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Protein

Vasopressin-neurophysin 2-copeptin

Gene

Avp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: Ensembl
  • neuropeptide hormone activity Source: RGD
  • protein kinase activity Source: Ensembl
  • signal transducer activity Source: Ensembl
  • V1A vasopressin receptor binding Source: RGD
  • V1B vasopressin receptor binding Source: RGD
  • V2 vasopressin receptor binding Source: RGD

GO - Biological processi

  • ERK1 and ERK2 cascade Source: Ensembl
  • grooming behavior Source: RGD
  • hyperosmotic salinity response Source: RGD
  • locomotory behavior Source: RGD
  • maternal aggressive behavior Source: RGD
  • maternal behavior Source: RGD
  • multicellular organismal water homeostasis Source: RGD
  • negative regulation of female receptivity Source: RGD
  • negative regulation of release of cytochrome c from mitochondria Source: Ensembl
  • negative regulation of transmission of nerve impulse Source: RGD
  • penile erection Source: RGD
  • positive regulation of cAMP biosynthetic process Source: Ensembl
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cellular pH reduction Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of gene expression Source: Ensembl
  • positive regulation of glutamate secretion Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  • positive regulation of prostaglandin biosynthetic process Source: RGD
  • positive regulation of systemic arterial blood pressure Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • protein kinase C signaling Source: Ensembl
  • regulation of renal sodium excretion Source: RGD
  • response to ethanol Source: RGD
  • response to nicotine Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to testosterone Source: RGD
  • smooth muscle contraction Source: RGD
  • social behavior Source: RGD
  • temperature homeostasis Source: RGD
  • vasoconstriction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-RNO-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-I
Gene namesi
Name:Avp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2184. Avp.

Subcellular locationi

GO - Cellular componenti

  • dendrite Source: RGD
  • extracellular space Source: RGD
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Peptidei24 – 329Arg-vasopressinPRO_0000020524
Chaini36 – 12893Neurophysin 2PRO_0000020525Add
BLAST
Peptidei130 – 16839CopeptinPRO_0000020526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 29
Modified residuei32 – 321Glycine amide1 Publication
Disulfide bondi45 ↔ 89By similarity
Disulfide bondi48 ↔ 62By similarity
Disulfide bondi56 ↔ 79By similarity
Disulfide bondi63 ↔ 69By similarity
Disulfide bondi96 ↔ 108By similarity
Disulfide bondi102 ↔ 120By similarity
Disulfide bondi109 ↔ 114By similarity
Glycosylationi135 – 1351N-linked (GlcNAc...)

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01186.
PRIDEiP01186.

Expressioni

Gene expression databases

GenevisibleiP01186. RN.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: RGD
  • V1A vasopressin receptor binding Source: RGD
  • V1B vasopressin receptor binding Source: RGD
  • V2 vasopressin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028833.

Structurei

3D structure databases

ProteinModelPortaliP01186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01186.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG7NW6C5.
PhylomeDBiP01186.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAMMLNTTL SACFLSLLAL TSACYFQNCP RGGKRATSDM ELRQCLPCGP
60 70 80 90 100
GGKGRCFGPS ICCADELGCF LGTAEALRCQ EENYLPSPCQ SGQKPCGSGG
110 120 130 140 150
RCAAAGICCS DESCVAEPEC REGFFRLTRA REQSNATQLD GPARELLLRL
160
VQLAGTQESV DSAKPRVY
Length:168
Mass (Da):17,923
Last modified:July 21, 1986 - v1
Checksum:iDB369FED09A74698
GO

Sequence cautioni

The sequence AAA42342.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59496 Genomic DNA. Translation: CAA42086.1.
M25646 mRNA. Translation: AAA42342.1. Different initiation.
V01275 Genomic DNA. Translation: CAA24582.1.
V01276 Genomic DNA. Translation: CAA24583.1.
X01637 Genomic DNA. Translation: CAA25795.2.
PIRiA90982. NVRT2.
RefSeqiNP_058688.2. NM_016992.2.
UniGeneiRn.9976.

Genome annotation databases

EnsembliENSRNOT00000028833; ENSRNOP00000028833; ENSRNOG00000021229.
GeneIDi24221.
KEGGirno:24221.
UCSCiRGD:2184. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59496 Genomic DNA. Translation: CAA42086.1.
M25646 mRNA. Translation: AAA42342.1. Different initiation.
V01275 Genomic DNA. Translation: CAA24582.1.
V01276 Genomic DNA. Translation: CAA24583.1.
X01637 Genomic DNA. Translation: CAA25795.2.
PIRiA90982. NVRT2.
RefSeqiNP_058688.2. NM_016992.2.
UniGeneiRn.9976.

3D structure databases

ProteinModelPortaliP01186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028833.

Proteomic databases

PaxDbiP01186.
PRIDEiP01186.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028833; ENSRNOP00000028833; ENSRNOG00000021229.
GeneIDi24221.
KEGGirno:24221.
UCSCiRGD:2184. rat.

Organism-specific databases

CTDi551.
RGDi2184. Avp.

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01186.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG7NW6C5.
PhylomeDBiP01186.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-RNO-879518. Transport of organic anions.

Miscellaneous databases

NextBioi602655.
PROiP01186.

Gene expression databases

GenevisibleiP01186. RN.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat vasopressin and oxytocin genes are linked by a long interspersed repeated DNA element (LINE): sequence and transcriptional analysis of LINE."
    Schmitz E., Mohr E., Richter D.
    DNA Cell Biol. 10:81-91(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Liver.
  2. "The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation."
    Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.
    Biol. Chem. Hoppe-Seyler 367:695-704(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Structural organization of the rat gene for the arginine vasopressin-neurophysin precursor."
    Schmale H., Heinsohn S., Richter D.
    EMBO J. 2:763-767(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The mutant vasopressin gene from diabetes insipidus (Brattleboro) rats is transcribed but the message is not efficiently translated."
    Schmale H., Ivell R., Breindl M., Darmer D., Richter D.
    EMBO J. 3:3289-3293(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Evolution of neurohypophyseal hormones: isolation of active principles from rabbits and rats."
    Chauvet J., Chauvet M.-T., Acher R.
    Biochimie 53:1099-1104(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: AMINO-ACID COMPOSITION OF 24-32, AMIDATION AT GLY-32.
  6. "Identification of rat neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins."
    Chauvet M.-T., Chauvet J., Acher R.
    Biochem. Biophys. Res. Commun. 103:595-603(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 36-128.
  7. "A comparative study of partial neurophysin protein sequences of cod, guinea pig, rat and sheep."
    Schlesinger D.H., Pickering B.T., Watkins W.B., Peek J.C., Moore L.G., Audhya T.K., Walter R.
    FEBS Lett. 80:371-373(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 36-68.
  8. "The glycopeptide domain of the rat vasopressin precursor."
    Chauvet M.-T., Chauvet J., Acher R.
    FEBS Lett. 163:257-260(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 130-168.
  9. "Isolation and primary structure of novel neurointermediate pituitary peptides derived from the C-terminal of the rat vasopressin-neurophysin precursor (propressophysin)."
    Burbach J.P.H., Seidah N.G., Chretien M.
    Eur. J. Biochem. 156:137-142(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 130-168.

Entry informationi

Entry nameiNEU2_RAT
AccessioniPrimary (citable) accession number: P01186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.