Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lutropin subunit beta

Gene

LHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • hormone-mediated signaling pathway Source: GO_Central
  • male gonad development Source: ProtInc
  • ovulation Source: GO_Central
  • peptide hormone processing Source: Reactome
  • progesterone biosynthetic process Source: BHF-UCL
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104826-MONOMER.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-193993. Mineralocorticoid biosynthesis.
R-HSA-209822. Glycoprotein hormones.
R-HSA-375281. Hormone ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-975578. Reactions specific to the complex N-glycan synthesis pathway.
SIGNORiP01229.

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin subunit beta
Short name:
Lutropin beta chain
Alternative name(s):
Luteinizing hormone subunit beta
Short name:
LH-B
Short name:
LSH-B
Short name:
LSH-beta
Gene namesi
Name:LHB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6584. LHB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: GO_Central
  • Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 23 without anosmia (HH23)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
See also OMIM:228300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00318974Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant rs5030773dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

DisGeNETi3972.
MalaCardsiLHB.
MIMi228300. phenotype.
OpenTargetsiENSG00000104826.
Orphaneti325448. Leydig cell hypoplasia due to LHB deficiency.
PharmGKBiPA30356.

Polymorphism and mutation databases

BioMutaiLHB.
DMDMi1170834.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001172621 – 141Lutropin subunit betaAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 77By similarity
Disulfide bondi43 ↔ 92By similarity
Disulfide bondi46 ↔ 130By similarity
GlycosylationiCAR_00004550N-linked (GlcNAc...)1
Disulfide bondi54 ↔ 108By similarity
Disulfide bondi58 ↔ 110By similarity
Disulfide bondi113 ↔ 120By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01229.
PeptideAtlasiP01229.
PRIDEiP01229.

PTM databases

iPTMnetiP01229.
UniCarbKBiP01229.

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSG00000104826.
CleanExiHS_LHB.
ExpressionAtlasiP01229. baseline and differential.
GenevisibleiP01229. HS.

Organism-specific databases

HPAiHPA038925.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

IntActiP01229. 1 interactor.
STRINGi9606.ENSP00000221421.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M92model-A1-141[»]
ProteinModelPortaliP01229.
SMRiP01229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01229.
KOiK08521.
PhylomeDBiP01229.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINAILAVEK EGCPVCITVN
60 70 80 90 100
TTICAGYCPT MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV
110 120 130 140
SFPVALSCRC GPCRRSTSDC GGPKDHPLTC DHPQLSGLLF L
Length:141
Mass (Da):15,345
Last modified:November 1, 1995 - v3
Checksum:iE411766253113F7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39E → Q AA sequence (PubMed:1191677).Curated1
Sequence conflicti76Missing AA sequence (PubMed:1191677).Curated1
Sequence conflicti132 – 135HPQL → PQH AA sequence (PubMed:1191677).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03409815M → I.Corresponds to variant rs34247911dbSNPEnsembl.1
Natural variantiVAR_01567218A → T More effective in stimulating IP3 but not cAMP production. 1 PublicationCorresponds to variant rs5030775dbSNPEnsembl.1
Natural variantiVAR_01458928W → R.1 PublicationCorresponds to variant rs1800447dbSNPEnsembl.1
Natural variantiVAR_01459035I → T.1 PublicationCorresponds to variant rs34349826dbSNPEnsembl.1
Natural variantiVAR_00318974Q → R in HH23; lack of receptor binding. 1 PublicationCorresponds to variant rs5030773dbSNPEnsembl.1
Natural variantiVAR_015673122G → S May be implicated in female infertility. 1 PublicationCorresponds to variant rs5030774dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00264 Genomic DNA. Translation: CAA25067.1.
S71273 Genomic DNA. Translation: AAD14960.1. Sequence problems.
CCDSiCCDS12748.1.
PIRiI37994. UTHUB.
RefSeqiNP_000885.1. NM_000894.2.
UniGeneiHs.154704.

Genome annotation databases

EnsembliENST00000221421; ENSP00000221421; ENSG00000104826.
GeneIDi3972.
KEGGihsa:3972.
UCSCiuc002plt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Luteinizing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00264 Genomic DNA. Translation: CAA25067.1.
S71273 Genomic DNA. Translation: AAD14960.1. Sequence problems.
CCDSiCCDS12748.1.
PIRiI37994. UTHUB.
RefSeqiNP_000885.1. NM_000894.2.
UniGeneiHs.154704.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M92model-A1-141[»]
ProteinModelPortaliP01229.
SMRiP01229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01229. 1 interactor.
STRINGi9606.ENSP00000221421.

PTM databases

iPTMnetiP01229.
UniCarbKBiP01229.

Polymorphism and mutation databases

BioMutaiLHB.
DMDMi1170834.

Proteomic databases

PaxDbiP01229.
PeptideAtlasiP01229.
PRIDEiP01229.

Protocols and materials databases

DNASUi3972.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221421; ENSP00000221421; ENSG00000104826.
GeneIDi3972.
KEGGihsa:3972.
UCSCiuc002plt.4. human.

Organism-specific databases

CTDi3972.
DisGeNETi3972.
GeneCardsiLHB.
HGNCiHGNC:6584. LHB.
HPAiHPA038925.
MalaCardsiLHB.
MIMi152780. gene.
228300. phenotype.
neXtProtiNX_P01229.
OpenTargetsiENSG00000104826.
Orphaneti325448. Leydig cell hypoplasia due to LHB deficiency.
PharmGKBiPA30356.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP01229.
KOiK08521.
PhylomeDBiP01229.
TreeFamiTF332940.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104826-MONOMER.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-193993. Mineralocorticoid biosynthesis.
R-HSA-209822. Glycoprotein hormones.
R-HSA-375281. Hormone ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-975578. Reactions specific to the complex N-glycan synthesis pathway.
SIGNORiP01229.

Miscellaneous databases

GeneWikiiLuteinizing_hormone_beta_polypeptide.
GenomeRNAii3972.
PROiP01229.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104826.
CleanExiHS_LHB.
ExpressionAtlasiP01229. baseline and differential.
GenevisibleiP01229. HS.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLSHB_HUMAN
AccessioniPrimary (citable) accession number: P01229
Secondary accession number(s): Q9UDI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.