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Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin: Endogenous orexigenic opiate.
Met-enkephalin: Endogenous opiate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 11 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Melanotropin beta
Gene namesi
Name:POMC
OrganismiMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000002498527 – 99NPPAdd BLAST73
PeptideiPRO_000002498677 – 87Melanotropin gammaAdd BLAST11
PeptideiPRO_000002498791 – 131Potential peptideAdd BLAST41
PeptideiPRO_0000024988135 – 173CorticotropinAdd BLAST39
PeptideiPRO_0000024989135 – 147Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_0000024990153 – 173Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000024991176 – 264Lipotropin betaAdd BLAST89
PeptideiPRO_0000024992176 – 231Lipotropin gammaAdd BLAST56
PeptideiPRO_0000024993214 – 231Melanocyte-stimulating hormone betaAdd BLAST18
PeptideiPRO_0000024994234 – 264Beta-endorphinAdd BLAST31
PeptideiPRO_0000024995234 – 238Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87Phenylalanine amide1 Publication1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei131Glutamic acid 1-amide1 Publication1
Modified residuei135N-acetylserine; in CorticotropinBy similarity1
Modified residuei147Valine amide2 Publications1
Modified residuei165PhosphoserineBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004341.

Family and domain databases

InterProiView protein in InterPro
IPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
PfamiView protein in Pfam
PF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
PRINTSiPR00383. MELANOCORTIN.
SMARTiView protein in SMART
SM01363. ACTH_domain. 3 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01201-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC
60 70 80 90 100
KPDLSAETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSGSAHQK
110 120 130 140 150
REDVAAGEDR GLLPEGGPEP RGDGAGPGPR EGKRSYSMEH FRWGKPVGKK
160 170 180 190 200
RRPVKVYPNG AEDESAEAFP LEFKRELTGQ RPRAGDGPDG PADDGAGPRA
210 220 230 240 250
DLEHSLLVAA EKKDEGPYRM EHFRWGSPPK DKRYGGFMTS EKSQTPLVTL
260
FKNAIIKNAY KKGQ
Length:264
Mass (Da):29,172
Last modified:May 1, 1991 - v2
Checksum:iBC73B100D9BAD052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19658 mRNA. Translation: AAA66022.1.
PIRiA31855. CTMKP.

Similar proteinsi

Entry informationi

Entry nameiCOLI_MACNE
AccessioniPrimary (citable) accession number: P01201
Secondary accession number(s): P19403
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 1, 1991
Last modified: August 30, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families