P01211Q2T9T4PENK_BOVINProenkephalin-ASynenkephalinMet-enkephalinOpioid growth factorOGFPENK(111-130)PENK(140-179)Met-enkephalin-Arg-Gly-LeuLeu-enkephalinEnkelytinPENK(233-254)Met-enkephalin-Arg-PhePENKBos taurusBovineEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBosCloning and sequence analysis of cDNA for bovine adrenal preproenkephalin.NUCLEOTIDE SEQUENCE [MRNA]NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides.NUCLEOTIDE SEQUENCE [MRNA] OF 47-263Partial characterization of the mRNA that codes for enkephalins in bovine adrenal medulla and human pheochromocytoma.NUCLEOTIDE SEQUENCE [MRNA] OF 211-229The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity.PROTEIN SEQUENCE OF 233-261FUNCTIONCathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.PROTEOLYTIC CLEAVAGETISSUE SPECIFICITYSUBCELLULAR LOCATIONMet-enkephalinNeuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.Leu-enkephalinNeuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.Met-enkephalin-Arg-PheMet-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.PENK(111-130)Increases glutamate release in the striatum and decreases GABA concentration in the striatum.PENK(233-254)Increases glutamate release in the striatum.EnkelytinEnkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium.Cytoplasmic vesicleSecretory vesicleChromaffin granule lumenSecretedSecreted by neuroendocrine chromaffin cells through cromaffin granules.Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin.Met-enkephalinProcessed and degraded by ACE.Leu-enkephalinProcessed and degraded by ACE.Met-enkephalin-Arg-Gly-LeuProbably cleaved by ACE.Met-enkephalin-Arg-PheProcessed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain.The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.Belongs to the opioid neuropeptide precursor family.3D-structureAntibioticAntimicrobialCleavage on pair of basic residuesCytoplasmic vesicleDirect protein sequencingDisulfide bondEndorphinNeuropeptideOpioid peptidePhosphoproteinReference proteomeSecretedSignalMARFLGLCTWLLALGPGLLATVRAECSQDCATCSYRLARPTDLNPLACTLECEGKLPSLKTWETCKELLQLTKLELPPDATSALSKQEESHLLAKKYGGFMKRYGGFMKKMDELYPLEVEEEANGGEVLGKRYGGFMKKDAEEDDGLGNSSNLLKELLGAGDQREGSLHQEGSDAEDVSKRYGGFMRGLKRSPHLEDETKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEPLPSEEEGESYSKEVPEMEKRYGGFMRF
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