Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01233 (CGHB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 169. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choriogonadotropin subunit beta

Short name=CG-beta
Alternative name(s):
Chorionic gonadotrophin chain beta
Gene names
Name:CGB
Synonyms:CGB3
AND
Name:CGB5
AND
Name:CGB7
AND
Name:CGB8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Subunit structure

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location

Secreted.

Tissue specificity

Placenta.

Developmental stage

Made by the first trimester placenta.

Pharmaceutical use

Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets.

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

Sequence caution

The sequence CAA25068.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAA25069.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P01233-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P01233-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MEMF → MGRPGLGAAVSDPGEAVSLS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.1 Ref.12 Ref.13
Chain21 – 165145Choriogonadotropin subunit beta
PRO_0000011676

Amino acid modifications

Glycosylation331N-linked (GlcNAc...)
CAR_000042
Glycosylation501N-linked (GlcNAc...)
CAR_000043
Glycosylation1411O-linked (GalNAc...) Ref.12
Glycosylation1471O-linked (GalNAc...) Ref.12
Glycosylation1521O-linked (GalNAc...) Ref.12
Glycosylation1581O-linked (GalNAc...) Ref.12
Disulfide bond29 ↔ 77 Ref.14 Ref.15 Ref.17
Disulfide bond43 ↔ 92 Ref.14 Ref.15 Ref.17
Disulfide bond46 ↔ 130 Ref.14 Ref.15 Ref.17
Disulfide bond54 ↔ 108 Ref.14 Ref.15 Ref.17
Disulfide bond58 ↔ 110 Ref.14 Ref.15 Ref.17
Disulfide bond113 ↔ 120 Ref.14 Ref.15 Ref.17

Natural variations

Alternative sequence1 – 44MEMF → MGRPGLGAAVSDPGEAVSLS in isoform 2.
VSP_038396
Natural variant41F → L. Ref.8
Corresponds to variant rs6516 [ dbSNP | Ensembl ].
VAR_014585
Natural variant181T → A. Ref.11
VAR_015231
Natural variant221K → R. Ref.11
Corresponds to variant rs6518 [ dbSNP | Ensembl ].
VAR_014586
Natural variant241P → M Requires 2 nucleotide substitutions. Ref.3 Ref.11
VAR_015232
Natural variant281R → W. Ref.11
VAR_015233
Natural variant301R → H. Ref.11
VAR_015234
Natural variant351T → I. Ref.11
Corresponds to variant rs6515 [ dbSNP | Ensembl ].
VAR_014587
Natural variant971N → D.
Corresponds to variant rs6519 [ dbSNP | Ensembl ].
VAR_014588
Natural variant1371D → A in gene 6. Ref.2 Ref.3 Ref.8 Ref.11
Corresponds to variant rs7452 [ dbSNP | Ensembl ].
VAR_003188
Natural variant1471S → C. Ref.11
VAR_015235

Experimental info

Sequence conflict1231P → T in AAL69709. Ref.11
Isoform 2:
Sequence conflict71G → R in CAA25069. Ref.2
Sequence conflict91A → V in CAA25069. Ref.2
Sequence conflict121D → G in CAA25069. Ref.2

Secondary structure

............ 165
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 5598FB9E51A05748

FASTA16517,739
        10         20         30         40         50         60 
MEMFQGLLLL LLLSMGGTWA SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT 

        70         80         90        100        110        120 
MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC 

       130        140        150        160 
GGPKDHPLTC DDPRFQDSSS SKAPPPSLPS PSRLPGPSDT PILPQ 

« Hide

Isoform 2 [UniParc].

Checksum: 853B736271867359
Show »

FASTA18119,053

References

« Hide 'large scale' references
[1]"The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region."
Fiddes J.C., Goodman H.M.
Nature 286:684-687(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone."
Talmadge K., Vamvakopoulos N.C., Fiddes J.C.
Nature 307:37-40(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-137.
[3]"The beta subunit of human chorionic gonadotropin is encoded by multiple genes."
Policastro P., Ovitt C.E., Hoshina M., Fukuoka H., Boothby M.R., Boime I.
J. Biol. Chem. 258:11492-11499(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-24 AND ALA-137.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[6]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-4 AND ALA-137.
Tissue: Brain and Placenta.
[9]"The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin."
Birken S., Fetherston J., Canfield R.E., Boime I.
J. Biol. Chem. 256:1816-1823(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-20.
[10]"A map of the hCG beta-LH beta gene cluster."
Policastro P.F., Daniels-Mcqueen S., Carle G., Boime I.
J. Biol. Chem. 261:5907-5916(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5.
[11]"Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection."
Maston G.A., Ruvolo M.
Mol. Biol. Evol. 19:320-335(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-164, VARIANTS ALA-18; ARG-22; MET-24; TRP-28; HIS-30; ILE-35; ALA-137 AND CYS-147.
[12]"The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit."
Morgan F.J., Birken S., Canfield R.E.
J. Biol. Chem. 250:5247-5258(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-165.
[13]"Human chorionic gonadotropin. Linear amino acid sequence of the beta subunit."
Carlsen R.B., Bahl O.P., Swaminathan N.
J. Biol. Chem. 248:6810-6827(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PROTEIN SEQUENCE OF 21-165.
[14]"Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin."
Mise T., Bahl O.P.
J. Biol. Chem. 256:6587-6592(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS.
[15]"Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form."
Saccuzo Beebe J., Mountjoy K., Krzesicki R.F., Perini F., Ruddon R.W.
J. Biol. Chem. 265:312-317(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[16]"Site-specific N-glycosylation of human chorionic gonadotrophin --structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy."
Weisshaar G., Hiyama J., Renwick A.G.C.
Glycobiology 1:393-404(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE OF CARBOHYDRATES.
[17]"Crystal structure of human chorionic gonadotropin."
Lapthorn A.J., Harris D.C., Littlejohn A., Lustbader J.W., Canfield R.E., Machin K.J., Morgan F.J., Isaacs N.W.
Nature 369:455-461(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
+Additional computationally mapped references.

Web resources

Wikipedia

Chorionic gonadotropin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00117 mRNA. Translation: AAA96690.1.
X00265 Genomic DNA. Translation: CAA25068.1. Different initiation.
X00266 Genomic DNA. Translation: CAA25069.1. Different initiation.
K03189, K03187, K03188 Genomic DNA. Translation: AAA53288.1.
K03183, K00092, K03182 Genomic DNA. Translation: AAA53287.1.
BT006890 mRNA. Translation: AAP35536.1.
AK291552 mRNA. Translation: BAF84241.1.
AC008687 Genomic DNA. No translation available.
CH471177 Genomic DNA. Translation: EAW52434.1.
CH471177 Genomic DNA. Translation: EAW52437.1.
CH471177 Genomic DNA. Translation: EAW52438.1.
CH471177 Genomic DNA. Translation: EAW52439.1.
BC006290 mRNA. Translation: AAH06290.1.
BC022796 mRNA. Translation: AAH22796.1.
BC030994 mRNA. Translation: AAH30994.1.
BC041054 mRNA. Translation: AAH41054.1.
BC051378 mRNA. Translation: AAH51378.1.
BC069526 mRNA. Translation: AAH69526.1.
BC103969 mRNA. Translation: AAI03970.1.
BC103970 mRNA. Translation: AAI03971.1.
BC103971 mRNA. Translation: AAI03972.1.
BC106059 mRNA. Translation: AAI06060.1.
BC106723 mRNA. Translation: AAI06724.1.
BC106724 mRNA. Translation: AAI06725.1.
BC128603 mRNA. Translation: AAI28604.1.
M13503 Genomic DNA. Translation: AAA52009.1.
M13504 Genomic DNA. Translation: AAA52005.1.
M13505 Genomic DNA. Translation: AAA52008.1.
AF397576 Genomic DNA. Translation: AAL69704.1.
AF397577 Genomic DNA. Translation: AAL69705.1.
AF397578 Genomic DNA. Translation: AAL69706.1.
AF397579 Genomic DNA. Translation: AAL69707.1.
AF397580 Genomic DNA. Translation: AAL69708.1.
AF397581 Genomic DNA. Translation: AAL69709.1.
PIRKTHUB. A93230.
I37231.
RefSeqNP_000728.1. NM_000737.3.
NP_149032.1. NM_033043.1.
NP_149133.1. NM_033142.1.
NP_149439.1. NM_033183.2.
XP_005258480.1. XM_005258423.1.
XP_005259480.1. XM_005259423.1.
XP_005259483.1. XM_005259426.1.
UniGeneHs.172944.
Hs.446683.
Hs.659014.
Hs.681647.
Hs.743279.
Hs.745468.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HCNX-ray2.60B21-165[»]
1HRPX-ray3.00B21-165[»]
1QFWX-ray3.50B21-165[»]
1XULmodel-B21-165[»]
DisProtDP00013.
ProteinModelPortalP01233.
SMRP01233. Positions 22-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107508. 2 interactions.
DIPDIP-6183N.
MINTMINT-1510897.

Chemistry

DrugBankDB00097. Choriogonadotropin alfa.

PTM databases

PhosphoSiteP01233.
UniCarbKBP01233.

Polymorphism databases

DMDM116184.

Proteomic databases

PaxDbP01233.
PeptideAtlasP01233.
PRIDEP01233.

Protocols and materials databases

DNASU1082.
93659.
94027.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301408; ENSP00000301408; ENSG00000189052. [P01233-1]
ENST00000357383; ENSP00000349954; ENSG00000104827. [P01233-1]
ENST00000377280; ENSP00000366493; ENSG00000196337.
ENST00000448456; ENSP00000403649; ENSG00000213030. [P01233-1]
ENST00000596965; ENSP00000469076; ENSG00000196337.
ENST00000597853; ENSP00000470813; ENSG00000196337.
GeneID1082.
93659.
94027.
94115.
KEGGhsa:1082.
hsa:93659.
hsa:94027.
hsa:94115.
UCSCuc002plv.2. human. [P01233-1]

Organism-specific databases

CTD1082.
93659.
94027.
94115.
GeneCardsGC19M049526.
GC19M049550.
GC19M049557.
GC19P049547.
HGNCHGNC:1886. CGB.
HGNC:16452. CGB5.
HGNC:16451. CGB7.
HGNC:16453. CGB8.
HPACAB000042.
CAB010884.
HPA038925.
HPA038934.
MIM118860. gene.
608825. gene.
608826. gene.
608827. gene.
neXtProtNX_P01233.
PharmGKBPA26439.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284462.
HOVERGENHBG006698.
InParanoidP01233.
KOK10045.
OMATWASSEP.
OrthoDBEOG7JQBQF.
PhylomeDBP01233.
TreeFamTF332940.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

BgeeP01233.
CleanExHS_CGB.
HS_CGB5.
HS_CGB7.
GenevestigatorP01233.

Family and domain databases

InterProIPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERPTHR11515. PTHR11515. 1 hit.
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00068. GHB. 1 hit.
[Graphical view]
PROSITEPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01233.
GeneWikiCGB7.
Chorionic_gonadotropin_beta.
NextBio4508.
PROP01233.
SOURCESearch...

Entry information

Entry nameCGHB_HUMAN
AccessionPrimary (citable) accession number: P01233
Secondary accession number(s): A1A5E0 expand/collapse secondary AC list , B9ZVP5, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5, Q8WXL1, Q8WXL2, Q8WXL3, Q8WXL4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM