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Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: AgBase
  • neuropeptide hormone activity Source: GO_Central

GO - Biological processi

  • cortisol secretion Source: AgBase
  • neuropeptide signaling pathway Source: GO_Central
  • regulation of corticosterone secretion Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 10 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Alpha-MSH
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Beta-MSH
Gene namesi
Name:POMC
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Peptidei27 – 10680NPPPRO_0000025015Add
BLAST
Peptidei77 – 8711Melanotropin gammaPRO_0000025016Add
BLAST
Propeptidei109 – 13325PRO_0000025017Add
BLAST
Peptidei136 – 17439CorticotropinPRO_0000025018Add
BLAST
Peptidei136 – 14813Melanotropin alphaPRO_0000025019Add
BLAST
Peptidei154 – 17421Corticotropin-like intermediary peptidePRO_0000025020Add
BLAST
Peptidei177 – 26791Lipotropin betaPRO_0000025021Add
BLAST
Peptidei177 – 23458Lipotropin gammaPRO_0000025022Add
BLAST
Peptidei217 – 23418Melanotropin betaPRO_0000025023Add
BLAST
Peptidei237 – 26731Beta-endorphinPRO_0000025024Add
BLAST
Peptidei237 – 2415Met-enkephalinPRO_0000025025

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871Phenylalanine amide
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Modified residuei136 – 1361N-acetylserine; in CorticotropinBy similarity
Modified residuei148 – 1481Valine amide

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP01192.

Expressioni

Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: AgBase
  • neuropeptide hormone activity Source: GO_Central

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024582.

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOVERGENiHBG004341.
InParanoidiP01192.
KOiK05228.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLCGSRSG ALLLTLLLQA SMGVRGWCLE SSQCQDLSTE SNLLACIRAC
60 70 80 90 100
KPDLSAETPV FPGNGDAQPL TENPRKYVMG HFRWDRFGRR NGSSSGGGGG
110 120 130 140 150
GGGAGQKREE EEVAAGEGPG PRGDGVAPGP RQDKRSYSME HFRWGKPVGK
160 170 180 190 200
KRRPVKVYPN GAEDELAEAF PLEFRRELAG APPEPARDPE APAEGAAARA
210 220 230 240 250
ELEYGLVAEA EAAEKKDEGP YKMEHFRWGS PPKDKRYGGF MTSEKSQTPL
260
VTLFKNAIVK NAHKKGQ
Length:267
Mass (Da):28,895
Last modified:October 23, 1986 - v1
Checksum:iA6DB487A5032B648
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → S (PubMed:7958386).Curated
Sequence conflicti6 – 61G → S (PubMed:6547437).Curated
Sequence conflicti15 – 151T → A (PubMed:7958386).Curated
Sequence conflicti15 – 151T → A (PubMed:6547437).Curated
Sequence conflicti23 – 231G → E (PubMed:7958386).Curated
Sequence conflicti23 – 231G → E (PubMed:6547437).Curated
Sequence conflicti49 – 491A → S (PubMed:6547437).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti143 – 1431R → T.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03561 mRNA. Translation: CAA27248.1.
X00135 mRNA. Translation: CAA24968.1.
S73519 mRNA. Translation: AAB32312.1.
PIRiA93496. CTPGP.
RefSeqiNP_999023.1. NM_213858.1.
UniGeneiSsc.14556.

Genome annotation databases

GeneIDi396863.
KEGGissc:396863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03561 mRNA. Translation: CAA27248.1.
X00135 mRNA. Translation: CAA24968.1.
S73519 mRNA. Translation: AAB32312.1.
PIRiA93496. CTPGP.
RefSeqiNP_999023.1. NM_213858.1.
UniGeneiSsc.14556.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000024582.

Proteomic databases

PaxDbiP01192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396863.
KEGGissc:396863.

Organism-specific databases

CTDi5443.

Phylogenomic databases

eggNOGiENOG410IKR5. Eukaryota.
ENOG410Z5R4. LUCA.
HOVERGENiHBG004341.
InParanoidiP01192.
KOiK05228.

Family and domain databases

InterProiIPR001941. Mcortin_ACTH.
IPR013531. Mcrtin_ACTH_cent.
IPR013593. Melanocortin_N.
IPR013532. Opioid_neuropept.
[Graphical view]
PfamiPF00976. ACTH_domain. 3 hits.
PF08384. NPP. 1 hit.
PF08035. Op_neuropeptide. 1 hit.
[Graphical view]
PRINTSiPR00383. MELANOCORTIN.
SMARTiSM01363. ACTH_domain. 2 hits.
SM01364. NPP. 1 hit.
SM01365. Op_neuropeptide. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOLI_PIG
AccessioniPrimary (citable) accession number: P01192
Secondary accession number(s): Q95246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.