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Protein

Vasopressin-neurophysin 2-copeptin

Gene

AVP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).By similarity

Miscellaneous

Fetal neurophysin is the major neurophysin present in the neurohypophysis of 7 to 9 month fetuses and its sequence appears to be identical with that of the adult.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei28Important for agonist activity on V1aR/AVPR1ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-BTA-388479 Vasopressin-like receptors
R-BTA-416476 G alpha (q) signalling events
R-BTA-418555 G alpha (s) signalling events
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-879518 Transport of organic anions
R-BTA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-BTA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-II
Gene namesi
Name:AVP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:26356 AVP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
PeptideiPRO_000002050920 – 28Arg-vasopressin9
ChainiPRO_000002051032 – 126Neurophysin 2Add BLAST95
PeptideiPRO_0000020511128 – 166CopeptinAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 251 Publication
Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 851 Publication
Disulfide bondi44 ↔ 581 Publication
Disulfide bondi52 ↔ 751 Publication
Disulfide bondi59 ↔ 651 Publication
Disulfide bondi92 ↔ 1041 Publication
Disulfide bondi98 ↔ 1161 Publication
Disulfide bondi105 ↔ 1101 Publication
Glycosylationi133N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01180

Expressioni

Gene expression databases

BgeeiENSBTAG00000008027

Interactioni

Subunit structurei

Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010555

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni22 – 24Combined sources3
Helixi35 – 37Combined sources3
Beta strandi43 – 45Combined sources3
Helixi46 – 48Combined sources3
Beta strandi50 – 54Combined sources5
Beta strandi57 – 60Combined sources4
Turni61 – 63Combined sources3
Beta strandi64 – 69Combined sources6
Helixi70 – 80Combined sources11
Beta strandi89 – 92Combined sources4
Turni93 – 95Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi103 – 105Combined sources3
Beta strandi110 – 112Combined sources3
Helixi114 – 116Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK4X-ray2.30A38-126[»]
B20-26[»]
1JK6X-ray2.40A/C38-126[»]
1NPOX-ray3.00A/C32-126[»]
2BN2X-ray2.80A/C/E/G32-126[»]
ProteinModelPortaliP01180
SMRiP01180
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01180

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5 Eukaryota
ENOG4111S8B LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01180
KOiK05242
OMAiSGLCCNS
OrthoDBiEOG091G0V8Z
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDATLPACF LSLLAFTSAC YFQNCPRGGK RAMSDLELRQ CLPCGPGGKG
60 70 80 90 100
RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120 130 140 150
AGICCNDESC VTEPECREGV GFPRRVRAND RSNATLLDGP SGALLLRLVQ
160
LAGAPEPAEP AQPGVY
Length:166
Mass (Da):17,325
Last modified:July 21, 1986 - v1
Checksum:i0441DC255288D8F6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti120V → I in 30% of the molecules. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00113 mRNA Translation: CAA23447.1
X00503 Genomic DNA Translation: CAA25195.1
M25645 mRNA Translation: AAA30806.1
BC102897 mRNA Translation: AAI02898.1
PIRiS09580 NVBO2
RefSeqiNP_789824.1, NM_176854.2
UniGeneiBt.49210

Genome annotation databases

EnsembliENSBTAT00000010555; ENSBTAP00000010555; ENSBTAG00000008027
GeneIDi280728
KEGGibta:280728

Entry informationi

Entry nameiNEU2_BOVIN
AccessioniPrimary (citable) accession number: P01180
Secondary accession number(s): Q3SZF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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