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Protein

Prolactin

Gene

PRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • prolactin receptor binding Source: ProtInc

GO - Biological processi

  • cell proliferation Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • cellular protein metabolic process Source: Reactome
  • female pregnancy Source: ProtInc
  • JAK-STAT cascade involved in growth hormone signaling pathway Source: Reactome
  • lactation Source: UniProtKB-KW
  • negative regulation of angiogenesis Source: BHF-UCL
  • negative regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of JAK-STAT cascade Source: BHF-UCL
  • positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
  • regulation of multicellular organism growth Source: BHF-UCL

Keywordsi

Molecular functionHormone
Biological processLactation

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-977225 Amyloid fiber formation
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP01236
SIGNORiP01236

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000172179.11
HGNCiHGNC:9445 PRL
MIMi176760 gene
neXtProtiNX_P01236

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi157G → D, F, L, N, R, V or Y: Inhibits signaling via PRLR; mutant PRL acts as PRLR antagonist. 1 Publication1

Organism-specific databases

DisGeNETi5617
OpenTargetsiENSG00000172179
PharmGKBiPA33790

Polymorphism and mutation databases

BioMutaiPRL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
ChainiPRO_000003291629 – 227ProlactinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 391 Publication
Modified residuei54PhosphoserineBy similarity1
Glycosylationi59N-linked (GlcNAc...) asparagine; partial1
Modified residuei62PhosphoserineBy similarity1
Disulfide bondi86 ↔ 2021 Publication
Modified residuei118PhosphoserineBy similarity1
Modified residuei163Phosphoserine1 Publication1
Modified residuei194Phosphoserine1 Publication1
Disulfide bondi219 ↔ 2271 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01236
PeptideAtlasiP01236
PRIDEiP01236

PTM databases

iPTMnetiP01236
PhosphoSitePlusiP01236

Miscellaneous databases

PMAP-CutDBiP01236

Expressioni

Gene expression databases

BgeeiENSG00000172179
CleanExiHS_PRL
ExpressionAtlasiP01236 baseline and differential
GenevisibleiP01236 HS

Organism-specific databases

HPAiCAB023353
HPA042416
HPA062017

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • prolactin receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi111602, 3 interactors
CORUMiP01236
DIPiDIP-59635N
IntActiP01236, 3 interactors
STRINGi9606.ENSP00000302150

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 34Combined sources4
Helixi43 – 72Combined sources30
Turni73 – 75Combined sources3
Helixi78 – 82Combined sources5
Turni87 – 90Combined sources4
Helixi97 – 102Combined sources6
Helixi105 – 118Combined sources14
Helixi120 – 131Combined sources12
Beta strandi133 – 135Combined sources3
Helixi138 – 165Combined sources28
Beta strandi166 – 168Combined sources3
Helixi181 – 185Combined sources5
Helixi189 – 223Combined sources35

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RW5NMR-A29-227[»]
2Q98X-ray2.70A38-227[»]
3D48X-ray2.50P40-227[»]
3EW3X-ray3.80A39-227[»]
3MZGX-ray2.10A43-227[»]
3N06X-ray2.00A43-227[»]
3N0PX-ray2.10A43-227[»]
3NCBX-ray2.10A43-227[»]
3NCCX-ray2.50A43-227[»]
3NCEX-ray2.00A43-227[»]
3NCFX-ray2.80A43-227[»]
3NPZX-ray3.35A29-227[»]
ProteinModelPortaliP01236
SMRiP01236
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01236

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
GeneTreeiENSGT00730000110805
HOGENOMiHOG000264241
HOVERGENiHBG104895
InParanoidiP01236
KOiK05439
PhylomeDBiP01236
TreeFamiTF332592

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIKGSPWKG SLLLLLVSNL LLCQSVAPLP ICPGGAARCQ VTLRDLFDRA
60 70 80 90 100
VVLSHYIHNL SSEMFSEFDK RYTHGRGFIT KAINSCHTSS LATPEDKEQA
110 120 130 140 150
QQMNQKDFLS LIVSILRSWN EPLYHLVTEV RGMQEAPEAI LSKAVEIEEQ
160 170 180 190 200
TKRLLEGMEL IVSQVHPETK ENEIYPVWSG LPSLQMADEE SRLSAYYNLL
210 220
HCLRRDSHKI DNYLKLLKCR IIHNNNC
Length:227
Mass (Da):25,876
Last modified:July 21, 1986 - v1
Checksum:i952BBA1B6A955527
GO

Sequence cautioni

The sequence CAA38264 differs from that shown. Reason: Frameshift at position 8.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42T → A in AAB70858 (PubMed:9266104).Curated1
Sequence conflicti110 – 111SL → VS AA sequence (PubMed:925136).Curated2
Sequence conflicti113 – 114VS → L AA sequence (PubMed:925136).Curated2
Sequence conflicti118S → P in AAB70858 (PubMed:9266104).Curated1
Sequence conflicti148E → Q in BAA00312 (PubMed:6146607).Curated1
Sequence conflicti172N → D AA sequence (PubMed:925136).Curated1
Sequence conflicti190 – 191ES → SE AA sequence (PubMed:925136).Curated2
Sequence conflicti206D → H in AAA60173 (PubMed:6146607).Curated1
Sequence conflicti206D → H in BAA00312 (PubMed:6146607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00566 mRNA Translation: CAA23829.1
X00540
, X00541, X00543, X00544 Genomic DNA Translation: CAA25214.1
X54393 mRNA Translation: CAA38263.1 Frameshift.
X54393 mRNA Translation: CAA38264.1 Frameshift.
BC015850 mRNA Translation: AAH15850.1
M29386 mRNA Translation: AAA60173.1
D00411 mRNA Translation: BAA00312.1
U75583 mRNA Translation: AAB70858.1
CCDSiCCDS4548.1
PIRiA61402
A90998 LCHU
RefSeqiNP_000939.1, NM_000948.5
NP_001157030.1, NM_001163558.2
UniGeneiHs.1905
Hs.735971

Genome annotation databases

EnsembliENST00000306482; ENSP00000302150; ENSG00000172179
GeneIDi5617
KEGGihsa:5617

Similar proteinsi

Entry informationi

Entry nameiPRL_HUMAN
AccessioniPrimary (citable) accession number: P01236
Secondary accession number(s): Q15199, Q92996
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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