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P01212

- PENKA_XENLA

UniProt

P01212 - PENKA_XENLA

Protein

Proenkephalin-A-A

Gene

penk-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-A-A
    Cleaved into the following 4 chains:
    Gene namesi
    Name:penk-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Peptidei25 – 9369SynenkephalinPRO_0000008294Add
    BLAST
    Peptidei96 – 1005Met-enkephalinPRO_0000008295
    Peptidei103 – 1075Met-enkephalinPRO_0000008296
    Propeptidei110 – 13122PRO_0000008297Add
    BLAST
    Peptidei132 – 1365Met-enkephalinPRO_0000008298
    Propeptidei139 – 17739PRO_0000008299Add
    BLAST
    Peptidei180 – 1878Met-enkephalin-Arg-Gly-TyrPRO_0000008300
    Propeptidei190 – 20112PRO_0000008301Add
    BLAST
    Peptidei204 – 2085Met-enkephalinPRO_0000008302
    Propeptidei211 – 22111PRO_0000008303Add
    BLAST
    Peptidei224 – 2285Met-enkephalinPRO_0000008304
    Propeptidei229 – 25325PRO_0000008305Add
    BLAST
    Peptidei256 – 2627Met-enkephalin-Arg-PhePRO_0000008306

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 48By similarity
    Disulfide bondi30 ↔ 52By similarity
    Disulfide bondi33 ↔ 65By similarity

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG000063.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01029. PENKAPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01212-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLEARHCCM FLLVFASLSV EIRADCSKDC ASCALHLGQQ REINSLACTL    50
    ECEGKLPSAK AWGTCKELLL LTKVDNVQDG EKYQDNNDSH YAAKKYGGFM 100
    KRYGGFMKKM DELYHAEPEE DDAGGEILAK NYGGFMKKEY DSDRDAADLL 150
    RELLATSGDP ESSIYHDNNS ETPGEINKRY GGFMRGYRRS TDLEDETSGI 200
    QKRYGGFMRR VGRPEWWEDY QKRYGGFMTR FTDSFLPSDE DGESYSKENP 250
    DMEKRYGGFM RF 262
    Length:262
    Mass (Da):29,932
    Last modified:October 1, 1996 - v2
    Checksum:i5B51C6133218B072
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S72932, S72930 Genomic DNA. Translation: AAB20686.1.
    X00852 Genomic DNA. Translation: CAA25405.1.
    PIRiA43949. EQXL.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S72932 , S72930 Genomic DNA. Translation: AAB20686.1 .
    X00852 Genomic DNA. Translation: CAA25405.1 .
    PIRi A43949. EQXL.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000063.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000703. Proenkphlin_A.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF3. PTHR11438:SF3. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01029. PENKAPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of Xenopus laevis proenkephalin gene."
      Wong M., Rius R.A., Loh Y.P.
      Brain Res. Mol. Brain Res. 11:197-205(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
      Martens G.J.M., Herbert E.
      Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-262.

    Entry informationi

    Entry nameiPENKA_XENLA
    AccessioniPrimary (citable) accession number: P01212
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3