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Protein

Neurophysin 2

Gene

AVP

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds the midbrain peptide hormone vasopressin.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Neurophysin 2
Gene namesi
Name:AVP
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000160936‹1 – 92Neurophysin 2Add BLAST›92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 51By similarity
Disulfide bondi10 ↔ 24By similarity
Disulfide bondi18 ↔ 41By similarity
Disulfide bondi25 ↔ 31By similarity
Disulfide bondi58 ↔ 70By similarity
Disulfide bondi64 ↔ 82By similarity
Disulfide bondi71 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01182.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000022402.

Structurei

3D structure databases

ProteinModelPortaliP01182.
SMRiP01182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
InParanoidiP01182.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiView protein in InterPro
IPR000981. Neurhyp_horm.
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiView protein in Pfam
PF00184. Hormone_5. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676. Neurhyp_horm. 1 hit.
SMARTiView protein in SMART
SM00003. NH. 1 hit.
SUPFAMiSSF49606. SSF49606. 1 hit.

Sequencei

Sequence statusi: Fragment.

P01182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DLELRQCLPC GPGGKGRCFG PSICCGDELG CFVGTAEALR CQEENYLPSP
60 70 80 90
CQSGQKPCGS GGRCAAAGIC CNDESCVTEP ECREGAGLPR RA
Length:92
Mass (Da):9,502
Last modified:July 21, 1986 - v1
Checksum:i8B163CBE5D8C5CF8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

PIRiA01444. NFHO2.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNEU2_HORSE
AccessioniPrimary (citable) accession number: P01182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families