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Protein

Neurophysin 2

Gene

AVP

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds the midbrain peptide hormone vasopressin.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Neurophysin 2
Gene namesi
Name:AVP
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000160936‹1 – 92Neurophysin 2Add BLAST›92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 51By similarity
Disulfide bondi10 ↔ 24By similarity
Disulfide bondi18 ↔ 41By similarity
Disulfide bondi25 ↔ 31By similarity
Disulfide bondi58 ↔ 70By similarity
Disulfide bondi64 ↔ 82By similarity
Disulfide bondi71 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01182.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000022402.

Structurei

3D structure databases

ProteinModelPortaliP01182.
SMRiP01182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
InParanoidiP01182.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiView protein in InterPro
IPR000981. Neurhyp_horm.
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiView protein in Pfam
PF00184. Hormone_5. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676. Neurhyp_horm. 1 hit.
SMARTiView protein in SMART
SM00003. NH. 1 hit.
SUPFAMiSSF49606. SSF49606. 1 hit.

Sequencei

Sequence statusi: Fragment.

P01182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DLELRQCLPC GPGGKGRCFG PSICCGDELG CFVGTAEALR CQEENYLPSP
60 70 80 90
CQSGQKPCGS GGRCAAAGIC CNDESCVTEP ECREGAGLPR RA
Length:92
Mass (Da):9,502
Last modified:July 21, 1986 - v1
Checksum:i8B163CBE5D8C5CF8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

PIRiA01444. NFHO2.

Cross-referencesi

Sequence databases

PIRiA01444. NFHO2.

3D structure databases

ProteinModelPortaliP01182.
SMRiP01182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000022402.

Proteomic databases

PaxDbiP01182.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
InParanoidiP01182.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiView protein in InterPro
IPR000981. Neurhyp_horm.
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiView protein in Pfam
PF00184. Hormone_5. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676. Neurhyp_horm. 1 hit.
SMARTiView protein in SMART
SM00003. NH. 1 hit.
SUPFAMiSSF49606. SSF49606. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_HORSE
AccessioniPrimary (citable) accession number: P01182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.