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Protein

Vasopressin-neurophysin 2-copeptin

Gene

AVP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-BTA-388479. Vasopressin-like receptors.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-418555. G alpha (s) signalling events.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-879518. Transport of organic anions.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-II
Gene namesi
Name:AVP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
PeptideiPRO_000002050920 – 28Arg-vasopressin9
ChainiPRO_000002051032 – 126Neurophysin 2Add BLAST95
PeptideiPRO_0000020511128 – 166CopeptinAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 251 Publication
Modified residuei28Glycine amide1
Disulfide bondi41 ↔ 851 Publication
Disulfide bondi44 ↔ 581 Publication
Disulfide bondi52 ↔ 751 Publication
Disulfide bondi59 ↔ 651 Publication
Disulfide bondi92 ↔ 1041 Publication
Disulfide bondi98 ↔ 1161 Publication
Disulfide bondi105 ↔ 1101 Publication
Glycosylationi133N-linked (GlcNAc...)1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01180.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008027.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010555.

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni22 – 24Combined sources3
Helixi35 – 37Combined sources3
Beta strandi43 – 45Combined sources3
Helixi46 – 48Combined sources3
Beta strandi50 – 54Combined sources5
Beta strandi57 – 60Combined sources4
Turni61 – 63Combined sources3
Beta strandi64 – 69Combined sources6
Helixi70 – 80Combined sources11
Beta strandi89 – 92Combined sources4
Turni93 – 95Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi103 – 105Combined sources3
Beta strandi110 – 112Combined sources3
Helixi114 – 116Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK4X-ray2.30A38-126[»]
B20-26[»]
1JK6X-ray2.40A/C38-126[»]
1NPOX-ray3.00A/C32-126[»]
2BN2X-ray2.80A/C/E/G32-126[»]
ProteinModelPortaliP01180.
SMRiP01180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01180.

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01180.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG091G0V8Z.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDATLPACF LSLLAFTSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG
60 70 80 90 100
RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120 130 140 150
AGICCNDESC VTEPECREGV GFPRRVRAND RSNATLLDGP SGALLLRLVQ
160
LAGAPEPAEP AQPGVY
Length:166
Mass (Da):17,325
Last modified:July 21, 1986 - v1
Checksum:i0441DC255288D8F6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti120V → I in 30% of the molecules. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00113 mRNA. Translation: CAA23447.1.
X00503 Genomic DNA. Translation: CAA25195.1.
M25645 mRNA. Translation: AAA30806.1.
BC102897 mRNA. Translation: AAI02898.1.
PIRiS09580. NVBO2.
RefSeqiNP_789824.1. NM_176854.2.
UniGeneiBt.49210.

Genome annotation databases

EnsembliENSBTAT00000010555; ENSBTAP00000010555; ENSBTAG00000008027.
GeneIDi280728.
KEGGibta:280728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00113 mRNA. Translation: CAA23447.1.
X00503 Genomic DNA. Translation: CAA25195.1.
M25645 mRNA. Translation: AAA30806.1.
BC102897 mRNA. Translation: AAI02898.1.
PIRiS09580. NVBO2.
RefSeqiNP_789824.1. NM_176854.2.
UniGeneiBt.49210.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK4X-ray2.30A38-126[»]
B20-26[»]
1JK6X-ray2.40A/C38-126[»]
1NPOX-ray3.00A/C32-126[»]
2BN2X-ray2.80A/C/E/G32-126[»]
ProteinModelPortaliP01180.
SMRiP01180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010555.

Proteomic databases

PaxDbiP01180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010555; ENSBTAP00000010555; ENSBTAG00000008027.
GeneIDi280728.
KEGGibta:280728.

Organism-specific databases

CTDi551.

Phylogenomic databases

eggNOGiENOG410IXM5. Eukaryota.
ENOG4111S8B. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01180.
KOiK05242.
OMAiESCMTEP.
OrthoDBiEOG091G0V8Z.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiR-BTA-388479. Vasopressin-like receptors.
R-BTA-416476. G alpha (q) signalling events.
R-BTA-418555. G alpha (s) signalling events.
R-BTA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-BTA-879518. Transport of organic anions.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

EvolutionaryTraceiP01180.

Gene expression databases

BgeeiENSBTAG00000008027.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_BOVIN
AccessioniPrimary (citable) accession number: P01180
Secondary accession number(s): Q3SZF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Fetal neurophysin is the major neurophysin present in the neurohypophysis of 7 to 9 month fetuses and its sequence appears to be identical with that of the adult.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.