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Protein

Lutropin subunit beta

Gene

LHB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-SSC-193048. Androgen biosynthesis.
R-SSC-193993. Mineralocorticoid biosynthesis.
R-SSC-209822. Glycoprotein hormones.
R-SSC-375281. Hormone ligand-binding receptors.
R-SSC-418555. G alpha (s) signalling events.
R-SSC-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-SSC-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:LHB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001173221 – 141Lutropin subunit beta1 PublicationAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Blocked amino end (Ser)1 Publication1
Disulfide bondi29 ↔ 77By similarity
Glycosylationi33N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01232.
PRIDEiP01232.

Expressioni

Gene expression databases

BgeeiENSSSCG00000003151.
GenevisibleiP01232. SS.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003414.

Structurei

3D structure databases

ProteinModelPortaliP01232.
SMRiP01232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01232.
KOiK08521.
OMAiTTTICAG.
OrthoDBiEOG091G0XFH.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiView protein in Pfam
PF00007. Cys_knot. 1 hit.
SMARTiView protein in SMART
SM00068. GHB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLQGLLLW LLLSVAGVWA SRGPLRPLCR PINATLAAEN EACPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELSFASIRLP GCPPGVDPTV
110 120 130 140
SFPVALSCHC GPCRLSSSDC GGPRAQPLAC DRPLLPGLLF L
Length:141
Mass (Da):14,889
Last modified:November 1, 1990 - v2
Checksum:i803E8E7C59F3C2CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6G → R in AAP92114 (Ref. 3) Curated1
Sequence conflicti40N → D AA sequence (PubMed:4770795).Curated1
Sequence conflicti57Y → D in AAP92114 (Ref. 3) Curated1
Sequence conflicti62V → R AA sequence (PubMed:4770795).Curated1
Sequence conflicti83S → I AA sequence (PubMed:4770795).Curated1
Sequence conflicti87I → S AA sequence (PubMed:4770795).Curated1
Sequence conflicti122 – 123GP → PG AA sequence (PubMed:4770795).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30R → Z. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00579 Genomic DNA. Translation: BAA00457.1.
AY329372 mRNA. Translation: AAP92114.1.
PIRiA48170. UTPGB.
RefSeqiNP_999245.1. NM_214080.1.
UniGeneiSsc.15715.

Genome annotation databases

EnsembliENSSSCT00000003497; ENSSSCP00000003414; ENSSSCG00000003151.
GeneIDi397153.
KEGGissc:397153.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLSHB_PIG
AccessioniPrimary (citable) accession number: P01232
Secondary accession number(s): Q7YRL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: June 7, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families