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P01193

- COLI_MOUSE

UniProt

P01193 - COLI_MOUSE

Protein

Pro-opiomelanocortin

Gene

Pomc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    ACTH stimulates the adrenal glands to release cortisol.
    MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
    Beta-endorphin and Met-enkephalin are endogenous opiates.

    GO - Molecular functioni

    1. G-protein coupled receptor binding Source: UniProtKB
    2. hormone activity Source: MGI
    3. type 1 melanocortin receptor binding Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: UniProtKB
    2. cellular pigmentation Source: UniProtKB
    3. generation of precursor metabolites and energy Source: UniProtKB
    4. glucose homeostasis Source: MGI
    5. negative regulation of tumor necrosis factor production Source: UniProtKB
    6. neuropeptide signaling pathway Source: UniProtKB-KW
    7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. regulation of appetite Source: UniProtKB
    9. regulation of blood pressure Source: MGI
    10. regulation of corticosterone secretion Source: MGI
    11. regulation of glycogen metabolic process Source: MGI
    12. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Endorphin, Hormone

    Enzyme and pathway databases

    ReactomeiREACT_205726. G-protein activation.
    REACT_207160. Glucocorticoid biosynthesis.
    REACT_220332. Androgen biosynthesis.
    REACT_227038. Endogenous sterols.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-opiomelanocortin
    Short name:
    POMC
    Alternative name(s):
    Corticotropin-lipotropin
    Cleaved into the following 10 chains:
    Alternative name(s):
    Gamma-MSH
    Alternative name(s):
    Adrenocorticotropic hormone
    Short name:
    ACTH
    Alternative name(s):
    Alpha-MSH
    Alternative name(s):
    Beta-LPH
    Alternative name(s):
    Gamma-LPH
    Alternative name(s):
    Beta-MSH
    Gene namesi
    Name:Pomc
    Synonyms:Pomc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:97742. Pomc.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: UniProtKB
    3. peroxisomal matrix Source: Ensembl
    4. secretory granule Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626By similarityAdd
    BLAST
    Peptidei27 – 10074NPPPRO_0000024996Add
    BLAST
    Peptidei77 – 8711Melanotropin gammaPRO_0000024997Add
    BLAST
    Propeptidei103 – 12119PRO_0000024998Add
    BLAST
    Peptidei124 – 16239CorticotropinPRO_0000024999Add
    BLAST
    Peptidei124 – 13613Melanotropin alphaPRO_0000025000Add
    BLAST
    Peptidei142 – 16221Corticotropin-like intermediary peptidePRO_0000025001Add
    BLAST
    Peptidei165 – 23571Lipotropin betaPRO_0000025002Add
    BLAST
    Peptidei165 – 20238Lipotropin gammaPRO_0000025003Add
    BLAST
    Peptidei185 – 20218Melanotropin betaPRO_0000025004Add
    BLAST
    Peptidei205 – 23531Beta-endorphinPRO_0000025005Add
    BLAST
    Peptidei205 – 2095Met-enkephalinPRO_0000025006

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei87 – 871Phenylalanine amideBy similarity
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Modified residuei124 – 1241N-acetylserineBy similarity
    Modified residuei136 – 1361Valine amideBy similarity
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Modified residuei154 – 1541PhosphoserineBy similarity

    Post-translational modificationi

    Specific enzymatic cleavages at paired basic residues yield the different active peptides.

    Keywords - PTMi

    Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP01193.
    PRIDEiP01193.

    PTM databases

    PhosphoSiteiP01193.
    UniCarbKBiP01193.

    Miscellaneous databases

    PMAP-CutDBP01193.

    Expressioni

    Tissue specificityi

    ACTH and MSH are produced by the pituitary gland.

    Gene expression databases

    BgeeiP01193.
    CleanExiMM_POMC.
    GenevestigatoriP01193.

    Structurei

    3D structure databases

    ProteinModelPortaliP01193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the POMC family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45039.
    GeneTreeiENSGT00390000016811.
    HOGENOMiHOG000111887.
    HOVERGENiHBG004341.
    InParanoidiP01193.
    KOiK05228.
    OMAiRACKPDL.
    OrthoDBiEOG74TX0W.
    PhylomeDBiP01193.
    TreeFamiTF333215.

    Family and domain databases

    InterProiIPR001941. Mcortin_ACTH.
    IPR013531. Mcrtin_ACTH_cent.
    IPR013593. Melanocortin_N.
    IPR013532. Opioid_neuropept.
    [Graphical view]
    PfamiPF00976. ACTH_domain. 1 hit.
    PF08384. NPP. 1 hit.
    PF08035. Op_neuropeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00383. MELANOCORTIN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01193-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC    50
    KLDLSLETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ 100
    RRAEEEAVWG DGSPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA 150
    ENESAEAFPL EFKRELEGER PLGLEQVLES DAEKDDGPYR VEHFRWSNPP 200
    KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ 235
    Length:235
    Mass (Da):26,707
    Last modified:July 21, 1986 - v1
    Checksum:iEF98C0A95D6B4991
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761Q → H in CAA24770. (PubMed:6308009)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00612, J00611 Genomic DNA. Translation: AAB59729.1.
    V01528 Genomic DNA. Translation: CAA24769.1.
    V01529 Genomic DNA. Translation: CAA24770.1.
    AK017492 mRNA. Translation: BAB30771.1.
    AK017581 mRNA. Translation: BAB30818.1.
    AK030714 mRNA. Translation: BAC27095.1.
    AK077426 mRNA. Translation: BAC36795.1.
    AK133592 mRNA. Translation: BAE21739.1.
    AK133646 mRNA. Translation: BAE21764.1.
    AK133740 mRNA. Translation: BAE21815.1.
    AK133776 mRNA. Translation: BAE21833.1.
    AK133800 mRNA. Translation: BAE21850.1.
    BC061215 mRNA. Translation: AAH61215.1.
    M30489 mRNA. Translation: AAA37169.1.
    V00831 mRNA. No translation available.
    CCDSiCCDS25785.1.
    PIRiA91312. CTMSP.
    RefSeqiNP_001265510.1. NM_001278581.1.
    NP_001265511.1. NM_001278582.1.
    NP_001265512.1. NM_001278583.1.
    NP_001265513.1. NM_001278584.1.
    NP_032921.1. NM_008895.4.
    UniGeneiMm.277996.

    Genome annotation databases

    EnsembliENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660.
    GeneIDi18976.
    KEGGimmu:18976.
    UCSCiuc007mxe.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00612 , J00611 Genomic DNA. Translation: AAB59729.1 .
    V01528 Genomic DNA. Translation: CAA24769.1 .
    V01529 Genomic DNA. Translation: CAA24770.1 .
    AK017492 mRNA. Translation: BAB30771.1 .
    AK017581 mRNA. Translation: BAB30818.1 .
    AK030714 mRNA. Translation: BAC27095.1 .
    AK077426 mRNA. Translation: BAC36795.1 .
    AK133592 mRNA. Translation: BAE21739.1 .
    AK133646 mRNA. Translation: BAE21764.1 .
    AK133740 mRNA. Translation: BAE21815.1 .
    AK133776 mRNA. Translation: BAE21833.1 .
    AK133800 mRNA. Translation: BAE21850.1 .
    BC061215 mRNA. Translation: AAH61215.1 .
    M30489 mRNA. Translation: AAA37169.1 .
    V00831 mRNA. No translation available.
    CCDSi CCDS25785.1.
    PIRi A91312. CTMSP.
    RefSeqi NP_001265510.1. NM_001278581.1.
    NP_001265511.1. NM_001278582.1.
    NP_001265512.1. NM_001278583.1.
    NP_001265513.1. NM_001278584.1.
    NP_032921.1. NM_008895.4.
    UniGenei Mm.277996.

    3D structure databases

    ProteinModelPortali P01193.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P01193.
    UniCarbKBi P01193.

    Proteomic databases

    PaxDbi P01193.
    PRIDEi P01193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020990 ; ENSMUSP00000020990 ; ENSMUSG00000020660 .
    GeneIDi 18976.
    KEGGi mmu:18976.
    UCSCi uc007mxe.1. mouse.

    Organism-specific databases

    CTDi 5443.
    MGIi MGI:97742. Pomc.

    Phylogenomic databases

    eggNOGi NOG45039.
    GeneTreei ENSGT00390000016811.
    HOGENOMi HOG000111887.
    HOVERGENi HBG004341.
    InParanoidi P01193.
    KOi K05228.
    OMAi RACKPDL.
    OrthoDBi EOG74TX0W.
    PhylomeDBi P01193.
    TreeFami TF333215.

    Enzyme and pathway databases

    Reactomei REACT_205726. G-protein activation.
    REACT_207160. Glucocorticoid biosynthesis.
    REACT_220332. Androgen biosynthesis.
    REACT_227038. Endogenous sterols.

    Miscellaneous databases

    ChiTaRSi POMC. mouse.
    NextBioi 295340.
    PMAP-CutDB P01193.
    PROi P01193.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01193.
    CleanExi MM_POMC.
    Genevestigatori P01193.

    Family and domain databases

    InterProi IPR001941. Mcortin_ACTH.
    IPR013531. Mcrtin_ACTH_cent.
    IPR013593. Melanocortin_N.
    IPR013532. Opioid_neuropept.
    [Graphical view ]
    Pfami PF00976. ACTH_domain. 1 hit.
    PF08384. NPP. 1 hit.
    PF08035. Op_neuropeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00383. MELANOCORTIN.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene."
      Notake M., Tobimatsu T., Watanabe Y., Takahashi H., Mishina M., Numa S.
      FEBS Lett. 156:67-71(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The mouse genome contains two nonallelic pro-opiomelanocortin genes."
      Uhler M., Herbert E., D'Eustachio P., Ruddle F.D.
      J. Biol. Chem. 258:9444-9453(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pituitary.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    5. "Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing."
      Thorne B.A., Caton L.W., Thomas G.
      J. Biol. Chem. 264:3545-3552(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-36.
    6. "Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide."
      Smith E.M., Galin F.S., Leboeuf R.D., Coppenhaver D.H., Harbour D.V., Blalock E.J.
      Proc. Natl. Acad. Sci. U.S.A. 87:1057-1060(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-162.
      Strain: C3H.
      Tissue: Lymphocyte.
    7. "Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor."
      Roberts J.L., Seeburg P.H., Shine J., Herbert E., Baxter J.D., Goodman H.M.
      Proc. Natl. Acad. Sci. U.S.A. 76:2153-2157(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-234.

    Entry informationi

    Entry nameiCOLI_MOUSE
    AccessioniPrimary (citable) accession number: P01193
    Secondary accession number(s): P01200, Q544U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3