Reviewed, UniProtKB/Swiss-Prot P01201 (COLI_MACNE)

Names and origin

Protein names

Recommended name:
    Pro-opiomelanocortin
      Short name=POMC
Alternative name(s):
    Corticotropin-lipotropin
Cleaved into the following 11 chains:
    1- Recommended name:
            NPP
    2- Recommended name:
            Melanotropin gamma
        Alternative name(s):
            Gamma-MSH
    3- Recommended name:
            Potential peptide
    4- Recommended name:
            Corticotropin
        Alternative name(s):
            Adrenocorticotropic hormone
              Short name=ACTH
    5- Recommended name:
            Melanotropin alpha
        Alternative name(s):
            Alpha-MSH
    6- Recommended name:
            Corticotropin-like intermediary peptide
                Short name=CLIP
    7- Recommended name:
            Lipotropin beta
        Alternative name(s):
            Beta-LPH
    8- Recommended name:
            Lipotropin gamma
        Alternative name(s):
            Gamma-LPH
    9- Recommended name:
            Melanotropin beta
        Alternative name(s):
            Beta-MSH
    10- Recommended name:
            Beta-endorphin
    11- Recommended name:
            Met-enkephalin

Gene names

Name:

POMC

Organism

Macaca nemestrina (Pig-tailed macaque)

Taxonomic identifier

9545 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates.
Tissue specificity	ACTH and MSH are produced by the pituitary gland.
Post-translational modification	Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Sequence similarities	Belongs to the POMC family.

Ontologies

Keywords
Domain	Signal
Molecular function	Endorphin Hormone
PTM	Acetylation Amidation Cleavage on pair of basic residues Glycoprotein Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Peptide	27 – 99	73	NPP		PRO_0000024985
	Peptide	77 – 87	11	Melanotropin gamma		PRO_0000024986
	Peptide	91 – 131	41	Potential peptide		PRO_0000024987
	Peptide	135 – 173	39	Corticotropin		PRO_0000024988
	Peptide	135 – 147	13	Melanotropin alpha Ref.2		PRO_0000024989
	Peptide	153 – 173	21	Corticotropin-like intermediary peptide		PRO_0000024990
	Peptide	176 – 264	89	Lipotropin beta		PRO_0000024991
	Peptide	176 – 231	56	Lipotropin gamma		PRO_0000024992
	Peptide	214 – 231	18	Melanotropin beta		PRO_0000024993
	Peptide	234 – 264	31	Beta-endorphin		PRO_0000024994
	Peptide	234 – 238	5	Met-enkephalin		PRO_0000024995
Amino acid modifications
	Modified residue	87	1	Phenylalanine amide
	Modified residue	131	1	Glutamic acid 1-amide
	Modified residue	135	1	N-acetylserine
	Modified residue	147	1	Valine amide
	Modified residue	165	1	Phosphoserine By similarity
	Glycosylation	91	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P01201-1 [UniParc]. Last modified May 1, 1991. Version 2. Checksum: BC73B100D9BAD052	FASTA	264	29,172
	10 20 30 40 50 60 MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC KPDLSAETPV 70 80 90 100 110 120 FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSGSAHQK REDVAAGEDR GLLPEGGPEP 130 140 150 160 170 180 RGDGAGPGPR EGKRSYSMEH FRWGKPVGKK RRPVKVYPNG AEDESAEAFP LEFKRELTGQ 190 200 210 220 230 240 RPRAGDGPDG PADDGAGPRA DLEHSLLVAA EKKDEGPYRM EHFRWGSPPK DKRYGGFMTS 250 260 EKSQTPLVTL FKNAIIKNAY KKGQ

References

[1]	"Characterization of pro-opiomelanocortin cDNA from the Old World monkey, Macaca nemestrina." Patel P.D., Sherman T.G., Watson S.J. DNA 7:627-635(1988) [PubMed: 3229286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The isolation and structure of alpha- and beta-melanocyte-stimulating hormones from monkey pituitary glands." Lee T.H., Lerner A.B., Buettner-Janusch V. J. Biol. Chem. 236:1390-1394(1961) [PubMed: 13760276] [Abstract] Cited for: PROTEIN SEQUENCE OF 135-147 AND 214-231.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M19658 mRNA. Translation: AAA66022.1.
PIR	CTMKP. A31855.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P01201.
Family and domain databases
InterPro	IPR001941. Mcortin_ACTH. IPR013533. Mcortin_ACTH_C. IPR013531. Mcrtin_ACTH_cent. IPR013593. Melanocortin_N. IPR013532. Opioid_neuropept. [Graphical view]
PANTHER	PTHR11416. Mcortin_ACTH. 1 hit.
Pfam	PF00976. ACTH_domain. 1 hit. PF08384. NPP. 1 hit. PF08035. Op_neuropeptide. 1 hit. [Graphical view]
PRINTS	PR00383. MELANOCORTIN.
ProtoNet	Search...

Entry information

Entry name

COLI_MACNE

Accession

Primary (citable) accession number: P01201
Secondary accession number(s): P19403

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	May 1, 1991
Last modified:	November 24, 2009
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)