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P01229

- LSHB_HUMAN

UniProt

P01229 - LSHB_HUMAN

Protein

Lutropin subunit beta

Gene

LHB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cellular protein metabolic process Source: Reactome
    3. male gonad development Source: ProtInc
    4. peptide hormone processing Source: Reactome
    5. progesterone biosynthetic process Source: BHF-UCL
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_11047. Mineralocorticoid biosynthesis.
    REACT_11059. Androgen biosynthesis.
    REACT_15398. Glycoprotein hormones.
    REACT_16942. Hormone ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lutropin subunit beta
    Short name:
    Lutropin beta chain
    Alternative name(s):
    Luteinizing hormone subunit beta
    Short name:
    LH-B
    Short name:
    LSH-B
    Short name:
    LSH-beta
    Gene namesi
    Name:LHB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6584. LHB.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741Q → R in HGON-LHB; lack of receptor-binding. 1 Publication
    Corresponds to variant rs5030773 [ dbSNP | Ensembl ].
    VAR_003189

    Keywords - Diseasei

    Disease mutation, Pseudohermaphroditism

    Organism-specific databases

    MIMi152780. gene+phenotype.
    Orphaneti325448. Leydig cell hypoplasia due to LHB deficiency.
    PharmGKBiPA30356.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 141121Lutropin subunit betaPRO_0000011726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 77By similarity
    Disulfide bondi43 ↔ 92By similarity
    Disulfide bondi46 ↔ 130By similarity
    Glycosylationi50 – 501N-linked (GlcNAc...)CAR_000045
    Disulfide bondi54 ↔ 108By similarity
    Disulfide bondi58 ↔ 110By similarity
    Disulfide bondi113 ↔ 120By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01229.
    PRIDEiP01229.

    PTM databases

    UniCarbKBiP01229.

    Expressioni

    Tissue specificityi

    Pituitary gland.

    Gene expression databases

    ArrayExpressiP01229.
    BgeeiP01229.
    CleanExiHS_LHB.
    GenevestigatoriP01229.

    Organism-specific databases

    HPAiHPA038925.

    Interactioni

    Subunit structurei

    Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000221421.

    Structurei

    Secondary structure

    1
    141
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 233
    Beta strandi28 – 3811
    Beta strandi47 – 559
    Beta strandi75 – 8814
    Beta strandi99 – 11214
    Turni115 – 1173

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1M92model-A1-141[»]
    ProteinModelPortaliP01229.
    SMRiP01229. Positions 22-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44551.
    HOGENOMiHOG000116098.
    HOVERGENiHBG006698.
    InParanoidiP01229.
    KOiK08521.
    OMAiVCVTFTT.
    OrthoDBiEOG7JQBQF.
    PhylomeDBiP01229.
    TreeFamiTF332940.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view]
    PANTHERiPTHR11515. PTHR11515. 1 hit.
    PfamiPF00007. Cys_knot. 1 hit.
    [Graphical view]
    SMARTiSM00068. GHB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01229-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN    50
    TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV 100
    SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L 141
    Length:141
    Mass (Da):15,345
    Last modified:November 1, 1995 - v3
    Checksum:iE411766253113F7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391E → Q AA sequence (PubMed:1191677)Curated
    Sequence conflicti76 – 761Missing AA sequence (PubMed:1191677)Curated
    Sequence conflicti132 – 1354HPQL → PQH AA sequence (PubMed:1191677)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151M → I.
    Corresponds to variant rs34247911 [ dbSNP | Ensembl ].
    VAR_034098
    Natural varianti18 – 181A → T More effective in stimulating IP3 but not cAMP production. 1 Publication
    Corresponds to variant rs5030775 [ dbSNP | Ensembl ].
    VAR_015672
    Natural varianti28 – 281W → R.1 Publication
    Corresponds to variant rs1800447 [ dbSNP | Ensembl ].
    VAR_014589
    Natural varianti35 – 351I → T.1 Publication
    Corresponds to variant rs34349826 [ dbSNP | Ensembl ].
    VAR_014590
    Natural varianti74 – 741Q → R in HGON-LHB; lack of receptor-binding. 1 Publication
    Corresponds to variant rs5030773 [ dbSNP | Ensembl ].
    VAR_003189
    Natural varianti122 – 1221G → S May be implicated in female infertility. 1 Publication
    Corresponds to variant rs5030774 [ dbSNP | Ensembl ].
    VAR_015673

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00264 Genomic DNA. Translation: CAA25067.1.
    S71273 Genomic DNA. Translation: AAD14960.1. Sequence problems.
    CCDSiCCDS12748.1.
    PIRiI37994. UTHUB.
    RefSeqiNP_000885.1. NM_000894.2.
    UniGeneiHs.154704.

    Genome annotation databases

    EnsembliENST00000221421; ENSP00000221421; ENSG00000104826.
    GeneIDi3972.
    KEGGihsa:3972.
    UCSCiuc002plt.3. human.

    Polymorphism databases

    DMDMi1170834.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Wikipedia

    Luteinizing hormone entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00264 Genomic DNA. Translation: CAA25067.1 .
    S71273 Genomic DNA. Translation: AAD14960.1 . Sequence problems.
    CCDSi CCDS12748.1.
    PIRi I37994. UTHUB.
    RefSeqi NP_000885.1. NM_000894.2.
    UniGenei Hs.154704.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1M92 model - A 1-141 [» ]
    ProteinModelPortali P01229.
    SMRi P01229. Positions 22-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000221421.

    Chemistry

    DrugBanki DB00044. Lutropin alfa.
    DB00032. Menotropins.

    PTM databases

    UniCarbKBi P01229.

    Polymorphism databases

    DMDMi 1170834.

    Proteomic databases

    PaxDbi P01229.
    PRIDEi P01229.

    Protocols and materials databases

    DNASUi 3972.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221421 ; ENSP00000221421 ; ENSG00000104826 .
    GeneIDi 3972.
    KEGGi hsa:3972.
    UCSCi uc002plt.3. human.

    Organism-specific databases

    CTDi 3972.
    GeneCardsi GC19M049519.
    HGNCi HGNC:6584. LHB.
    HPAi HPA038925.
    MIMi 152780. gene+phenotype.
    neXtProti NX_P01229.
    Orphaneti 325448. Leydig cell hypoplasia due to LHB deficiency.
    PharmGKBi PA30356.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44551.
    HOGENOMi HOG000116098.
    HOVERGENi HBG006698.
    InParanoidi P01229.
    KOi K08521.
    OMAi VCVTFTT.
    OrthoDBi EOG7JQBQF.
    PhylomeDBi P01229.
    TreeFami TF332940.

    Enzyme and pathway databases

    Reactomei REACT_11047. Mineralocorticoid biosynthesis.
    REACT_11059. Androgen biosynthesis.
    REACT_15398. Glycoprotein hormones.
    REACT_16942. Hormone ligand-binding receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Luteinizing_hormone_beta_polypeptide.
    GenomeRNAii 3972.
    NextBioi 15570.
    PROi P01229.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01229.
    Bgeei P01229.
    CleanExi HS_LHB.
    Genevestigatori P01229.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view ]
    PANTHERi PTHR11515. PTHR11515. 1 hit.
    Pfami PF00007. Cys_knot. 1 hit.
    [Graphical view ]
    SMARTi SM00068. GHB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone."
      Talmadge K., Vamvakopoulos N.C., Fiddes J.C.
      Nature 307:37-40(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit."
      Sairam M.R., Li C.H.
      Biochim. Biophys. Acta 412:70-81(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-141.
    3. "The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH)."
      Shome B., Parlow A.F.
      J. Clin. Endocrinol. Metab. 36:618-621(1973) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PROTEIN SEQUENCE OF 21-141.
    4. "Structure and significance of human luteinizing hormone-beta core fragment purified from human pituitary extracts."
      Birken S., Chen Y., Gawinowicz M.A., Agosto G.M., Canfield R.E., Hartree A.S.
      Endocrinology 133:985-989(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-40 AND 75-89.
      Tissue: Pituitary.
    5. "Human luteinizing hormone. The amino acid sequence of the subunit."
      Closset J., Hennen G., Lequin R.M.
      FEBS Lett. 29:97-100(1973) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PARTIAL PROTEIN SEQUENCE.
    6. "NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin."
      Weisshaar G., Hiyama J., Renwick A.G.C., Nimtz M.
      Eur. J. Biochem. 195:257-268(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE OF CARBOHYDRATE.
    7. "Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy."
      Keutmann H.T., Hua Q.-X., Weiss M.A.
      Mol. Endocrinol. 6:904-913(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 58-77.
    8. "Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone."
      Weiss J., Axelrod L., Whitcomb R.W., Harris P.E., Crowley W.F. Jr., Jameson J.L.
      N. Engl. J. Med. 326:179-183(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HGON-LHB ARG-74.
    9. "A new molecular variant of luteinizing hormone associated with female infertility."
      Liao W.X., Roy A.C., Chan C., Arulkumaran S., Ratnam S.S.
      Fertil. Steril. 69:102-106(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-122.
    10. "Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients."
      Takahashi K., Kurioka H., Ozaki T., Kanasaki H., Kohsaka M., Miyazaki K., Karino K.
      Hum. Reprod. 13:3338-3344(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-28 AND THR-35.
    11. "A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone."
      Jiang M., Lamminen T., Pakarinen P., Hellman J., Manna P., Herrera R.J., Huhtaniemi I.
      Mol. Hum. Reprod. 8:201-212(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-18.

    Entry informationi

    Entry nameiLSHB_HUMAN
    AccessioniPrimary (citable) accession number: P01229
    Secondary accession number(s): Q9UDI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 152 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3