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P01233

- CGHB_HUMAN

UniProt

P01233 - CGHB_HUMAN

Protein

Choriogonadotropin subunit beta

Gene

CGB

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell-cell signaling Source: ProtInc
    3. cellular protein metabolic process Source: Reactome
    4. female gamete generation Source: ProtInc
    5. peptide hormone processing Source: Reactome
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_15398. Glycoprotein hormones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choriogonadotropin subunit beta
    Short name:
    CG-beta
    Alternative name(s):
    Chorionic gonadotrophin chain beta
    Gene namesi
    Name:CGB
    Synonyms:CGB3
    AND
    Name:CGB5
    AND
    Name:CGB7
    AND
    Name:CGB8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1886. CGB.
    HGNC:16452. CGB5.
    HGNC:16451. CGB7.
    HGNC:16453. CGB8.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets.

    Organism-specific databases

    PharmGKBiPA26439.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20202 PublicationsAdd
    BLAST
    Chaini21 – 165145Choriogonadotropin subunit betaPRO_0000011676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 772 Publications
    Glycosylationi33 – 331N-linked (GlcNAc...)CAR_000042
    Disulfide bondi43 ↔ 922 Publications
    Disulfide bondi46 ↔ 1302 Publications
    Glycosylationi50 – 501N-linked (GlcNAc...)CAR_000043
    Disulfide bondi54 ↔ 1082 Publications
    Disulfide bondi58 ↔ 1102 Publications
    Disulfide bondi113 ↔ 1202 Publications
    Glycosylationi141 – 1411O-linked (GalNAc...)1 Publication
    Glycosylationi147 – 1471O-linked (GalNAc...)1 Publication
    Glycosylationi152 – 1521O-linked (GalNAc...)1 Publication
    Glycosylationi158 – 1581O-linked (GalNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP01233.
    PaxDbiP01233.
    PeptideAtlasiP01233.
    PRIDEiP01233.

    PTM databases

    PhosphoSiteiP01233.
    UniCarbKBiP01233.

    Expressioni

    Tissue specificityi

    Placenta.

    Developmental stagei

    Made by the first trimester placenta.

    Gene expression databases

    BgeeiP01233.
    CleanExiHS_CGB.
    HS_CGB5.
    HS_CGB7.
    GenevestigatoriP01233.

    Organism-specific databases

    HPAiCAB000042.
    CAB010884.
    HPA038925.
    HPA038934.

    Interactioni

    Subunit structurei

    Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Protein-protein interaction databases

    BioGridi107508. 2 interactions.
    DIPiDIP-6183N.
    MINTiMINT-1510897.

    Structurei

    Secondary structure

    1
    165
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 3814
    Beta strandi47 – 6014
    Beta strandi75 – 8814
    Beta strandi99 – 11214
    Turni115 – 1173
    Beta strandi118 – 1214

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HCNX-ray2.60B21-165[»]
    1HRPX-ray3.00B21-165[»]
    1QFWX-ray3.50B21-165[»]
    1XULmodel-B21-165[»]
    DisProtiDP00013.
    ProteinModelPortaliP01233.
    SMRiP01233. Positions 22-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01233.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284462.
    HOVERGENiHBG006698.
    InParanoidiP01233.
    KOiK10045.
    OMAiTVNATIC.
    OrthoDBiEOG7JQBQF.
    PhylomeDBiP01233.
    TreeFamiTF332940.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view]
    PANTHERiPTHR11515. PTHR11515. 1 hit.
    PfamiPF00007. Cys_knot. 1 hit.
    [Graphical view]
    SMARTiSM00068. GHB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P01233-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN    50
    TTICAGYCPT MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV 100
    SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS 150
    PSRLPGPSDT PILPQ 165
    Length:165
    Mass (Da):17,739
    Last modified:July 21, 1986 - v1
    Checksum:i5598FB9E51A05748
    GO
    Isoform 2 (identifier: P01233-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MEMF → MGRPGLGAAVSDPGEAVSLS

    Show »
    Length:181
    Mass (Da):19,053
    Checksum:i853B736271867359
    GO

    Sequence cautioni

    The sequence CAA25068.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA25069.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231P → T in AAL69709. (PubMed:11861891)Curated
    Isoform 2 (identifier: P01233-2)
    Sequence conflicti7 – 71G → R in CAA25069. (PubMed:6690982)Curated
    Sequence conflicti9 – 91A → V in CAA25069. (PubMed:6690982)Curated
    Sequence conflicti12 – 121D → G in CAA25069. (PubMed:6690982)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41F → L.1 Publication
    Corresponds to variant rs6516 [ dbSNP | Ensembl ].
    VAR_014585
    Natural varianti18 – 181T → A.1 Publication
    VAR_015231
    Natural varianti22 – 221K → R.1 Publication
    Corresponds to variant rs6518 [ dbSNP | Ensembl ].
    VAR_014586
    Natural varianti24 – 241P → M Requires 2 nucleotide substitutions. 2 Publications
    VAR_015232
    Natural varianti28 – 281R → W.1 Publication
    VAR_015233
    Natural varianti30 – 301R → H.1 Publication
    VAR_015234
    Natural varianti35 – 351T → I.1 Publication
    Corresponds to variant rs6515 [ dbSNP | Ensembl ].
    VAR_014587
    Natural varianti97 – 971N → D.
    Corresponds to variant rs6519 [ dbSNP | Ensembl ].
    VAR_014588
    Natural varianti137 – 1371D → A in gene 6. 4 Publications
    Corresponds to variant rs7452 [ dbSNP | Ensembl ].
    VAR_003188
    Natural varianti147 – 1471S → C.1 Publication
    VAR_015235

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44MEMF → MGRPGLGAAVSDPGEAVSLS in isoform 2. CuratedVSP_038396

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00117 mRNA. Translation: AAA96690.1.
    X00265 Genomic DNA. Translation: CAA25068.1. Different initiation.
    X00266 Genomic DNA. Translation: CAA25069.1. Different initiation.
    K03189, K03187, K03188 Genomic DNA. Translation: AAA53288.1.
    K03183, K00092, K03182 Genomic DNA. Translation: AAA53287.1.
    BT006890 mRNA. Translation: AAP35536.1.
    AK291552 mRNA. Translation: BAF84241.1.
    AC008687 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52434.1.
    CH471177 Genomic DNA. Translation: EAW52437.1.
    CH471177 Genomic DNA. Translation: EAW52438.1.
    CH471177 Genomic DNA. Translation: EAW52439.1.
    BC006290 mRNA. Translation: AAH06290.1.
    BC022796 mRNA. Translation: AAH22796.1.
    BC030994 mRNA. Translation: AAH30994.1.
    BC041054 mRNA. Translation: AAH41054.1.
    BC051378 mRNA. Translation: AAH51378.1.
    BC069526 mRNA. Translation: AAH69526.1.
    BC103969 mRNA. Translation: AAI03970.1.
    BC103970 mRNA. Translation: AAI03971.1.
    BC103971 mRNA. Translation: AAI03972.1.
    BC106059 mRNA. Translation: AAI06060.1.
    BC106723 mRNA. Translation: AAI06724.1.
    BC106724 mRNA. Translation: AAI06725.1.
    BC128603 mRNA. Translation: AAI28604.1.
    M13503 Genomic DNA. Translation: AAA52009.1.
    M13504 Genomic DNA. Translation: AAA52005.1.
    M13505 Genomic DNA. Translation: AAA52008.1.
    AF397576 Genomic DNA. Translation: AAL69704.1.
    AF397577 Genomic DNA. Translation: AAL69705.1.
    AF397578 Genomic DNA. Translation: AAL69706.1.
    AF397579 Genomic DNA. Translation: AAL69707.1.
    AF397580 Genomic DNA. Translation: AAL69708.1.
    AF397581 Genomic DNA. Translation: AAL69709.1.
    CCDSiCCDS12749.1. [P01233-1]
    PIRiA93230. KTHUB.
    I37231.
    RefSeqiNP_000728.1. NM_000737.3. [P01233-1]
    NP_149032.1. NM_033043.1. [P01233-1]
    NP_149133.1. NM_033142.1.
    NP_149439.1. NM_033183.2. [P01233-1]
    XP_005258480.1. XM_005258423.1. [P01233-2]
    XP_005259480.1. XM_005259423.1. [P01233-2]
    XP_005259483.1. XM_005259426.1.
    XP_006723568.1. XM_006723505.1.
    UniGeneiHs.172944.
    Hs.446683.
    Hs.659014.
    Hs.681647.
    Hs.743279.
    Hs.745468.

    Genome annotation databases

    EnsembliENST00000301408; ENSP00000301408; ENSG00000189052. [P01233-1]
    ENST00000357383; ENSP00000349954; ENSG00000104827. [P01233-1]
    ENST00000377280; ENSP00000366493; ENSG00000196337.
    ENST00000448456; ENSP00000403649; ENSG00000213030. [P01233-1]
    ENST00000596965; ENSP00000469076; ENSG00000196337.
    ENST00000597853; ENSP00000470813; ENSG00000196337.
    GeneIDi1082.
    93659.
    94027.
    94115.
    KEGGihsa:1082.
    hsa:93659.
    hsa:94027.
    hsa:94115.
    UCSCiuc002plv.2. human. [P01233-1]

    Polymorphism databases

    DMDMi116184.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Chorionic gonadotropin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00117 mRNA. Translation: AAA96690.1 .
    X00265 Genomic DNA. Translation: CAA25068.1 . Different initiation.
    X00266 Genomic DNA. Translation: CAA25069.1 . Different initiation.
    K03189 , K03187 , K03188 Genomic DNA. Translation: AAA53288.1 .
    K03183 , K00092 , K03182 Genomic DNA. Translation: AAA53287.1 .
    BT006890 mRNA. Translation: AAP35536.1 .
    AK291552 mRNA. Translation: BAF84241.1 .
    AC008687 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52434.1 .
    CH471177 Genomic DNA. Translation: EAW52437.1 .
    CH471177 Genomic DNA. Translation: EAW52438.1 .
    CH471177 Genomic DNA. Translation: EAW52439.1 .
    BC006290 mRNA. Translation: AAH06290.1 .
    BC022796 mRNA. Translation: AAH22796.1 .
    BC030994 mRNA. Translation: AAH30994.1 .
    BC041054 mRNA. Translation: AAH41054.1 .
    BC051378 mRNA. Translation: AAH51378.1 .
    BC069526 mRNA. Translation: AAH69526.1 .
    BC103969 mRNA. Translation: AAI03970.1 .
    BC103970 mRNA. Translation: AAI03971.1 .
    BC103971 mRNA. Translation: AAI03972.1 .
    BC106059 mRNA. Translation: AAI06060.1 .
    BC106723 mRNA. Translation: AAI06724.1 .
    BC106724 mRNA. Translation: AAI06725.1 .
    BC128603 mRNA. Translation: AAI28604.1 .
    M13503 Genomic DNA. Translation: AAA52009.1 .
    M13504 Genomic DNA. Translation: AAA52005.1 .
    M13505 Genomic DNA. Translation: AAA52008.1 .
    AF397576 Genomic DNA. Translation: AAL69704.1 .
    AF397577 Genomic DNA. Translation: AAL69705.1 .
    AF397578 Genomic DNA. Translation: AAL69706.1 .
    AF397579 Genomic DNA. Translation: AAL69707.1 .
    AF397580 Genomic DNA. Translation: AAL69708.1 .
    AF397581 Genomic DNA. Translation: AAL69709.1 .
    CCDSi CCDS12749.1. [P01233-1 ]
    PIRi A93230. KTHUB.
    I37231.
    RefSeqi NP_000728.1. NM_000737.3. [P01233-1 ]
    NP_149032.1. NM_033043.1. [P01233-1 ]
    NP_149133.1. NM_033142.1.
    NP_149439.1. NM_033183.2. [P01233-1 ]
    XP_005258480.1. XM_005258423.1. [P01233-2 ]
    XP_005259480.1. XM_005259423.1. [P01233-2 ]
    XP_005259483.1. XM_005259426.1.
    XP_006723568.1. XM_006723505.1.
    UniGenei Hs.172944.
    Hs.446683.
    Hs.659014.
    Hs.681647.
    Hs.743279.
    Hs.745468.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HCN X-ray 2.60 B 21-165 [» ]
    1HRP X-ray 3.00 B 21-165 [» ]
    1QFW X-ray 3.50 B 21-165 [» ]
    1XUL model - B 21-165 [» ]
    DisProti DP00013.
    ProteinModelPortali P01233.
    SMRi P01233. Positions 22-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107508. 2 interactions.
    DIPi DIP-6183N.
    MINTi MINT-1510897.

    Chemistry

    DrugBanki DB00097. Choriogonadotropin alfa.

    PTM databases

    PhosphoSitei P01233.
    UniCarbKBi P01233.

    Polymorphism databases

    DMDMi 116184.

    Proteomic databases

    MaxQBi P01233.
    PaxDbi P01233.
    PeptideAtlasi P01233.
    PRIDEi P01233.

    Protocols and materials databases

    DNASUi 1082.
    93659.
    94027.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301408 ; ENSP00000301408 ; ENSG00000189052 . [P01233-1 ]
    ENST00000357383 ; ENSP00000349954 ; ENSG00000104827 . [P01233-1 ]
    ENST00000377280 ; ENSP00000366493 ; ENSG00000196337 .
    ENST00000448456 ; ENSP00000403649 ; ENSG00000213030 . [P01233-1 ]
    ENST00000596965 ; ENSP00000469076 ; ENSG00000196337 .
    ENST00000597853 ; ENSP00000470813 ; ENSG00000196337 .
    GeneIDi 1082.
    93659.
    94027.
    94115.
    KEGGi hsa:1082.
    hsa:93659.
    hsa:94027.
    hsa:94115.
    UCSCi uc002plv.2. human. [P01233-1 ]

    Organism-specific databases

    CTDi 1082.
    93659.
    94027.
    94115.
    GeneCardsi GC19M049526.
    GC19M049550.
    GC19M049557.
    GC19P049547.
    HGNCi HGNC:1886. CGB.
    HGNC:16452. CGB5.
    HGNC:16451. CGB7.
    HGNC:16453. CGB8.
    HPAi CAB000042.
    CAB010884.
    HPA038925.
    HPA038934.
    MIMi 118860. gene.
    608825. gene.
    608826. gene.
    608827. gene.
    neXtProti NX_P01233.
    PharmGKBi PA26439.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284462.
    HOVERGENi HBG006698.
    InParanoidi P01233.
    KOi K10045.
    OMAi TVNATIC.
    OrthoDBi EOG7JQBQF.
    PhylomeDBi P01233.
    TreeFami TF332940.

    Enzyme and pathway databases

    Reactomei REACT_15398. Glycoprotein hormones.

    Miscellaneous databases

    EvolutionaryTracei P01233.
    GeneWikii CGB7.
    Chorionic_gonadotropin_beta.
    NextBioi 4508.
    PROi P01233.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01233.
    CleanExi HS_CGB.
    HS_CGB5.
    HS_CGB7.
    Genevestigatori P01233.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view ]
    PANTHERi PTHR11515. PTHR11515. 1 hit.
    Pfami PF00007. Cys_knot. 1 hit.
    [Graphical view ]
    SMARTi SM00068. GHB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region."
      Fiddes J.C., Goodman H.M.
      Nature 286:684-687(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone."
      Talmadge K., Vamvakopoulos N.C., Fiddes J.C.
      Nature 307:37-40(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-137.
    3. "The beta subunit of human chorionic gonadotropin is encoded by multiple genes."
      Policastro P., Ovitt C.E., Hoshina M., Fukuoka H., Boothby M.R., Boime I.
      J. Biol. Chem. 258:11492-11499(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-24 AND ALA-137.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-4 AND ALA-137.
      Tissue: Brain and Placenta.
    9. "The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin."
      Birken S., Fetherston J., Canfield R.E., Boime I.
      J. Biol. Chem. 256:1816-1823(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-20.
    10. "A map of the hCG beta-LH beta gene cluster."
      Policastro P.F., Daniels-Mcqueen S., Carle G., Boime I.
      J. Biol. Chem. 261:5907-5916(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
    11. "Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection."
      Maston G.A., Ruvolo M.
      Mol. Biol. Evol. 19:320-335(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-164, VARIANTS ALA-18; ARG-22; MET-24; TRP-28; HIS-30; ILE-35; ALA-137 AND CYS-147.
    12. "The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit."
      Morgan F.J., Birken S., Canfield R.E.
      J. Biol. Chem. 250:5247-5258(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-165.
    13. "Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit."
      Carlsen R.B., Bahl O.P., Swaminathan N.
      J. Biol. Chem. 248:6810-6827(1973) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 21-165.
    14. "Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin."
      Mise T., Bahl O.P.
      J. Biol. Chem. 256:6587-6592(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS.
    15. "Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form."
      Saccuzo Beebe J., Mountjoy K., Krzesicki R.F., Perini F., Ruddon R.W.
      J. Biol. Chem. 265:312-317(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    16. "Site-specific N-glycosylation of human chorionic gonadotrophin --structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy."
      Weisshaar G., Hiyama J., Renwick A.G.C.
      Glycobiology 1:393-404(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE OF CARBOHYDRATES.
    17. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).

    Entry informationi

    Entry nameiCGHB_HUMAN
    AccessioniPrimary (citable) accession number: P01233
    Secondary accession number(s): A1A5E0
    , B9ZVP5, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5, Q8WXL1, Q8WXL2, Q8WXL3, Q8WXL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 174 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3