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P01178

- NEU1_HUMAN

UniProt

P01178 - NEU1_HUMAN

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Protein

Oxytocin-neurophysin 1

Gene

OXT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

GO - Biological processi

  1. drinking behavior Source: Ensembl
  2. eating behavior Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. grooming behavior Source: Ensembl
  5. heart development Source: Ensembl
  6. hyperosmotic salinity response Source: Ensembl
  7. male mating behavior Source: Ensembl
  8. maternal aggressive behavior Source: Ensembl
  9. maternal behavior Source: Ensembl
  10. memory Source: Ensembl
  11. negative regulation of blood pressure Source: Ensembl
  12. negative regulation of gastric acid secretion Source: Ensembl
  13. negative regulation of urine volume Source: Ensembl
  14. positive regulation of blood pressure Source: Ensembl
  15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  16. positive regulation of female receptivity Source: Ensembl
  17. positive regulation of hindgut contraction Source: Ensembl
  18. positive regulation of norepinephrine secretion Source: Ensembl
  19. positive regulation of ossification Source: Ensembl
  20. positive regulation of penile erection Source: Ensembl
  21. positive regulation of prostaglandin secretion Source: Ensembl
  22. positive regulation of renal sodium excretion Source: Ensembl
  23. positive regulation of synapse assembly Source: Ensembl
  24. positive regulation of synaptic transmission Source: Ensembl
  25. positive regulation of uterine smooth muscle contraction Source: Ensembl
  26. regulation of heart rate Source: Ensembl
  27. regulation of sensory perception of pain Source: Ensembl
  28. response to activity Source: Ensembl
  29. response to amphetamine Source: Ensembl
  30. response to cAMP Source: Ensembl
  31. response to cocaine Source: Ensembl
  32. response to electrical stimulus Source: Ensembl
  33. response to estradiol Source: Ensembl
  34. response to ether Source: Ensembl
  35. response to food Source: Ensembl
  36. response to glucocorticoid Source: Ensembl
  37. response to peptide hormone Source: Ensembl
  38. response to progesterone Source: Ensembl
  39. response to prostaglandin E Source: Ensembl
  40. response to retinoic acid Source: Ensembl
  41. response to sucrose Source: Ensembl
  42. signal transduction Source: ProtInc
  43. sleep Source: Ensembl
  44. social behavior Source: Ensembl
  45. sperm ejaculation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:OXT
Synonyms:OT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:8528. OXT.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: Ensembl
  3. secretory granule Source: Ensembl
  4. terminal bouton Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.

Organism-specific databases

PharmGKBiPA32857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Peptidei20 – 289OxytocinPRO_0000020495
Chaini32 – 12594Neurophysin 1PRO_0000020496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 25
Modified residuei28 – 281Glycine amide1 Publication
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01178.
PeptideAtlasiP01178.
PRIDEiP01178.

Miscellaneous databases

PMAP-CutDBP01178.

Expressioni

Gene expression databases

BgeeiP01178.
CleanExiHS_OXT.
ExpressionAtlasiP01178. baseline and differential.
GenevestigatoriP01178.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163331EBI-1762651,EBI-389883

Protein-protein interaction databases

BioGridi111060. 2 interactions.
IntActiP01178. 1 interaction.
STRINGi9606.ENSP00000217386.

Structurei

3D structure databases

ProteinModelPortaliP01178.
SMRiP01178. Positions 38-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44533.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01178.
KOiK05243.
OMAiPCESGRK.
OrthoDBiEOG7NW6C5.
PhylomeDBiP01178.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01178-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG
60 70 80 90 100
RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV
110 120
LGLCCSPDGC HADPACDAEA TFSQR
Length:125
Mass (Da):12,722
Last modified:January 1, 1988 - v1
Checksum:iC65BB544731A0E7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941S → G in AAA59979. (PubMed:2249637)Curated
Sequence conflicti100 – 1012VL → AA AA sequence (PubMed:7262323)Curated
Sequence conflicti100 – 1001Missing in AAA98806. (PubMed:2991279)Curated
Sequence conflicti124 – 1241Q → L AA sequence (PubMed:7262323)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25650 mRNA. Translation: AAA59977.1.
M11186 Genomic DNA. Translation: AAA98806.1.
AY082910 Genomic DNA. Translation: AAL92860.1.
AL160414 Genomic DNA. Translation: CAC10204.1.
BC069144 mRNA. Translation: AAH69144.1.
BC101841 mRNA. Translation: AAI01842.1.
BC101843 mRNA. Translation: AAI01844.1.
X03173 mRNA. Translation: CAA26936.1.
M62611 mRNA. Translation: AAA59979.1.
CCDSiCCDS13044.1.
PIRiA94676. NFHU1.
RefSeqiNP_000906.1. NM_000915.3.
UniGeneiHs.113216.

Genome annotation databases

EnsembliENST00000217386; ENSP00000217386; ENSG00000101405.
GeneIDi5020.
KEGGihsa:5020.
UCSCiuc002wht.1. human.

Polymorphism databases

DMDMi128071.

Cross-referencesi

Web resourcesi

Wikipedia

Oxytocin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25650 mRNA. Translation: AAA59977.1 .
M11186 Genomic DNA. Translation: AAA98806.1 .
AY082910 Genomic DNA. Translation: AAL92860.1 .
AL160414 Genomic DNA. Translation: CAC10204.1 .
BC069144 mRNA. Translation: AAH69144.1 .
BC101841 mRNA. Translation: AAI01842.1 .
BC101843 mRNA. Translation: AAI01844.1 .
X03173 mRNA. Translation: CAA26936.1 .
M62611 mRNA. Translation: AAA59979.1 .
CCDSi CCDS13044.1.
PIRi A94676. NFHU1.
RefSeqi NP_000906.1. NM_000915.3.
UniGenei Hs.113216.

3D structure databases

ProteinModelPortali P01178.
SMRi P01178. Positions 38-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111060. 2 interactions.
IntActi P01178. 1 interaction.
STRINGi 9606.ENSP00000217386.

Chemistry

DrugBanki DB00107. Oxytocin.

Polymorphism databases

DMDMi 128071.

Proteomic databases

PaxDbi P01178.
PeptideAtlasi P01178.
PRIDEi P01178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217386 ; ENSP00000217386 ; ENSG00000101405 .
GeneIDi 5020.
KEGGi hsa:5020.
UCSCi uc002wht.1. human.

Organism-specific databases

CTDi 5020.
GeneCardsi GC20P003064.
HGNCi HGNC:8528. OXT.
MIMi 167050. gene.
neXtProti NX_P01178.
PharmGKBi PA32857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44533.
HOGENOMi HOG000113768.
HOVERGENi HBG004462.
InParanoidi P01178.
KOi K05243.
OMAi PCESGRK.
OrthoDBi EOG7NW6C5.
PhylomeDBi P01178.
TreeFami TF333018.

Enzyme and pathway databases

Reactomei REACT_17041. Vasopressin-like receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Neurophysin_I.
Oxytocin.
GenomeRNAii 5020.
NextBioi 19328.
PMAP-CutDB P01178.
PROi P01178.
SOURCEi Search...

Gene expression databases

Bgeei P01178.
CleanExi HS_OXT.
ExpressionAtlasi P01178. baseline and differential.
Genevestigatori P01178.

Family and domain databases

Gene3Di 2.60.9.10. 1 hit.
InterProi IPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view ]
PANTHERi PTHR11681. PTHR11681. 1 hit.
Pfami PF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSi PR00831. NEUROPHYSIN.
ProDomi PD001676. Neurhyp_horm. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00003. NH. 1 hit.
[Graphical view ]
SUPFAMi SSF49606. SSF49606. 1 hit.
PROSITEi PS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation."
    Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.
    Biol. Chem. Hoppe-Seyler 367:695-704(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line."
    Sausville E., Carney D., Battey J.
    J. Biol. Chem. 260:10236-10241(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Lack of sequence polymorphism in the oxytocin gene of autistic patients."
    Grunwald W.C. Jr., Cool D.R.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues."
    Ivell R., Furuya K., Brackmann B., Dawood Y., Khan-Dawood F.
    Endocrinology 127:2990-2996(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-110.
  7. "Expression of the vasopressin and oxytocin genes in human hypothalami."
    Mohr E., Hillers M., Ivell R., Haulica I.D., Richter D.
    FEBS Lett. 193:12-16(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-125.
  8. "Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins."
    Chauvet M.-T., Hurpet D., Chauvet J., Acher R.
    Proc. Natl. Acad. Sci. U.S.A. 80:2839-2843(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-125.
  9. "A comparative study of mammalian neurophysin protein sequences."
    Schlesinger D.H., Audhya T.K.
    FEBS Lett. 128:325-328(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-125.
  10. "On the nature of oxytocin and vasopressin from human pituitary."
    Light A., du Vigneaud V.
    Proc. Soc. Exp. Biol. Med. 98:692-696(1958) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-28, AMIDATION AT GLY-28.

Entry informationi

Entry nameiNEU1_HUMAN
AccessioniPrimary (citable) accession number: P01178
Secondary accession number(s): Q3MIG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: October 29, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3