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Protein

Oxytocin-neurophysin 1

Gene

OXT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

GO - Biological processi

  • response to estrogen Source: CACAO
  • response to external biotic stimulus Source: AgBase
  • response to food Source: AgBase
  • response to mechanical stimulus Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-BTA-388479. Vasopressin-like receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:OXT
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular region Source: UniProtKB-SubCell
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
PeptideiPRO_000002049120 – 28Oxytocin9
ChainiPRO_000002049232 – 125Neurophysin 1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 252 Publications
Modified residuei28Glycine amide2 Publications1
Disulfide bondi41 ↔ 85Combined sources
Disulfide bondi44 ↔ 58Combined sources
Disulfide bondi52 ↔ 75Combined sources
Disulfide bondi59 ↔ 65Combined sources
Disulfide bondi92 ↔ 104Combined sources
Disulfide bondi98 ↔ 116Combined sources
Disulfide bondi105 ↔ 110Combined sources

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01175.
PRIDEiP01175.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008026.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010554.

Structurei

Secondary structure

1125
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 38Combined sources3
Beta strandi43 – 45Combined sources3
Helixi46 – 48Combined sources3
Beta strandi50 – 54Combined sources5
Beta strandi57 – 60Combined sources4
Turni61 – 63Combined sources3
Beta strandi64 – 69Combined sources6
Helixi70 – 80Combined sources11
Beta strandi89 – 92Combined sources4
Turni93 – 95Combined sources3
Beta strandi96 – 100Combined sources5
Beta strandi103 – 106Combined sources4
Beta strandi109 – 112Combined sources4
Helixi114 – 116Combined sources3
Beta strandi117 – 121Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L5CNMR-A32-123[»]
1L5DNMR-A32-123[»]
1XY1X-ray1.04A/B21-28[»]
1XY2X-ray1.20A21-28[»]
2HNUX-ray2.00A/B/C/D/E38-118[»]
2HNVX-ray2.50A/B/C/D/E38-118[»]
2HNWX-ray2.90A/B/C/D/E38-117[»]
2LBHNMR-A/B32-123[»]
2LBNNMR-A32-123[»]
ProteinModelPortaliP01175.
SMRiP01175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01175.

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8. Eukaryota.
ENOG41124QF. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01175.
KOiK05243.
OMAiDGCRTDP.
OrthoDBiEOG091G0V8Z.
TreeFamiTF333018.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRT CLPCGPGGKG
60 70 80 90 100
RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120
AGICCSPDGC HEDPACDPEA AFSQH
Length:125
Mass (Da):12,665
Last modified:January 1, 1988 - v1
Checksum:i3B4E4E79A0B7F032
GO

Sequence cautioni

The sequence CAA23450 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA25194 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124Q → L AA sequence (PubMed:428540).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00502 Genomic DNA. Translation: CAA25194.1. Sequence problems.
M25648 mRNA. Translation: AAA30680.1.
BC141997 mRNA. Translation: AAI41998.1.
V00114 mRNA. Translation: CAA23448.1.
V00114 mRNA. Translation: CAA23450.1. Different initiation.
V00114 mRNA. Translation: CAA23449.1. Sequence problems.
X00950 mRNA. Translation: CAA25462.1.
PIRiS07332. NFBO1.
RefSeqiNP_789825.1. NM_176855.1.
UniGeneiBt.183.

Genome annotation databases

EnsembliENSBTAT00000010554; ENSBTAP00000010554; ENSBTAG00000008026.
GeneIDi280888.
KEGGibta:280888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00502 Genomic DNA. Translation: CAA25194.1. Sequence problems.
M25648 mRNA. Translation: AAA30680.1.
BC141997 mRNA. Translation: AAI41998.1.
V00114 mRNA. Translation: CAA23448.1.
V00114 mRNA. Translation: CAA23450.1. Different initiation.
V00114 mRNA. Translation: CAA23449.1. Sequence problems.
X00950 mRNA. Translation: CAA25462.1.
PIRiS07332. NFBO1.
RefSeqiNP_789825.1. NM_176855.1.
UniGeneiBt.183.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L5CNMR-A32-123[»]
1L5DNMR-A32-123[»]
1XY1X-ray1.04A/B21-28[»]
1XY2X-ray1.20A21-28[»]
2HNUX-ray2.00A/B/C/D/E38-118[»]
2HNVX-ray2.50A/B/C/D/E38-118[»]
2HNWX-ray2.90A/B/C/D/E38-117[»]
2LBHNMR-A/B32-123[»]
2LBNNMR-A32-123[»]
ProteinModelPortaliP01175.
SMRiP01175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010554.

Proteomic databases

PaxDbiP01175.
PRIDEiP01175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010554; ENSBTAP00000010554; ENSBTAG00000008026.
GeneIDi280888.
KEGGibta:280888.

Organism-specific databases

CTDi5020.

Phylogenomic databases

eggNOGiENOG410J3A8. Eukaryota.
ENOG41124QF. LUCA.
GeneTreeiENSGT00390000004511.
HOGENOMiHOG000113768.
HOVERGENiHBG004462.
InParanoidiP01175.
KOiK05243.
OMAiDGCRTDP.
OrthoDBiEOG091G0V8Z.
TreeFamiTF333018.

Enzyme and pathway databases

ReactomeiR-BTA-388479. Vasopressin-like receptors.
R-BTA-416476. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTraceiP01175.

Gene expression databases

BgeeiENSBTAG00000008026.

Family and domain databases

Gene3Di2.60.9.10. 1 hit.
InterProiIPR000981. Neurhyp_horm.
IPR022423. Neurohypophysial_hormone_CS.
[Graphical view]
PANTHERiPTHR11681. PTHR11681. 1 hit.
PfamiPF00220. Hormone_4. 1 hit.
PF00184. Hormone_5. 1 hit.
[Graphical view]
PIRSFiPIRSF001815. Nonapeptide_hormone_precursor. 1 hit.
PRINTSiPR00831. NEUROPHYSIN.
ProDomiPD001676. Neurhyp_horm. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00003. NH. 1 hit.
[Graphical view]
SUPFAMiSSF49606. SSF49606. 1 hit.
PROSITEiPS00264. NEUROHYPOPHYS_HORM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEU1_BOVIN
AccessioniPrimary (citable) accession number: P01175
Secondary accession number(s): A5PJ78, P01188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.