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Protein

Lutropin subunit beta

Gene

Lhb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:Lhb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3006. Lhb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001173321 – 141Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 77By similarity
Glycosylationi33N-linked (GlcNAc...)Curated1
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01230.

Expressioni

Gene expression databases

ExpressionAtlasiP01230. differential.
GenevisibleiP01230. RN.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060360.

Structurei

3D structure databases

ProteinModelPortaliP01230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01230.
KOiK08521.
OMAiCRCGPCR.
OrthoDBiEOG091G0XFH.
PhylomeDBiP01230.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELRFASVRLP GCPPGVDPIV
110 120 130 140
SFPVALSCRC GPCRLSSSDC GGPRTQPMTC DLPHLPGLLL F
Length:141
Mass (Da):15,177
Last modified:July 21, 1986 - v1
Checksum:i50796FB8E32F83BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01542 mRNA. Translation: CAA24783.1.
J00749 Genomic DNA. Translation: AAA96703.1.
D00576 mRNA. Translation: BAA00454.1.
PIRiA01498. UTRTB.
RefSeqiNP_001029147.1. NM_001033975.1.
NP_036990.1. NM_012858.2.
UniGeneiRn.10108.
Rn.224467.

Genome annotation databases

EnsembliENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000047040.
GeneIDi25329.
KEGGirno:25329.
UCSCiRGD:3006. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01542 mRNA. Translation: CAA24783.1.
J00749 Genomic DNA. Translation: AAA96703.1.
D00576 mRNA. Translation: BAA00454.1.
PIRiA01498. UTRTB.
RefSeqiNP_001029147.1. NM_001033975.1.
NP_036990.1. NM_012858.2.
UniGeneiRn.10108.
Rn.224467.

3D structure databases

ProteinModelPortaliP01230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060360.

Proteomic databases

PaxDbiP01230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000047040.
GeneIDi25329.
KEGGirno:25329.
UCSCiRGD:3006. rat.

Organism-specific databases

CTDi3972.
RGDi3006. Lhb.

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01230.
KOiK08521.
OMAiCRCGPCR.
OrthoDBiEOG091G0XFH.
PhylomeDBiP01230.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

PROiP01230.

Gene expression databases

ExpressionAtlasiP01230. differential.
GenevisibleiP01230. RN.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHB_RAT
AccessioniPrimary (citable) accession number: P01230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.