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Protein

Proenkephalin-A

Gene

PENK

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum.
Enkelytin possesses antibacterial activity against Gram-positive bacteria such as Micrococcus luteus and Bacillus megaterium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Endorphin, Neuropeptide, Opioid peptide

Enzyme and pathway databases

ReactomeiR-BTA-375276 Peptide ligand-binding receptors
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-418594 G alpha (i) signalling events
R-BTA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 9 chains:
Gene namesi
Name:PENK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:32746 PENK

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PeptideiPRO_000000820625 – 94SynenkephalinAdd BLAST70
PeptideiPRO_000000820797 – 101Met-enkephalin5
PeptideiPRO_0000008208104 – 108Met-enkephalin5
PeptideiPRO_0000377682111 – 130PENK(111-130)By similarityAdd BLAST20
PeptideiPRO_0000008210133 – 137Met-enkephalin5
PeptideiPRO_0000377683140 – 179PENK(140-179)By similarityAdd BLAST40
PeptideiPRO_0000008212182 – 189Met-enkephalin-Arg-Gly-Leu8
PropeptideiPRO_0000008213192 – 203Add BLAST12
PeptideiPRO_0000008214206 – 210Met-enkephalin5
PropeptideiPRO_0000008215213 – 223Add BLAST11
PeptideiPRO_0000008216226 – 230Leu-enkephalin5
PeptideiPRO_0000008217233 – 261EnkelytinAdd BLAST29
PeptideiPRO_0000377684233 – 254PENK(233-254)By similarityAdd BLAST22
PeptideiPRO_0000008218257 – 263Met-enkephalin-Arg-Phe7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 48By similarity
Disulfide bondi30 ↔ 52By similarity
Disulfide bondi33 ↔ 65By similarity
Modified residuei247PhosphoserineBy similarity1

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP01211
PRIDEiP01211

PTM databases

iPTMnetiP01211

Expressioni

Gene expression databases

BgeeiENSBTAG00000004924

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006478

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJUY Eukaryota
ENOG4110ZYD LUCA
GeneTreeiENSGT00530000063761
HOGENOMiHOG000013003
HOVERGENiHBG000063
InParanoidiP01211
KOiK18832
OMAiGFMKKMD
OrthoDBiEOG091G0HV8
TreeFamiTF332620

Family and domain databases

InterProiView protein in InterPro
IPR006024 Opioid_neupept
IPR000703 Proenkphlin_A
PANTHERiPTHR11438 PTHR11438, 1 hit
PTHR11438:SF3 PTHR11438:SF3, 1 hit
PfamiView protein in Pfam
PF01160 Opiods_neuropep, 1 hit
PRINTSiPR01028 OPIOIDPRCRSR
PR01029 PENKAPRCRSR
PROSITEiView protein in PROSITE
PS01252 OPIOIDS_PRECURSOR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFLGLCTW LLALGPGLLA TVRAECSQDC ATCSYRLARP TDLNPLACTL
60 70 80 90 100
ECEGKLPSLK TWETCKELLQ LTKLELPPDA TSALSKQEES HLLAKKYGGF
110 120 130 140 150
MKRYGGFMKK MDELYPLEVE EEANGGEVLG KRYGGFMKKD AEEDDGLGNS
160 170 180 190 200
SNLLKELLGA GDQREGSLHQ EGSDAEDVSK RYGGFMRGLK RSPHLEDETK
210 220 230 240 250
ELQKRYGGFM RRVGRPEWWM DYQKRYGGFL KRFAEPLPSE EEGESYSKEV
260
PEMEKRYGGF MRF
Length:263
Mass (Da):29,788
Last modified:July 21, 1986 - v1
Checksum:i0E400338A228B0D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00109 mRNA Translation: CAA23443.1
BC111279 mRNA Translation: AAI11280.1
V00108 mRNA Translation: CAA23442.1
J00012 mRNA Translation: AAA30673.1
PIRiA93272 EQBOA
RefSeqiNP_776566.1, NM_174141.2
UniGeneiBt.166

Genome annotation databases

EnsembliENSBTAT00000006478; ENSBTAP00000006478; ENSBTAG00000004924
GeneIDi281387
KEGGibta:281387

Similar proteinsi

Entry informationi

Entry nameiPENK_BOVIN
AccessioniPrimary (citable) accession number: P01211
Secondary accession number(s): Q2T9T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health