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P01160

- ANF_HUMAN

UniProt

P01160 - ANF_HUMAN

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Protein

Natriuretic peptides A

Gene

NPPA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei123 – 1242Cleavage; by CORIN

GO - Molecular functioni

  1. receptor binding Source: UniProtKB

GO - Biological processi

  1. cardiac muscle hypertrophy in response to stress Source: Ensembl
  2. cellular response to mechanical stimulus Source: Ensembl
  3. cGMP biosynthetic process Source: UniProtKB
  4. female pregnancy Source: UniProtKB
  5. gene expression Source: Reactome
  6. negative regulation of cell growth Source: Ensembl
  7. negative regulation of systemic arterial blood pressure Source: Ensembl
  8. receptor guanylyl cyclase signaling pathway Source: UniProtKB
  9. regulation of blood pressure Source: UniProtKB
  10. regulation of blood vessel size Source: UniProtKB-KW
  11. response to hypoxia Source: Ensembl
  12. response to insulin Source: Ensembl
  13. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Enzyme and pathway databases

ReactomeiREACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides A
Alternative name(s):
CDD-ANF
Prepronatriodilatin
Cleaved into the following 2 chains:
Alternative name(s):
Atrial natriuretic peptide
Short name:
ANP
Gene namesi
Name:NPPA
Synonyms:ANP, PND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:7939. NPPA.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: Ensembl
  3. mast cell granule Source: Ensembl
  4. nucleus Source: Ensembl
  5. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Atrial standstill 2 (ATRST2) [MIM:615745]: A rare arrhythmia characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti150 – 1501R → Q in ATRST2. 1 Publication
VAR_071307
Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi123 – 1231R → G: Loss of cleavage by CORIN. 1 Publication

Keywords - Diseasei

Atrial fibrillation, Cardiomyopathy, Disease mutation

Organism-specific databases

MIMi612201. phenotype.
615745. phenotype.
Orphaneti1344. Atrial stand still.
334. Familial atrial fibrillation.
PharmGKBiPA256.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Peptidei26 – 5530Cardiodilatin-related peptidePRO_0000001492Add
BLAST
Propeptidei56 – 123682 PublicationsPRO_0000001493Add
BLAST
Peptidei124 – 15128Atrial natriuretic factor1 PublicationPRO_0000001494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi130 ↔ 1461 Publication

Post-translational modificationi

Cleaved by CORIN upon secretion to produce the functional hormone.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01160.
PRIDEiP01160.

PTM databases

PhosphoSiteiP01160.

Miscellaneous databases

PMAP-CutDBQ5JZE1.

Expressioni

Gene expression databases

BgeeiP01160.
CleanExiHS_NPPA.
ExpressionAtlasiP01160. baseline.
GenevestigatoriP01160.

Organism-specific databases

HPAiHPA058269.

Interactioni

Protein-protein interaction databases

BioGridi110938. 10 interactions.
IntActiP01160. 1 interaction.
MINTiMINT-2861355.
STRINGi9606.ENSP00000365663.

Structurei

Secondary structure

1
153
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi139 – 1413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ANPNMR-A124-151[»]
1YK0X-ray2.40E129-149[»]
3N57X-ray3.03C/D124-151[»]
DisProtiDP00747.
ProteinModelPortaliP01160.
SMRiP01160. Positions 122-149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01160.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42244.
GeneTreeiENSGT00510000048659.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP01160.
KOiK12334.
OrthoDBiEOG7K9K4Q.
PhylomeDBiP01160.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01160-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK
60 70 80 90 100
MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG
110 120 130 140 150
PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR

YRR
Length:153
Mass (Da):16,708
Last modified:August 13, 1987 - v1
Checksum:iB38F03AA066A73EC
GO

Sequence cautioni

The sequence CAA15955.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651E → D in AAA35529. (PubMed:3158606)Curated

Polymorphismi

There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321V → M.
Corresponds to variant rs5063 [ dbSNP | Ensembl ].
VAR_014579
Natural varianti150 – 1501R → Q in ATRST2. 1 Publication
VAR_071307
Natural varianti152 – 1532Missing in allele 2.
VAR_000594

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02043 Genomic DNA. Translation: AAB59379.1.
M30262 mRNA. Translation: AAA35669.1.
X01470, X02558 Genomic DNA. Translation: CAA25699.1.
X01471 Genomic DNA. Translation: CAA25700.2.
M54951, M54947 Genomic DNA. Translation: AAA35529.1.
AL021155 Genomic DNA. Translation: CAA15955.2. Different initiation.
AL021155 Genomic DNA. Translation: CAI23398.1.
EU326308 Genomic DNA. Translation: ACA05916.1.
BC005893 mRNA. Translation: AAH05893.1.
K02399 Genomic DNA. Translation: AAA35528.1.
K02044 mRNA. Translation: AAA51730.1.
PIRiA22693. AWHU.
RefSeqiNP_006163.1. NM_006172.3.
UniGeneiHs.75640.

Genome annotation databases

EnsembliENST00000376480; ENSP00000365663; ENSG00000175206.
GeneIDi4878.
KEGGihsa:4878.
UCSCiuc001ati.3. human.

Polymorphism databases

DMDMi113864.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Atrial natriuretic peptide entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K02043 Genomic DNA. Translation: AAB59379.1 .
M30262 mRNA. Translation: AAA35669.1 .
X01470 , X02558 Genomic DNA. Translation: CAA25699.1 .
X01471 Genomic DNA. Translation: CAA25700.2 .
M54951 , M54947 Genomic DNA. Translation: AAA35529.1 .
AL021155 Genomic DNA. Translation: CAA15955.2 . Different initiation.
AL021155 Genomic DNA. Translation: CAI23398.1 .
EU326308 Genomic DNA. Translation: ACA05916.1 .
BC005893 mRNA. Translation: AAH05893.1 .
K02399 Genomic DNA. Translation: AAA35528.1 .
K02044 mRNA. Translation: AAA51730.1 .
PIRi A22693. AWHU.
RefSeqi NP_006163.1. NM_006172.3.
UniGenei Hs.75640.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ANP NMR - A 124-151 [» ]
1YK0 X-ray 2.40 E 129-149 [» ]
3N57 X-ray 3.03 C/D 124-151 [» ]
DisProti DP00747.
ProteinModelPortali P01160.
SMRi P01160. Positions 122-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110938. 10 interactions.
IntActi P01160. 1 interaction.
MINTi MINT-2861355.
STRINGi 9606.ENSP00000365663.

Chemistry

BindingDBi P01160.
ChEMBLi CHEMBL1293193.

PTM databases

PhosphoSitei P01160.

Polymorphism databases

DMDMi 113864.

Proteomic databases

PaxDbi P01160.
PRIDEi P01160.

Protocols and materials databases

DNASUi 4878.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376480 ; ENSP00000365663 ; ENSG00000175206 .
GeneIDi 4878.
KEGGi hsa:4878.
UCSCi uc001ati.3. human.

Organism-specific databases

CTDi 4878.
GeneCardsi GC01M011909.
H-InvDB HIX0199955.
HGNCi HGNC:7939. NPPA.
HPAi HPA058269.
MIMi 108780. gene.
612201. phenotype.
615745. phenotype.
neXtProti NX_P01160.
Orphaneti 1344. Atrial stand still.
334. Familial atrial fibrillation.
PharmGKBi PA256.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42244.
GeneTreei ENSGT00510000048659.
HOGENOMi HOG000033937.
HOVERGENi HBG004227.
InParanoidi P01160.
KOi K12334.
OrthoDBi EOG7K9K4Q.
PhylomeDBi P01160.
TreeFami TF106304.

Enzyme and pathway databases

Reactomei REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
REACT_75925. Amyloids.

Miscellaneous databases

EvolutionaryTracei P01160.
GeneWikii Atrial_natriuretic_peptide.
GenomeRNAii 4878.
NextBioi 18776.
PMAP-CutDB Q5JZE1.
PROi P01160.
SOURCEi Search...

Gene expression databases

Bgeei P01160.
CleanExi HS_NPPA.
ExpressionAtlasi P01160. baseline.
Genevestigatori P01160.

Family and domain databases

InterProi IPR000663. Natr_peptide.
IPR002407. Natriuretic_peptide_atrial.
[Graphical view ]
Pfami PF00212. ANP. 1 hit.
[Graphical view ]
PRINTSi PR00711. ANATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTi SM00183. NAT_PEP. 1 hit.
[Graphical view ]
PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide."
    Oikawa S., Imai M., Ueno A., Tanaka S., Noguchi T., Nakazato H., Kangawa K., Fukuda A., Matsuo H.
    Nature 309:724-726(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
  2. "mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria."
    Nakayama K., Ohkubo H., Hirose T., Inayama S., Nakanishi S.
    Nature 310:699-701(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
  3. "Gene structure of human cardiac hormone precursor, pronatriodilatin."
    Nemer M., Chamberland M., Sirois D., Argentin S., Drouin J., Dixon R.A.F., Zivin R.A., Condra J.H.
    Nature 312:654-656(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  4. "Nucleotide sequence of the gene encoding human atrial natriuretic factor precursor."
    Greenberg B.D., Bencen G.H., Seilhamer J.J., Lewicki J.A., Fiddes J.C.
    Nature 312:656-658(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  5. "Nucleotide sequences of the human and mouse atrial natriuretic factor genes."
    Seidman C.E., Bloch K.D., Klein K.A., Smith J.A., Seidman J.G.
    Science 226:1206-1209(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  6. "Molecular studies of the atrial natriuretic factor gene."
    Seidman C.E., Bloch K.D., Zisfein J., Smit J., Haber E., Homcy C., Duby A.D., Choi E., Graham R.M., Seidman J.G.
    Hypertension 7:I31-I34(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  7. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE 2).
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE 1).
    Tissue: Prostate.
  10. "Cloning of genomic DNA for human atrial natriuretic factor."
    Maki M., Parmentier M., Inagami T.
    Biochem. Biophys. Res. Commun. 125:797-802(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
  11. "Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors."
    Zivin R.A., Condra J.H., Dixon R.A.F., Seidah N.G., Chretien M., Nemer M., Chamberland M., Drouin J.
    Proc. Natl. Acad. Sci. U.S.A. 81:6325-6329(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-153 (ALLELE 1).
  12. "Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)."
    Kangawa K., Matsuo H.
    Biochem. Biophys. Res. Commun. 118:131-139(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 124-151.
  13. "Hydrolysis of intact and Cys-Phe-cleaved human atrial natriuretic peptide in vitro by human tissue kallikrein."
    Vanneste Y., Michel A., Deschodt-Lanckman M.
    Eur. J. Biochem. 196:281-286(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 124-151.
  14. "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
    Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J., Henzel W., Lowe D.G.
    J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: RECEPTOR-BINDING.
  15. "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
    Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
    Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."
    Yan W., Wu F., Morser J., Wu Q.
    Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, MUTAGENESIS OF ARG-123.
  17. "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."
    Knappe S., Wu F., Masikat M.R., Morser J., Wu Q.
    J. Biol. Chem. 278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  18. "Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor."
    Fairbrother W.J., McDowell R.S., Cunningham B.C.
    Biochemistry 33:8897-8904(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 124-151 MUTANT SELECTIVE FOR NPR-C RECEPTOR.
  19. "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
    He X.-L., Dukkipati A., Garcia K.C.
    J. Mol. Biol. 361:698-714(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 129-149 IN COMPLEX WITH NPR3, DISULFIDE BOND.
  20. Cited for: INVOLVEMENT IN ATFB6.
  21. "Autosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of natriuretic peptide precursor A."
    Disertori M., Quintarelli S., Grasso M., Pilotto A., Narula N., Favalli V., Canclini C., Diegoli M., Mazzola S., Marini M., Del Greco M., Bonmassari R., Mase M., Ravelli F., Specchia C., Arbustini E.
    Circ. Cardiovasc. Genet. 6:27-36(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ATRST2, VARIANT ATRST2 GLN-150.

Entry informationi

Entry nameiANF_HUMAN
AccessioniPrimary (citable) accession number: P01160
Secondary accession number(s): Q13766, Q5JZE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: October 29, 2014
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3