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P01217

- GLHA_BOVIN

UniProt

P01217 - GLHA_BOVIN

Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. cellular response to hormone stimulus Source: Ensembl
    2. developmental growth Source: Ensembl
    3. follicle-stimulating hormone secretion Source: Ensembl
    4. gonad development Source: Ensembl
    5. luteinizing hormone secretion Source: Ensembl
    6. negative regulation of organ growth Source: Ensembl
    7. thyroid gland development Source: Ensembl
    8. thyroid hormone generation Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_206547. G alpha (s) signalling events.
    REACT_210620. Hormone ligand-binding receptors.
    REACT_212422. Androgen biosynthesis.
    REACT_218655. Glycoprotein hormones.
    REACT_227794. Mineralocorticoid biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycoprotein hormones alpha chain
    Alternative name(s):
    Anterior pituitary glycoprotein hormones common subunit alpha
    Follicle-stimulating hormone alpha chain
    Short name:
    FSH-alpha
    Follitropin alpha chain
    Luteinizing hormone alpha chain
    Short name:
    LSH-alpha
    Lutropin alpha chain
    Thyroid-stimulating hormone alpha chain
    Short name:
    TSH-alpha
    Thyrotropin alpha chain
    Gene namesi
    Name:CGA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 9

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 12096Glycoprotein hormones alpha chainPRO_0000011633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 59By similarity
    Disulfide bondi38 ↔ 88By similarity
    Disulfide bondi56 ↔ 110By similarity
    Disulfide bondi60 ↔ 112By similarity
    Glycosylationi67 – 671O-linked (GalNAc...)CAR_000035
    Glycosylationi80 – 801N-linked (GlcNAc...)1 Publication
    Disulfide bondi87 ↔ 115
    Glycosylationi106 – 1061N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP01217.

    PTM databases

    UniCarbKBiP01217.

    Interactioni

    Subunit structurei

    Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000021481.

    Structurei

    3D structure databases

    ProteinModelPortaliP01217.
    SMRiP01217. Positions 32-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44826.
    GeneTreeiENSGT00390000012242.
    HOGENOMiHOG000232008.
    HOVERGENiHBG000452.
    InParanoidiP01217.
    KOiK08522.
    OMAiDGEFTMQ.
    OrthoDBiEOG73FQPJ.
    TreeFamiTF332733.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR000476. Glyco_hormone.
    [Graphical view]
    PANTHERiPTHR11509. PTHR11509. 1 hit.
    PfamiPF00236. Hormone_6. 1 hit.
    [Graphical view]
    PRINTSiPR00274. GLYCOHORMONE.
    SMARTiSM00067. GHA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
    PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
    PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01217-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYYRKYAAV ILAILSLFLQ ILHSFPDGEF TMQGCPECKL KENKYFSKPD    50
    APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG 100
    NVRVENHTEC HCSTCYYHKS 120
    Length:120
    Mass (Da):13,616
    Last modified:October 23, 1986 - v1
    Checksum:i246B415F86D04230
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131A → T in CAA24932. (PubMed:6688736)Curated
    Sequence conflicti37 – 371E → Q AA sequence (PubMed:5101174)Curated
    Sequence conflicti52 – 521P → A in CAA24932. (PubMed:6688736)Curated
    Sequence conflicti84 – 874EATC → AZCT AA sequence (PubMed:5107231)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00003, X00004 Genomic DNA. Translation: CAA24907.1.
    X00050 mRNA. Translation: CAA24932.1.
    PIRiA93489. TTBOA.
    RefSeqiNP_776326.1. NM_173901.3.
    XP_005210946.1. XM_005210889.1.
    UniGeneiBt.304.

    Genome annotation databases

    EnsembliENSBTAT00000021481; ENSBTAP00000021481; ENSBTAG00000016138.
    GeneIDi280749.
    KEGGibta:280749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00003 , X00004 Genomic DNA. Translation: CAA24907.1 .
    X00050 mRNA. Translation: CAA24932.1 .
    PIRi A93489. TTBOA.
    RefSeqi NP_776326.1. NM_173901.3.
    XP_005210946.1. XM_005210889.1.
    UniGenei Bt.304.

    3D structure databases

    ProteinModelPortali P01217.
    SMRi P01217. Positions 32-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000021481.

    PTM databases

    UniCarbKBi P01217.

    Proteomic databases

    PRIDEi P01217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021481 ; ENSBTAP00000021481 ; ENSBTAG00000016138 .
    GeneIDi 280749.
    KEGGi bta:280749.

    Organism-specific databases

    CTDi 1081.

    Phylogenomic databases

    eggNOGi NOG44826.
    GeneTreei ENSGT00390000012242.
    HOGENOMi HOG000232008.
    HOVERGENi HBG000452.
    InParanoidi P01217.
    KOi K08522.
    OMAi DGEFTMQ.
    OrthoDBi EOG73FQPJ.
    TreeFami TF332733.

    Enzyme and pathway databases

    Reactomei REACT_206547. G alpha (s) signalling events.
    REACT_210620. Hormone ligand-binding receptors.
    REACT_212422. Androgen biosynthesis.
    REACT_218655. Glycoprotein hormones.
    REACT_227794. Mineralocorticoid biosynthesis.

    Miscellaneous databases

    NextBioi 20804917.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR000476. Glyco_hormone.
    [Graphical view ]
    PANTHERi PTHR11509. PTHR11509. 1 hit.
    Pfami PF00236. Hormone_6. 1 hit.
    [Graphical view ]
    PRINTSi PR00274. GLYCOHORMONE.
    SMARTi SM00067. GHA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
    PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
    PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones."
      Goodwin R.G., Moncman C.L., Rottman F.M., Nilson J.H.
      Nucleic Acids Res. 11:6873-6882(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of cloned complementary deoxyribonucleic acid for the alpha subunit of bovine pituitary glycoprotein hormones."
      Erwin C., Croyle M.L., Donelson J., Maurer R.
      Biochemistry 22:4856-4860(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Nucleotide sequence of a cDNA for the common alpha subunit of the bovine pituitary glycoprotein hormones. Conservation of nucleotides in the 3'-untranslated region of bovine and human pre-alpha subunit mRNAs."
      Nilson J.H., Thomason A.R., Cserbak M.T., Moncman C.L., Woychik R.P.
      J. Biol. Chem. 258:4679-4682(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-120.
    4. "The primary structure of bovine thyrotropin. II. The amino acid sequences of the reduced, S-carboxymethyl alpha and beta chains."
      Liao T.-H., Pierce J.G.
      J. Biol. Chem. 246:850-865(1971) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-120.
    5. "Comparisons between the alpha chain of bovine thyrotropin and the CI chain of luteinizing hormone. Compositions of tryptic peptides, cyanogen bromide fragments, and carbohydrate moieties."
      Pierce J.G., Liao T.-H., Carlsen R.B., Reimo T.
      J. Biol. Chem. 246:866-872(1971) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY PARTIAL PROTEIN SEQUENCE.
    6. "Bovine luteinizing hormone. Study of the primary structure around the carbohydrate attachment sites of the luteinizing hormone alpha-subunit."
      Maghuin-Rogister G., Hennen G.P.
      Eur. J. Biochem. 21:489-497(1971) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 80-91 AND 100-120.
    7. "Studies on the disulfide bonds of glycoprotein hormones. Locations in the alpha chain based on partial reductions and formation of 14C-labeled S-carboxymethyl derivatives."
      Cornell J.S., Pierce J.G.
      J. Biol. Chem. 249:4166-4174(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS.

    Entry informationi

    Entry nameiGLHA_BOVIN
    AccessioniPrimary (citable) accession number: P01217
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 23, 1986
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3