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P01193 (COLI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-opiomelanocortin

Short name=POMC
Alternative name(s):
Corticotropin-lipotropin

Cleaved into the following 10 chains:

  1. NPP
  2. Melanotropin gamma
    Alternative name(s):
    Gamma-MSH
  3. Corticotropin
    Alternative name(s):
    Adrenocorticotropic hormone
    Short name=ACTH
  4. Melanotropin alpha
    Alternative name(s):
    Alpha-MSH
  5. Corticotropin-like intermediary peptide
    Short name=CLIP
  6. Lipotropin beta
    Alternative name(s):
    Beta-LPH
  7. Lipotropin gamma
    Alternative name(s):
    Gamma-LPH
  8. Melanotropin beta
    Alternative name(s):
    Beta-MSH
  9. Beta-endorphin
  10. Met-enkephalin
Gene names
Name:Pomc
Synonyms:Pomc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

ACTH stimulates the adrenal glands to release cortisol.

MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.

Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular location

Secreted By similarity.

Tissue specificity

ACTH and MSH are produced by the pituitary gland.

Post-translational modification

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Sequence similarities

Belongs to the POMC family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEndorphin
Hormone
   PTMAcetylation
Amidation
Cleavage on pair of basic residues
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell-cell signaling

Inferred from sequence or structural similarity. Source: UniProtKB

cellular pigmentation

Inferred from sequence or structural similarity. Source: UniProtKB

generation of precursor metabolites and energy

Inferred from sequence or structural similarity. Source: UniProtKB

glucose homeostasis

Inferred from mutant phenotype PubMed 21184805. Source: MGI

negative regulation of tumor necrosis factor production

Inferred from sequence or structural similarity. Source: UniProtKB

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of appetite

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of blood pressure

Inferred from genetic interaction PubMed 16243970. Source: MGI

regulation of corticosterone secretion

Inferred from mutant phenotype PubMed 21184805. Source: MGI

regulation of glycogen metabolic process

Inferred from mutant phenotype PubMed 21184805. Source: MGI

signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 18388149. Source: MGI

extracellular space

Inferred from sequence or structural similarity. Source: UniProtKB

peroxisomal matrix

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from direct assay PubMed 1329576. Source: MGI

   Molecular_functionG-protein coupled receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

hormone activity

Inferred from direct assay PubMed 15467755. Source: MGI

type 1 melanocortin receptor binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Peptide27 – 10074NPP
PRO_0000024996
Peptide77 – 8711Melanotropin gamma
PRO_0000024997
Propeptide103 – 12119
PRO_0000024998
Peptide124 – 16239Corticotropin
PRO_0000024999
Peptide124 – 13613Melanotropin alpha
PRO_0000025000
Peptide142 – 16221Corticotropin-like intermediary peptide
PRO_0000025001
Peptide165 – 23571Lipotropin beta
PRO_0000025002
Peptide165 – 20238Lipotropin gamma
PRO_0000025003
Peptide185 – 20218Melanotropin beta
PRO_0000025004
Peptide205 – 23531Beta-endorphin
PRO_0000025005
Peptide205 – 2095Met-enkephalin
PRO_0000025006

Amino acid modifications

Modified residue871Phenylalanine amide By similarity
Modified residue1241N-acetylserine By similarity
Modified residue1361Valine amide By similarity
Modified residue1541Phosphoserine By similarity
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1761Q → H in CAA24770. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P01193 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: EF98C0A95D6B4991

FASTA23526,707
        10         20         30         40         50         60 
MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC KLDLSLETPV 

        70         80         90        100        110        120 
FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ RRAEEEAVWG DGSPEPSPRE 

       130        140        150        160        170        180 
GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA ENESAEAFPL EFKRELEGER PLGLEQVLES 

       190        200        210        220        230 
DAEKDDGPYR VEHFRWSNPP KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene."
Notake M., Tobimatsu T., Watanabe Y., Takahashi H., Mishina M., Numa S.
FEBS Lett. 156:67-71(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The mouse genome contains two nonallelic pro-opiomelanocortin genes."
Uhler M., Herbert E., D'Eustachio P., Ruddle F.D.
J. Biol. Chem. 258:9444-9453(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Pituitary.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[5]"Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing."
Thorne B.A., Caton L.W., Thomas G.
J. Biol. Chem. 264:3545-3552(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-36.
[6]"Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide."
Smith E.M., Galin F.S., Leboeuf R.D., Coppenhaver D.H., Harbour D.V., Blalock E.J.
Proc. Natl. Acad. Sci. U.S.A. 87:1057-1060(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-162.
Strain: C3H.
Tissue: Lymphocyte.
[7]"Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor."
Roberts J.L., Seeburg P.H., Shine J., Herbert E., Baxter J.D., Goodman H.M.
Proc. Natl. Acad. Sci. U.S.A. 76:2153-2157(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-234.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00612, J00611 Genomic DNA. Translation: AAB59729.1.
V01528 Genomic DNA. Translation: CAA24769.1.
V01529 Genomic DNA. Translation: CAA24770.1.
AK017492 mRNA. Translation: BAB30771.1.
AK017581 mRNA. Translation: BAB30818.1.
AK030714 mRNA. Translation: BAC27095.1.
AK077426 mRNA. Translation: BAC36795.1.
AK133592 mRNA. Translation: BAE21739.1.
AK133646 mRNA. Translation: BAE21764.1.
AK133740 mRNA. Translation: BAE21815.1.
AK133776 mRNA. Translation: BAE21833.1.
AK133800 mRNA. Translation: BAE21850.1.
BC061215 mRNA. Translation: AAH61215.1.
M30489 mRNA. Translation: AAA37169.1.
V00831 mRNA. No translation available.
PIRCTMSP. A91312.
RefSeqNP_001265510.1. NM_001278581.1.
NP_001265511.1. NM_001278582.1.
NP_001265512.1. NM_001278583.1.
NP_001265513.1. NM_001278584.1.
NP_032921.1. NM_008895.4.
UniGeneMm.277996.

3D structure databases

ProteinModelPortalP01193.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP01193.
UniCarbKBP01193.

Proteomic databases

PaxDbP01193.
PRIDEP01193.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660.
GeneID18976.
KEGGmmu:18976.
UCSCuc007mxe.1. mouse.

Organism-specific databases

CTD5443.
MGIMGI:97742. Pomc.

Phylogenomic databases

eggNOGNOG45039.
GeneTreeENSGT00390000016811.
HOGENOMHOG000111887.
HOVERGENHBG004341.
InParanoidP01193.
KOK05228.
OMARACKPDL.
OrthoDBEOG74TX0W.
PhylomeDBP01193.
TreeFamTF333215.

Gene expression databases

BgeeP01193.
CleanExMM_POMC.
GenevestigatorP01193.

Family and domain databases

InterProIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamPF00976. ACTH_domain. 1 hit.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSPR00383. MELANOCORTIN.
ProtoNetSearch...

Other

ChiTaRSPOMC. mouse.
NextBio295340.
PMAP-CutDBP01193.
PROP01193.
SOURCESearch...

Entry information

Entry nameCOLI_MOUSE
AccessionPrimary (citable) accession number: P01193
Secondary accession number(s): P01200, Q544U4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot