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P01242

- SOM2_HUMAN

UniProt

P01242 - SOM2_HUMAN

Protein

Growth hormone variant

Gene

GH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 3 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc

    GO - Biological processi

    1. JAK-STAT cascade involved in growth hormone signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_111133. Growth hormone receptor signaling.
    REACT_115697. Prolactin receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth hormone variant
    Short name:
    GH-V
    Alternative name(s):
    Growth hormone 2
    Placenta-specific growth hormone
    Gene namesi
    Name:GH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4262. GH2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28672.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26261 PublicationAdd
    BLAST
    Chaini27 – 217191Growth hormone variantPRO_0000033061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi79 ↔ 191By similarity
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi208 ↔ 215By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01242.
    PRIDEiP01242.

    Expressioni

    Tissue specificityi

    Expressed in the placenta.

    Gene expression databases

    BgeeiP01242.
    CleanExiHS_GH2.
    GenevestigatoriP01242.

    Organism-specific databases

    HPAiHPA043715.

    Interactioni

    Subunit structurei

    Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333157.

    Structurei

    3D structure databases

    ProteinModelPortaliP01242.
    SMRiP01242. Positions 27-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatotropin/prolactin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG26152.
    HOGENOMiHOG000068443.
    HOVERGENiHBG011318.
    KOiK05438.
    OMAiRTTMTHC.
    OrthoDBiEOG7F7W9X.
    PhylomeDBiP01242.
    TreeFamiTF332592.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view]
    PANTHERiPTHR11417. PTHR11417. 1 hit.
    PfamiPF00103. Hormone_1. 1 hit.
    [Graphical view]
    PRINTSiPR00836. SOMATOTROPIN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
    PS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P01242-1) [UniParc]FASTAAdd to Basket

    Also known as: GH-V1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGSRTSLL LAFGLLCLSW LQEGSAFPTI PLSRLFDNAM LRARRLYQLA    50
    YDTYQEFEEA YILKEQKYSF LQNPQTSLCF SESIPTPSNR VKTQQKSNLE 100
    LLRISLLLIQ SWLEPVQLLR SVFANSLVYG ASDSNVYRHL KDLEEGIQTL 150
    MWRLEDGSPR TGQIFNQSYS KFDTKSHNDD ALLKNYGLLY CFRKDMDKVE 200
    TFLRIVQCRS VEGSCGF 217
    Length:217
    Mass (Da):25,000
    Last modified:March 27, 2002 - v3
    Checksum:i7B9324698E822F96
    GO
    Isoform 2 (identifier: P01242-2) [UniParc]FASTAAdd to Basket

    Also known as: GH-V2

    The sequence of this isoform differs from the canonical sequence as follows:
         153-217: RLEDGSPRTG...CRSVEGSCGF → VRVAPGIPNP...ADLQSVLQQV

    Note: No experimental confirmation available.

    Show »
    Length:256
    Mass (Da):28,875
    Checksum:i5D1C10B75BA49EC6
    GO
    Isoform 3 (identifier: P01242-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-72: Missing.

    Show »
    Length:202
    Mass (Da):23,128
    Checksum:i38B64D011A9197C6
    GO
    Isoform 4 (identifier: P01242-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         151-217: MWRLEDGSPR...CRSVEGSCGF → IGWKMAAPGL...VLLQCPPALS

    Note: No experimental confirmation available.

    Show »
    Length:245
    Mass (Da):27,101
    Checksum:i14CC7F8CD75D91C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441Missing AA sequence (PubMed:2196278)Curated
    Sequence conflicti109 – 1091I → T in AAB59547. (PubMed:3379057)Curated
    Sequence conflicti109 – 1091I → T in AAB59548. (PubMed:3379057)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901R → W.
    Corresponds to variant rs5389 [ dbSNP | Ensembl ].
    VAR_014591

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei58 – 7215Missing in isoform 3. 2 PublicationsVSP_043206Add
    BLAST
    Alternative sequencei151 – 21767MWRLE…GSCGF → IGWKMAAPGLGRSSISPTAS LTQNRTTMTHCSRTTGCSTA SGRTWTRSRHSCASCSAALW RAAVASSCPGGIPVTPPQCL SWSWKVLLQCPPALS in isoform 4. 1 PublicationVSP_043480Add
    BLAST
    Alternative sequencei153 – 21765RLEDG…GSCGF → VRVAPGIPNPGAPLASRDWG EKHCCPLFSSQALTQENSPY SSFPLVNPPGLSLQPGGEGG KWMNERGREQCPSAWPLLLF LHFAEAGRWQPPDWADLQSV LQQV in isoform 2. 2 PublicationsVSP_006203Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00470 Genomic DNA. Translation: AAA98619.1.
    J03756 mRNA. Translation: AAB59547.1.
    J03756 mRNA. Translation: AAB59548.1.
    M38451 mRNA. Translation: AAA35891.1.
    J03071 Genomic DNA. Translation: AAA52552.1.
    AF006060 mRNA. Translation: AAB71828.1.
    AF006061 mRNA. Translation: AAB71829.1.
    EU421715 Genomic DNA. Translation: ABZ88719.1.
    EU421715 Genomic DNA. Translation: ABZ88720.1.
    EU421715 Genomic DNA. Translation: ABZ88721.1.
    EU421715 Genomic DNA. Translation: ABZ88722.1.
    AK312194 mRNA. Translation: BAG35127.1.
    AB451332 mRNA. Translation: BAG70146.1.
    AB451477 mRNA. Translation: BAG70291.1.
    AC040958 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94238.1.
    CH471109 Genomic DNA. Translation: EAW94248.1.
    CH471109 Genomic DNA. Translation: EAW94252.1.
    CH471109 Genomic DNA. Translation: EAW94258.1.
    BC020760 mRNA. Translation: AAH20760.1.
    CCDSiCCDS11647.1. [P01242-1]
    CCDS11648.1. [P01242-2]
    CCDS45757.1. [P01242-4]
    CCDS45758.1. [P01242-3]
    PIRiA28072. STHUV2.
    D32435. STHUV.
    RefSeqiNP_002050.1. NM_002059.4. [P01242-1]
    NP_072050.1. NM_022556.3. [P01242-3]
    NP_072051.1. NM_022557.3. [P01242-2]
    NP_072052.1. NM_022558.3. [P01242-4]
    UniGeneiHs.406754.
    Hs.654390.

    Genome annotation databases

    GeneIDi2689.
    KEGGihsa:2689.
    UCSCiuc002jcl.2. human. [P01242-2]
    uc002jcm.2. human. [P01242-4]
    uc002jcn.2. human. [P01242-3]
    uc002jco.2. human. [P01242-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K00470 Genomic DNA. Translation: AAA98619.1 .
    J03756 mRNA. Translation: AAB59547.1 .
    J03756 mRNA. Translation: AAB59548.1 .
    M38451 mRNA. Translation: AAA35891.1 .
    J03071 Genomic DNA. Translation: AAA52552.1 .
    AF006060 mRNA. Translation: AAB71828.1 .
    AF006061 mRNA. Translation: AAB71829.1 .
    EU421715 Genomic DNA. Translation: ABZ88719.1 .
    EU421715 Genomic DNA. Translation: ABZ88720.1 .
    EU421715 Genomic DNA. Translation: ABZ88721.1 .
    EU421715 Genomic DNA. Translation: ABZ88722.1 .
    AK312194 mRNA. Translation: BAG35127.1 .
    AB451332 mRNA. Translation: BAG70146.1 .
    AB451477 mRNA. Translation: BAG70291.1 .
    AC040958 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94238.1 .
    CH471109 Genomic DNA. Translation: EAW94248.1 .
    CH471109 Genomic DNA. Translation: EAW94252.1 .
    CH471109 Genomic DNA. Translation: EAW94258.1 .
    BC020760 mRNA. Translation: AAH20760.1 .
    CCDSi CCDS11647.1. [P01242-1 ]
    CCDS11648.1. [P01242-2 ]
    CCDS45757.1. [P01242-4 ]
    CCDS45758.1. [P01242-3 ]
    PIRi A28072. STHUV2.
    D32435. STHUV.
    RefSeqi NP_002050.1. NM_002059.4. [P01242-1 ]
    NP_072050.1. NM_022556.3. [P01242-3 ]
    NP_072051.1. NM_022557.3. [P01242-2 ]
    NP_072052.1. NM_022558.3. [P01242-4 ]
    UniGenei Hs.406754.
    Hs.654390.

    3D structure databases

    ProteinModelPortali P01242.
    SMRi P01242. Positions 27-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333157.

    Proteomic databases

    PaxDbi P01242.
    PRIDEi P01242.

    Protocols and materials databases

    DNASUi 2689.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2689.
    KEGGi hsa:2689.
    UCSCi uc002jcl.2. human. [P01242-2 ]
    uc002jcm.2. human. [P01242-4 ]
    uc002jcn.2. human. [P01242-3 ]
    uc002jco.2. human. [P01242-1 ]

    Organism-specific databases

    CTDi 2689.
    GeneCardsi GC17M061957.
    HGNCi HGNC:4262. GH2.
    HPAi HPA043715.
    MIMi 139240. gene.
    neXtProti NX_P01242.
    PharmGKBi PA28672.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26152.
    HOGENOMi HOG000068443.
    HOVERGENi HBG011318.
    KOi K05438.
    OMAi RTTMTHC.
    OrthoDBi EOG7F7W9X.
    PhylomeDBi P01242.
    TreeFami TF332592.

    Enzyme and pathway databases

    Reactomei REACT_111133. Growth hormone receptor signaling.
    REACT_115697. Prolactin receptor signaling.

    Miscellaneous databases

    GeneWikii Growth_hormone_2.
    GenomeRNAii 2689.
    NextBioi 10626.
    PROi P01242.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01242.
    CleanExi HS_GH2.
    Genevestigatori P01242.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view ]
    PANTHERi PTHR11417. PTHR11417. 1 hit.
    Pfami PF00103. Hormone_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00836. SOMATOTROPIN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00266. SOMATOTROPIN_1. 1 hit.
    PS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone."
      Seeburg P.H.
      DNA 1:239-249(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    2. "Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins."
      Cooke N.E., Ray J., Emery J.G., Liebhaber S.A.
      J. Biol. Chem. 263:9001-9006(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    3. "Cloning and nucleotide sequence of placental hGH-V cDNA."
      Igout A., Scippo M.L., Frankenne F., Hennen G.
      Arch. Int. Physiol. Biochim. 96:63-67(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "The human growth hormone locus: nucleotide sequence, biology, and evolution."
      Chen E.Y., Liao Y.C., Smith D.H., Barrera-Saldana H.A., Gelinas R.E., Seeburg P.H.
      Genomics 4:479-497(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    5. "Cloning of two novel growth hormone transcripts expressed in human placenta."
      Boguszewski C.L., Svensson P.A., Jansson T., Clark R., Carlsson L.M.S., Carlsson B.
      J. Clin. Endocrinol. Metab. 83:2878-2885(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
      Tissue: Placenta.
    6. "Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes."
      Sedman L., Padhukasahasram B., Kelgo P., Laan M.
      Hum. Mutat. 29:1181-1193(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    8. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    9. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    12. "Identification of placental human growth hormone as the growth hormone-V gene expression product."
      Frankenne F., Scippo M.L., Van Beeumen J., Igout A., Hennen G.
      J. Clin. Endocrinol. Metab. 71:15-18(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-57.
    13. "Growth hormone heterogeneity in human pituitary and plasma."
      Baumann G.
      Horm. Res. 51 Suppl. 1:2-6(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiSOM2_HUMAN
    AccessioniPrimary (citable) accession number: P01242
    Secondary accession number(s): B1A4H5
    , B1A4H7, O14643, O14644, P09587
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 143 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3