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P01193

- COLI_MOUSE

UniProt

P01193 - COLI_MOUSE

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Protein
Pro-opiomelanocortin
Gene
Pomc, Pomc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: UniProtKB
  2. hormone activity Source: MGI
  3. type 1 melanocortin receptor binding Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: UniProtKB
  2. cellular pigmentation Source: UniProtKB
  3. generation of precursor metabolites and energy Source: UniProtKB
  4. glucose homeostasis Source: MGI
  5. negative regulation of tumor necrosis factor production Source: UniProtKB
  6. neuropeptide signaling pathway Source: UniProtKB-KW
  7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. regulation of appetite Source: UniProtKB
  9. regulation of blood pressure Source: MGI
  10. regulation of corticosterone secretion Source: MGI
  11. regulation of glycogen metabolic process Source: MGI
  12. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Hormone

Enzyme and pathway databases

ReactomeiREACT_205726. G-protein activation.
REACT_207160. Glucocorticoid biosynthesis.
REACT_220332. Androgen biosynthesis.
REACT_227038. Endogenous sterols.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Alpha-MSH
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Beta-MSH
Gene namesi
Name:Pomc
Synonyms:Pomc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:97742. Pomc.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: UniProtKB
  3. peroxisomal matrix Source: Ensembl
  4. secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarity
Add
BLAST
Peptidei27 – 10074NPP
PRO_0000024996Add
BLAST
Peptidei77 – 8711Melanotropin gamma
PRO_0000024997Add
BLAST
Propeptidei103 – 12119
PRO_0000024998Add
BLAST
Peptidei124 – 16239Corticotropin
PRO_0000024999Add
BLAST
Peptidei124 – 13613Melanotropin alpha
PRO_0000025000Add
BLAST
Peptidei142 – 16221Corticotropin-like intermediary peptide
PRO_0000025001Add
BLAST
Peptidei165 – 23571Lipotropin beta
PRO_0000025002Add
BLAST
Peptidei165 – 20238Lipotropin gamma
PRO_0000025003Add
BLAST
Peptidei185 – 20218Melanotropin beta
PRO_0000025004Add
BLAST
Peptidei205 – 23531Beta-endorphin
PRO_0000025005Add
BLAST
Peptidei205 – 2095Met-enkephalin
PRO_0000025006

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871Phenylalanine amide By similarity
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Modified residuei124 – 1241N-acetylserine By similarity
Modified residuei136 – 1361Valine amide By similarity
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Modified residuei154 – 1541Phosphoserine By similarity

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP01193.
PRIDEiP01193.

PTM databases

PhosphoSiteiP01193.
UniCarbKBiP01193.

Miscellaneous databases

PMAP-CutDBP01193.

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Gene expression databases

BgeeiP01193.
CleanExiMM_POMC.
GenevestigatoriP01193.

Structurei

3D structure databases

ProteinModelPortaliP01193.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45039.
GeneTreeiENSGT00390000016811.
HOGENOMiHOG000111887.
HOVERGENiHBG004341.
InParanoidiP01193.
KOiK05228.
OMAiRACKPDL.
OrthoDBiEOG74TX0W.
PhylomeDBiP01193.
TreeFamiTF333215.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 1 hit.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01193-1 [UniParc]FASTAAdd to Basket

« Hide

MPRFCYSRSG ALLLALLLQT SIDVWSWCLE SSQCQDLTTE SNLLACIRAC    50
KLDLSLETPV FPGNGDEQPL TENPRKYVMG HFRWDRFGPR NSSSAGSAAQ 100
RRAEEEAVWG DGSPEPSPRE GKRSYSMEHF RWGKPVGKKR RPVKVYPNVA 150
ENESAEAFPL EFKRELEGER PLGLEQVLES DAEKDDGPYR VEHFRWSNPP 200
KDKRYGGFMT SEKSQTPLVT LFKNAIIKNA HKKGQ 235
Length:235
Mass (Da):26,707
Last modified:July 21, 1986 - v1
Checksum:iEF98C0A95D6B4991
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761Q → H in CAA24770. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00612, J00611 Genomic DNA. Translation: AAB59729.1.
V01528 Genomic DNA. Translation: CAA24769.1.
V01529 Genomic DNA. Translation: CAA24770.1.
AK017492 mRNA. Translation: BAB30771.1.
AK017581 mRNA. Translation: BAB30818.1.
AK030714 mRNA. Translation: BAC27095.1.
AK077426 mRNA. Translation: BAC36795.1.
AK133592 mRNA. Translation: BAE21739.1.
AK133646 mRNA. Translation: BAE21764.1.
AK133740 mRNA. Translation: BAE21815.1.
AK133776 mRNA. Translation: BAE21833.1.
AK133800 mRNA. Translation: BAE21850.1.
BC061215 mRNA. Translation: AAH61215.1.
M30489 mRNA. Translation: AAA37169.1.
V00831 mRNA. No translation available.
CCDSiCCDS25785.1.
PIRiA91312. CTMSP.
RefSeqiNP_001265510.1. NM_001278581.1.
NP_001265511.1. NM_001278582.1.
NP_001265512.1. NM_001278583.1.
NP_001265513.1. NM_001278584.1.
NP_032921.1. NM_008895.4.
UniGeneiMm.277996.

Genome annotation databases

EnsembliENSMUST00000020990; ENSMUSP00000020990; ENSMUSG00000020660.
GeneIDi18976.
KEGGimmu:18976.
UCSCiuc007mxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00612 , J00611 Genomic DNA. Translation: AAB59729.1 .
V01528 Genomic DNA. Translation: CAA24769.1 .
V01529 Genomic DNA. Translation: CAA24770.1 .
AK017492 mRNA. Translation: BAB30771.1 .
AK017581 mRNA. Translation: BAB30818.1 .
AK030714 mRNA. Translation: BAC27095.1 .
AK077426 mRNA. Translation: BAC36795.1 .
AK133592 mRNA. Translation: BAE21739.1 .
AK133646 mRNA. Translation: BAE21764.1 .
AK133740 mRNA. Translation: BAE21815.1 .
AK133776 mRNA. Translation: BAE21833.1 .
AK133800 mRNA. Translation: BAE21850.1 .
BC061215 mRNA. Translation: AAH61215.1 .
M30489 mRNA. Translation: AAA37169.1 .
V00831 mRNA. No translation available.
CCDSi CCDS25785.1.
PIRi A91312. CTMSP.
RefSeqi NP_001265510.1. NM_001278581.1.
NP_001265511.1. NM_001278582.1.
NP_001265512.1. NM_001278583.1.
NP_001265513.1. NM_001278584.1.
NP_032921.1. NM_008895.4.
UniGenei Mm.277996.

3D structure databases

ProteinModelPortali P01193.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P01193.
UniCarbKBi P01193.

Proteomic databases

PaxDbi P01193.
PRIDEi P01193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020990 ; ENSMUSP00000020990 ; ENSMUSG00000020660 .
GeneIDi 18976.
KEGGi mmu:18976.
UCSCi uc007mxe.1. mouse.

Organism-specific databases

CTDi 5443.
MGIi MGI:97742. Pomc.

Phylogenomic databases

eggNOGi NOG45039.
GeneTreei ENSGT00390000016811.
HOGENOMi HOG000111887.
HOVERGENi HBG004341.
InParanoidi P01193.
KOi K05228.
OMAi RACKPDL.
OrthoDBi EOG74TX0W.
PhylomeDBi P01193.
TreeFami TF333215.

Enzyme and pathway databases

Reactomei REACT_205726. G-protein activation.
REACT_207160. Glucocorticoid biosynthesis.
REACT_220332. Androgen biosynthesis.
REACT_227038. Endogenous sterols.

Miscellaneous databases

ChiTaRSi POMC. mouse.
NextBioi 295340.
PMAP-CutDB P01193.
PROi P01193.
SOURCEi Search...

Gene expression databases

Bgeei P01193.
CleanExi MM_POMC.
Genevestigatori P01193.

Family and domain databases

InterProi IPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view ]
Pfami PF00976. ACTH_domain. 1 hit.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view ]
PRINTSi PR00383. MELANOCORTIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene."
    Notake M., Tobimatsu T., Watanabe Y., Takahashi H., Mishina M., Numa S.
    FEBS Lett. 156:67-71(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The mouse genome contains two nonallelic pro-opiomelanocortin genes."
    Uhler M., Herbert E., D'Eustachio P., Ruddle F.D.
    J. Biol. Chem. 258:9444-9453(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pituitary.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. "Expression of mouse proopiomelanocortin in an insulinoma cell line. Requirements for beta-endorphin processing."
    Thorne B.A., Caton L.W., Thomas G.
    J. Biol. Chem. 264:3545-3552(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-36.
  6. "Nucleotide and amino acid sequence of lymphocyte-derived corticotropin: endotoxin induction of a truncated peptide."
    Smith E.M., Galin F.S., Leboeuf R.D., Coppenhaver D.H., Harbour D.V., Blalock E.J.
    Proc. Natl. Acad. Sci. U.S.A. 87:1057-1060(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-162.
    Strain: C3H.
    Tissue: Lymphocyte.
  7. "Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor."
    Roberts J.L., Seeburg P.H., Shine J., Herbert E., Baxter J.D., Goodman H.M.
    Proc. Natl. Acad. Sci. U.S.A. 76:2153-2157(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 187-234.

Entry informationi

Entry nameiCOLI_MOUSE
AccessioniPrimary (citable) accession number: P01193
Secondary accession number(s): P01200, Q544U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi