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Protein

Oxytocin-neurophysin 1

Gene

Oxt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

GO - Molecular functioni

  • neuropeptide hormone activity Source: RGD
  • oxytocin receptor binding Source: RGD

GO - Biological processi

  • drinking behavior Source: RGD
  • eating behavior Source: RGD
  • female pregnancy Source: RGD
  • grooming behavior Source: RGD
  • heart development Source: RGD
  • hyperosmotic salinity response Source: RGD
  • lactation Source: RGD
  • male mating behavior Source: RGD
  • maternal aggressive behavior Source: RGD
  • maternal behavior Source: RGD
  • memory Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • parturition Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of female receptivity Source: RGD
  • positive regulation of hindgut contraction Source: RGD
  • positive regulation of norepinephrine secretion Source: RGD
  • positive regulation of ossification Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • regulation of digestive system process Source: RGD
  • regulation of heart rate Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to activity Source: RGD
  • response to amphetamine Source: RGD
  • response to cAMP Source: RGD
  • response to cocaine Source: RGD
  • response to electrical stimulus Source: RGD
  • response to estradiol Source: RGD
  • response to ether Source: RGD
  • response to external biotic stimulus Source: AgBase
  • response to food Source: AgBase
  • response to glucocorticoid Source: RGD
  • response to mechanical stimulus Source: AgBase
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to progesterone Source: RGD
  • response to prostaglandin E Source: RGD
  • response to retinoic acid Source: RGD
  • response to steroid hormone Source: RGD
  • response to sucrose Source: RGD
  • sleep Source: RGD
  • social behavior Source: RGD
  • sperm ejaculation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:Oxt
Synonyms:Ot
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3238. Oxt.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • secretory granule Source: RGD
  • terminal bouton Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Peptidei20 – 289Oxytocin1 PublicationPRO_0000020503
Chaini32 – 12594Neurophysin 1PRO_0000020504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 251 Publication
Modified residuei28 – 281Glycine amide1 Publication
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01179.

Miscellaneous databases

PMAP-CutDBP01179.

Expressioni

Gene expression databases

GenevisibleiP01179. RN.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: RGD
  • oxytocin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028829.

Structurei

3D structure databases

ProteinModelPortaliP01179.
SMRiP01179. Positions 32-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8. Eukaryota.
ENOG41124QF. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01179.
KOiK05243.
OMAiDGCRTDP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP01179.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAALDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAT
110 120
AGICCSPDGC RTDPACDPES AFSER
Length:125
Mass (Da):12,823
Last modified:July 1, 1989 - v2
Checksum:iDC98F90BADC5551F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001T → A AA sequence (PubMed:7238864).Curated
Sequence conflicti124 – 1252ER → Q AA sequence (PubMed:7036996).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01701 Genomic DNA. Translation: AAA98733.1.
M25649 mRNA. Translation: AAA41773.1.
X12792 Genomic DNA. Translation: CAA31281.1.
X59496 Genomic DNA. Translation: CAA42085.1.
PIRiA21183. NFRT1.
RefSeqiNP_037128.1. NM_012996.3.
UniGeneiRn.48915.

Genome annotation databases

EnsembliENSRNOT00000028829; ENSRNOP00000028829; ENSRNOG00000021225.
GeneIDi25504.
KEGGirno:25504.
UCSCiRGD:3238. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01701 Genomic DNA. Translation: AAA98733.1.
M25649 mRNA. Translation: AAA41773.1.
X12792 Genomic DNA. Translation: CAA31281.1.
X59496 Genomic DNA. Translation: CAA42085.1.
PIRiA21183. NFRT1.
RefSeqiNP_037128.1. NM_012996.3.
UniGeneiRn.48915.

3D structure databases

ProteinModelPortaliP01179.
SMRiP01179. Positions 32-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028829.

Proteomic databases

PaxDbiP01179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028829; ENSRNOP00000028829; ENSRNOG00000021225.
GeneIDi25504.
KEGGirno:25504.
UCSCiRGD:3238. rat.

Organism-specific databases

CTDi5020.
RGDi3238. Oxt.

Phylogenomic databases

eggNOGiENOG410J3A8. Eukaryota.
ENOG41124QF. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01179.
KOiK05243.
OMAiDGCRTDP.
OrthoDBiEOG091G0V8Z.
PhylomeDBiP01179.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PMAP-CutDBP01179.
PROiP01179.

Gene expression databases

GenevisibleiP01179. RN.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU1_RAT
AccessioniPrimary (citable) accession number: P01179
Secondary accession number(s): Q53WU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.