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P01178 (NEU1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxytocin-neurophysin 1

Short name=OT-NPI

Cleaved into the following 2 chains:

  1. Oxytocin
    Alternative name(s):
    Ocytocin
  2. Neurophysin 1
Gene names
Name:OXT
Synonyms:OT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

Subcellular location

Secreted.

Pharmaceutical use

Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.

Sequence similarities

Belongs to the vasopressin/oxytocin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Direct protein sequencing
Pharmaceutical
Reference proteome
Gene Ontology (GO)
   Biological_processdrinking behavior

Inferred from electronic annotation. Source: Ensembl

eating behavior

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

grooming behavior

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

hyperosmotic salinity response

Inferred from electronic annotation. Source: Ensembl

male mating behavior

Inferred from electronic annotation. Source: Ensembl

maternal aggressive behavior

Inferred from electronic annotation. Source: Ensembl

maternal behavior

Inferred from electronic annotation. Source: Ensembl

memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of urine volume

Inferred from electronic annotation. Source: Ensembl

positive regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of female receptivity

Inferred from electronic annotation. Source: Ensembl

positive regulation of hindgut contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of norepinephrine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of ossification

Inferred from electronic annotation. Source: Ensembl

positive regulation of penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of synapse assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Ensembl

positive regulation of uterine smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from electronic annotation. Source: Ensembl

response to amphetamine

Inferred from electronic annotation. Source: Ensembl

response to cAMP

Inferred from electronic annotation. Source: Ensembl

response to cocaine

Inferred from electronic annotation. Source: Ensembl

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to ether

Inferred from electronic annotation. Source: Ensembl

response to food

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to progesterone

Inferred from electronic annotation. Source: Ensembl

response to prostaglandin E

Inferred from electronic annotation. Source: Ensembl

response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

response to sucrose

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement PubMed 10218979. Source: ProtInc

sleep

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from electronic annotation. Source: Ensembl

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: Ensembl

secretory granule

Inferred from electronic annotation. Source: Ensembl

terminal bouton

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NCK1P163331EBI-1762651,EBI-389883

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.10
Peptide20 – 289Oxytocin Ref.10
PRO_0000020495
Chain32 – 12594Neurophysin 1
PRO_0000020496

Amino acid modifications

Modified residue281Glycine amide Ref.10
Disulfide bond20 ↔ 25
Disulfide bond41 ↔ 85 By similarity
Disulfide bond44 ↔ 58 By similarity
Disulfide bond52 ↔ 75 By similarity
Disulfide bond59 ↔ 65 By similarity
Disulfide bond92 ↔ 104 By similarity
Disulfide bond98 ↔ 116 By similarity
Disulfide bond105 ↔ 110 By similarity

Experimental info

Sequence conflict941S → G in AAA59979. Ref.6
Sequence conflict100 – 1012VL → AA AA sequence Ref.9
Sequence conflict1001Missing in AAA98806. Ref.2
Sequence conflict1241Q → L AA sequence Ref.9

Sequences

Sequence LengthMass (Da)Tools
P01178 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: C65BB544731A0E7C

FASTA12512,722
        10         20         30         40         50         60 
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA 

        70         80         90        100        110        120 
EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA 


TFSQR 

« Hide

References

« Hide 'large scale' references
[1]"The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation."
Rehbein M., Hillers M., Mohr E., Ivell R., Morley S., Schmale H., Richter D.
Biol. Chem. Hoppe-Seyler 367:695-704(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line."
Sausville E., Carney D., Battey J.
J. Biol. Chem. 260:10236-10241(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Lack of sequence polymorphism in the oxytocin gene of autistic patients."
Grunwald W.C. Jr., Cool D.R.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues."
Ivell R., Furuya K., Brackmann B., Dawood Y., Khan-Dawood F.
Endocrinology 127:2990-2996(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-110.
[7]"Expression of the vasopressin and oxytocin genes in human hypothalami."
Mohr E., Hillers M., Ivell R., Haulica I.D., Richter D.
FEBS Lett. 193:12-16(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-125.
[8]"Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins."
Chauvet M.-T., Hurpet D., Chauvet J., Acher R.
Proc. Natl. Acad. Sci. U.S.A. 80:2839-2843(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-125.
[9]"A comparative study of mammalian neurophysin protein sequences."
Schlesinger D.H., Audhya T.K.
FEBS Lett. 128:325-328(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 32-125.
[10]"On the nature of oxytocin and vasopressin from human pituitary."
Light A., du Vigneaud V.
Proc. Soc. Exp. Biol. Med. 98:692-696(1958) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-28, AMIDATION AT GLY-28.
+Additional computationally mapped references.

Web resources

Wikipedia

Oxytocin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25650 mRNA. Translation: AAA59977.1.
M11186 Genomic DNA. Translation: AAA98806.1.
AY082910 Genomic DNA. Translation: AAL92860.1.
AL160414 Genomic DNA. Translation: CAC10204.1.
BC069144 mRNA. Translation: AAH69144.1.
BC101841 mRNA. Translation: AAI01842.1.
BC101843 mRNA. Translation: AAI01844.1.
X03173 mRNA. Translation: CAA26936.1.
M62611 mRNA. Translation: AAA59979.1.
CCDSCCDS13044.1.
PIRNFHU1. A94676.
RefSeqNP_000906.1. NM_000915.3.
UniGeneHs.113216.

3D structure databases

ProteinModelPortalP01178.
SMRP01178. Positions 38-117.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111060. 2 interactions.
IntActP01178. 1 interaction.
STRING9606.ENSP00000217386.

Chemistry

DrugBankDB00107. Oxytocin.

Polymorphism databases

DMDM128071.

Proteomic databases

PaxDbP01178.
PeptideAtlasP01178.
PRIDEP01178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000217386; ENSP00000217386; ENSG00000101405.
GeneID5020.
KEGGhsa:5020.
UCSCuc002wht.1. human.

Organism-specific databases

CTD5020.
GeneCardsGC20P003047.
HGNCHGNC:8528. OXT.
MIM167050. gene.
neXtProtNX_P01178.
PharmGKBPA32857.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44533.
HOGENOMHOG000113768.
HOVERGENHBG004462.
InParanoidP01178.
KOK05243.
OMAPCESGRK.
OrthoDBEOG7NW6C5.
PhylomeDBP01178.
TreeFamTF333018.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP01178.
CleanExHS_OXT.
GenevestigatorP01178.

Family and domain databases

Gene3D2.60.9.10. 1 hit.
InterProIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERPTHR11681. PTHR11681. 1 hit.
PfamPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSPR00831. NEUROPHYSIN.
ProDomPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00003. NH. 1 hit.
[Graphical view]
SUPFAMSSF49606. SSF49606. 1 hit.
PROSITEPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeurophysin_I.
Oxytocin.
GenomeRNAi5020.
NextBio19328.
PMAP-CutDBP01178.
PROP01178.
SOURCESearch...

Entry information

Entry nameNEU1_HUMAN
AccessionPrimary (citable) accession number: P01178
Secondary accession number(s): Q3MIG0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM