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P01216

- GLHA_MOUSE

UniProt

P01216 - GLHA_MOUSE

Protein

Glycoprotein hormones alpha chain

Gene

Cga

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Biological processi

    1. cellular response to hormone stimulus Source: MGI
    2. developmental growth Source: MGI
    3. follicle-stimulating hormone secretion Source: MGI
    4. gonad development Source: MGI
    5. luteinizing hormone secretion Source: MGI
    6. negative regulation of organ growth Source: MGI
    7. thyroid gland development Source: MGI
    8. thyroid hormone generation Source: MGI

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_204887. Mineralocorticoid biosynthesis.
    REACT_219697. Thyroxine biosynthesis.
    REACT_220332. Androgen biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycoprotein hormones alpha chain
    Alternative name(s):
    Anterior pituitary glycoprotein hormones common subunit alpha
    Follicle-stimulating hormone alpha chain
    Short name:
    FSH-alpha
    Follitropin alpha chain
    Luteinizing hormone alpha chain
    Short name:
    LSH-alpha
    Lutropin alpha chain
    Thyroid-stimulating hormone alpha chain
    Short name:
    TSH-alpha
    Thyrotropin alpha chain
    Gene namesi
    Name:Cga
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:88390. Cga.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 12096Glycoprotein hormones alpha chainPRO_0000011648Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 59By similarity
    Disulfide bondi38 ↔ 88By similarity
    Disulfide bondi56 ↔ 110By similarity
    Disulfide bondi60 ↔ 112By similarity
    Glycosylationi80 – 801N-linked (GlcNAc...)Curated
    Disulfide bondi87 ↔ 115By similarity
    Glycosylationi106 – 1061N-linked (GlcNAc...)Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01216.
    PRIDEiP01216.

    PTM databases

    PhosphoSiteiP01216.

    Expressioni

    Gene expression databases

    BgeeiP01216.
    CleanExiMM_CGA.
    GenevestigatoriP01216.

    Interactioni

    Subunit structurei

    Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000103765.

    Structurei

    3D structure databases

    ProteinModelPortaliP01216.
    SMRiP01216. Positions 35-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44826.
    GeneTreeiENSGT00390000012242.
    HOGENOMiHOG000232008.
    HOVERGENiHBG000452.
    InParanoidiP01216.
    KOiK08522.
    OMAiYENSTAR.
    OrthoDBiEOG73FQPJ.
    PhylomeDBiP01216.
    TreeFamiTF332733.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR000476. Glyco_hormone.
    [Graphical view]
    PANTHERiPTHR11509. PTHR11509. 1 hit.
    PfamiPF00236. Hormone_6. 1 hit.
    [Graphical view]
    PRINTSiPR00274. GLYCOHORMONE.
    SMARTiSM00067. GHA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
    PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
    PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01216-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYYRKYAAV ILVMLSMFLH ILHSLPDGDF IIQGCPECKL KENKYFSKLG    50
    APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG 100
    NARVENHTEC HCSTCYYHKS 120
    Length:120
    Mass (Da):13,565
    Last modified:July 21, 1986 - v1
    Checksum:iF2FA2E4632716DBC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 62RK → KR in CAA24566. (PubMed:6177696)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00643 mRNA. Translation: AAA96700.1.
    V01253 mRNA. Translation: CAA24566.1.
    M22991 Genomic DNA. No translation available.
    M22992 Genomic DNA. Translation: AAA99228.1.
    AF307151 mRNA. Translation: AAG30279.1.
    BC087926 mRNA. Translation: AAH87926.1.
    CCDSiCCDS18035.1.
    PIRiA31598. TTMSA.
    RefSeqiNP_034019.1. NM_009889.2.
    XP_006537649.1. XM_006537586.1.
    UniGeneiMm.1361.

    Genome annotation databases

    EnsembliENSMUST00000029975; ENSMUSP00000029975; ENSMUSG00000028298.
    ENSMUST00000108130; ENSMUSP00000103765; ENSMUSG00000028298.
    GeneIDi12640.
    KEGGimmu:12640.
    UCSCiuc008sgq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00643 mRNA. Translation: AAA96700.1 .
    V01253 mRNA. Translation: CAA24566.1 .
    M22991 Genomic DNA. No translation available.
    M22992 Genomic DNA. Translation: AAA99228.1 .
    AF307151 mRNA. Translation: AAG30279.1 .
    BC087926 mRNA. Translation: AAH87926.1 .
    CCDSi CCDS18035.1.
    PIRi A31598. TTMSA.
    RefSeqi NP_034019.1. NM_009889.2.
    XP_006537649.1. XM_006537586.1.
    UniGenei Mm.1361.

    3D structure databases

    ProteinModelPortali P01216.
    SMRi P01216. Positions 35-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000103765.

    PTM databases

    PhosphoSitei P01216.

    Proteomic databases

    PaxDbi P01216.
    PRIDEi P01216.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029975 ; ENSMUSP00000029975 ; ENSMUSG00000028298 .
    ENSMUST00000108130 ; ENSMUSP00000103765 ; ENSMUSG00000028298 .
    GeneIDi 12640.
    KEGGi mmu:12640.
    UCSCi uc008sgq.1. mouse.

    Organism-specific databases

    CTDi 1081.
    MGIi MGI:88390. Cga.

    Phylogenomic databases

    eggNOGi NOG44826.
    GeneTreei ENSGT00390000012242.
    HOGENOMi HOG000232008.
    HOVERGENi HBG000452.
    InParanoidi P01216.
    KOi K08522.
    OMAi YENSTAR.
    OrthoDBi EOG73FQPJ.
    PhylomeDBi P01216.
    TreeFami TF332733.

    Enzyme and pathway databases

    Reactomei REACT_204887. Mineralocorticoid biosynthesis.
    REACT_219697. Thyroxine biosynthesis.
    REACT_220332. Androgen biosynthesis.

    Miscellaneous databases

    NextBioi 281836.
    PROi P01216.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01216.
    CleanExi MM_CGA.
    Genevestigatori P01216.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR000476. Glyco_hormone.
    [Graphical view ]
    PANTHERi PTHR11509. PTHR11509. 1 hit.
    Pfami PF00236. Hormone_6. 1 hit.
    [Graphical view ]
    PRINTSi PR00274. GLYCOHORMONE.
    SMARTi SM00067. GHA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
    PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
    PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin."
      Chin W.W., Kronenberg H.M., Dee P.C., Maloof F., Habener J.F.
      Proc. Natl. Acad. Sci. U.S.A. 78:5329-5333(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Alpha subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs."
      Godine J.E., Chin W.W., Habener J.F.
      J. Biol. Chem. 257:8368-8371(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Organization and nucleotide sequence of the mouse alpha-subunit gene of the pituitary glycoprotein hormones."
      Gordon D.F., Wood W.M., Ridgway E.C.
      DNA 7:679-690(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Comparison of glycoprotein hormone alpha-subunits of laboratory animals."
      Suzuki O., Mochida K., Yamamoto Y., Noguchi Y., Takano K., Matsuda J., Ogura A.
      Mol. Reprod. Dev. 62:335-342(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: JF1.
      Tissue: Pituitary.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiGLHA_MOUSE
    AccessioniPrimary (citable) accession number: P01216
    Secondary accession number(s): P11963, Q5M8P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    PubMed:6177696 sequence was originally thought to originate from rat.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3