1442.
1443.
KEGGhsa:1442.
hsa:1443.
UCSCuc002jch.3. human.

Organism-specific databases

CTD1442.
1443.
GeneCardsGC17M061949.
GC17M061972.
HGNCHGNC:2440. CSH1.
HGNC:2441. CSH2.
HPACAB026374.
HPA043715.
MIM118820. gene.
150200. gene.
neXtProtNX_P01243.
PharmGKBPA26944.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000068443.
HOVERGENHBG011318.
KOK05438.
OMARSIFAND.
PhylomeDBP01243.
TreeFamTF332592.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP01243.
BgeeP01243.
CleanExHS_CSH1.
HS_CSH2.
GenevestigatorP01243.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERPTHR11417. PTHR11417. 1 hit.
PfamPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSPR00836. SOMATOTROPIN.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCSH1. human.
CSH2. human.
EvolutionaryTraceP01243.
NextBio5911.
PROP01243.
SOURCESearch...

Entry information

Entry nameCSH_HUMAN
AccessionPrimary (citable) accession number: P01243
Secondary accession number(s): Q0VDB1, Q14407
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: April 16, 2014
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM