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P01212 (PENKA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proenkephalin-A-A
Gene names
Name:penk-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEndorphin
Neuropeptide
Opioid peptide
   PTMCleavage on pair of basic residues
Disulfide bond
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Peptide25 – 9369Synenkephalin
PRO_0000008294
Peptide96 – 1005Met-enkephalin
PRO_0000008295
Peptide103 – 1075Met-enkephalin
PRO_0000008296
Propeptide110 – 13122
PRO_0000008297
Peptide132 – 1365Met-enkephalin
PRO_0000008298
Propeptide139 – 17739
PRO_0000008299
Peptide180 – 1878Met-enkephalin-Arg-Gly-Tyr
PRO_0000008300
Propeptide190 – 20112
PRO_0000008301
Peptide204 – 2085Met-enkephalin
PRO_0000008302
Propeptide211 – 22111
PRO_0000008303
Peptide224 – 2285Met-enkephalin
PRO_0000008304
Propeptide229 – 25325
PRO_0000008305
Peptide256 – 2627Met-enkephalin-Arg-Phe
PRO_0000008306

Amino acid modifications

Disulfide bond26 ↔ 48 By similarity
Disulfide bond30 ↔ 52 By similarity
Disulfide bond33 ↔ 65 By similarity

Sequences

Sequence LengthMass (Da)Tools
P01212 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 5B51C6133218B072

FASTA26229,932
        10         20         30         40         50         60 
MGLEARHCCM FLLVFASLSV EIRADCSKDC ASCALHLGQQ REINSLACTL ECEGKLPSAK 

        70         80         90        100        110        120 
AWGTCKELLL LTKVDNVQDG EKYQDNNDSH YAAKKYGGFM KRYGGFMKKM DELYHAEPEE 

       130        140        150        160        170        180 
DDAGGEILAK NYGGFMKKEY DSDRDAADLL RELLATSGDP ESSIYHDNNS ETPGEINKRY 

       190        200        210        220        230        240 
GGFMRGYRRS TDLEDETSGI QKRYGGFMRR VGRPEWWEDY QKRYGGFMTR FTDSFLPSDE 

       250        260 
DGESYSKENP DMEKRYGGFM RF 

« Hide

References

[1]"Characterization of Xenopus laevis proenkephalin gene."
Wong M., Rius R.A., Loh Y.P.
Brain Res. Mol. Brain Res. 11:197-205(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
Martens G.J.M., Herbert E.
Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-262.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S72932, S72930 Genomic DNA. Translation: AAB20686.1.
X00852 Genomic DNA. Translation: CAA25405.1.
PIREQXL. A43949.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000063.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePENKA_XENLA
AccessionPrimary (citable) accession number: P01212
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families