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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei123 – 1242Cleavage; by CORIN1 Publication
Sitei130 – 1312Cleavage; by MME1 Publication

GO - Molecular functioni

  1. neuropeptide hormone activity Source: BHF-UCL
  2. neuropeptide receptor binding Source: BHF-UCL
  3. receptor binding Source: UniProtKB

GO - Biological processi

  1. cardiac muscle hypertrophy in response to stress Source: Ensembl
  2. cellular response to mechanical stimulus Source: Ensembl
  3. cGMP biosynthetic process Source: UniProtKB
  4. female pregnancy Source: UniProtKB
  5. gene expression Source: Reactome
  6. negative regulation of cell growth Source: Ensembl
  7. negative regulation of systemic arterial blood pressure Source: Ensembl
  8. neuropeptide signaling pathway Source: BHF-UCL
  9. positive regulation of cardiac muscle contraction Source: BHF-UCL
  10. positive regulation of delayed rectifier potassium channel activity Source: BHF-UCL
  11. positive regulation of heart rate Source: BHF-UCL
  12. positive regulation of potassium ion export across plasma membrane Source: BHF-UCL
  13. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  14. regulation of atrial cardiac muscle cell membrane repolarization Source: BHF-UCL
  15. regulation of blood pressure Source: UniProtKB
  16. regulation of blood vessel size Source: UniProtKB-KW
  17. regulation of generation of L-type calcium current Source: BHF-UCL
  18. regulation of high voltage-gated calcium channel activity Source: BHF-UCL
  19. response to hypoxia Source: Ensembl
  20. response to insulin Source: Ensembl
  21. response to muscle stretch Source: BHF-UCL
  22. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Enzyme and pathway databases

ReactomeiREACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
CDD-ANF
Cardiodilatin
Short name:
CDD
Cardiodilatin-related peptide
Short name:
CDP
Prepronatriodilatin
Cleaved into the following chain:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
Synonyms:ANP, PND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7939. NPPA.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: Ensembl
  3. mast cell granule Source: Ensembl
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Atrial standstill 2 (ATRST2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.

See also OMIM:615745
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501R → Q in ATRST2. 1 Publication
VAR_071307
Atrial fibrillation, familial, 6 (ATFB6)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

See also OMIM:612201

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi123 – 1231R → G: Loss of cleavage by CORIN. 1 Publication

Keywords - Diseasei

Atrial fibrillation, Cardiomyopathy, Disease mutation

Organism-specific databases

MIMi612201. phenotype.
615745. phenotype.
Orphaneti1344. Atrial stand still.
334. Familial atrial fibrillation.
PharmGKBiPA256.

Polymorphism and mutation databases

BioMutaiNPPA.
DMDMi113864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Propeptidei26 – 12398CuratedPRO_0000001493Add
BLAST
Peptidei124 – 15128Atrial natriuretic factor2 PublicationsPRO_0000001494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi130 ↔ 1461 Publication

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.2 Publications
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01160.
PRIDEiP01160.

PTM databases

PhosphoSiteiP01160.

Miscellaneous databases

PMAP-CutDBQ5JZE1.

Expressioni

Gene expression databases

BgeeiP01160.
CleanExiHS_NPPA.
ExpressionAtlasiP01160. baseline and differential.
GenevestigatoriP01160.

Organism-specific databases

HPAiHPA058269.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA12Q6FHH83EBI-953859,EBI-10178394
UBQLN1Q9UMX03EBI-953859,EBI-741480

Protein-protein interaction databases

BioGridi110938. 12 interactions.
IntActiP01160. 3 interactions.
MINTiMINT-2861355.
STRINGi9606.ENSP00000365663.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi139 – 1413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ANPNMR-A124-151[»]
1YK0X-ray2.40E129-149[»]
3N57X-ray3.03C/D124-151[»]
DisProtiDP00747.
ProteinModelPortaliP01160.
SMRiP01160. Positions 122-149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01160.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42244.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP01160.
KOiK12334.
OrthoDBiEOG7K9K4Q.
PhylomeDBiP01160.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK
60 70 80 90 100
MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG
110 120 130 140 150
PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR

YRR
Length:153
Mass (Da):16,708
Last modified:August 13, 1987 - v1
Checksum:iB38F03AA066A73EC
GO

Sequence cautioni

The sequence CAA15955.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651E → D in AAA35529 (PubMed:3158606).Curated

Polymorphismi

There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321V → M.
Corresponds to variant rs5063 [ dbSNP | Ensembl ].
VAR_014579
Natural varianti150 – 1501R → Q in ATRST2. 1 Publication
VAR_071307
Natural varianti152 – 1532Missing in allele 2.
VAR_000594

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02043 Genomic DNA. Translation: AAB59379.1.
M30262 mRNA. Translation: AAA35669.1.
X01470, X02558 Genomic DNA. Translation: CAA25699.1.
X01471 Genomic DNA. Translation: CAA25700.2.
M54951, M54947 Genomic DNA. Translation: AAA35529.1.
AL021155 Genomic DNA. Translation: CAA15955.2. Different initiation.
AL021155 Genomic DNA. Translation: CAI23398.1.
EU326308 Genomic DNA. Translation: ACA05916.1.
BC005893 mRNA. Translation: AAH05893.1.
K02399 Genomic DNA. Translation: AAA35528.1.
K02044 mRNA. Translation: AAA51730.1.
PIRiA22693. AWHU.
RefSeqiNP_006163.1. NM_006172.3.
UniGeneiHs.75640.

Genome annotation databases

EnsembliENST00000376480; ENSP00000365663; ENSG00000175206.
GeneIDi4878.
KEGGihsa:4878.
UCSCiuc001ati.3. human.

Polymorphism and mutation databases

BioMutaiNPPA.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Atrial natriuretic peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02043 Genomic DNA. Translation: AAB59379.1.
M30262 mRNA. Translation: AAA35669.1.
X01470, X02558 Genomic DNA. Translation: CAA25699.1.
X01471 Genomic DNA. Translation: CAA25700.2.
M54951, M54947 Genomic DNA. Translation: AAA35529.1.
AL021155 Genomic DNA. Translation: CAA15955.2. Different initiation.
AL021155 Genomic DNA. Translation: CAI23398.1.
EU326308 Genomic DNA. Translation: ACA05916.1.
BC005893 mRNA. Translation: AAH05893.1.
K02399 Genomic DNA. Translation: AAA35528.1.
K02044 mRNA. Translation: AAA51730.1.
PIRiA22693. AWHU.
RefSeqiNP_006163.1. NM_006172.3.
UniGeneiHs.75640.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ANPNMR-A124-151[»]
1YK0X-ray2.40E129-149[»]
3N57X-ray3.03C/D124-151[»]
DisProtiDP00747.
ProteinModelPortaliP01160.
SMRiP01160. Positions 122-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110938. 12 interactions.
IntActiP01160. 3 interactions.
MINTiMINT-2861355.
STRINGi9606.ENSP00000365663.

Chemistry

BindingDBiP01160.
ChEMBLiCHEMBL1293193.

PTM databases

PhosphoSiteiP01160.

Polymorphism and mutation databases

BioMutaiNPPA.
DMDMi113864.

Proteomic databases

PaxDbiP01160.
PRIDEiP01160.

Protocols and materials databases

DNASUi4878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376480; ENSP00000365663; ENSG00000175206.
GeneIDi4878.
KEGGihsa:4878.
UCSCiuc001ati.3. human.

Organism-specific databases

CTDi4878.
GeneCardsiGC01M011909.
H-InvDBHIX0199955.
HGNCiHGNC:7939. NPPA.
HPAiHPA058269.
MIMi108780. gene.
612201. phenotype.
615745. phenotype.
neXtProtiNX_P01160.
Orphaneti1344. Atrial stand still.
334. Familial atrial fibrillation.
PharmGKBiPA256.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42244.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP01160.
KOiK12334.
OrthoDBiEOG7K9K4Q.
PhylomeDBiP01160.
TreeFamiTF106304.

Enzyme and pathway databases

ReactomeiREACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_75925. Amyloids.

Miscellaneous databases

EvolutionaryTraceiP01160.
GeneWikiiAtrial_natriuretic_peptide.
GenomeRNAii4878.
NextBioi18776.
PMAP-CutDBQ5JZE1.
PROiP01160.
SOURCEiSearch...

Gene expression databases

BgeeiP01160.
CleanExiHS_NPPA.
ExpressionAtlasiP01160. baseline and differential.
GenevestigatoriP01160.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide."
    Oikawa S., Imai M., Ueno A., Tanaka S., Noguchi T., Nakazato H., Kangawa K., Fukuda A., Matsuo H.
    Nature 309:724-726(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
  2. "mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria."
    Nakayama K., Ohkubo H., Hirose T., Inayama S., Nakanishi S.
    Nature 310:699-701(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
  3. "Gene structure of human cardiac hormone precursor, pronatriodilatin."
    Nemer M., Chamberland M., Sirois D., Argentin S., Drouin J., Dixon R.A.F., Zivin R.A., Condra J.H.
    Nature 312:654-656(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  4. "Nucleotide sequence of the gene encoding human atrial natriuretic factor precursor."
    Greenberg B.D., Bencen G.H., Seilhamer J.J., Lewicki J.A., Fiddes J.C.
    Nature 312:656-658(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  5. "Nucleotide sequences of the human and mouse atrial natriuretic factor genes."
    Seidman C.E., Bloch K.D., Klein K.A., Smith J.A., Seidman J.G.
    Science 226:1206-1209(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  6. "Molecular studies of the atrial natriuretic factor gene."
    Seidman C.E., Bloch K.D., Zisfein J., Smit J., Haber E., Homcy C., Duby A.D., Choi E., Graham R.M., Seidman J.G.
    Hypertension 7:I31-I34(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  7. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE 2).
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE 1).
    Tissue: Prostate.
  10. "Cloning of genomic DNA for human atrial natriuretic factor."
    Maki M., Parmentier M., Inagami T.
    Biochem. Biophys. Res. Commun. 125:797-802(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
  11. "Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors."
    Zivin R.A., Condra J.H., Dixon R.A.F., Seidah N.G., Chretien M., Nemer M., Chamberland M., Drouin J.
    Proc. Natl. Acad. Sci. U.S.A. 81:6325-6329(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-153 (ALLELE 1).
  12. "Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)."
    Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 118:131-139(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 124-151.
  13. "Hydrolysis of intact and Cys-Phe-cleaved human atrial natriuretic peptide in vitro by human tissue kallikrein."
    Vanneste Y., Michel A., Deschodt-Lanckman M.
    Eur. J. Biochem. 196:281-286(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 124-151.
  14. "Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site."
    Vanneste Y., Michel A., Dimaline R., Najdovski T., Deschodt-Lanckman M.
    Biochem. J. 254:531-537(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING BY MME, CLEAVAGE SITE.
  15. "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
    Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J., Henzel W., Lowe D.G.
    J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR-BINDING.
  16. "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
    Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
    Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."
    Yan W., Wu F., Morser J., Wu Q.
    Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, MUTAGENESIS OF ARG-123.
  18. "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."
    Knappe S., Wu F., Masikat M.R., Morser J., Wu Q.
    J. Biol. Chem. 278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  19. "Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor."
    Fairbrother W.J., McDowell R.S., Cunningham B.C.
    Biochemistry 33:8897-8904(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 124-151 MUTANT SELECTIVE FOR NPR-C RECEPTOR.
  20. "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
    He X.-L., Dukkipati A., Garcia K.C.
    J. Mol. Biol. 361:698-714(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 129-149 IN COMPLEX WITH NPR3, DISULFIDE BOND.
  21. Cited for: INVOLVEMENT IN ATFB6.
  22. "Autosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of natriuretic peptide precursor A."
    Disertori M., Quintarelli S., Grasso M., Pilotto A., Narula N., Favalli V., Canclini C., Diegoli M., Mazzola S., Marini M., Del Greco M., Bonmassari R., Mase M., Ravelli F., Specchia C., Arbustini E.
    Circ. Cardiovasc. Genet. 6:27-36(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ATRST2, VARIANT ATRST2 GLN-150.

Entry informationi

Entry nameiANF_HUMAN
AccessioniPrimary (citable) accession number: P01160
Secondary accession number(s): Q13766, Q5JZE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: April 29, 2015
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.