Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prolactin

Gene

Prl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

  • hormone activity Source: RGD
  • prolactin receptor binding Source: RGD

GO - Biological processi

  • cellular response to hormone stimulus Source: RGD
  • circadian rhythm Source: RGD
  • lactation Source: RGD
  • multicellular organismal response to stress Source: RGD
  • ovulation cycle Source: RGD
  • parturition Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of epithelial cell proliferation Source: RGD
  • regulation of ossification Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nutrient Source: RGD
  • response to organic cyclic compound Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Enzyme and pathway databases

ReactomeiR-RNO-1170546. Prolactin receptor signaling.
R-RNO-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:Prl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3403. Prl.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: RGD
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 292 PublicationsAdd BLAST29
ChainiPRO_000003292530 – 226ProlactinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 38By similarity
Modified residuei53PhosphoserineBy similarity1
Disulfide bondi85 ↔ 201By similarity
Modified residuei117PhosphoserineBy similarity1
Disulfide bondi218 ↔ 226By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01237.
PRIDEiP01237.

PTM databases

iPTMnetiP01237.
PhosphoSitePlusiP01237.

Expressioni

Gene expression databases

ExpressionAtlasiP01237. differential.
GenevisibleiP01237. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD
  • prolactin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023412.

Structurei

3D structure databases

ProteinModelPortaliP01237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP01237.
KOiK05439.
OMAiLHCLRRD.
OrthoDBiEOG091G0O08.
PhylomeDBiP01237.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQVSARKA GTLLLLMMSN LLFCQNVQTL PVCSGGDCQT PLPELFDRVV
60 70 80 90 100
MLSHYIHTLY TDMFIEFDKQ YVQDREFIAK AINDCPTSSL ATPEDKEQAQ
110 120 130 140 150
KVPPEVLLNL ILSLVHSWND PLFQLITGLG GIHEAPDAII SRAKEIEEQN
160 170 180 190 200
KRLLEGIEKI ISQAYPEAKG NEIYLVWSQL PSLQGVDEES KDLAFYNNIR
210 220
CLRRDSHKVD NYLKFLRCQI VHKNNC
Length:226
Mass (Da):25,753
Last modified:July 21, 1986 - v1
Checksum:i755E2874A26862C7
GO

Sequence cautioni

The sequence described in PubMed:925136 differs from that shown. Differs at a number of positions and in the total number of residues.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10Missing (PubMed:6251061).Curated1
Sequence conflicti10Missing (PubMed:6993473).Curated1
Sequence conflicti162S → G (PubMed:6251061).Curated1
Sequence conflicti162S → G (PubMed:6993473).Curated1
Sequence conflicti163Q → QE in CAA24561 (PubMed:6283362).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01244
, V01245, V01246, V01247, V01248 Genomic DNA. Translation: CAA24561.1.
J00769
, J00766, J00767, J00768 Genomic DNA. Translation: AAA41939.1.
V01249 mRNA. Translation: CAA24562.1.
AF022935 mRNA. Translation: AAC78688.1.
PIRiA93279. LCRT.
RefSeqiNP_036761.1. NM_012629.1.
UniGeneiRn.9759.

Genome annotation databases

EnsembliENSRNOT00000023412; ENSRNOP00000023412; ENSRNOG00000017374.
GeneIDi24683.
KEGGirno:24683.
UCSCiRGD:3403. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01244
, V01245, V01246, V01247, V01248 Genomic DNA. Translation: CAA24561.1.
J00769
, J00766, J00767, J00768 Genomic DNA. Translation: AAA41939.1.
V01249 mRNA. Translation: CAA24562.1.
AF022935 mRNA. Translation: AAC78688.1.
PIRiA93279. LCRT.
RefSeqiNP_036761.1. NM_012629.1.
UniGeneiRn.9759.

3D structure databases

ProteinModelPortaliP01237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023412.

PTM databases

iPTMnetiP01237.
PhosphoSitePlusiP01237.

Proteomic databases

PaxDbiP01237.
PRIDEiP01237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023412; ENSRNOP00000023412; ENSRNOG00000017374.
GeneIDi24683.
KEGGirno:24683.
UCSCiRGD:3403. rat.

Organism-specific databases

CTDi5617.
RGDi3403. Prl.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP01237.
KOiK05439.
OMAiLHCLRRD.
OrthoDBiEOG091G0O08.
PhylomeDBiP01237.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-RNO-1170546. Prolactin receptor signaling.
R-RNO-982772. Growth hormone receptor signaling.

Miscellaneous databases

PROiP01237.

Gene expression databases

ExpressionAtlasiP01237. differential.
GenevisibleiP01237. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRL_RAT
AccessioniPrimary (citable) accession number: P01237
Secondary accession number(s): P70520
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.