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P01229 (LSHB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lutropin subunit beta

Short name=Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name=LH-B
Short name=LSH-B
Short name=LSH-beta
Gene names
Name:LHB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length141 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Subunit structure

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location

Secreted.

Tissue specificity

Pituitary gland.

Involvement in disease

Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.2 Ref.3
Chain21 – 141121Lutropin subunit beta
PRO_0000011726

Amino acid modifications

Glycosylation501N-linked (GlcNAc...)
CAR_000045
Disulfide bond29 ↔ 77 By similarity
Disulfide bond43 ↔ 92 By similarity
Disulfide bond46 ↔ 130 By similarity
Disulfide bond54 ↔ 108 By similarity
Disulfide bond58 ↔ 110 By similarity
Disulfide bond113 ↔ 120 By similarity

Natural variations

Natural variant151M → I.
Corresponds to variant rs34247911 [ dbSNP | Ensembl ].
VAR_034098
Natural variant181A → T More effective in stimulating IP3 but not cAMP production. Ref.11
Corresponds to variant rs5030775 [ dbSNP | Ensembl ].
VAR_015672
Natural variant281W → R. Ref.10
Corresponds to variant rs1800447 [ dbSNP | Ensembl ].
VAR_014589
Natural variant351I → T. Ref.10
Corresponds to variant rs34349826 [ dbSNP | Ensembl ].
VAR_014590
Natural variant741Q → R in HGON-LHB; lack of receptor-binding. Ref.8
Corresponds to variant rs5030773 [ dbSNP | Ensembl ].
VAR_003189
Natural variant1221G → S May be implicated in female infertility. Ref.9
Corresponds to variant rs5030774 [ dbSNP | Ensembl ].
VAR_015673

Experimental info

Sequence conflict391E → Q AA sequence Ref.2
Sequence conflict761Missing AA sequence Ref.2
Sequence conflict132 – 1354HPQL → PQH AA sequence Ref.2

Secondary structure

............. 141
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01229 [UniParc].

Last modified November 1, 1995. Version 3.
Checksum: E411766253113F7C

FASTA14115,345
        10         20         30         40         50         60 
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN TTICAGYCPT 

        70         80         90        100        110        120 
MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV SFPVALSCRC GPCRRSTSDC 

       130        140 
GGPKDHPLTC DHPQLSGLLF L 

« Hide

References

[1]"Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone."
Talmadge K., Vamvakopoulos N.C., Fiddes J.C.
Nature 307:37-40(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit."
Sairam M.R., Li C.H.
Biochim. Biophys. Acta 412:70-81(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-141.
[3]"The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH)."
Shome B., Parlow A.F.
J. Clin. Endocrinol. Metab. 36:618-621(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PROTEIN SEQUENCE OF 21-141.
[4]"Structure and significance of human luteinizing hormone-beta core fragment purified from human pituitary extracts."
Birken S., Chen Y., Gawinowicz M.A., Agosto G.M., Canfield R.E., Hartree A.S.
Endocrinology 133:985-989(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-40 AND 75-89.
Tissue: Pituitary.
[5]"Human luteinizing hormone. The amino acid sequence of the subunit."
Closset J., Hennen G., Lequin R.M.
FEBS Lett. 29:97-100(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PARTIAL PROTEIN SEQUENCE.
[6]"NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin."
Weisshaar G., Hiyama J., Renwick A.G.C., Nimtz M.
Eur. J. Biochem. 195:257-268(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE OF CARBOHYDRATE.
[7]"Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy."
Keutmann H.T., Hua Q.-X., Weiss M.A.
Mol. Endocrinol. 6:904-913(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 58-77.
[8]"Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone."
Weiss J., Axelrod L., Whitcomb R.W., Harris P.E., Crowley W.F. Jr., Jameson J.L.
N. Engl. J. Med. 326:179-183(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HGON-LHB ARG-74.
[9]"A new molecular variant of luteinizing hormone associated with female infertility."
Liao W.X., Roy A.C., Chan C., Arulkumaran S., Ratnam S.S.
Fertil. Steril. 69:102-106(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT SER-122.
[10]"Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients."
Takahashi K., Kurioka H., Ozaki T., Kanasaki H., Kohsaka M., Miyazaki K., Karino K.
Hum. Reprod. 13:3338-3344(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARG-28 AND THR-35.
[11]"A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone."
Jiang M., Lamminen T., Pakarinen P., Hellman J., Manna P., Herrera R.J., Huhtaniemi I.
Mol. Hum. Reprod. 8:201-212(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT THR-18.
+Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Luteinizing hormone entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00264 Genomic DNA. Translation: CAA25067.1.
S71273 Genomic DNA. Translation: AAD14960.1. Sequence problems.
CCDSCCDS12748.1.
PIRUTHUB. I37994.
RefSeqNP_000885.1. NM_000894.2.
UniGeneHs.154704.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1M92model-A1-141[»]
ProteinModelPortalP01229.
SMRP01229. Positions 22-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000221421.

Chemistry

DrugBankDB00044. Lutropin alfa.
DB00032. Menotropins.

PTM databases

UniCarbKBP01229.

Polymorphism databases

DMDM1170834.

Proteomic databases

PaxDbP01229.
PRIDEP01229.

Protocols and materials databases

DNASU3972.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221421; ENSP00000221421; ENSG00000104826.
GeneID3972.
KEGGhsa:3972.
UCSCuc002plt.3. human.

Organism-specific databases

CTD3972.
GeneCardsGC19M049519.
HGNCHGNC:6584. LHB.
HPAHPA038925.
MIM152780. gene+phenotype.
neXtProtNX_P01229.
Orphanet325448. Leydig cell hypoplasia due to LHB deficiency.
PharmGKBPA30356.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44551.
HOGENOMHOG000116098.
HOVERGENHBG006698.
InParanoidP01229.
KOK08521.
OMAVCVTFTT.
OrthoDBEOG7JQBQF.
PhylomeDBP01229.
TreeFamTF332940.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressP01229.
BgeeP01229.
CleanExHS_LHB.
GenevestigatorP01229.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERPTHR11515. PTHR11515. 1 hit.
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLuteinizing_hormone_beta_polypeptide.
GenomeRNAi3972.
NextBio15570.
PROP01229.
SOURCESearch...

Entry information

Entry nameLSHB_HUMAN
AccessionPrimary (citable) accession number: P01229
Secondary accession number(s): Q9UDI0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM