SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P01211

- PENK_BOVIN

UniProt

P01211 - PENK_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proenkephalin-A

Gene
PENK
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum.
Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium.

GO - Biological processi

  1. aggressive behavior Source: Ensembl
  2. behavioral fear response Source: Ensembl
  3. defense response to bacterium Source: UniProtKB-KW
  4. locomotory behavior Source: Ensembl
  5. neuropeptide signaling pathway Source: UniProtKB-KW
  6. sensory perception of pain Source: Ensembl
  7. startle response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Endorphin, Neuropeptide, Opioid peptide

Enzyme and pathway databases

ReactomeiREACT_210568. G alpha (i) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 9 chains:
Gene namesi
Name:PENK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Peptidei25 – 9470SynenkephalinPRO_0000008206Add
BLAST
Peptidei97 – 1015Met-enkephalinPRO_0000008207
Peptidei104 – 1085Met-enkephalinPRO_0000008208
Peptidei111 – 13020PENK(111-130) By similarityPRO_0000377682Add
BLAST
Peptidei133 – 1375Met-enkephalinPRO_0000008210
Peptidei140 – 17940PENK(140-179) By similarityPRO_0000377683Add
BLAST
Peptidei182 – 1898Met-enkephalin-Arg-Gly-LeuPRO_0000008212
Propeptidei192 – 20312PRO_0000008213Add
BLAST
Peptidei206 – 2105Met-enkephalinPRO_0000008214
Propeptidei213 – 22311PRO_0000008215Add
BLAST
Peptidei226 – 2305Leu-enkephalinPRO_0000008216
Peptidei233 – 26129Enkelytin1 PublicationPRO_0000008217Add
BLAST
Peptidei233 – 25422PENK(233-254) By similarityPRO_0000377684Add
BLAST
Peptidei257 – 2637Met-enkephalin-Arg-PhePRO_0000008218

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 48 By similarity
Disulfide bondi30 ↔ 52 By similarity
Disulfide bondi33 ↔ 65 By similarity

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP01211.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006478.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40630.
GeneTreeiENSGT00530000063761.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP01211.
OMAiGGFMKKD.
OrthoDBiEOG75TMCR.
TreeFamiTF332620.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01211-1 [UniParc]FASTAAdd to Basket

« Hide

MARFLGLCTW LLALGPGLLA TVRAECSQDC ATCSYRLARP TDLNPLACTL    50
ECEGKLPSLK TWETCKELLQ LTKLELPPDA TSALSKQEES HLLAKKYGGF 100
MKRYGGFMKK MDELYPLEVE EEANGGEVLG KRYGGFMKKD AEEDDGLGNS 150
SNLLKELLGA GDQREGSLHQ EGSDAEDVSK RYGGFMRGLK RSPHLEDETK 200
ELQKRYGGFM RRVGRPEWWM DYQKRYGGFL KRFAEPLPSE EEGESYSKEV 250
PEMEKRYGGF MRF 263
Length:263
Mass (Da):29,788
Last modified:July 21, 1986 - v1
Checksum:i0E400338A228B0D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00109 mRNA. Translation: CAA23443.1.
BC111279 mRNA. Translation: AAI11280.1.
V00108 mRNA. Translation: CAA23442.1.
J00012 mRNA. Translation: AAA30673.1.
PIRiA93272. EQBOA.
RefSeqiNP_776566.1. NM_174141.2.
UniGeneiBt.166.

Genome annotation databases

EnsembliENSBTAT00000006478; ENSBTAP00000006478; ENSBTAG00000004924.
GeneIDi281387.
KEGGibta:281387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00109 mRNA. Translation: CAA23443.1 .
BC111279 mRNA. Translation: AAI11280.1 .
V00108 mRNA. Translation: CAA23442.1 .
J00012 mRNA. Translation: AAA30673.1 .
PIRi A93272. EQBOA.
RefSeqi NP_776566.1. NM_174141.2.
UniGenei Bt.166.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000006478.

Proteomic databases

PRIDEi P01211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006478 ; ENSBTAP00000006478 ; ENSBTAG00000004924 .
GeneIDi 281387.
KEGGi bta:281387.

Organism-specific databases

CTDi 5179.

Phylogenomic databases

eggNOGi NOG40630.
GeneTreei ENSGT00530000063761.
HOGENOMi HOG000013003.
HOVERGENi HBG000063.
InParanoidi P01211.
OMAi GGFMKKD.
OrthoDBi EOG75TMCR.
TreeFami TF332620.

Enzyme and pathway databases

Reactomei REACT_210568. G alpha (i) signalling events.
REACT_219025. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi 20805387.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin."
    Noda M., Furutani Y., Takahashi H., Toyosato M., Hirose T., Inayama S., Nakanishi S., Numa S.
    Nature 295:202-206(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  3. "Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides."
    Gubler U., Seeburg P., Hoffman B.J., Gage L.P., Udenfriend S.
    Nature 295:206-208(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-263.
  4. "Partial characterization of the mRNA that codes for enkephalins in bovine adrenal medulla and human pheochromocytoma."
    Comb M., Herbert E., Crea R.
    Proc. Natl. Acad. Sci. U.S.A. 79:360-364(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-229.
  5. "The C-terminal bisphosphorylated proenkephalin-A-(209-237)-peptide from adrenal medullary chromaffin granules possesses antibacterial activity."
    Goumon Y., Strub J.-M., Moniatte M., Nulans G., Poteur L., Hubert P., van Dorsselaer A., Aunis D., Metz-Boutigue M.-H.
    Eur. J. Biochem. 235:516-525(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 233-261.
    Tissue: Chromaffin cell.

Entry informationi

Entry nameiPENK_BOVIN
AccessioniPrimary (citable) accession number: P01211
Secondary accession number(s): Q2T9T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi