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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-BTA-193048 Androgen biosynthesis
R-BTA-193993 Mineralocorticoid biosynthesis
R-BTA-209822 Glycoprotein hormones
R-BTA-375281 Hormone ligand-binding receptors
R-BTA-418555 G alpha (s) signalling events
R-BTA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-BTA-975578 Reactions specific to the complex N-glycan synthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:CGA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:27257 CGA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001163325 – 120Glycoprotein hormones alpha chainAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
GlycosylationiCAR_00003567O-linked (GalNAc...) threonine1
Glycosylationi80N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi87 ↔ 115
Glycosylationi106N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01217
PRIDEiP01217

PTM databases

GlyConnecti164
193
349
601
iPTMnetiP01217
UniCarbKBiP01217

Expressioni

Gene expression databases

BgeeiENSBTAG00000016138
ExpressionAtlasiP01217 baseline

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021481

Structurei

3D structure databases

ProteinModelPortaliP01217
SMRiP01217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWI0 Eukaryota
ENOG4111Q75 LUCA
GeneTreeiENSGT00390000012242
HOGENOMiHOG000232008
HOVERGENiHBG000452
InParanoidiP01217
KOiK08522
OMAiFTKATVM
OrthoDBiEOG091G0TRG
TreeFamiTF332733

Family and domain databases

Gene3Di2.10.90.101 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SMARTiView protein in SMART
SM00067 GHA, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00779 GLYCO_HORMONE_ALPHA_1, 1 hit
PS00780 GLYCO_HORMONE_ALPHA_2, 1 hit
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAV ILAILSLFLQ ILHSFPDGEF TMQGCPECKL KENKYFSKPD
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NVRVENHTEC HCSTCYYHKS
Length:120
Mass (Da):13,616
Last modified:October 23, 1986 - v1
Checksum:i246B415F86D04230
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13A → T in CAA24932 (PubMed:6688736).Curated1
Sequence conflicti37E → Q AA sequence (PubMed:5101174).Curated1
Sequence conflicti52P → A in CAA24932 (PubMed:6688736).Curated1
Sequence conflicti84 – 87EATC → AZCT AA sequence (PubMed:5107231).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00003, X00004 Genomic DNA Translation: CAA24907.1
X00050 mRNA Translation: CAA24932.1
PIRiA93489 TTBOA
RefSeqiNP_776326.1, NM_173901.3
UniGeneiBt.304

Genome annotation databases

EnsembliENSBTAT00000021481; ENSBTAP00000021481; ENSBTAG00000016138
GeneIDi280749
KEGGibta:280749

Similar proteinsi

Entry informationi

Entry nameiGLHA_BOVIN
AccessioniPrimary (citable) accession number: P01217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome