Skip Header

Contribute Send feedback
Read comments (0) or add your own

P01194 (COLI_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 13, 2010. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
Customize displayNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Names and origin

Protein namesRecommended name:
Pro-opiomelanocortin
Short name=POMC
Alternative name(s):
Corticotropin-lipotropin

Cleaved into the following 10 chains:

  1. NPP
  2. Melanotropin gamma
    Alternative name(s):
    Gamma-MSH
  3. Corticotropin
    Alternative name(s):
    Adrenocorticotropic hormone
    Short name=ACTH
  4. Melanotropin alpha
    Alternative name(s):
    Alpha-MSH
  5. Corticotropin-like intermediary peptide
    Short name=CLIP
  6. Lipotropin beta
    Alternative name(s):
    Beta-LPH
  7. Lipotropin gamma
    Alternative name(s):
    Gamma-LPH
  8. Melanotropin beta
    Alternative name(s):
    Beta-MSH
  9. Beta-endorphin
  10. Met-enkephalin
Gene names
Name:Pomc
Synonyms:Pomc2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

ACTH stimulates the adrenal glands to release cortisol.

MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.

Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular location

Secreted.

Tissue specificity

ACTH and MSH are produced by the pituitary gland.

Post-translational modification

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Sequence similarities

Belongs to the POMC family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEndorphin
Hormone
   PTMAmidation
Cleavage on pair of basic residues
Glycoprotein
Phosphoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processfeeding behavior

Non-traceable author statement. Source: RGD

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from direct assay. Source: RGD

   Molecular functionhormone activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Peptide27 – 10074NPP
PRO_0000025029
Peptide77 – 8711Melanotropin gamma
PRO_0000025030
Peptide124 – 16239Corticotropin
PRO_0000025031
Peptide124 – 13613Melanotropin alpha
PRO_0000025032
Peptide142 – 16221Corticotropin-like intermediary peptide
PRO_0000025033
Peptide165 – 23571Lipotropin beta
PRO_0000025034
Peptide165 – 20238Lipotropin gamma
PRO_0000025035
Peptide185 – 20218Melanotropin beta
PRO_0000025036
Peptide205 – 23531Beta-endorphin
PRO_0000025037
Peptide205 – 2095Met-enkephalin
PRO_0000025038

Amino acid modifications

Modified residue871Phenylalanine amide By similarity
Modified residue1361Valine amide By similarity
Modified residue1541Phosphoserine By similarity
Glycosylation1521N-linked (GlcNAc...) Probable

Experimental info

Sequence conflict61N → Y in CAA26937. Ref.1
Sequence conflict61N → Y in AAA41903. Ref.1
Sequence conflict401E → Y Ref.2

Sequences

Sequence LengthMass (Da)Tools
P01194-1 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: A1AEC6AC9DBF1C13

FASTA23526,540
        10         20         30         40         50         60 
MPRFCNSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC RLDLSAETPV 

        70         80         90        100        110        120 
FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGGSAQ RRAEEETAGG DGRPEPSPRE 

       130        140        150        160        170        180 
GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA ENESAEAFPL EFKRELEGEQ PDGLEQVLEP 

       190        200        210        220        230 
DTEKADGPYR VEHFRWGNPP KDKRYGGFMT SEKSQTPLVT LFKNAIIKNV HKKGQ

« Hide

References

[1]"Structure of the rat pro-opiomelanocortin (POMC) gene."
Drouin J., Chamberland M., Charron J., Jeannotte L., Nemer M.
FEBS Lett. 193:54-58(1985) [PubMed: 2998878] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"5' sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine and two rat forms."
Oates E., Herbert E.
J. Biol. Chem. 259:7421-7425(1984) [PubMed: 6547437] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
[3]"Most of the coding region of rat ACTH beta-LPH precursor gene lacks intervening sequences."
Drouin J., Goodman H.M.
Nature 288:610-613(1980) [PubMed: 6255341] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 45-235.
[4]"The isolation of characterization of gamma 3-melanotropin from the neurointermediary lobe of the rat pituitary."
Browne C.A., Bennett H.P., Solomon S.
Biochem. Biophys. Res. Commun. 100:336-343(1981) [PubMed: 7259753] [Abstract]
Cited for: PROTEIN SEQUENCE OF 76-100.
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X03176 Genomic DNA. Translation: CAA26937.1.
K01877 Genomic DNA. No translation available.
J00759, K01878 Genomic DNA. Translation: AAA41903.1.
IPIIPI00211001.
PIRCTRTP. A91353.
UniGeneRn.108195.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP01194.

Genome annotation databases

EnsemblENSRNOT00000016976; ENSRNOP00000016976; ENSRNOG00000012686; Rattus norvegicus. [Genome view]
UCSCNM_139326. rat.

Organism-specific databases

RGD3366. Pomc.

Phylogenomic databases

eggNOGroNOG05718.
HOVERGENHBG004341.
InParanoidP01194.

Gene expression databases

ArrayExpressP01194.
GenevestigatorP01194.
GermOnlineENSRNOG00000012686. Rattus norvegicus.

Family and domain databases

InterProIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PANTHERPTHR11416. Mcortin_ACTH. 1 hit.
PfamPF00976. ACTH_domain. 1 hit.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSPR00383. MELANOCORTIN.
ProtoNetSearch...

Entry information

Entry nameCOLI_RAT
AccessionPrimary (citable) accession number: P01194
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: July 13, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents