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Protein

Oxytocin-neurophysin 1

Gene

OXT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • response to estrogen Source: CACAO
  • response to external biotic stimulus Source: AgBase
  • response to food Source: AgBase
  • response to mechanical stimulus Source: AgBase

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-BTA-388479 Vasopressin-like receptors
R-BTA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:OXT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:32515 OXT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
PeptideiPRO_000002049120 – 28Oxytocin9
ChainiPRO_000002049232 – 125Neurophysin 1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 252 Publications
Modified residuei28Glycine amide2 Publications1
Disulfide bondi41 ↔ 85Combined sources
Disulfide bondi44 ↔ 58Combined sources
Disulfide bondi52 ↔ 75Combined sources
Disulfide bondi59 ↔ 65Combined sources
Disulfide bondi92 ↔ 104Combined sources
Disulfide bondi98 ↔ 116Combined sources
Disulfide bondi105 ↔ 110Combined sources

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01175
PRIDEiP01175

Expressioni

Gene expression databases

BgeeiENSBTAG00000008026

Interactioni

Subunit structurei

Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010554

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 38Combined sources3
Beta strandi43 – 45Combined sources3
Helixi46 – 48Combined sources3
Beta strandi50 – 54Combined sources5
Beta strandi57 – 60Combined sources4
Turni61 – 63Combined sources3
Beta strandi64 – 69Combined sources6
Helixi70 – 80Combined sources11
Beta strandi89 – 92Combined sources4
Turni93 – 95Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi103 – 106Combined sources4
Beta strandi109 – 112Combined sources4
Helixi114 – 116Combined sources3
Beta strandi117 – 121Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L5CNMR-A32-123[»]
1L5DNMR-A32-123[»]
1XY1X-ray1.04A/B21-28[»]
1XY2X-ray1.20A21-28[»]
2HNUX-ray2.00A/B/C/D/E38-118[»]
2HNVX-ray2.50A/B/C/D/E38-118[»]
2HNWX-ray2.90A/B/C/D/E38-117[»]
2LBHNMR-A/B32-123[»]
2LBNNMR-A32-123[»]
ProteinModelPortaliP01175
SMRiP01175
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01175

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP01175
KOiK05243
OMAiKGHCFGP
OrthoDBiEOG091G0V8Z
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRT CLPCGPGGKG
60 70 80 90 100
RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120
AGICCSPDGC HEDPACDPEA AFSQH
Length:125
Mass (Da):12,665
Last modified:January 1, 1988 - v1
Checksum:i3B4E4E79A0B7F032
GO

Sequence cautioni

The sequence CAA23450 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA25194 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124Q → L AA sequence (PubMed:428540).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00502 Genomic DNA Translation: CAA25194.1 Sequence problems.
M25648 mRNA Translation: AAA30680.1
BC141997 mRNA Translation: AAI41998.1
V00114 mRNA Translation: CAA23448.1
V00114 mRNA Translation: CAA23450.1 Different initiation.
V00114 mRNA Translation: CAA23449.1 Sequence problems.
X00950 mRNA Translation: CAA25462.1
PIRiS07332 NFBO1
RefSeqiNP_789825.1, NM_176855.1
UniGeneiBt.183

Genome annotation databases

EnsembliENSBTAT00000010554; ENSBTAP00000010554; ENSBTAG00000008026
GeneIDi280888
KEGGibta:280888

Similar proteinsi

Entry informationi

Entry nameiNEU1_BOVIN
AccessioniPrimary (citable) accession number: P01175
Secondary accession number(s): A5PJ78, P01188
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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