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Protein

Proenkephalin-A-A

Gene

penk-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A-A
Cleaved into the following 4 chains:
Gene namesi
Name:penk-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Peptidei25 – 9369SynenkephalinPRO_0000008294Add
BLAST
Peptidei96 – 1005Met-enkephalinPRO_0000008295
Peptidei103 – 1075Met-enkephalinPRO_0000008296
Propeptidei110 – 13122PRO_0000008297Add
BLAST
Peptidei132 – 1365Met-enkephalinPRO_0000008298
Propeptidei139 – 17739PRO_0000008299Add
BLAST
Peptidei180 – 1878Met-enkephalin-Arg-Gly-TyrPRO_0000008300
Propeptidei190 – 20112PRO_0000008301Add
BLAST
Peptidei204 – 2085Met-enkephalinPRO_0000008302
Propeptidei211 – 22111PRO_0000008303Add
BLAST
Peptidei224 – 2285Met-enkephalinPRO_0000008304
Propeptidei229 – 25325PRO_0000008305Add
BLAST
Peptidei256 – 2627Met-enkephalin-Arg-PhePRO_0000008306

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48By similarity
Disulfide bondi30 ↔ 52By similarity
Disulfide bondi33 ↔ 65By similarity

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLEARHCCM FLLVFASLSV EIRADCSKDC ASCALHLGQQ REINSLACTL
60 70 80 90 100
ECEGKLPSAK AWGTCKELLL LTKVDNVQDG EKYQDNNDSH YAAKKYGGFM
110 120 130 140 150
KRYGGFMKKM DELYHAEPEE DDAGGEILAK NYGGFMKKEY DSDRDAADLL
160 170 180 190 200
RELLATSGDP ESSIYHDNNS ETPGEINKRY GGFMRGYRRS TDLEDETSGI
210 220 230 240 250
QKRYGGFMRR VGRPEWWEDY QKRYGGFMTR FTDSFLPSDE DGESYSKENP
260
DMEKRYGGFM RF
Length:262
Mass (Da):29,932
Last modified:October 1, 1996 - v2
Checksum:i5B51C6133218B072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72932, S72930 Genomic DNA. Translation: AAB20686.1.
X00852 Genomic DNA. Translation: CAA25405.1.
PIRiA43949. EQXL.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72932, S72930 Genomic DNA. Translation: AAB20686.1.
X00852 Genomic DNA. Translation: CAA25405.1.
PIRiA43949. EQXL.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000063.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of Xenopus laevis proenkephalin gene."
    Wong M., Rius R.A., Loh Y.P.
    Brain Res. Mol. Brain Res. 11:197-205(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Polymorphism and absence of Leu-enkephalin sequences in proenkephalin genes in Xenopus laevis."
    Martens G.J.M., Herbert E.
    Nature 310:251-254(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-262.

Entry informationi

Entry nameiPENKA_XENLA
AccessioniPrimary (citable) accession number: P01212
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.