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Protein

Oxytocin-neurophysin 1

Gene

OXT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed:18174156).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP01178

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:OXT
Synonyms:OT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101405.3
HGNCiHGNC:8528 OXT
MIMi167050 gene
neXtProtiNX_P01178

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28G → V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 310-fold decrease in affinity for oxytocin receptor (OXTR), 13-fold decrease in affinity for V1aR/AVPR1A, and complete loss of affinity for V1bR/AVPR1B and V2R/AVPR2. 1 Publication1

Organism-specific databases

DisGeNETi5020
OpenTargetsiENSG00000101405
PharmGKBiPA32857

Chemistry databases

DrugBankiDB00107 Oxytocin

Polymorphism and mutation databases

DMDMi128071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000002049520 – 28Oxytocin1 Publication9
ChainiPRO_000002049632 – 125Neurophysin 12 PublicationsAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 25
Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01178
PeptideAtlasiP01178
PRIDEiP01178
ProteomicsDBi51341

Miscellaneous databases

PMAP-CutDBiP01178

Expressioni

Gene expression databases

BgeeiENSG00000101405
CleanExiHS_OXT
ExpressionAtlasiP01178 baseline and differential
GenevisibleiP01178 HS

Organism-specific databases

HPAiHPA071892

Interactioni

Subunit structurei

Interacts with oxytocin receptor (Ki=1.5 nM) (PubMed:18174156). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM) and V2R/AVPR2 receptors (Ki=823 nM) (PubMed:18174156).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111060, 7 interactors
IntActiP01178, 1 interactor
STRINGi9606.ENSP00000217386

Structurei

3D structure databases

ProteinModelPortaliP01178
SMRiP01178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01178
KOiK05243
OMAiKGHCFGP
OrthoDBiEOG091G0V8Z
PhylomeDBiP01178
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG
60 70 80 90 100
RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV
110 120
LGLCCSPDGC HADPACDAEA TFSQR
Length:125
Mass (Da):12,722
Last modified:January 1, 1988 - v1
Checksum:iC65BB544731A0E7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94S → G in AAA59979 (PubMed:2249637).Curated1
Sequence conflicti100 – 101VL → AA AA sequence (PubMed:7262323).Curated2
Sequence conflicti100Missing in AAA98806 (PubMed:2991279).Curated1
Sequence conflicti124Q → L AA sequence (PubMed:7262323).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25650 mRNA Translation: AAA59977.1
M11186 Genomic DNA Translation: AAA98806.1
AY082910 Genomic DNA Translation: AAL92860.1
AL160414 Genomic DNA No translation available.
BC069144 mRNA Translation: AAH69144.1
BC101841 mRNA Translation: AAI01842.1
BC101843 mRNA Translation: AAI01844.1
X03173 mRNA Translation: CAA26936.1
M62611 mRNA Translation: AAA59979.1
CCDSiCCDS13044.1
PIRiA94676 NFHU1
RefSeqiNP_000906.1, NM_000915.3
XP_011527540.1, XM_011529238.1
UniGeneiHs.113216

Genome annotation databases

EnsembliENST00000217386; ENSP00000217386; ENSG00000101405
GeneIDi5020
KEGGihsa:5020

Similar proteinsi

Entry informationi

Entry nameiNEU1_HUMAN
AccessioniPrimary (citable) accession number: P01178
Secondary accession number(s): Q3MIG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: June 20, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

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