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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • hormone activity Source: AgBase

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • peptide hormone processing Source: Reactome
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135346-MONOMER.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-193993. Mineralocorticoid biosynthesis.
R-HSA-209822. Glycoprotein hormones.
R-HSA-209968. Thyroxine biosynthesis.
R-HSA-375281. Hormone ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-HSA-975578. Reactions specific to the complex N-glycan synthesis pathway.
SIGNORiP01215.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Choriogonadotropin alpha chain
Chorionic gonadotrophin subunit alpha
Short name:
CG-alpha
Follicle-stimulating hormone alpha chain
Short name:
FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name:
LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name:
TSH-alpha
Thyrotropin alpha chain
Gene namesi
Name:CGA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1885. CGA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1081.
OpenTargetsiENSG00000135346.
PharmGKBiPA26433.

Chemistry databases

ChEMBLiCHEMBL2146305.

Polymorphism and mutation databases

BioMutaiCGA.
DMDMi121312.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 244 PublicationsAdd BLAST24
ChainiPRO_000001164025 – 116Glycoprotein hormones alpha chainAdd BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 552 Publications
Disulfide bondi34 ↔ 842 Publications
Disulfide bondi52 ↔ 1062 Publications
Disulfide bondi56 ↔ 1082 Publications
GlycosylationiCAR_00003676N-linked (GlcNAc...)1 Publication1
Disulfide bondi83 ↔ 1112 Publications
GlycosylationiCAR_000037102N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01215.
PeptideAtlasiP01215.
PRIDEiP01215.

PTM databases

iPTMnetiP01215.
PhosphoSitePlusiP01215.
UniCarbKBiP01215.

Expressioni

Gene expression databases

BgeeiENSG00000135346.
CleanExiHS_CGA.
ExpressionAtlasiP01215. baseline and differential.
GenevisibleiP01215. HS.

Organism-specific databases

HPAiCAB023350.
HPA029698.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FSHBP012252EBI-718913,EBI-1030645

GO - Molecular functioni

  • hormone activity Source: AgBase

Protein-protein interaction databases

BioGridi107507. 5 interactors.
DIPiDIP-6182N.
IntActiP01215. 3 interactors.
MINTiMINT-1197885.
STRINGi9606.ENSP00000358595.

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 38Combined sources6
Turni40 – 42Combined sources3
Beta strandi50 – 62Combined sources13
Helixi65 – 68Combined sources4
Beta strandi76 – 80Combined sources5
Beta strandi83 – 94Combined sources12
Turni95 – 97Combined sources3
Beta strandi98 – 109Combined sources12
Beta strandi112 – 114Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DZ7NMR-A25-116[»]
1E9JNMR-A25-116[»]
1FL7X-ray3.00A/C25-116[»]
1HCNX-ray2.60A25-116[»]
1HD4NMR-A25-116[»]
1HRPX-ray3.00A25-116[»]
1QFWX-ray3.50A25-116[»]
1XULmodel-A25-116[»]
1XWDX-ray2.92A/D25-116[»]
4AY9X-ray2.50A/D/G25-116[»]
4MQWX-ray2.90A/D/G25-116[»]
ProteinModelPortaliP01215.
SMRiP01215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01215.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP01215.
KOiK08522.
PhylomeDBiP01215.
TreeFamiTF332733.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60 70 80 90 100
QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV
110
ENHTACHCST CYYHKS
Length:116
Mass (Da):13,075
Last modified:July 21, 1986 - v1
Checksum:iF0623CD8CC90CFCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29Q → E AA sequence (PubMed:1158880).Curated1
Sequence conflicti108 – 109CS → SC AA sequence (PubMed:890569).Curated2
Sequence conflicti108 – 109CS → SC AA sequence (PubMed:5065401).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00152, J00150, J00151 Genomic DNA. Translation: AAD13690.1.
S70585, S70583, S70584 Genomic DNA. Translation: AAB30827.1.
BC020782 mRNA. Translation: AAH20782.1.
BC055080 mRNA. Translation: AAH55080.1.
V00518 mRNA. Translation: CAA23777.1.
CCDSiCCDS5007.1.
PIRiA93213. TTHUAP.
RefSeqiNP_000726.1. NM_000735.3.
NP_001239312.1. NM_001252383.1.
UniGeneiHs.119689.

Genome annotation databases

EnsembliENST00000627148; ENSP00000486024; ENSG00000135346.
GeneIDi1081.
KEGGihsa:1081.
UCSCiuc063pyi.1. human.

Cross-referencesi

Web resourcesi

Protein Spotlight

Proteic grace - Issue 77 of December 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00152, J00150, J00151 Genomic DNA. Translation: AAD13690.1.
S70585, S70583, S70584 Genomic DNA. Translation: AAB30827.1.
BC020782 mRNA. Translation: AAH20782.1.
BC055080 mRNA. Translation: AAH55080.1.
V00518 mRNA. Translation: CAA23777.1.
CCDSiCCDS5007.1.
PIRiA93213. TTHUAP.
RefSeqiNP_000726.1. NM_000735.3.
NP_001239312.1. NM_001252383.1.
UniGeneiHs.119689.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DZ7NMR-A25-116[»]
1E9JNMR-A25-116[»]
1FL7X-ray3.00A/C25-116[»]
1HCNX-ray2.60A25-116[»]
1HD4NMR-A25-116[»]
1HRPX-ray3.00A25-116[»]
1QFWX-ray3.50A25-116[»]
1XULmodel-A25-116[»]
1XWDX-ray2.92A/D25-116[»]
4AY9X-ray2.50A/D/G25-116[»]
4MQWX-ray2.90A/D/G25-116[»]
ProteinModelPortaliP01215.
SMRiP01215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107507. 5 interactors.
DIPiDIP-6182N.
IntActiP01215. 3 interactors.
MINTiMINT-1197885.
STRINGi9606.ENSP00000358595.

Chemistry databases

ChEMBLiCHEMBL2146305.

PTM databases

iPTMnetiP01215.
PhosphoSitePlusiP01215.
UniCarbKBiP01215.

Polymorphism and mutation databases

BioMutaiCGA.
DMDMi121312.

Proteomic databases

PaxDbiP01215.
PeptideAtlasiP01215.
PRIDEiP01215.

Protocols and materials databases

DNASUi1081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000627148; ENSP00000486024; ENSG00000135346.
GeneIDi1081.
KEGGihsa:1081.
UCSCiuc063pyi.1. human.

Organism-specific databases

CTDi1081.
DisGeNETi1081.
GeneCardsiCGA.
HGNCiHGNC:1885. CGA.
HPAiCAB023350.
HPA029698.
MIMi118850. gene.
neXtProtiNX_P01215.
OpenTargetsiENSG00000135346.
PharmGKBiPA26433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWI0. Eukaryota.
ENOG4111Q75. LUCA.
GeneTreeiENSGT00390000012242.
HOGENOMiHOG000232008.
HOVERGENiHBG000452.
InParanoidiP01215.
KOiK08522.
PhylomeDBiP01215.
TreeFamiTF332733.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135346-MONOMER.
ReactomeiR-HSA-193048. Androgen biosynthesis.
R-HSA-193993. Mineralocorticoid biosynthesis.
R-HSA-209822. Glycoprotein hormones.
R-HSA-209968. Thyroxine biosynthesis.
R-HSA-375281. Hormone ligand-binding receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-HSA-975578. Reactions specific to the complex N-glycan synthesis pathway.
SIGNORiP01215.

Miscellaneous databases

ChiTaRSiCGA. human.
EvolutionaryTraceiP01215.
GeneWikiiChorionic_gonadotropin_alpha.
GenomeRNAii1081.
PROiP01215.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135346.
CleanExiHS_CGA.
ExpressionAtlasiP01215. baseline and differential.
GenevisibleiP01215. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR000476. Glyco_hormone.
[Graphical view]
PANTHERiPTHR11509. PTHR11509. 1 hit.
PfamiPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSiPR00274. GLYCOHORMONE.
SMARTiSM00067. GHA. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLHA_HUMAN
AccessioniPrimary (citable) accession number: P01215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 178 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.