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Protein

Glycoprotein hormones alpha chain

Gene

Cga

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hormone activity Source: MGI

GO - Biological processi

  1. cellular response to hormone stimulus Source: MGI
  2. developmental growth Source: MGI
  3. follicle-stimulating hormone secretion Source: MGI
  4. gonad development Source: MGI
  5. luteinizing hormone secretion Source: MGI
  6. negative regulation of organ growth Source: MGI
  7. thyroid gland development Source: MGI
  8. thyroid hormone generation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_287438. Glycoprotein hormones.
REACT_295506. Hormone ligand-binding receptors.
REACT_295803. Mineralocorticoid biosynthesis.
REACT_305222. Androgen biosynthesis.
REACT_313192. G alpha (s) signalling events.
REACT_330649. Thyroxine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:Cga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88390. Cga.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 12096Glycoprotein hormones alpha chainPRO_0000011648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 59By similarity
Disulfide bondi38 ↔ 88By similarity
Disulfide bondi56 ↔ 110By similarity
Disulfide bondi60 ↔ 112By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Curated
Disulfide bondi87 ↔ 115By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01216.
PRIDEiP01216.

PTM databases

PhosphoSiteiP01216.

Expressioni

Gene expression databases

BgeeiP01216.
CleanExiMM_CGA.
ExpressionAtlasiP01216. differential.
GenevestigatoriP01216.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103765.

Structurei

3D structure databases

ProteinModelPortaliP01216.
SMRiP01216. Positions 35-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44826.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP01216.
KOiK08522.
OMAiDGEFTMQ.
OrthoDBiEOG73FQPJ.
PhylomeDBiP01216.
TreeFamiTF332733.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAV ILVMLSMFLH ILHSLPDGDF IIQGCPECKL KENKYFSKLG
60 70 80 90 100
APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG
110 120
NARVENHTEC HCSTCYYHKS
Length:120
Mass (Da):13,565
Last modified:July 20, 1986 - v1
Checksum:iF2FA2E4632716DBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 62RK → KR in CAA24566 (PubMed:6177696).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00643 mRNA. Translation: AAA96700.1.
V01253 mRNA. Translation: CAA24566.1.
M22991 Genomic DNA. No translation available.
M22992 Genomic DNA. Translation: AAA99228.1.
AF307151 mRNA. Translation: AAG30279.1.
BC087926 mRNA. Translation: AAH87926.1.
CCDSiCCDS18035.1.
PIRiA31598. TTMSA.
RefSeqiNP_034019.1. NM_009889.2.
XP_006537649.1. XM_006537586.2.
UniGeneiMm.1361.

Genome annotation databases

EnsembliENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298.
ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298.
GeneIDi12640.
KEGGimmu:12640.
UCSCiuc008sgq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00643 mRNA. Translation: AAA96700.1.
V01253 mRNA. Translation: CAA24566.1.
M22991 Genomic DNA. No translation available.
M22992 Genomic DNA. Translation: AAA99228.1.
AF307151 mRNA. Translation: AAG30279.1.
BC087926 mRNA. Translation: AAH87926.1.
CCDSiCCDS18035.1.
PIRiA31598. TTMSA.
RefSeqiNP_034019.1. NM_009889.2.
XP_006537649.1. XM_006537586.2.
UniGeneiMm.1361.

3D structure databases

ProteinModelPortaliP01216.
SMRiP01216. Positions 35-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103765.

PTM databases

PhosphoSiteiP01216.

Proteomic databases

PaxDbiP01216.
PRIDEiP01216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298.
ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298.
GeneIDi12640.
KEGGimmu:12640.
UCSCiuc008sgq.1. mouse.

Organism-specific databases

CTDi1081.
MGIiMGI:88390. Cga.

Phylogenomic databases

eggNOGiNOG44826.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP01216.
KOiK08522.
OMAiDGEFTMQ.
OrthoDBiEOG73FQPJ.
PhylomeDBiP01216.
TreeFamiTF332733.

Enzyme and pathway databases

ReactomeiREACT_287438. Glycoprotein hormones.
REACT_295506. Hormone ligand-binding receptors.
REACT_295803. Mineralocorticoid biosynthesis.
REACT_305222. Androgen biosynthesis.
REACT_313192. G alpha (s) signalling events.
REACT_330649. Thyroxine biosynthesis.

Miscellaneous databases

NextBioi281836.
PROiP01216.
SOURCEiSearch...

Gene expression databases

BgeeiP01216.
CleanExiMM_CGA.
ExpressionAtlasiP01216. differential.
GenevestigatoriP01216.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin."
    Chin W.W., Kronenberg H.M., Dee P.C., Maloof F., Habener J.F.
    Proc. Natl. Acad. Sci. U.S.A. 78:5329-5333(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Alpha subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs."
    Godine J.E., Chin W.W., Habener J.F.
    J. Biol. Chem. 257:8368-8371(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Organization and nucleotide sequence of the mouse alpha-subunit gene of the pituitary glycoprotein hormones."
    Gordon D.F., Wood W.M., Ridgway E.C.
    DNA 7:679-690(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Comparison of glycoprotein hormone alpha-subunits of laboratory animals."
    Suzuki O., Mochida K., Yamamoto Y., Noguchi Y., Takano K., Matsuda J., Ogura A.
    Mol. Reprod. Dev. 62:335-342(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: JF1.
    Tissue: Pituitary.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiGLHA_MOUSE
AccessioniPrimary (citable) accession number: P01216
Secondary accession number(s): P11963, Q5M8P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: July 20, 1986
Last modified: March 31, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

PubMed:6177696 sequence was originally thought to originate from rat.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.