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P01217 (GLHA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name=FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name=LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name=TSH-alpha
Thyrotropin alpha chain
Gene names
Name:CGA
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glycoprotein hormones subunit alpha family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.4
Chain25 – 12096Glycoprotein hormones alpha chain
PRO_0000011633

Amino acid modifications

Glycosylation671O-linked (GalNAc...)
CAR_000035
Glycosylation801N-linked (GlcNAc...) Ref.4
Glycosylation1061N-linked (GlcNAc...) Ref.4
Disulfide bond35 ↔ 59 By similarity
Disulfide bond38 ↔ 88 By similarity
Disulfide bond56 ↔ 110 By similarity
Disulfide bond60 ↔ 112 By similarity
Disulfide bond87 ↔ 115 Ref.7

Experimental info

Sequence conflict131A → T in CAA24932. Ref.2
Sequence conflict371E → Q AA sequence Ref.4
Sequence conflict521P → A in CAA24932. Ref.2
Sequence conflict84 – 874EATC → AZCT AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P01217 [UniParc].

Last modified October 23, 1986. Version 1.
Checksum: 246B415F86D04230

FASTA12013,616
        10         20         30         40         50         60 
MDYYRKYAAV ILAILSLFLQ ILHSFPDGEF TMQGCPECKL KENKYFSKPD APIYQCMGCC 

        70         80         90        100        110        120 
FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG NVRVENHTEC HCSTCYYHKS 

« Hide

References

[1]"Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones."
Goodwin R.G., Moncman C.L., Rottman F.M., Nilson J.H.
Nucleic Acids Res. 11:6873-6882(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of cloned complementary deoxyribonucleic acid for the alpha subunit of bovine pituitary glycoprotein hormones."
Erwin C., Croyle M.L., Donelson J., Maurer R.
Biochemistry 22:4856-4860(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Nucleotide sequence of a cDNA for the common alpha subunit of the bovine pituitary glycoprotein hormones. Conservation of nucleotides in the 3'-untranslated region of bovine and human pre-alpha subunit mRNAs."
Nilson J.H., Thomason A.R., Cserbak M.T., Moncman C.L., Woychik R.P.
J. Biol. Chem. 258:4679-4682(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-120.
[4]"The primary structure of bovine thyrotropin. II. The amino acid sequences of the reduced, S-carboxymethyl alpha and beta chains."
Liao T.-H., Pierce J.G.
J. Biol. Chem. 246:850-865(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-120.
[5]"Comparisons between the alpha chain of bovine thyrotropin and the CI chain of luteinizing hormone. Compositions of tryptic peptides, cyanogen bromide fragments, and carbohydrate moieties."
Pierce J.G., Liao T.-H., Carlsen R.B., Reimo T.
J. Biol. Chem. 246:866-872(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY PARTIAL PROTEIN SEQUENCE.
[6]"Bovine luteinizing hormone. Study of the primary structure around the carbohydrate attachment sites of the luteinizing hormone alpha-subunit."
Maghuin-Rogister G., Hennen G.P.
Eur. J. Biochem. 21:489-497(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 80-91 AND 100-120.
[7]"Studies on the disulfide bonds of glycoprotein hormones. Locations in the alpha chain based on partial reductions and formation of 14C-labeled S-carboxymethyl derivatives."
Cornell J.S., Pierce J.G.
J. Biol. Chem. 249:4166-4174(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00003, X00004 Genomic DNA. Translation: CAA24907.1.
X00050 mRNA. Translation: CAA24932.1.
PIRTTBOA. A93489.
RefSeqNP_776326.1. NM_173901.3.
XP_005210946.1. XM_005210889.1.
UniGeneBt.304.

3D structure databases

ProteinModelPortalP01217.
SMRP01217. Positions 32-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000021481.

PTM databases

UniCarbKBP01217.

Proteomic databases

PRIDEP01217.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000021481; ENSBTAP00000021481; ENSBTAG00000016138.
GeneID280749.
KEGGbta:280749.

Organism-specific databases

CTD1081.

Phylogenomic databases

eggNOGNOG44826.
GeneTreeENSGT00390000012242.
HOGENOMHOG000232008.
HOVERGENHBG000452.
InParanoidP01217.
KOK08522.
OMATCCVAKS.
OrthoDBEOG73FQPJ.
TreeFamTF332733.

Family and domain databases

InterProIPR000476. Glyco_hormone.
[Graphical view]
PANTHERPTHR11509. PTHR11509. 1 hit.
PfamPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSPR00274. GLYCOHORMONE.
SMARTSM00067. GHA. 1 hit.
[Graphical view]
PROSITEPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804917.

Entry information

Entry nameGLHA_BOVIN
AccessionPrimary (citable) accession number: P01217
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: February 19, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families