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Protein

Pro-opiomelanocortin

Gene

Pomc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

GO - Molecular functioni

GO - Biological processi

  • feeding behavior Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • regulation of corticosterone secretion Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 11 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Alpha-MSH
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Beta-MSH
Gene namesi
Name:Pomc
Synonyms:Pomc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3366. Pomc.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: RGD
  • extracellular space Source: GO_Central
  • secretory granule Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000002502927 – 100NPPAdd BLAST74
PeptideiPRO_000002503077 – 87Melanotropin gammaAdd BLAST11
PeptideiPRO_0000437245101 – 123Potential peptideAdd BLAST23
PeptideiPRO_0000025031124 – 162CorticotropinAdd BLAST39
PeptideiPRO_0000025032124 – 136Melanotropin alphaAdd BLAST13
PeptideiPRO_0000025033142 – 162Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000025034165 – 235Lipotropin betaAdd BLAST71
PeptideiPRO_0000025035165 – 202Lipotropin gammaAdd BLAST38
PeptideiPRO_0000025036185 – 202Melanotropin betaAdd BLAST18
PeptideiPRO_0000025037205 – 235Beta-endorphinAdd BLAST31
PeptideiPRO_0000025038205 – 209Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87Phenylalanine amideBy similarity1
Modified residuei124N-acetylserine; in CorticotropinBy similarity1
Modified residuei136Valine amideBy similarity1
Glycosylationi152N-linked (GlcNAc...)Curated1
Modified residuei154PhosphoserineBy similarity1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01194.
PRIDEiP01194.

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016976.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP01194.
PhylomeDBiP01194.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRFCNSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC
60 70 80 90 100
RLDLSAETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGGSAQ
110 120 130 140 150
RRAEEETAGG DGRPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA
160 170 180 190 200
ENESAEAFPL EFKRELEGEQ PDGLEQVLEP DTEKADGPYR VEHFRWGNPP
210 220 230
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNV HKKGQ
Length:235
Mass (Da):26,540
Last modified:January 1, 1988 - v1
Checksum:iA1AEC6AC9DBF1C13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6N → Y in CAA26937 (PubMed:2998878).Curated1
Sequence conflicti6N → Y in AAA41903 (PubMed:2998878).Curated1
Sequence conflicti40E → Y (PubMed:6547437).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03176 Genomic DNA. Translation: CAA26937.1.
K01877 Genomic DNA. No translation available.
J00759, K01878 Genomic DNA. Translation: AAA41903.1.
PIRiA91353. CTRTP.
UniGeneiRn.108195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03176 Genomic DNA. Translation: CAA26937.1.
K01877 Genomic DNA. No translation available.
J00759, K01878 Genomic DNA. Translation: AAA41903.1.
PIRiA91353. CTRTP.
UniGeneiRn.108195.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016976.

Proteomic databases

PaxDbiP01194.
PRIDEiP01194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi3366. Pomc.

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP01194.
PhylomeDBiP01194.

Miscellaneous databases

PROiP01194.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOLI_RAT
AccessioniPrimary (citable) accession number: P01194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.