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Protein

Prolactin

Gene

PRL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Biological processi

  • cellular response to hypoxia Source: AgBase
  • lactation Source: UniProtKB-KW
  • negative regulation of estrogen biosynthetic process Source: AgBase
  • negative regulation of hydrogen peroxide biosynthetic process Source: AgBase
  • negative regulation of nitric oxide biosynthetic process Source: AgBase
  • negative regulation of progesterone biosynthetic process Source: AgBase
  • positive regulation of endothelial cell proliferation Source: AgBase
  • positive regulation of vascular endothelial growth factor production Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 30301 PublicationAdd
BLAST
Chaini31 – 229199ProlactinPRO_0000032923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 41
Modified residuei56 – 561PhosphoserineBy similarity
Glycosylationi61 – 611N-linked (GlcNAc...); partial
Modified residuei64 – 641PhosphoserineBy similarity
Disulfide bondi88 ↔ 204
Modified residuei120 – 1201PhosphoserineBy similarity
Disulfide bondi221 ↔ 229

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01238.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001152.

Structurei

3D structure databases

ProteinModelPortaliP01238.
SMRiP01238. Positions 31-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP01238.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRGSSQKG SLLLLLLLVS NLFLCKSVAS LPICPSGAVN CQVSLRDLFD
60 70 80 90 100
RAVILSHYIH NLSSEMFNEF DKRYAQGRGF ITKAINSCHT SSLSTPEDKE
110 120 130 140 150
QAQQIHHEVL LNLILRVLRS WNDPLYHLVT EVRGMQEAPD AILSRAIEIE
160 170 180 190 200
EQNKRLLEGM EKIVGQVHPG IKENEVYSVW SGLPSLQMAD EDTRLFAFYN
210 220
LLHCLRRDSH KIDNYLKLLK CRIIYDSNC
Length:229
Mass (Da):26,141
Last modified:October 1, 1994 - v3
Checksum:i9D8507EE6DA33B47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41R → T in CAA32231 (PubMed:2726463).Curated
Sequence conflicti43 – 431V → M in CAA32231 (PubMed:2726463).Curated
Sequence conflicti152 – 1521Q → E AA sequence (PubMed:1270193).Curated
Sequence conflicti226 – 2261D → N AA sequence (PubMed:1270193).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14068 mRNA. Translation: CAA32231.1.
PIRiS04077. LCPG.
RefSeqiNP_999091.1. NM_213926.1.
UniGeneiSsc.8204.

Genome annotation databases

GeneIDi396965.
KEGGissc:396965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14068 mRNA. Translation: CAA32231.1.
PIRiS04077. LCPG.
RefSeqiNP_999091.1. NM_213926.1.
UniGeneiSsc.8204.

3D structure databases

ProteinModelPortaliP01238.
SMRiP01238. Positions 31-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001152.

Proteomic databases

PaxDbiP01238.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396965.
KEGGissc:396965.

Organism-specific databases

CTDi5617.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP01238.
KOiK05439.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of cDNA for porcine prolactin precursor."
    Kato Y., Hirai T., Kato T.
    J. Mol. Endocrinol. 4:135-142(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Studies on pituitary lactogenic hormone. The primary structure of the porcine hormone."
    Li C.H.
    Int. J. Pept. Protein Res. 8:205-224(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 31-229.

Entry informationi

Entry nameiPRL_PIG
AccessioniPrimary (citable) accession number: P01238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: November 11, 2015
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.