Reviewed,
UniProtKB/Swiss-Prot P01236 (PRL_HUMAN)
Last modified
November 25, 2008.
Version 98.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Prolactin Short name=PRL | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 227 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Prolactin acts primarily on the mammary gland by promoting lactation. |
| Subcellular location | |
| Sequence similarities | Belongs to the somatotropin/prolactin family. |
| Sequence caution | The sequence CAA38264.1 differs from that shown. Reason: Frameshift at position 8. |
Ontologies
Keywords | |
|---|---|
| Biological process | Lactation |
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hormone |
| PTM | Glycoprotein |
| Technical term | 3D-structure Direct protein sequencing |
Gene Ontology (GO) | |
| Biological process | cell proliferation Traceable author statement. Source: ProtInc cell surface receptor linked signal transductionTraceable author statement. Source: ProtInc female pregnancyNon-traceable author statement. Source: ProtInc lactationInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extracellular region Inferred from electronic annotation. Source: InterPro |
| Molecular function | hormone activity Inferred from electronic annotation. Source: InterPro prolactin receptor bindingTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 28 | 28 | |||||||||||||||||||||||||
| Chain | 29 – 227 | 199 | Prolactin | PRO_0000032916 | |||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||
| Glycosylation | 59 | 1 | N-linked (GlcNAc...); partial | ||||||||||||||||||||||||
| Disulfide bond | 32 ↔ 39 | By similarity | |||||||||||||||||||||||||
| Disulfide bond | 86 ↔ 202 | By similarity | |||||||||||||||||||||||||
| Disulfide bond | 219 ↔ 227 | By similarity | |||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||
| Sequence conflict | 42 | 1 | T → A in AAB70858. Ref.6 | ||||||||||||||||||||||||
| Sequence conflict | 110 – 111 | 2 | SL → VS AA sequence Ref.7 | ||||||||||||||||||||||||
| Sequence conflict | 113 – 114 | 2 | VS → L AA sequence Ref.7 | ||||||||||||||||||||||||
| Sequence conflict | 118 | 1 | S → P in AAB70858. Ref.6 | ||||||||||||||||||||||||
| Sequence conflict | 148 | 1 | E → Q in BAA00312. Ref.5 | ||||||||||||||||||||||||
| Sequence conflict | 172 | 1 | N → D AA sequence Ref.7 | ||||||||||||||||||||||||
| Sequence conflict | 190 – 191 | 2 | ES → SE AA sequence Ref.7 | ||||||||||||||||||||||||
| Sequence conflict | 206 | 1 | D → H in AAA60173 and BAA00312. Ref.5 | ||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||
| Helix | 43 – 73 | 31 | |||||||||||||||||||||||||
| Beta strand | 74 – 76 | 3 | |||||||||||||||||||||||||
| Helix | 87 – 90 | 4 | |||||||||||||||||||||||||
| Beta strand | 95 – 97 | 3 | |||||||||||||||||||||||||
| Helix | 98 – 102 | 5 | |||||||||||||||||||||||||
| Helix | 105 – 118 | 14 | |||||||||||||||||||||||||
| Helix | 120 – 131 | 12 | |||||||||||||||||||||||||
| Helix | 138 – 165 | 28 | |||||||||||||||||||||||||
| Helix | 181 – 184 | 4 | |||||||||||||||||||||||||
| Helix | 189 – 221 | 33 | |||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human prolactin. cDNA structural analysis and evolutionary comparisons." Cooke N.E., Coit D., Shine J., Baxter J.D., Martial J.A. J. Biol. Chem. 256:4007-4016(1981) [PubMed: 6260780] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Isolation and characterization of the human prolactin gene." Truong A.T., Duez C., Belayew A., Renard A., Pictet R.L., Bell G.I., Martial J.A. EMBO J. 3:429-437(1984) [PubMed: 6325171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "A placenta-specific 5'non-coding exon of human prolactin." Hiraoka Y., Tatsumi K., Shiozawa M., Aiso S., Fukasawa T., Yasuda K., Miyai K. Mol. Cell. Endocrinol. 75:71-80(1990) [PubMed: 2050267] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [5] | "Molecular cloning and nucleotide sequence of DNA complementary to human decidual prolactin mRNA." Takahashi H., Nabeshima Y., Nabeshima Y., Ogata K., Takeuchi S. J. Biochem. 95:1491-1499(1984) [PubMed: 6146607] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 11-227. |
| [6] | "Expression of the prolactin gene in normal and neoplastic human breast tissues and human mammary cell lines: promoter usage and alternative mRNA splicing." Shaw-Bruha C.M., Pirrucello S.J., Shull J.D. Breast Cancer Res. Treat. 44:243-253(1997) [PubMed: 9266104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-201. Tissue: Mammary gland. |
| [7] | "Human pituitary prolactin (hPRL): the entire linear amino acid sequence." Shome B., Parlow A.F. J. Clin. Endocrinol. Metab. 45:1112-1115(1977) [PubMed: 925136] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-227. |
| [8] | "High sensitivity automated sequence determination of polypeptides." Jacobs J.W., Niall H.D. J. Biol. Chem. 250:3629-3636(1975) [PubMed: 1126929] [Abstract] Cited for: PROTEIN SEQUENCE OF 29-53. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| V00566 mRNA. Translation: CAA23829.1. X00540 X00544 Genomic DNA. Translation: CAA25214.1. X54393 mRNA. Translation: CAA38263.1. Frameshift. X54393 mRNA. Translation: CAA38264.1. Frameshift. BC015850 mRNA. Translation: AAH15850.1. M29386 mRNA. Translation: AAA60173.1. D00411 mRNA. Translation: BAA00312.1. U75583 mRNA. Translation: AAB70858.1. | |||||||||||||||||||||||||||||||
| PIR | A61402. LCHU. A90998. | ||||||||||||||||||||||||||||||
| RefSeq | NP_000939.1. | ||||||||||||||||||||||||||||||
| UniGene | Hs.1905 | ||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||||||||
| PhosphoSite | P01236. | ||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||
| Ensembl | ENSG00000172179. Homo sapiens. [Contig view] | ||||||||||||||||||||||||||||||
| GeneID | 5617. | ||||||||||||||||||||||||||||||
| KEGG | hsa:5617. | ||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||
| H-InvDB | HIX0005617. | ||||||||||||||||||||||||||||||
| HGNC | HGNC:9445. PRL. | ||||||||||||||||||||||||||||||
| MIM | 176760. gene. | ||||||||||||||||||||||||||||||
| PharmGKB | PA33790. | ||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||
| GeneCards | Search... | ||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||
| HOVERGEN | P01236. | ||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||
| ArrayExpress | P01236. | ||||||||||||||||||||||||||||||
| CleanEx | HS_PRL. | ||||||||||||||||||||||||||||||
| GermOnline | ENSG00000172179. Homo sapiens. | ||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||
| InterPro | IPR012351. 4_helix_cytokine_core. IPR001400. Somatotropin. [Graphical view] | ||||||||||||||||||||||||||||||
| Gene3D | G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit. | ||||||||||||||||||||||||||||||
| PANTHER | PTHR11417. Somatotropin. 1 hit. | ||||||||||||||||||||||||||||||
| Pfam | PF00103. Hormone_1. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| PRINTS | PR00836. SOMATOTROPIN. | ||||||||||||||||||||||||||||||
| PROSITE | PS00266. SOMATOTROPIN_1. 1 hit. PS00338. SOMATOTROPIN_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||||||||
| LinkHub | P01236. | ||||||||||||||||||||||||||||||
| NextBio | 21828. | ||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||
Entry information
| Entry name | PRL_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P01236 Secondary accession number(s): Q15199, Q92996 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


