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Protein

Proenkephalin-B

Gene

PDYN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:PDYN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 172152PRO_0000008191Add
BLAST
Peptidei175 – 18410Alpha-neoendorphinBy similarityPRO_0000306358
Peptidei175 – 1839Beta-neoendorphinPRO_0000008192
Peptidei175 – 1795Leu-enkephalinBy similarityPRO_0000306359
Propeptidei186 – 20621PRO_0000008193Add
BLAST
Peptidei209 – 24032Big dynorphinBy similarityPRO_0000306360Add
BLAST
Peptidei209 – 22517Dynorphin A(1-17)PRO_0000306361Add
BLAST
Peptidei209 – 22113Dynorphin A(1-13)PRO_0000306362Add
BLAST
Peptidei209 – 2168Dynorphin A(1-8)PRO_0000306363
Peptidei209 – 2135Leu-enkephalinBy similarityPRO_0000306364
Peptidei228 – 25629LeumorphinPRO_0000008195Add
BLAST
Peptidei228 – 24013RimorphinPRO_0000008196Add
BLAST
Peptidei228 – 2325Leu-enkephalinPRO_0000008197

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007643.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP01214.
KOiK15840.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWQGLLLAA CLLVLPSTMA DCLSGCSLCA VKTQDGPKPI NPLICSLECQ
60 70 80 90 100
AALQPAEEWE RCQGLLSFLA PLSLGLEGKE DLESKAALEE PSSELVKYMG
110 120 130 140 150
PFLKELEKNR FLLSTPAEET SLSRSLVEKL RSLPGRLGEE TESELMGDAQ
160 170 180 190 200
QNDGAMEAAA LDSSVEDPKE QVKRYGGFLR KYPKRSSEVA GEGDGDRDKV
210 220 230 240 250
GHEDLYKRYG GFLRRIRPKL KWDNQKRYGG FLRRQFKVVT RSQEDPNAYY

EELFDV
Length:256
Mass (Da):28,617
Last modified:July 21, 1986 - v1
Checksum:i6814412E3A8DB3AE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471G → E.
Natural varianti197 – 1971R → G.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01362 mRNA. Translation: CAA24650.1.
PIRiA93280. DFPG.
RefSeqiNP_001004040.1. NM_001004040.1.
UniGeneiSsc.121.

Genome annotation databases

GeneIDi445529.
KEGGissc:445529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01362 mRNA. Translation: CAA24650.1.
PIRiA93280. DFPG.
RefSeqiNP_001004040.1. NM_001004040.1.
UniGeneiSsc.121.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445529.
KEGGissc:445529.

Organism-specific databases

CTDi5173.

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP01214.
KOiK15840.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor."
    Kakidani H., Furutani Y., Takahashi H., Noda M., Morimoto Y., Hirose T., Asai M., Inayama S., Nakanishi S., Numa S.
    Nature 298:245-249(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. Cited for: PROTEIN SEQUENCE OF 209-221, IDENTIFICATION, CHARACTERIZATION OF DYNORPHIN A(1-13).
  3. "A new opioid octapeptide related to dynorphin from porcine hypothalamus."
    Minamino N., Kangawa K., Fukuda A., Matsuo H., Iagarashi M.
    Biochem. Biophys. Res. Commun. 95:1475-1481(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 209-216, IDENTIFICATION OF DYNORPHIN A(1-8).
    Tissue: Hypothalamus.
  4. Cited for: IDENTIFICATION OF LEUMORPHIN AND RIMORPHIN.

Entry informationi

Entry nameiPDYN_PIG
AccessioniPrimary (citable) accession number: P01214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.