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P01178

- NEU1_HUMAN

UniProt

P01178 - NEU1_HUMAN

Protein

Oxytocin-neurophysin 1

Gene

OXT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Neurophysin 1 specifically binds oxytocin.
    Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

    GO - Biological processi

    1. drinking behavior Source: Ensembl
    2. eating behavior Source: Ensembl
    3. female pregnancy Source: Ensembl
    4. grooming behavior Source: Ensembl
    5. heart development Source: Ensembl
    6. hyperosmotic salinity response Source: Ensembl
    7. male mating behavior Source: Ensembl
    8. maternal aggressive behavior Source: Ensembl
    9. maternal behavior Source: Ensembl
    10. memory Source: Ensembl
    11. negative regulation of blood pressure Source: Ensembl
    12. negative regulation of gastric acid secretion Source: Ensembl
    13. negative regulation of urine volume Source: Ensembl
    14. positive regulation of blood pressure Source: Ensembl
    15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    16. positive regulation of female receptivity Source: Ensembl
    17. positive regulation of hindgut contraction Source: Ensembl
    18. positive regulation of norepinephrine secretion Source: Ensembl
    19. positive regulation of ossification Source: Ensembl
    20. positive regulation of penile erection Source: Ensembl
    21. positive regulation of prostaglandin secretion Source: Ensembl
    22. positive regulation of renal sodium excretion Source: Ensembl
    23. positive regulation of synapse assembly Source: Ensembl
    24. positive regulation of synaptic transmission Source: Ensembl
    25. positive regulation of uterine smooth muscle contraction Source: Ensembl
    26. regulation of heart rate Source: Ensembl
    27. regulation of sensory perception of pain Source: Ensembl
    28. response to activity Source: Ensembl
    29. response to amphetamine Source: Ensembl
    30. response to cAMP Source: Ensembl
    31. response to cocaine Source: Ensembl
    32. response to electrical stimulus Source: Ensembl
    33. response to estradiol Source: Ensembl
    34. response to ether Source: Ensembl
    35. response to food Source: Ensembl
    36. response to glucocorticoid Source: Ensembl
    37. response to peptide hormone Source: Ensembl
    38. response to progesterone Source: Ensembl
    39. response to prostaglandin E Source: Ensembl
    40. response to retinoic acid Source: Ensembl
    41. response to sucrose Source: Ensembl
    42. signal transduction Source: ProtInc
    43. sleep Source: Ensembl
    44. social behavior Source: Ensembl
    45. sperm ejaculation Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxytocin-neurophysin 1
    Short name:
    OT-NPI
    Cleaved into the following 2 chains:
    Alternative name(s):
    Ocytocin
    Gene namesi
    Name:OXT
    Synonyms:OT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:8528. OXT.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: Ensembl
    3. secretory granule Source: Ensembl
    4. terminal bouton Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.

    Organism-specific databases

    PharmGKBiPA32857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Peptidei20 – 289OxytocinPRO_0000020495
    Chaini32 – 12594Neurophysin 1PRO_0000020496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 25
    Modified residuei28 – 281Glycine amide1 Publication
    Disulfide bondi41 ↔ 85By similarity
    Disulfide bondi44 ↔ 58By similarity
    Disulfide bondi52 ↔ 75By similarity
    Disulfide bondi59 ↔ 65By similarity
    Disulfide bondi92 ↔ 104By similarity
    Disulfide bondi98 ↔ 116By similarity
    Disulfide bondi105 ↔ 110By similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiP01178.
    PeptideAtlasiP01178.
    PRIDEiP01178.

    Miscellaneous databases

    PMAP-CutDBP01178.

    Expressioni

    Gene expression databases

    BgeeiP01178.
    CleanExiHS_OXT.
    GenevestigatoriP01178.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163331EBI-1762651,EBI-389883

    Protein-protein interaction databases

    BioGridi111060. 2 interactions.
    IntActiP01178. 1 interaction.
    STRINGi9606.ENSP00000217386.

    Structurei

    3D structure databases

    ProteinModelPortaliP01178.
    SMRiP01178. Positions 38-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vasopressin/oxytocin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44533.
    HOGENOMiHOG000113768.
    HOVERGENiHBG004462.
    InParanoidiP01178.
    KOiK05243.
    OMAiPCESGRK.
    OrthoDBiEOG7NW6C5.
    PhylomeDBiP01178.
    TreeFamiTF333018.

    Family and domain databases

    Gene3Di2.60.9.10. 1 hit.
    InterProiIPR000981. Neurhyp_horm.
    IPR022423. Neurohypophysial_hormone_CS.
    [Graphical view]
    PANTHERiPTHR11681. PTHR11681. 1 hit.
    PfamiPF00220. Hormone_4. 1 hit.
    PF00184. Hormone_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
    PRINTSiPR00831. NEUROPHYSIN.
    ProDomiPD001676. Neurhyp_horm. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00003. NH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49606. SSF49606. 1 hit.
    PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01178-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG    50
    RCFGPNICCA EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV 100
    LGLCCSPDGC HADPACDAEA TFSQR 125
    Length:125
    Mass (Da):12,722
    Last modified:January 1, 1988 - v1
    Checksum:iC65BB544731A0E7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941S → G in AAA59979. (PubMed:2249637)Curated
    Sequence conflicti100 – 1012VL → AA AA sequence (PubMed:7262323)Curated
    Sequence conflicti100 – 1001Missing in AAA98806. (PubMed:2991279)Curated
    Sequence conflicti124 – 1241Q → L AA sequence (PubMed:7262323)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25650 mRNA. Translation: AAA59977.1.
    M11186 Genomic DNA. Translation: AAA98806.1.
    AY082910 Genomic DNA. Translation: AAL92860.1.
    AL160414 Genomic DNA. Translation: CAC10204.1.
    BC069144 mRNA. Translation: AAH69144.1.
    BC101841 mRNA. Translation: AAI01842.1.
    BC101843 mRNA. Translation: AAI01844.1.
    X03173 mRNA. Translation: CAA26936.1.
    M62611 mRNA. Translation: AAA59979.1.
    CCDSiCCDS13044.1.
    PIRiA94676. NFHU1.
    RefSeqiNP_000906.1. NM_000915.3.
    UniGeneiHs.113216.

    Genome annotation databases

    EnsembliENST00000217386; ENSP00000217386; ENSG00000101405.
    GeneIDi5020.
    KEGGihsa:5020.
    UCSCiuc002wht.1. human.

    Polymorphism databases

    DMDMi128071.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Oxytocin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25650 mRNA. Translation: AAA59977.1 .
    M11186 Genomic DNA. Translation: AAA98806.1 .
    AY082910 Genomic DNA. Translation: AAL92860.1 .
    AL160414 Genomic DNA. Translation: CAC10204.1 .
    BC069144 mRNA. Translation: AAH69144.1 .
    BC101841 mRNA. Translation: AAI01842.1 .
    BC101843 mRNA. Translation: AAI01844.1 .
    X03173 mRNA. Translation: CAA26936.1 .
    M62611 mRNA. Translation: AAA59979.1 .
    CCDSi CCDS13044.1.
    PIRi A94676. NFHU1.
    RefSeqi NP_000906.1. NM_000915.3.
    UniGenei Hs.113216.

    3D structure databases

    ProteinModelPortali P01178.
    SMRi P01178. Positions 38-117.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111060. 2 interactions.
    IntActi P01178. 1 interaction.
    STRINGi 9606.ENSP00000217386.

    Chemistry

    DrugBanki DB00107. Oxytocin.

    Polymorphism databases

    DMDMi 128071.

    Proteomic databases

    PaxDbi P01178.
    PeptideAtlasi P01178.
    PRIDEi P01178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217386 ; ENSP00000217386 ; ENSG00000101405 .
    GeneIDi 5020.
    KEGGi hsa:5020.
    UCSCi uc002wht.1. human.

    Organism-specific databases

    CTDi 5020.
    GeneCardsi GC20P003047.
    HGNCi HGNC:8528. OXT.
    MIMi 167050. gene.
    neXtProti NX_P01178.
    PharmGKBi PA32857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44533.
    HOGENOMi HOG000113768.
    HOVERGENi HBG004462.
    InParanoidi P01178.
    KOi K05243.
    OMAi PCESGRK.
    OrthoDBi EOG7NW6C5.
    PhylomeDBi P01178.
    TreeFami TF333018.

    Enzyme and pathway databases

    Reactomei REACT_17041. Vasopressin-like receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Neurophysin_I.
    Oxytocin.
    GenomeRNAii 5020.
    NextBioi 19328.
    PMAP-CutDB P01178.
    PROi P01178.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01178.
    CleanExi HS_OXT.
    Genevestigatori P01178.

    Family and domain databases

    Gene3Di 2.60.9.10. 1 hit.
    InterProi IPR000981. Neurhyp_horm.
    IPR022423. Neurohypophysial_hormone_CS.
    [Graphical view ]
    PANTHERi PTHR11681. PTHR11681. 1 hit.
    Pfami PF00220. Hormone_4. 1 hit.
    PF00184. Hormone_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
    PRINTSi PR00831. NEUROPHYSIN.
    ProDomi PD001676. Neurhyp_horm. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00003. NH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49606. SSF49606. 1 hit.
    PROSITEi PS00264. NEUROHYPOPHYS_HORM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation."
      Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.
      Biol. Chem. Hoppe-Seyler 367:695-704(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line."
      Sausville E., Carney D., Battey J.
      J. Biol. Chem. 260:10236-10241(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Lack of sequence polymorphism in the oxytocin gene of autistic patients."
      Grunwald W.C. Jr., Cool D.R.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues."
      Ivell R., Furuya K., Brackmann B., Dawood Y., Khan-Dawood F.
      Endocrinology 127:2990-2996(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-110.
    7. "Expression of the vasopressin and oxytocin genes in human hypothalami."
      Mohr E., Hillers M., Ivell R., Haulica I.D., Richter D.
      FEBS Lett. 193:12-16(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-125.
    8. "Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins."
      Chauvet M.-T., Hurpet D., Chauvet J., Acher R.
      Proc. Natl. Acad. Sci. U.S.A. 80:2839-2843(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-125.
    9. "A comparative study of mammalian neurophysin protein sequences."
      Schlesinger D.H., Audhya T.K.
      FEBS Lett. 128:325-328(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-125.
    10. "On the nature of oxytocin and vasopressin from human pituitary."
      Light A., du Vigneaud V.
      Proc. Soc. Exp. Biol. Med. 98:692-696(1958) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-28, AMIDATION AT GLY-28.

    Entry informationi

    Entry nameiNEU1_HUMAN
    AccessioniPrimary (citable) accession number: P01178
    Secondary accession number(s): Q3MIG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3