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Protein

Pro-opiomelanocortin

Gene

Pomc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

GO - Biological processi

  • feeding behavior Source: RGD
  • neuropeptide signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Alpha-MSH
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Beta-MSH
Gene namesi
Name:Pomc
Synonyms:Pomc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3366. Pomc.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Peptidei27 – 10074NPPPRO_0000025029Add
BLAST
Peptidei77 – 8711Melanotropin gammaPRO_0000025030Add
BLAST
Peptidei124 – 16239CorticotropinPRO_0000025031Add
BLAST
Peptidei124 – 13613Melanotropin alphaPRO_0000025032Add
BLAST
Peptidei142 – 16221Corticotropin-like intermediary peptidePRO_0000025033Add
BLAST
Peptidei165 – 23571Lipotropin betaPRO_0000025034Add
BLAST
Peptidei165 – 20238Lipotropin gammaPRO_0000025035Add
BLAST
Peptidei185 – 20218Melanotropin betaPRO_0000025036Add
BLAST
Peptidei205 – 23531Beta-endorphinPRO_0000025037Add
BLAST
Peptidei205 – 2095Met-enkephalinPRO_0000025038

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871Phenylalanine amideBy similarity
Modified residuei124 – 1241N-acetylserine; in CorticotropinBy similarity
Modified residuei136 – 1361Valine amideBy similarity
Glycosylationi152 – 1521N-linked (GlcNAc...)Curated
Modified residuei154 – 1541PhosphoserineBy similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01194.
PRIDEiP01194.

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016976.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP01194.
PhylomeDBiP01194.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFCNSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC
60 70 80 90 100
RLDLSAETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGGSAQ
110 120 130 140 150
RRAEEETAGG DGRPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA
160 170 180 190 200
ENESAEAFPL EFKRELEGEQ PDGLEQVLEP DTEKADGPYR VEHFRWGNPP
210 220 230
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNV HKKGQ
Length:235
Mass (Da):26,540
Last modified:January 1, 1988 - v1
Checksum:iA1AEC6AC9DBF1C13
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61N → Y in CAA26937 (PubMed:2998878).Curated
Sequence conflicti6 – 61N → Y in AAA41903 (PubMed:2998878).Curated
Sequence conflicti40 – 401E → Y (PubMed:6547437).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03176 Genomic DNA. Translation: CAA26937.1.
K01877 Genomic DNA. No translation available.
J00759, K01878 Genomic DNA. Translation: AAA41903.1.
PIRiA91353. CTRTP.
UniGeneiRn.108195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03176 Genomic DNA. Translation: CAA26937.1.
K01877 Genomic DNA. No translation available.
J00759, K01878 Genomic DNA. Translation: AAA41903.1.
PIRiA91353. CTRTP.
UniGeneiRn.108195.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016976.

Proteomic databases

PaxDbiP01194.
PRIDEiP01194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3366. Pomc.

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP01194.
PhylomeDBiP01194.

Miscellaneous databases

PROiP01194.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the rat pro-opiomelanocortin (POMC) gene."
    Drouin J., Chamberland M., Charron J., Jeannotte L., Nemer M.
    FEBS Lett. 193:54-58(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "5' sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine and two rat forms."
    Oates E., Herbert E.
    J. Biol. Chem. 259:7421-7425(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
  3. "Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences."
    Drouin J., Goodman H.M.
    Nature 288:610-613(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 45-235.
  4. "The isolation of characterization of gamma 3-melanotropin from the neurointermediary lobe of the rat pituitary."
    Browne C.A., Bennett H.P., Solomon S.
    Biochem. Biophys. Res. Commun. 100:336-343(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 76-100.
    Tissue: Pituitary.

Entry informationi

Entry nameiCOLI_RAT
AccessioniPrimary (citable) accession number: P01194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.