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Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin: Endogenous orexigenic opiate.
Met-enkephalin: Endogenous opiate.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: AgBase
  • neuropeptide hormone activity Source: GO_Central

GO - Biological processi

  • cortisol secretion Source: AgBase
  • neuropeptide signaling pathway Source: GO_Central
  • regulation of corticosterone secretion Source: GO_Central

Keywordsi

Molecular functionEndorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Melanotropin beta
Gene namesi
Name:POMC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
PeptideiPRO_000002501527 – 106NPPAdd BLAST80
PeptideiPRO_000002501677 – 87Melanotropin gammaAdd BLAST11
PropeptideiPRO_0000025017109 – 133Add BLAST25
PeptideiPRO_0000025018136 – 174CorticotropinAdd BLAST39
PeptideiPRO_0000025019136 – 148Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_0000025020154 – 174Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000025021177 – 267Lipotropin betaAdd BLAST91
PeptideiPRO_0000025022177 – 234Lipotropin gammaAdd BLAST58
PeptideiPRO_0000025023217 – 234Melanocyte-stimulating hormone betaAdd BLAST18
PeptideiPRO_0000025024237 – 267Beta-endorphinAdd BLAST31
PeptideiPRO_0000025025237 – 241Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87Phenylalanine amideBy similarity1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei136N-acetylserine; in CorticotropinBy similarity1
Modified residuei148Valine amide1 Publication1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP01192.
PRIDEiP01192.

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: AgBase
  • neuropeptide hormone activity Source: GO_Central

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024582.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOVERGENiHBG004341.
InParanoidiP01192.
KOiK05228.

Family and domain databases

InterProiView protein in InterPro
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
IPR001941. PMOC.
PfamiView protein in Pfam
PF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
PRINTSiPR00383. MELANOCORTIN.
SMARTiView protein in SMART
SM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLCGSRSG ALLLTLLLQA SMGVRGWCLE SSQCQDLSTE SNLLACIRAC
60 70 80 90 100
KPDLSAETPV FPGNGDAQPL TENPRKYVMG HFRWDRFGRR NGSSSGGGGG
110 120 130 140 150
GGGAGQKREE EEVAAGEGPG PRGDGVAPGP RQDKRSYSME HFRWGKPVGK
160 170 180 190 200
KRRPVKVYPN GAEDELAEAF PLEFRRELAG APPEPARDPE APAEGAAARA
210 220 230 240 250
ELEYGLVAEA EAAEKKDEGP YKMEHFRWGS PPKDKRYGGF MTSEKSQTPL
260
VTLFKNAIVK NAHKKGQ
Length:267
Mass (Da):28,895
Last modified:October 23, 1986 - v1
Checksum:iA6DB487A5032B648
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6G → S (PubMed:7958386).Curated1
Sequence conflicti6G → S (PubMed:6547437).Curated1
Sequence conflicti15T → A (PubMed:7958386).Curated1
Sequence conflicti15T → A (PubMed:6547437).Curated1
Sequence conflicti23G → E (PubMed:7958386).Curated1
Sequence conflicti23G → E (PubMed:6547437).Curated1
Sequence conflicti49A → S (PubMed:6547437).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti143R → T. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03561 mRNA. Translation: CAA27248.1.
X00135 mRNA. Translation: CAA24968.1.
S73519 mRNA. Translation: AAB32312.1.
PIRiA93496. CTPGP.
RefSeqiNP_999023.1. NM_213858.1.
UniGeneiSsc.14556.

Genome annotation databases

GeneIDi396863.
KEGGissc:396863.

Similar proteinsi

Entry informationi

Entry nameiCOLI_PIG
AccessioniPrimary (citable) accession number: P01192
Secondary accession number(s): Q95246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families