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Protein

Oxytocin-neurophysin 1

Gene

Oxt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).By similarity

GO - Molecular functioni

  • neurohypophyseal hormone activity Source: InterPro
  • neuropeptide hormone activity Source: RGD
  • oxytocin receptor binding Source: RGD

GO - Biological processi

  • drinking behavior Source: RGD
  • eating behavior Source: RGD
  • female pregnancy Source: RGD
  • grooming behavior Source: RGD
  • heart development Source: RGD
  • hyperosmotic salinity response Source: RGD
  • lactation Source: RGD
  • male mating behavior Source: RGD
  • maternal aggressive behavior Source: RGD
  • maternal behavior Source: RGD
  • memory Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • parturition Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of female receptivity Source: RGD
  • positive regulation of hindgut contraction Source: RGD
  • positive regulation of norepinephrine secretion Source: RGD
  • positive regulation of ossification Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of prostaglandin secretion Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of synapse assembly Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of uterine smooth muscle contraction Source: RGD
  • regulation of digestive system process Source: RGD
  • regulation of heart rate Source: RGD
  • regulation of sensory perception of pain Source: RGD
  • response to activity Source: RGD
  • response to amphetamine Source: RGD
  • response to cAMP Source: RGD
  • response to cocaine Source: RGD
  • response to electrical stimulus Source: RGD
  • response to estradiol Source: RGD
  • response to ether Source: RGD
  • response to external biotic stimulus Source: AgBase
  • response to food Source: RGD
  • response to glucocorticoid Source: RGD
  • response to mechanical stimulus Source: AgBase
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD
  • response to progesterone Source: RGD
  • response to prostaglandin E Source: RGD
  • response to retinoic acid Source: RGD
  • response to steroid hormone Source: RGD
  • response to sucrose Source: RGD
  • sleep Source: RGD
  • social behavior Source: RGD
  • sperm ejaculation Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-388479 Vasopressin-like receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:Oxt
Synonyms:Ot
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3238 Oxt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000002050320 – 28Oxytocin1 Publication9
ChainiPRO_000002050432 – 125Neurophysin 1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 251 Publication
Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01179

Miscellaneous databases

PMAP-CutDBP01179

Expressioni

Gene expression databases

GenevisibleiP01179 RN

Interactioni

Subunit structurei

Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).By similarity

GO - Molecular functioni

  • neurohypophyseal hormone activity Source: InterPro
  • neuropeptide hormone activity Source: RGD
  • oxytocin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028829

Structurei

3D structure databases

ProteinModelPortaliP01179
SMRiP01179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01179
KOiK05243
OMAiKGHCFGP
OrthoDBiEOG091G0V8Z
PhylomeDBiP01179
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAALDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAT
110 120
AGICCSPDGC RTDPACDPES AFSER
Length:125
Mass (Da):12,823
Last modified:July 1, 1989 - v2
Checksum:iDC98F90BADC5551F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100T → A AA sequence (PubMed:7238864).Curated1
Sequence conflicti124 – 125ER → Q AA sequence (PubMed:7036996).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01701 Genomic DNA Translation: AAA98733.1
M25649 mRNA Translation: AAA41773.1
X12792 Genomic DNA Translation: CAA31281.1
X59496 Genomic DNA Translation: CAA42085.1
PIRiA21183 NFRT1
RefSeqiNP_037128.1, NM_012996.3
UniGeneiRn.48915

Genome annotation databases

EnsembliENSRNOT00000028829; ENSRNOP00000028829; ENSRNOG00000021225
GeneIDi25504
KEGGirno:25504
UCSCiRGD:3238 rat

Similar proteinsi

Entry informationi

Entry nameiNEU1_RAT
AccessioniPrimary (citable) accession number: P01179
Secondary accession number(s): Q53WU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health