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P01217

- GLHA_BOVIN

UniProt

P01217 - GLHA_BOVIN

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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular response to hormone stimulus Source: Ensembl
  2. developmental growth Source: Ensembl
  3. follicle-stimulating hormone secretion Source: Ensembl
  4. gonad development Source: Ensembl
  5. luteinizing hormone secretion Source: Ensembl
  6. negative regulation of organ growth Source: Ensembl
  7. thyroid gland development Source: Ensembl
  8. thyroid hormone generation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_206547. G alpha (s) signalling events.
REACT_210620. Hormone ligand-binding receptors.
REACT_212422. Androgen biosynthesis.
REACT_218655. Glycoprotein hormones.
REACT_227794. Mineralocorticoid biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:CGA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 9

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 12096Glycoprotein hormones alpha chainPRO_0000011633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi67 – 671O-linked (GalNAc...)CAR_000035
Glycosylationi80 – 801N-linked (GlcNAc...)1 Publication
Disulfide bondi87 ↔ 115
Glycosylationi106 – 1061N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP01217.

PTM databases

UniCarbKBiP01217.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021481.

Structurei

3D structure databases

ProteinModelPortaliP01217.
SMRiP01217. Positions 32-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44826.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP01217.
KOiK08522.
OMAiDGEFTMQ.
OrthoDBiEOG73FQPJ.
TreeFamiTF332733.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01217-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYYRKYAAV ILAILSLFLQ ILHSFPDGEF TMQGCPECKL KENKYFSKPD
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NVRVENHTEC HCSTCYYHKS
Length:120
Mass (Da):13,616
Last modified:October 23, 1986 - v1
Checksum:i246B415F86D04230
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131A → T in CAA24932. (PubMed:6688736)Curated
Sequence conflicti37 – 371E → Q AA sequence (PubMed:5101174)Curated
Sequence conflicti52 – 521P → A in CAA24932. (PubMed:6688736)Curated
Sequence conflicti84 – 874EATC → AZCT AA sequence (PubMed:5107231)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00003, X00004 Genomic DNA. Translation: CAA24907.1.
X00050 mRNA. Translation: CAA24932.1.
PIRiA93489. TTBOA.
RefSeqiNP_776326.1. NM_173901.3.
XP_005210946.1. XM_005210889.1.
UniGeneiBt.304.

Genome annotation databases

EnsembliENSBTAT00000021481; ENSBTAP00000021481; ENSBTAG00000016138.
GeneIDi280749.
KEGGibta:280749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00003 , X00004 Genomic DNA. Translation: CAA24907.1 .
X00050 mRNA. Translation: CAA24932.1 .
PIRi A93489. TTBOA.
RefSeqi NP_776326.1. NM_173901.3.
XP_005210946.1. XM_005210889.1.
UniGenei Bt.304.

3D structure databases

ProteinModelPortali P01217.
SMRi P01217. Positions 32-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000021481.

PTM databases

UniCarbKBi P01217.

Proteomic databases

PRIDEi P01217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021481 ; ENSBTAP00000021481 ; ENSBTAG00000016138 .
GeneIDi 280749.
KEGGi bta:280749.

Organism-specific databases

CTDi 1081.

Phylogenomic databases

eggNOGi NOG44826.
GeneTreei ENSGT00390000012242.
HOGENOMi HOG000232008.
HOVERGENi HBG000452.
InParanoidi P01217.
KOi K08522.
OMAi DGEFTMQ.
OrthoDBi EOG73FQPJ.
TreeFami TF332733.

Enzyme and pathway databases

Reactomei REACT_206547. G alpha (s) signalling events.
REACT_210620. Hormone ligand-binding receptors.
REACT_212422. Androgen biosynthesis.
REACT_218655. Glycoprotein hormones.
REACT_227794. Mineralocorticoid biosynthesis.

Miscellaneous databases

NextBioi 20804917.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view ]
PANTHERi PTHR11509. PTHR11509. 1 hit.
Pfami PF00236. Hormone_6. 1 hit.
[Graphical view ]
PRINTSi PR00274. GLYCOHORMONE.
SMARTi SM00067. GHA. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and nucleotide sequence of the gene for the common alpha subunit of the bovine pituitary glycoprotein hormones."
    Goodwin R.G., Moncman C.L., Rottman F.M., Nilson J.H.
    Nucleic Acids Res. 11:6873-6882(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of cloned complementary deoxyribonucleic acid for the alpha subunit of bovine pituitary glycoprotein hormones."
    Erwin C., Croyle M.L., Donelson J., Maurer R.
    Biochemistry 22:4856-4860(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Nucleotide sequence of a cDNA for the common alpha subunit of the bovine pituitary glycoprotein hormones. Conservation of nucleotides in the 3'-untranslated region of bovine and human pre-alpha subunit mRNAs."
    Nilson J.H., Thomason A.R., Cserbak M.T., Moncman C.L., Woychik R.P.
    J. Biol. Chem. 258:4679-4682(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-120.
  4. "The primary structure of bovine thyrotropin. II. The amino acid sequences of the reduced, S-carboxymethyl alpha and beta chains."
    Liao T.-H., Pierce J.G.
    J. Biol. Chem. 246:850-865(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-120.
  5. "Comparisons between the alpha chain of bovine thyrotropin and the CI chain of luteinizing hormone. Compositions of tryptic peptides, cyanogen bromide fragments, and carbohydrate moieties."
    Pierce J.G., Liao T.-H., Carlsen R.B., Reimo T.
    J. Biol. Chem. 246:866-872(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PARTIAL PROTEIN SEQUENCE.
  6. "Bovine luteinizing hormone. Study of the primary structure around the carbohydrate attachment sites of the luteinizing hormone alpha-subunit."
    Maghuin-Rogister G., Hennen G.P.
    Eur. J. Biochem. 21:489-497(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 80-91 AND 100-120.
  7. "Studies on the disulfide bonds of glycoprotein hormones. Locations in the alpha chain based on partial reductions and formation of 14C-labeled S-carboxymethyl derivatives."
    Cornell J.S., Pierce J.G.
    J. Biol. Chem. 249:4166-4174(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY ASSIGNMENT OF DISULFIDE BONDS.

Entry informationi

Entry nameiGLHA_BOVIN
AccessioniPrimary (citable) accession number: P01217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3