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Reviewed, UniProtKB/Swiss-Prot P01213 (PDYN_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Proenkephalin-B
Alternative name(s):
    Beta-neoendorphin-dynorphin
    Preprodynorphin
Cleaved into the following 9 chains:
    1- Recommended name:
            Alpha-neoendorphin
    2- Recommended name:
            Beta-neoendorphin
    3- Recommended name:
            Big dynorphin
                Short name=Big Dyn
    4- Recommended name:
            Dynorphin A(1-17)
                Short name=Dynorphin A
                Short name=Dyn-A17
    5- Recommended name:
            Dynorphin A(1-13)
    6- Recommended name:
            Dynorphin A(1-8)
    7- Recommended name:
            Leu-enkephalin
    8- Recommended name:
            Rimorphin
        Alternative name(s):
            Dynorphin B
              Short name=Dyn-B
            Dynorphin B(1-13)
    9- Recommended name:
            Leumorphin
        Alternative name(s):
            Dynorphin B-29
Gene names
Name: PDYN
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.

Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.

Leumorphin has a typical opiod activity and may have anti-apoptotic effect By similarity.

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEndorphin
Neuropeptide
Neurotransmitter
Opioid peptide
   PTMCleavage on pair of basic residues
Disulfide bond
Gene Ontology (GO)
   Biological processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

synaptic transmission

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane Ref.4

Inferred from direct assay. Source: UniProtKB

   Molecular functionopioid peptide activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Propeptide21 – 172152
PRO_0000008176
Peptide175 – 18410Alpha-neoendorphin
PRO_0000306347
Peptide175 – 1839Beta-neoendorphin
PRO_0000008177
Peptide175 – 1795Leu-enkephalin By similarity
PRO_0000306348
Propeptide186 – 20419
PRO_0000008178
Peptide207 – 23832Big dynorphin
PRO_0000306349
Peptide207 – 22317Dynorphin A(1-17)
PRO_0000008179
Peptide207 – 21913Dynorphin A(1-13) By similarity
PRO_0000306350
Peptide207 – 2148Dynorphin A(1-8) By similarity
PRO_0000306351
Peptide207 – 2115Leu-enkephalin By similarity
PRO_0000306352
Peptide226 – 25429Leumorphin
PRO_0000008180
Peptide226 – 23813Rimorphin
PRO_0000008181
Peptide226 – 2305Leu-enkephalin
PRO_0000008182

Sequences

Sequence LengthMass (Da)Tools
P01213-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 783E7D6AC068CE68

FASTA25428,385
        10         20         30         40         50         60 
MAWQGLVLAA CLLMFPSTTA DCLSRCSLCA VKTQDGPKPI NPLICSLQCQ AALLPSEEWE 

        70         80         90        100        110        120 
RCQSFLSFFT PSTLGLNDKE DLGSKSVGEG PYSELAKLSG SFLKELEKSK FLPSISTKEN 

       130        140        150        160        170        180 
TLSKSLEEKL RGLSDGFREG AESELMRDAQ LNDGAMETGT LYLAEEDPKE QVKRYGGFLR 

       190        200        210        220        230        240 
KYPKRSSEVA GEGDGDSMGH EDLYKRYGGF LRRIRPKLKW DNQKRYGGFL RRQFKVVTRS 

       250 
QEDPNAYSGE LFDA 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and structural organization of the human preproenkephalin B gene."
Horikawa S., Takai T., Toyosato M., Takahashi H., Noda M., Kakidani H., Kubo T., Hirose T., Inayama S., Hayashida H., Miyata T., Numa S.
Nature 306:611-614(1983) [PubMed: 6316163] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"NMR and structural model of dynorphin A (1-17) bound to dodecylphosphocholine micelles."
Tessmer M.R., Kallick D.A.
Biochemistry 36:1971-1981(1997) [PubMed: 9047294] [Abstract]
Cited for: STRUCTURE BY NMR OF DYNORPHIN A(1-17).
[5]"Dynorphin peptides differentially regulate the human kappa opioid receptor."
Chen Y., Chen C., Liu-Chen L.-Y.
Life Sci. 80:1439-1448(2007) [PubMed: 17316701] [Abstract]
Cited for: FUNCTION.
[6]"Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor."
Merg F., Filliol D., Usynin I., Bazov I., Bark N., Hurd Y.L., Yakovleva T., Kieffer B.L., Bakalkin G.
J. Neurochem. 97:292-301(2006) [PubMed: 16515546] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

X02536 Genomic DNA. No translation available.
K02267 Genomic DNA. No translation available.
K02268 Genomic DNA. Translation: AAA58456.2.
X00176 Genomic DNA. Translation: CAA24999.1.
AL034562 Genomic DNA. Translation: CAB38875.1.
BC026334 mRNA. Translation: AAH26334.1.
IPIIPI00000832.
PIRDFHU. A01478.
RefSeqNP_077722.1.
UniGeneHs.22584

3D structure databases

ModBaseSearch...

Protein family/group databases

TCDB1.C.89.1.1. dynorphin channel-forming neuropeptide (Dynorphin) family.

Proteomic databases

PeptideAtlasP01213.
PRIDEP01213.

Genome annotation databases

EnsemblENSG00000101327. Homo sapiens. [Contig view]
GeneID5173.
KEGGhsa:5173.

Organism-specific databases

GeneCardsGC20M001907.
H-InvDBHIX0015573.
HGNCHGNC:8820. PDYN.
MIM131340. gene.
PharmGKBPA33163.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP01213.
HOVERGENP01213.
OMAP01213. QEDPNAY.

Enzyme and pathway databases

ReactomeREACT_14797. Signaling by GPCR.

Gene expression databases

ArrayExpressP01213.
BgeeP01213.
CleanExHS_PDYN.
GermOnlineENSG00000101327. Homo sapiens.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERPTHR11438. Opioid_neupept. 1 hit.
PTHR11438:SF4. Proenkphlin_B. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio20018.
PMAP-CutDBP01213.
SOURCESearch...

Entry information

Entry namePDYN_HUMAN
AccessionPrimary (citable) accession number: P01213
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents