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P01210

- PENK_HUMAN

UniProt

P01210 - PENK_HUMAN

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Protein
Proenkephalin-A
Gene
PENK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

GO - Molecular functioni

  1. neuropeptide hormone activity Source: ProtInc
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. aggressive behavior Source: Ensembl
  2. behavioral fear response Source: Ensembl
  3. locomotory behavior Source: Ensembl
  4. neuropeptide signaling pathway Source: UniProtKB-KW
  5. sensory perception of pain Source: Ensembl
  6. signal transduction Source: ProtInc
  7. startle response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Opioid peptide

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

TCDBi1.C.89.1.2. the dynorphin channel-forming neuropeptide (dynorphin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-A
Cleaved into the following 8 chains:
Gene namesi
Name:PENK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:8831. PENK.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Peptidei25 – 9773Synenkephalin
PRO_0000008242Add
BLAST
Peptidei100 – 1045Met-enkephalin
PRO_0000008243
Peptidei107 – 1115Met-enkephalin
PRO_0000008244
Peptidei114 – 13320PENK(114-133) By similarity
PRO_0000377691Add
BLAST
Peptidei136 – 1405Met-enkephalin
PRO_0000008246
Peptidei143 – 18341PENK(143-183) By similarity
PRO_0000377692Add
BLAST
Peptidei186 – 1938Met-enkephalin-Arg-Gly-Leu
PRO_0000008248
Propeptidei196 – 20712
PRO_0000008249Add
BLAST
Peptidei210 – 2145Met-enkephalin
PRO_0000008250
Propeptidei217 – 22711
PRO_0000008251Add
BLAST
Peptidei230 – 2345Leu-enkephalin
PRO_0000008252
Peptidei237 – 25822PENK(237-258) By similarity
PRO_0000377693Add
BLAST
Peptidei261 – 2677Met-enkephalin-Arg-Phe
PRO_0000008254

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 481 Publication
Disulfide bondi30 ↔ 521 Publication
Disulfide bondi33 ↔ 651 Publication

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01210.
PRIDEiP01210.

PTM databases

PhosphoSiteiP01210.

Miscellaneous databases

PMAP-CutDBP01210.

Expressioni

Gene expression databases

ArrayExpressiP01210.
BgeeiP01210.
CleanExiHS_PENK.
GenevestigatoriP01210.

Organism-specific databases

HPAiCAB016390.
HPA013138.

Interactioni

Protein-protein interaction databases

BioGridi111205. 1 interaction.
IntActiP01210. 1 interaction.
STRINGi9606.ENSP00000324248.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni262 – 2643

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PLWNMR-A100-104[»]
1PLXNMR-A100-104[»]
2LWCNMR-A261-265[»]
ProteinModelPortaliP01210.

Miscellaneous databases

EvolutionaryTraceiP01210.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40630.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiP01210.
OMAiGGFMKKD.
PhylomeDBiP01210.
TreeFamiTF332620.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01210-1 [UniParc]FASTAAdd to Basket

« Hide

MARFLTLCTW LLLLGPGLLA TVRAECSQDC ATCSYRLVRP ADINFLACVM    50
ECEGKLPSLK IWETCKELLQ LSKPELPQDG TSTLRENSKP EESHLLAKRY 100
GGFMKRYGGF MKKMDELYPM EPEEEANGSE ILAKRYGGFM KKDAEEDDSL 150
ANSSDLLKEL LETGDNRERS HHQDGSDNEE EVSKRYGGFM RGLKRSPQLE 200
DEAKELQKRY GGFMRRVGRP EWWMDYQKRY GGFLKRFAEA LPSDEEGESY 250
SKEVPEMEKR YGGFMRF 267
Length:267
Mass (Da):30,787
Last modified:July 21, 1986 - v1
Checksum:i4189BA600C3FC8EE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831T → N.
Corresponds to variant rs11998459 [ dbSNP | Ensembl ].
VAR_048935
Natural varianti247 – 2471G → D.
Corresponds to variant rs1800567 [ dbSNP | Ensembl ].
VAR_014584

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191P → S in CAG46627. 1 Publication
Sequence conflicti152 – 1521N → I in CAG46607. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00509 Genomic DNA. Translation: CAA23767.1.
J00123, J00122 Genomic DNA. Translation: AAB59409.1.
AK314908 mRNA. Translation: BAG37420.1.
CR541808 mRNA. Translation: CAG46607.1.
CR541828 mRNA. Translation: CAG46627.1.
CH471068 Genomic DNA. Translation: EAW86785.1.
BC032505 mRNA. Translation: AAH32505.1.
CCDSiCCDS6168.1.
PIRiA93278. EQHUA.
RefSeqiNP_001129162.1. NM_001135690.1.
NP_006202.1. NM_006211.3.
UniGeneiHs.339831.

Genome annotation databases

EnsembliENST00000314922; ENSP00000324248; ENSG00000181195.
ENST00000451791; ENSP00000400894; ENSG00000181195.
GeneIDi5179.
KEGGihsa:5179.
UCSCiuc003xsz.2. human.

Polymorphism databases

DMDMi129770.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00509 Genomic DNA. Translation: CAA23767.1 .
J00123 , J00122 Genomic DNA. Translation: AAB59409.1 .
AK314908 mRNA. Translation: BAG37420.1 .
CR541808 mRNA. Translation: CAG46607.1 .
CR541828 mRNA. Translation: CAG46627.1 .
CH471068 Genomic DNA. Translation: EAW86785.1 .
BC032505 mRNA. Translation: AAH32505.1 .
CCDSi CCDS6168.1.
PIRi A93278. EQHUA.
RefSeqi NP_001129162.1. NM_001135690.1.
NP_006202.1. NM_006211.3.
UniGenei Hs.339831.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PLW NMR - A 100-104 [» ]
1PLX NMR - A 100-104 [» ]
2LWC NMR - A 261-265 [» ]
ProteinModelPortali P01210.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111205. 1 interaction.
IntActi P01210. 1 interaction.
STRINGi 9606.ENSP00000324248.

Protein family/group databases

TCDBi 1.C.89.1.2. the dynorphin channel-forming neuropeptide (dynorphin) family.

PTM databases

PhosphoSitei P01210.

Polymorphism databases

DMDMi 129770.

Proteomic databases

PaxDbi P01210.
PRIDEi P01210.

Protocols and materials databases

DNASUi 5179.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314922 ; ENSP00000324248 ; ENSG00000181195 .
ENST00000451791 ; ENSP00000400894 ; ENSG00000181195 .
GeneIDi 5179.
KEGGi hsa:5179.
UCSCi uc003xsz.2. human.

Organism-specific databases

CTDi 5179.
GeneCardsi GC08M057349.
HGNCi HGNC:8831. PENK.
HPAi CAB016390.
HPA013138.
MIMi 131330. gene.
neXtProti NX_P01210.
PharmGKBi PA33176.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40630.
HOGENOMi HOG000013003.
HOVERGENi HBG000063.
InParanoidi P01210.
OMAi GGFMKKD.
PhylomeDBi P01210.
TreeFami TF332620.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P01210.
GenomeRNAii 5179.
NextBioi 20046.
PMAP-CutDB P01210.
PROi P01210.
SOURCEi Search...

Gene expression databases

ArrayExpressi P01210.
Bgeei P01210.
CleanExi HS_PENK.
Genevestigatori P01210.

Family and domain databases

InterProi IPR006024. Opioid_neupept.
IPR000703. Proenkphlin_A.
[Graphical view ]
PANTHERi PTHR11438. PTHR11438. 1 hit.
PTHR11438:SF3. PTHR11438:SF3. 1 hit.
Pfami PF01160. Opiods_neuropep. 1 hit.
[Graphical view ]
PRINTSi PR01028. OPIOIDPRCRSR.
PR01029. PENKAPRCRSR.
PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA."
    Comb M., Seeburg P.H., Adelman J., Eiden L., Herbert E.
    Nature 295:663-666(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation and structural organization of the human preproenkephalin gene."
    Noda M., Teranishi Y., Takahashi H., Toyosato M., Notake M., Nakanishi S., Numa S.
    Nature 297:431-434(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "The structure of synenkephalin (pro-enkephalin 1-73) is dictated by three disulfide bonds."
    Lecchi P., Loh Y.P., Snell C.R., Pannell L.K.
    Biochem. Biophys. Res. Commun. 232:800-805(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.

Entry informationi

Entry nameiPENK_HUMAN
AccessioniPrimary (citable) accession number: P01210
Secondary accession number(s): B2RC23, Q6FHC6, Q6FHE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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