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P01216 (GLHA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name=FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name=LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name=TSH-alpha
Thyrotropin alpha chain
Gene names
Name:Cga
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glycoprotein hormones subunit alpha family.

Caution

Ref.2 sequence was originally thought to originate from rat.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 12096Glycoprotein hormones alpha chain
PRO_0000011648

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Probable
Glycosylation1061N-linked (GlcNAc...) Probable
Disulfide bond35 ↔ 59 By similarity
Disulfide bond38 ↔ 88 By similarity
Disulfide bond56 ↔ 110 By similarity
Disulfide bond60 ↔ 112 By similarity
Disulfide bond87 ↔ 115 By similarity

Experimental info

Sequence conflict5 – 62RK → KR in CAA24566. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P01216 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: F2FA2E4632716DBC

FASTA12013,565
        10         20         30         40         50         60 
MDYYRKYAAV ILVMLSMFLH ILHSLPDGDF IIQGCPECKL KENKYFSKLG APIYQCMGCC 

        70         80         90        100        110        120 
FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG NARVENHTEC HCSTCYYHKS

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin."
Chin W.W., Kronenberg H.M., Dee P.C., Maloof F., Habener J.F.
Proc. Natl. Acad. Sci. U.S.A. 78:5329-5333(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Alpha subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs."
Godine J.E., Chin W.W., Habener J.F.
J. Biol. Chem. 257:8368-8371(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Organization and nucleotide sequence of the mouse alpha-subunit gene of the pituitary glycoprotein hormones."
Gordon D.F., Wood W.M., Ridgway E.C.
DNA 7:679-690(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Comparison of glycoprotein hormone alpha-subunits of laboratory animals."
Suzuki O., Mochida K., Yamamoto Y., Noguchi Y., Takano K., Matsuda J., Ogura A.
Mol. Reprod. Dev. 62:335-342(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: JF1.
Tissue: Pituitary.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J00643 mRNA. Translation: AAA96700.1.
V01253 mRNA. Translation: CAA24566.1.
M22991 Genomic DNA. No translation available.
M22992 Genomic DNA. Translation: AAA99228.1.
AF307151 mRNA. Translation: AAG30279.1.
BC087926 mRNA. Translation: AAH87926.1.
IPIIPI00133165.
PIRTTMSA. A31598.
RefSeqNP_034019.1. NM_009889.2.
UniGeneMm.1361.

3D structure databases

ProteinModelPortalP01216.
SMRP01216. Positions 35-120.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000103765.

PTM databases

PhosphoSiteP01216.

Proteomic databases

PaxDbP01216.
PRIDEP01216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298.
ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298.
GeneID12640.
KEGGmmu:12640.

Organism-specific databases

CTD1081.
MGIMGI:88390. Cga.

Phylogenomic databases

eggNOGNOG44826.
GeneTreeENSGT00390000012242.
HOGENOMHOG000232008.
HOVERGENHBG000452.
InParanoidP01216.
KOK08522.
OMATCCVAKS.
OrthoDBEOG4G7C11.

Gene expression databases

ArrayExpressP01216.
BgeeP01216.
CleanExMM_CGA.
GenevestigatorP01216.
GermOnlineENSMUSG00000028298. Mus musculus.

Family and domain databases

InterProIPR000476. Glyco_hormone.
[Graphical view]
PANTHERPTHR11509. PTHR11509. 1 hit.
PfamPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSPR00274. GLYCOHORMONE.
SMARTSM00067. GHA. 1 hit.
[Graphical view]
PROSITEPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281836.
SOURCESearch...

Entry information

Entry nameGLHA_MOUSE
AccessionPrimary (citable) accession number: P01216
Secondary accession number(s): P11963, Q5M8P4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 3, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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