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P01212

- PENKA_XENLA

UniProt

P01212 - PENKA_XENLA

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Protein
Proenkephalin-A-A
Gene
penk-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A-A
Cleaved into the following 4 chains:
Gene namesi
Name:penk-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Peptidei25 – 9369Synenkephalin
PRO_0000008294Add
BLAST
Peptidei96 – 1005Met-enkephalin
PRO_0000008295
Peptidei103 – 1075Met-enkephalin
PRO_0000008296
Propeptidei110 – 13122
PRO_0000008297Add
BLAST
Peptidei132 – 1365Met-enkephalin
PRO_0000008298
Propeptidei139 – 17739
PRO_0000008299Add
BLAST
Peptidei180 – 1878Met-enkephalin-Arg-Gly-Tyr
PRO_0000008300
Propeptidei190 – 20112
PRO_0000008301Add
BLAST
Peptidei204 – 2085Met-enkephalin
PRO_0000008302
Propeptidei211 – 22111
PRO_0000008303Add
BLAST
Peptidei224 – 2285Met-enkephalin
PRO_0000008304
Propeptidei229 – 25325
PRO_0000008305Add
BLAST
Peptidei256 – 2627Met-enkephalin-Arg-Phe
PRO_0000008306

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48 By similarity
Disulfide bondi30 ↔ 52 By similarity
Disulfide bondi33 ↔ 65 By similarity

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01212-1 [UniParc]FASTAAdd to Basket

« Hide

MGLEARHCCM FLLVFASLSV EIRADCSKDC ASCALHLGQQ REINSLACTL    50
ECEGKLPSAK AWGTCKELLL LTKVDNVQDG EKYQDNNDSH YAAKKYGGFM 100
KRYGGFMKKM DELYHAEPEE DDAGGEILAK NYGGFMKKEY DSDRDAADLL 150
RELLATSGDP ESSIYHDNNS ETPGEINKRY GGFMRGYRRS TDLEDETSGI 200
QKRYGGFMRR VGRPEWWEDY QKRYGGFMTR FTDSFLPSDE DGESYSKENP 250
DMEKRYGGFM RF 262
Length:262
Mass (Da):29,932
Last modified:October 1, 1996 - v2
Checksum:i5B51C6133218B072
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72932, S72930 Genomic DNA. Translation: AAB20686.1.
X00852 Genomic DNA. Translation: CAA25405.1.
PIRiA43949. EQXL.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S72932 , S72930 Genomic DNA. Translation: AAB20686.1 .
X00852 Genomic DNA. Translation: CAA25405.1 .
PIRi A43949. EQXL.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000063.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of Xenopus laevis proenkephalin gene."
    Wong M., Rius R.A., Loh Y.P.
    Brain Res. Mol. Brain Res. 11:197-205(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
    Martens G.J.M., Herbert E.
    Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-262.

Entry informationi

Entry nameiPENKA_XENLA
AccessioniPrimary (citable) accession number: P01212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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