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P01214

- PDYN_PIG

UniProt

P01214 - PDYN_PIG

Protein

Proenkephalin-B

Gene

PDYN

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.By similarity
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-B
    Alternative name(s):
    Beta-neoendorphin-dynorphin
    Preprodynorphin
    Cleaved into the following 9 chains:
    Big dynorphin
    Short name:
    Big Dyn
    Dynorphin A(1-17)
    Short name:
    Dyn-A17
    Short name:
    Dynorphin A
    Alternative name(s):
    Dynorphin B
    Short name:
    Dyn-B
    Dynorphin B(1-13)
    Alternative name(s):
    Dynorphin B-29
    Gene namesi
    Name:PDYN
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 172152PRO_0000008191Add
    BLAST
    Peptidei175 – 18410Alpha-neoendorphinBy similarityPRO_0000306358
    Peptidei175 – 1839Beta-neoendorphinPRO_0000008192
    Peptidei175 – 1795Leu-enkephalinBy similarityPRO_0000306359
    Propeptidei186 – 20621PRO_0000008193Add
    BLAST
    Peptidei209 – 24032Big dynorphinBy similarityPRO_0000306360Add
    BLAST
    Peptidei209 – 22517Dynorphin A(1-17)PRO_0000306361Add
    BLAST
    Peptidei209 – 22113Dynorphin A(1-13)PRO_0000306362Add
    BLAST
    Peptidei209 – 2168Dynorphin A(1-8)PRO_0000306363
    Peptidei209 – 2135Leu-enkephalinBy similarityPRO_0000306364
    Peptidei228 – 25629LeumorphinPRO_0000008195Add
    BLAST
    Peptidei228 – 24013RimorphinPRO_0000008196Add
    BLAST
    Peptidei228 – 2325Leu-enkephalinPRO_0000008197

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000007643.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46156.
    HOGENOMiHOG000013003.
    HOVERGENiHBG000063.
    KOiK15840.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01214-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWQGLLLAA CLLVLPSTMA DCLSGCSLCA VKTQDGPKPI NPLICSLECQ    50
    AALQPAEEWE RCQGLLSFLA PLSLGLEGKE DLESKAALEE PSSELVKYMG 100
    PFLKELEKNR FLLSTPAEET SLSRSLVEKL RSLPGRLGEE TESELMGDAQ 150
    QNDGAMEAAA LDSSVEDPKE QVKRYGGFLR KYPKRSSEVA GEGDGDRDKV 200
    GHEDLYKRYG GFLRRIRPKL KWDNQKRYGG FLRRQFKVVT RSQEDPNAYY 250
    EELFDV 256
    Length:256
    Mass (Da):28,617
    Last modified:July 21, 1986 - v1
    Checksum:i6814412E3A8DB3AE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471G → E.
    Natural varianti197 – 1971R → G.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01362 mRNA. Translation: CAA24650.1.
    PIRiA93280. DFPG.
    RefSeqiNP_001004040.1. NM_001004040.1.
    UniGeneiSsc.121.

    Genome annotation databases

    GeneIDi445529.
    KEGGissc:445529.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01362 mRNA. Translation: CAA24650.1 .
    PIRi A93280. DFPG.
    RefSeqi NP_001004040.1. NM_001004040.1.
    UniGenei Ssc.121.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000007643.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 445529.
    KEGGi ssc:445529.

    Organism-specific databases

    CTDi 5173.

    Phylogenomic databases

    eggNOGi NOG46156.
    HOGENOMi HOG000013003.
    HOVERGENi HBG000063.
    KOi K15840.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor."
      Kakidani H., Furutani Y., Takahashi H., Noda M., Morimoto Y., Hirose T., Asai M., Inayama S., Nakanishi S., Numa S.
      Nature 298:245-249(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.
    2. Cited for: PROTEIN SEQUENCE OF 209-221, IDENTIFICATION, CHARACTERIZATION OF DYNORPHIN A(1-13).
    3. "A new opioid octapeptide related to dynorphin from porcine hypothalamus."
      Minamino N., Kangawa K., Fukuda A., Matsuo H., Iagarashi M.
      Biochem. Biophys. Res. Commun. 95:1475-1481(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 209-216, IDENTIFICATION OF DYNORPHIN A(1-8).
      Tissue: Hypothalamus.
    4. Cited for: IDENTIFICATION OF LEUMORPHIN AND RIMORPHIN.

    Entry informationi

    Entry nameiPDYN_PIG
    AccessioniPrimary (citable) accession number: P01214
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3