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Protein

Lutropin subunit beta

Gene

LHB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-193048. Androgen biosynthesis.
R-SSC-193993. Mineralocorticoid biosynthesis.
R-SSC-209822. Glycoprotein hormones.
R-SSC-375281. Hormone ligand-binding receptors.
R-SSC-418555. G alpha (s) signalling events.
R-SSC-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:LHB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 141121Lutropin subunit beta1 PublicationPRO_0000011732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Blocked amino end (Ser)1 Publication
Disulfide bondi29 ↔ 77By similarity
Glycosylationi33 – 331N-linked (GlcNAc...)1 Publication
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01232.

Expressioni

Gene expression databases

BgeeiENSSSCG00000003151.
GenevisibleiP01232. SS.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003414.

Structurei

3D structure databases

ProteinModelPortaliP01232.
SMRiP01232. Positions 24-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01232.
KOiK08521.
OMAiCRCGPCR.
OrthoDBiEOG091G0XFH.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLQGLLLW LLLSVAGVWA SRGPLRPLCR PINATLAAEN EACPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELSFASIRLP GCPPGVDPTV
110 120 130 140
SFPVALSCHC GPCRLSSSDC GGPRAQPLAC DRPLLPGLLF L
Length:141
Mass (Da):14,889
Last modified:November 1, 1990 - v2
Checksum:i803E8E7C59F3C2CF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → R in AAP92114 (Ref. 3) Curated
Sequence conflicti40 – 401N → D AA sequence (PubMed:4770795).Curated
Sequence conflicti57 – 571Y → D in AAP92114 (Ref. 3) Curated
Sequence conflicti62 – 621V → R AA sequence (PubMed:4770795).Curated
Sequence conflicti83 – 831S → I AA sequence (PubMed:4770795).Curated
Sequence conflicti87 – 871I → S AA sequence (PubMed:4770795).Curated
Sequence conflicti122 – 1232GP → PG AA sequence (PubMed:4770795).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301R → Z.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00579 Genomic DNA. Translation: BAA00457.1.
AY329372 mRNA. Translation: AAP92114.1.
PIRiA48170. UTPGB.
RefSeqiNP_999245.1. NM_214080.1.
UniGeneiSsc.15715.

Genome annotation databases

EnsembliENSSSCT00000003497; ENSSSCP00000003414; ENSSSCG00000003151.
GeneIDi397153.
KEGGissc:397153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00579 Genomic DNA. Translation: BAA00457.1.
AY329372 mRNA. Translation: AAP92114.1.
PIRiA48170. UTPGB.
RefSeqiNP_999245.1. NM_214080.1.
UniGeneiSsc.15715.

3D structure databases

ProteinModelPortaliP01232.
SMRiP01232. Positions 24-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003414.

Proteomic databases

PaxDbiP01232.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000003497; ENSSSCP00000003414; ENSSSCG00000003151.
GeneIDi397153.
KEGGissc:397153.

Organism-specific databases

CTDi3972.

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01232.
KOiK08521.
OMAiCRCGPCR.
OrthoDBiEOG091G0XFH.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-SSC-193048. Androgen biosynthesis.
R-SSC-193993. Mineralocorticoid biosynthesis.
R-SSC-209822. Glycoprotein hormones.
R-SSC-375281. Hormone ligand-binding receptors.
R-SSC-418555. G alpha (s) signalling events.
R-SSC-975578. Reactions specific to the complex N-glycan synthesis pathway.

Gene expression databases

BgeeiENSSSCG00000003151.
GenevisibleiP01232. SS.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHB_PIG
AccessioniPrimary (citable) accession number: P01232
Secondary accession number(s): Q7YRL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.