Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vasopressin-neurophysin 2-copeptin

Gene

AVP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  • neuropeptide hormone activity Source: ProtInc
  • protein kinase activity Source: UniProtKB
  • receptor binding Source: ProtInc
  • signal transducer activity Source: UniProtKB
  • V1A vasopressin receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).
R-HSA-879518. Transport of organic anions.
SIGNORiP01185.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-II
Gene namesi
Name:AVP
Synonyms:ARVP, VP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:894. AVP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Diabetes insipidus, neurohypophyseal (NDI)27 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood.
See also OMIM:125700
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171S → F in NDI. 1 Publication
VAR_004980
Natural varianti19 – 191A → T in NDI; probably causes insufficient processing of precursor. 6 Publications
Corresponds to variant rs387906511 [ dbSNP | Ensembl ].
VAR_004981
Natural varianti19 – 191A → V in NDI. 2 Publications
Corresponds to variant rs387906512 [ dbSNP | Ensembl ].
VAR_004982
Natural varianti21 – 211Y → H in NDI. 1 Publication
Corresponds to variant rs121964893 [ dbSNP | Ensembl ].
VAR_015262
Natural varianti26 – 261P → L in NDI; weakly active. 1 Publication
Corresponds to variant rs142886338 [ dbSNP | Ensembl ].
VAR_015263
Natural varianti45 – 451G → R in NDI. 1 Publication
VAR_004983
Natural varianti48 – 481G → V in NDI. 1 Publication
Corresponds to variant rs121964883 [ dbSNP | Ensembl ].
VAR_004984
Natural varianti51 – 511R → C in NDI. 1 Publication
VAR_004985
Natural varianti52 – 521C → R in NDI.
VAR_015264
Natural varianti54 – 541G → R in NDI. 3 Publications
Corresponds to variant rs121964888 [ dbSNP | Ensembl ].
VAR_015265
Natural varianti54 – 541G → V in NDI. 1 Publication
Corresponds to variant rs121964887 [ dbSNP | Ensembl ].
VAR_015266
Natural varianti55 – 551P → L in NDI. 1 Publication
VAR_004986
Natural varianti58 – 581C → F in NDI. 1 Publication
VAR_029997
Natural varianti59 – 591C → R in NDI.
VAR_015267
Natural varianti59 – 591C → Y in NDI. 1 Publication
VAR_015268
Natural varianti67 – 671V → A in NDI. 1 Publication
Corresponds to variant rs28934878 [ dbSNP | Ensembl ].
VAR_019273
Natural varianti78 – 781E → G in NDI. 2 Publications
VAR_004988
Natural varianti78 – 781Missing in NDI. 2 Publications
VAR_004987
Natural varianti81 – 811L → P in NDI. 1 Publication
VAR_004989
Natural varianti87 – 871S → F in NDI. 1 Publication
Corresponds to variant rs121964890 [ dbSNP | Ensembl ].
VAR_015269
Natural varianti88 – 881G → R in NDI. 1 Publication
VAR_004990
Natural varianti88 – 881G → S in NDI. 1 Publication
Corresponds to variant rs121964882 [ dbSNP | Ensembl ].
VAR_004991
Natural varianti92 – 921C → S in NDI. 2 Publications
VAR_004992
Natural varianti92 – 921C → Y in NDI. 2 Publications
Corresponds to variant rs121964891 [ dbSNP | Ensembl ].
VAR_015270
Natural varianti93 – 931G → W in NDI. 1 Publication
Corresponds to variant rs121964885 [ dbSNP | Ensembl ].
VAR_004993
Natural varianti96 – 961G → C in NDI. 2 Publications
VAR_004994
Natural varianti96 – 961G → D in NDI. 1 Publication
VAR_019274
Natural varianti96 – 961G → V in NDI.
Corresponds to variant rs121964886 [ dbSNP | Ensembl ].
VAR_015271
Natural varianti97 – 971R → C in NDI.
VAR_015272
Natural varianti97 – 971R → P in NDI. 1 Publication
VAR_015273
Natural varianti98 – 981C → G in NDI. 1 Publication
VAR_015274
Natural varianti98 – 981C → S in NDI. 1 Publication
VAR_029998
Natural varianti99 – 991A → P in NDI. 1 Publication
VAR_029999
Natural varianti104 – 1041C → F in NDI. 1 Publication
VAR_015275
Natural varianti104 – 1041C → G in NDI. 1 Publication
VAR_019275
Natural varianti105 – 1051C → R in NDI. 1 Publication
VAR_015276
Natural varianti105 – 1051C → Y in NDI. 1 Publication
VAR_015279
Natural varianti116 – 1161C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 Publications
Corresponds to variant rs74315383 [ dbSNP | Ensembl ].
VAR_015277
Natural varianti116 – 1161C → R in NDI. 1 Publication
VAR_015278
Natural varianti116 – 1161C → W in NDI. 1 Publication
VAR_019276

Keywords - Diseasei

Diabetes insipidus, Disease mutation

Organism-specific databases

MalaCardsiAVP.
MIMi125700. phenotype.
Orphaneti30925. Hereditary central diabetes insipidus.
PharmGKBiPA25186.

Polymorphism and mutation databases

BioMutaiAVP.
DMDMi128083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Peptidei20 – 289Arg-vasopressinPRO_0000020515
Chaini32 – 12493Neurophysin 2PRO_0000020516Add
BLAST
Peptidei126 – 16439CopeptinPRO_0000020517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 251 Publication
Modified residuei28 – 281Glycine amide1 Publication
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...)

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01185.
PeptideAtlasiP01185.
PRIDEiP01185.

PTM databases

iPTMnetiP01185.
PhosphoSiteiP01185.

Miscellaneous databases

PMAP-CutDBP01185.

Expressioni

Gene expression databases

BgeeiENSG00000101200.
CleanExiHS_AVP.
ExpressionAtlasiP01185. baseline and differential.
GenevisibleiP01185. HS.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: ProtInc
  • receptor binding Source: ProtInc
  • V1A vasopressin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107032. 24 interactions.
IntActiP01185. 1 interaction.
STRINGi9606.ENSP00000369647.

Structurei

3D structure databases

ProteinModelPortaliP01185.
SMRiP01185. Positions 32-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01185.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP01185.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDTMLPACF LGLLAFSSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAA
110 120 130 140 150
FGVCCNDESC VTEPECREGF HRRARASDRS NATQLDGPAG ALLLRLVQLA
160
GAPEPFEPAQ PDAY
Length:164
Mass (Da):17,325
Last modified:August 1, 1992 - v2
Checksum:i8F5EF9834700B9AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111L → P in AAA98772 (PubMed:2991279).Curated
Sequence conflicti48 – 481G → D in AAB86629 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171S → F in NDI. 1 Publication
VAR_004980
Natural varianti19 – 191A → T in NDI; probably causes insufficient processing of precursor. 6 Publications
Corresponds to variant rs387906511 [ dbSNP | Ensembl ].
VAR_004981
Natural varianti19 – 191A → V in NDI. 2 Publications
Corresponds to variant rs387906512 [ dbSNP | Ensembl ].
VAR_004982
Natural varianti21 – 211Y → H in NDI. 1 Publication
Corresponds to variant rs121964893 [ dbSNP | Ensembl ].
VAR_015262
Natural varianti26 – 261P → L in NDI; weakly active. 1 Publication
Corresponds to variant rs142886338 [ dbSNP | Ensembl ].
VAR_015263
Natural varianti45 – 451G → R in NDI. 1 Publication
VAR_004983
Natural varianti48 – 481G → V in NDI. 1 Publication
Corresponds to variant rs121964883 [ dbSNP | Ensembl ].
VAR_004984
Natural varianti51 – 511R → C in NDI. 1 Publication
VAR_004985
Natural varianti52 – 521C → R in NDI.
VAR_015264
Natural varianti54 – 541G → R in NDI. 3 Publications
Corresponds to variant rs121964888 [ dbSNP | Ensembl ].
VAR_015265
Natural varianti54 – 541G → V in NDI. 1 Publication
Corresponds to variant rs121964887 [ dbSNP | Ensembl ].
VAR_015266
Natural varianti55 – 551P → L in NDI. 1 Publication
VAR_004986
Natural varianti58 – 581C → F in NDI. 1 Publication
VAR_029997
Natural varianti59 – 591C → R in NDI.
VAR_015267
Natural varianti59 – 591C → Y in NDI. 1 Publication
VAR_015268
Natural varianti67 – 671V → A in NDI. 1 Publication
Corresponds to variant rs28934878 [ dbSNP | Ensembl ].
VAR_019273
Natural varianti78 – 781E → G in NDI. 2 Publications
VAR_004988
Natural varianti78 – 781Missing in NDI. 2 Publications
VAR_004987
Natural varianti81 – 811L → P in NDI. 1 Publication
VAR_004989
Natural varianti82 – 821P → L.
Corresponds to variant rs5195 [ dbSNP | Ensembl ].
VAR_011894
Natural varianti87 – 871S → F in NDI. 1 Publication
Corresponds to variant rs121964890 [ dbSNP | Ensembl ].
VAR_015269
Natural varianti88 – 881G → R in NDI. 1 Publication
VAR_004990
Natural varianti88 – 881G → S in NDI. 1 Publication
Corresponds to variant rs121964882 [ dbSNP | Ensembl ].
VAR_004991
Natural varianti92 – 921C → S in NDI. 2 Publications
VAR_004992
Natural varianti92 – 921C → Y in NDI. 2 Publications
Corresponds to variant rs121964891 [ dbSNP | Ensembl ].
VAR_015270
Natural varianti93 – 931G → W in NDI. 1 Publication
Corresponds to variant rs121964885 [ dbSNP | Ensembl ].
VAR_004993
Natural varianti96 – 961G → C in NDI. 2 Publications
VAR_004994
Natural varianti96 – 961G → D in NDI. 1 Publication
VAR_019274
Natural varianti96 – 961G → V in NDI.
Corresponds to variant rs121964886 [ dbSNP | Ensembl ].
VAR_015271
Natural varianti97 – 971R → C in NDI.
VAR_015272
Natural varianti97 – 971R → P in NDI. 1 Publication
VAR_015273
Natural varianti98 – 981C → G in NDI. 1 Publication
VAR_015274
Natural varianti98 – 981C → S in NDI. 1 Publication
VAR_029998
Natural varianti99 – 991A → P in NDI. 1 Publication
VAR_029999
Natural varianti104 – 1041C → F in NDI. 1 Publication
VAR_015275
Natural varianti104 – 1041C → G in NDI. 1 Publication
VAR_019275
Natural varianti105 – 1051C → R in NDI. 1 Publication
VAR_015276
Natural varianti105 – 1051C → Y in NDI. 1 Publication
VAR_015279
Natural varianti116 – 1161C → G in NDI; strong accumulation in the endoplasmic reticulum and an altered morphology of this organelle. 2 Publications
Corresponds to variant rs74315383 [ dbSNP | Ensembl ].
VAR_015277
Natural varianti116 – 1161C → R in NDI. 1 Publication
VAR_015278
Natural varianti116 – 1161C → W in NDI. 1 Publication
VAR_019276
Natural varianti119 – 1191G → V.1 Publication
Corresponds to variant rs1051744 [ dbSNP | Ensembl ].
VAR_011895

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11166 Genomic DNA. Translation: AAA98772.1.
M25647 mRNA. Translation: AAA61291.1.
X03172 mRNA. Translation: CAA26935.1.
X62890 Genomic DNA. Translation: CAA44681.1.
AF031476 mRNA. Translation: AAB86629.1.
AL160414 Genomic DNA. Translation: CAC10205.1.
X62891 Genomic DNA. Translation: CAA44682.1.
BC126196 mRNA. Translation: AAI26197.1.
BC126224 mRNA. Translation: AAI26225.1.
CCDSiCCDS13045.1.
PIRiA39269.
B94676. NVHU2.
RefSeqiNP_000481.2. NM_000490.4.
XP_011527569.1. XM_011529267.1.
UniGeneiHs.89648.

Genome annotation databases

EnsembliENST00000380293; ENSP00000369647; ENSG00000101200.
GeneIDi551.
KEGGihsa:551.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Vasopressin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11166 Genomic DNA. Translation: AAA98772.1.
M25647 mRNA. Translation: AAA61291.1.
X03172 mRNA. Translation: CAA26935.1.
X62890 Genomic DNA. Translation: CAA44681.1.
AF031476 mRNA. Translation: AAB86629.1.
AL160414 Genomic DNA. Translation: CAC10205.1.
X62891 Genomic DNA. Translation: CAA44682.1.
BC126196 mRNA. Translation: AAI26197.1.
BC126224 mRNA. Translation: AAI26225.1.
CCDSiCCDS13045.1.
PIRiA39269.
B94676. NVHU2.
RefSeqiNP_000481.2. NM_000490.4.
XP_011527569.1. XM_011529267.1.
UniGeneiHs.89648.

3D structure databases

ProteinModelPortaliP01185.
SMRiP01185. Positions 32-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107032. 24 interactions.
IntActiP01185. 1 interaction.
STRINGi9606.ENSP00000369647.

PTM databases

iPTMnetiP01185.
PhosphoSiteiP01185.

Polymorphism and mutation databases

BioMutaiAVP.
DMDMi128083.

Proteomic databases

PaxDbiP01185.
PeptideAtlasiP01185.
PRIDEiP01185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380293; ENSP00000369647; ENSG00000101200.
GeneIDi551.
KEGGihsa:551.

Organism-specific databases

CTDi551.
GeneCardsiAVP.
HGNCiHGNC:894. AVP.
MalaCardsiAVP.
MIMi125700. phenotype.
192340. gene.
neXtProtiNX_P01185.
Orphaneti30925. Hereditary central diabetes insipidus.
PharmGKBiPA25186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01185.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP01185.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiR-HSA-1368108. BMAL1:CLOCK,NPAS2 activates circadian gene expression.
R-HSA-388479. Vasopressin-like receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-HSA-5619099. Defective AVP causes neurohypophyseal diabetes insipidus (NDI).
R-HSA-879518. Transport of organic anions.
SIGNORiP01185.

Miscellaneous databases

GeneWikiiVasopressin.
GenomeRNAii551.
PMAP-CutDBP01185.
PROiP01185.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101200.
CleanExiHS_AVP.
ExpressionAtlasiP01185. baseline and differential.
GenevisibleiP01185. HS.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_HUMAN
AccessioniPrimary (citable) accession number: P01185
Secondary accession number(s): A0AV35, O14935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: September 7, 2016
This is version 178 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.