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Protein

Oxytocin-neurophysin 1

Gene

OXT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-SSC-388479. Vasopressin-like receptors.
R-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:OXT
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
PeptideiPRO_000002050120 – 28Oxytocin9
ChainiPRO_000002050232 – 125Neurophysin 1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 25
Modified residuei28Glycine amide1 Publication1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01177.
PRIDEiP01177.

Expressioni

Gene expression databases

BgeeiENSSSCG00000007164.
GenevisibleiP01177. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007626.

Structurei

3D structure databases

ProteinModelPortaliP01177.
SMRiP01177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8. Eukaryota.
ENOG41124QF. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01177.
KOiK05243.
OMAiKGHCFGP.
OrthoDBiEOG091G0V8Z.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiView protein in InterPro
IPR000981. Neurhyp_horm.
IPR036387. Neurhyp_horm_dom_sf.
IPR022423. Neurohypophysial_hormone_CS.
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiView protein in Pfam
PF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676. Neurhyp_horm. 1 hit.
SMARTiView protein in SMART
SM00003. NH. 1 hit.
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiView protein in PROSITE
PS00264. NEUROHYPOPHYS_HORM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01177-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSEGRCAA
110 120
AGICCNPDGC RFDPACDPEA TFSQR
Length:125
Mass (Da):12,887
Last modified:October 1, 1994 - v3
Checksum:iAA20808066E25B5F
GO

Sequence databases

PIRiB60970. NFPG1.
RefSeqiNP_001161061.1. NM_001167589.1.
UniGeneiSsc.15668.

Genome annotation databases

EnsembliENSSSCT00000007837; ENSSSCP00000007626; ENSSSCG00000007164.
GeneIDi100152272.
KEGGissc:100152272.

Similar proteinsi

Entry informationi

Entry nameiNEU1_PIG
AccessioniPrimary (citable) accession number: P01177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families