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Protein

Oxytocin-neurophysin 1

Gene

Oxt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

GO - Molecular functioni

  • neurohypophyseal hormone activity Source: InterPro
  • neuropeptide hormone activity Source: RGD
  • oxytocin receptor binding Source: RGD

GO - Biological processi

  • drinking behavior Source: RGD
  • eating behavior Source: RGD
  • female pregnancy Source: RGD
  • grooming behavior Source: RGD
  • heart development Source: RGD
  • hyperosmotic salinity response Source: RGD
  • lactation Source: RGD
  • male mating behavior Source: RGD
  • maternal aggressive behavior Source: RGD
  • maternal behavior Source: RGD
  • memory Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • parturition Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of female receptivity Source: RGD
  • positive regulation of hindgut contraction Source: RGD
  • positive regulation of norepinephrine secretion Source: RGD
  • positive regulation of ossification Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • regulation of digestive system process Source: RGD
  • regulation of heart rate Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to activity Source: RGD
  • response to amphetamine Source: RGD
  • response to cAMP Source: RGD
  • response to cocaine Source: RGD
  • response to electrical stimulus Source: RGD
  • response to estradiol Source: RGD
  • response to ether Source: RGD
  • response to external biotic stimulus Source: AgBase
  • response to food Source: RGD
  • response to glucocorticoid Source: RGD
  • response to mechanical stimulus Source: AgBase
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to progesterone Source: RGD
  • response to prostaglandin E Source: RGD
  • response to retinoic acid Source: RGD
  • response to steroid hormone Source: RGD
  • response to sucrose Source: RGD
  • sleep Source: RGD
  • social behavior Source: RGD
  • sperm ejaculation Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:Oxt
Synonyms:Ot
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3238. Oxt.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • secretory granule Source: RGD
  • terminal bouton Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000002050320 – 28Oxytocin1 Publication9
ChainiPRO_000002050432 – 125Neurophysin 1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 251 Publication
Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01179.
PRIDEiP01179.

Miscellaneous databases

PMAP-CutDBiP01179.

Expressioni

Gene expression databases

GenevisibleiP01179. RN.

Interactioni

GO - Molecular functioni

  • neurohypophyseal hormone activity Source: InterPro
  • neuropeptide hormone activity Source: RGD
  • oxytocin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028829.

Structurei

3D structure databases

ProteinModelPortaliP01179.
SMRiP01179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8. Eukaryota.
ENOG41124QF. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01179.
KOiK05243.
OMAiKGHCFGP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP01179.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiView protein in InterPro
IPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiView protein in Pfam
PF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676. Neurhyp_horm. 1 hit.
SMARTiView protein in SMART
SM00003. NH. 1 hit.
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiView protein in PROSITE
PS00264. NEUROHYPOPHYS_HORM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAALDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAT
110 120
AGICCSPDGC RTDPACDPES AFSER
Length:125
Mass (Da):12,823
Last modified:July 1, 1989 - v2
Checksum:iDC98F90BADC5551F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100T → A AA sequence (PubMed:7238864).Curated1
Sequence conflicti124 – 125ER → Q AA sequence (PubMed:7036996).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01701 Genomic DNA. Translation: AAA98733.1.
M25649 mRNA. Translation: AAA41773.1.
X12792 Genomic DNA. Translation: CAA31281.1.
X59496 Genomic DNA. Translation: CAA42085.1.
PIRiA21183. NFRT1.
RefSeqiNP_037128.1. NM_012996.3.
UniGeneiRn.48915.

Genome annotation databases

EnsembliENSRNOT00000028829; ENSRNOP00000028829; ENSRNOG00000021225.
GeneIDi25504.
KEGGirno:25504.
UCSCiRGD:3238. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNEU1_RAT
AccessioniPrimary (citable) accession number: P01179
Secondary accession number(s): Q53WU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: June 7, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families