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Protein

Proenkephalin-B

Gene

PDYN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:PDYN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000819121 – 172Add BLAST152
PeptideiPRO_0000306358175 – 184Alpha-neoendorphinBy similarity10
PeptideiPRO_0000008192175 – 183Beta-neoendorphin9
PeptideiPRO_0000306359175 – 179Leu-enkephalinBy similarity5
PropeptideiPRO_0000008193186 – 206Add BLAST21
PeptideiPRO_0000306360209 – 240Big dynorphinBy similarityAdd BLAST32
PeptideiPRO_0000306361209 – 225Dynorphin A(1-17)Add BLAST17
PeptideiPRO_0000306362209 – 221Dynorphin A(1-13)Add BLAST13
PeptideiPRO_0000306363209 – 216Dynorphin A(1-8)8
PeptideiPRO_0000306364209 – 213Leu-enkephalinBy similarity5
PeptideiPRO_0000008195228 – 256LeumorphinAdd BLAST29
PeptideiPRO_0000008196228 – 240RimorphinAdd BLAST13
PeptideiPRO_0000008197228 – 232Leu-enkephalin5

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01214.
PRIDEiP01214.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007643.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP01214.
KOiK15840.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWQGLLLAA CLLVLPSTMA DCLSGCSLCA VKTQDGPKPI NPLICSLECQ
60 70 80 90 100
AALQPAEEWE RCQGLLSFLA PLSLGLEGKE DLESKAALEE PSSELVKYMG
110 120 130 140 150
PFLKELEKNR FLLSTPAEET SLSRSLVEKL RSLPGRLGEE TESELMGDAQ
160 170 180 190 200
QNDGAMEAAA LDSSVEDPKE QVKRYGGFLR KYPKRSSEVA GEGDGDRDKV
210 220 230 240 250
GHEDLYKRYG GFLRRIRPKL KWDNQKRYGG FLRRQFKVVT RSQEDPNAYY

EELFDV
Length:256
Mass (Da):28,617
Last modified:July 21, 1986 - v1
Checksum:i6814412E3A8DB3AE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti147G → E.1
Natural varianti197R → G.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01362 mRNA. Translation: CAA24650.1.
PIRiA93280. DFPG.
RefSeqiNP_001004040.1. NM_001004040.1.
UniGeneiSsc.121.
Ssc.87911.

Genome annotation databases

GeneIDi445529.
KEGGissc:445529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01362 mRNA. Translation: CAA24650.1.
PIRiA93280. DFPG.
RefSeqiNP_001004040.1. NM_001004040.1.
UniGeneiSsc.121.
Ssc.87911.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007643.

Proteomic databases

PaxDbiP01214.
PRIDEiP01214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445529.
KEGGissc:445529.

Organism-specific databases

CTDi5173.

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP01214.
KOiK15840.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDYN_PIG
AccessioniPrimary (citable) accession number: P01214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 5, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.