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Protein

Lutropin subunit beta

Gene

Lhb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:Lhb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3006. Lhb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 141121Lutropin subunit betaPRO_0000011733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 77By similarity
Glycosylationi33 – 331N-linked (GlcNAc...)Curated
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01230.

Expressioni

Gene expression databases

ExpressionAtlasiP01230. baseline.
GenevisibleiP01230. RN.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060360.

Structurei

3D structure databases

ProteinModelPortaliP01230.
SMRiP01230. Positions 24-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01230.
KOiK08521.
PhylomeDBiP01230.
TreeFamiTF332940.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELRFASVRLP GCPPGVDPIV
110 120 130 140
SFPVALSCRC GPCRLSSSDC GGPRTQPMTC DLPHLPGLLL F
Length:141
Mass (Da):15,177
Last modified:July 21, 1986 - v1
Checksum:i50796FB8E32F83BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01542 mRNA. Translation: CAA24783.1.
J00749 Genomic DNA. Translation: AAA96703.1.
D00576 mRNA. Translation: BAA00454.1.
PIRiA01498. UTRTB.
RefSeqiNP_001029147.1. NM_001033975.1.
NP_036990.1. NM_012858.2.
UniGeneiRn.10108.
Rn.224467.

Genome annotation databases

EnsembliENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000047040.
GeneIDi25329.
KEGGirno:25329.
UCSCiRGD:3006. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01542 mRNA. Translation: CAA24783.1.
J00749 Genomic DNA. Translation: AAA96703.1.
D00576 mRNA. Translation: BAA00454.1.
PIRiA01498. UTRTB.
RefSeqiNP_001029147.1. NM_001033975.1.
NP_036990.1. NM_012858.2.
UniGeneiRn.10108.
Rn.224467.

3D structure databases

ProteinModelPortaliP01230.
SMRiP01230. Positions 24-131.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060360.

Proteomic databases

PaxDbiP01230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000047040.
GeneIDi25329.
KEGGirno:25329.
UCSCiRGD:3006. rat.

Organism-specific databases

CTDi3972.
RGDi3006. Lhb.

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01230.
KOiK08521.
PhylomeDBiP01230.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-RNO-193048. Androgen biosynthesis.
R-RNO-193993. Mineralocorticoid biosynthesis.
R-RNO-209822. Glycoprotein hormones.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-975578. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

PROiP01230.

Gene expression databases

ExpressionAtlasiP01230. baseline.
GenevisibleiP01230. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin."
    Chin W.W., Godine J.E., Klein D.R., Chang A.S., Tan L.K., Habener J.F.
    Proc. Natl. Acad. Sci. U.S.A. 80:4649-4653(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence."
    Jameson L., Chin W.W., Hollenberg A.N., Chang A.S., Habener J.F.
    J. Biol. Chem. 259:15474-15480(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Strain difference in nucleotide sequences of rat glycoprotein hormone subunit cDNAs and gene fragment."
    Kato Y., Ezashi T., Hirai T., Kato T.
    Zool. Sci. 7:877-885(1990)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-141.
    Strain: Wistar Imamichi.
    Tissue: Pituitary anterior lobe.

Entry informationi

Entry nameiLSHB_RAT
AccessioniPrimary (citable) accession number: P01230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.