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P01160

- ANF_HUMAN

UniProt

P01160 - ANF_HUMAN

Protein

Natriuretic peptides A

Gene

NPPA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei123 – 1242Cleavage; by CORIN

    GO - Molecular functioni

    1. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle hypertrophy in response to stress Source: Ensembl
    2. cellular response to mechanical stimulus Source: Ensembl
    3. cGMP biosynthetic process Source: UniProtKB
    4. female pregnancy Source: UniProtKB
    5. gene expression Source: Reactome
    6. negative regulation of cell growth Source: Ensembl
    7. negative regulation of systemic arterial blood pressure Source: Ensembl
    8. receptor guanylyl cyclase signaling pathway Source: UniProtKB
    9. regulation of blood pressure Source: UniProtKB
    10. regulation of blood vessel size Source: UniProtKB-KW
    11. response to hypoxia Source: Ensembl
    12. response to insulin Source: Ensembl
    13. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Hormone, Vasoactive

    Enzyme and pathway databases

    ReactomeiREACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_75925. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natriuretic peptides A
    Alternative name(s):
    CDD-ANF
    Prepronatriodilatin
    Cleaved into the following 2 chains:
    Alternative name(s):
    Atrial natriuretic peptide
    Short name:
    ANP
    Gene namesi
    Name:NPPA
    Synonyms:ANP, PND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7939. NPPA.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: Ensembl
    3. mast cell granule Source: Ensembl
    4. nucleus Source: Ensembl
    5. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Atrial fibrillation, familial, 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi123 – 1231R → G: Loss of cleavage by CORIN. 1 Publication

    Keywords - Diseasei

    Atrial fibrillation

    Organism-specific databases

    MIMi612201. phenotype.
    Orphaneti334. Familial atrial fibrillation.
    PharmGKBiPA256.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Peptidei26 – 5530Cardiodilatin-related peptidePRO_0000001492Add
    BLAST
    Propeptidei56 – 123682 PublicationsPRO_0000001493Add
    BLAST
    Peptidei124 – 15128Atrial natriuretic factor1 PublicationPRO_0000001494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi130 ↔ 1461 Publication

    Post-translational modificationi

    Cleaved by CORIN upon secretion to produce the functional hormone.

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01160.
    PRIDEiP01160.

    PTM databases

    PhosphoSiteiP01160.

    Miscellaneous databases

    PMAP-CutDBQ5JZE1.

    Expressioni

    Gene expression databases

    ArrayExpressiP01160.
    BgeeiP01160.
    CleanExiHS_NPPA.
    GenevestigatoriP01160.

    Organism-specific databases

    HPAiHPA058269.

    Interactioni

    Protein-protein interaction databases

    BioGridi110938. 10 interactions.
    IntActiP01160. 1 interaction.
    MINTiMINT-2861355.
    STRINGi9606.ENSP00000365663.

    Structurei

    Secondary structure

    1
    153
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi139 – 1413

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ANPNMR-A124-151[»]
    1YK0X-ray2.40E129-149[»]
    3N57X-ray3.03C/D124-151[»]
    DisProtiDP00747.
    ProteinModelPortaliP01160.
    SMRiP01160. Positions 122-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01160.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the natriuretic peptide family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42244.
    HOGENOMiHOG000033937.
    HOVERGENiHBG004227.
    InParanoidiP01160.
    KOiK12334.
    OrthoDBiEOG7K9K4Q.
    PhylomeDBiP01160.
    TreeFamiTF106304.

    Family and domain databases

    InterProiIPR000663. Natr_peptide.
    IPR002407. Natriuretic_peptide_atrial.
    [Graphical view]
    PfamiPF00212. ANP. 1 hit.
    [Graphical view]
    PRINTSiPR00711. ANATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTiSM00183. NAT_PEP. 1 hit.
    [Graphical view]
    PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01160-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK    50
    MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG 100
    PWDSSDRSAL LKSKLRALLT APRSLRRSSC FGGRMDRIGA QSGLGCNSFR 150
    YRR 153
    Length:153
    Mass (Da):16,708
    Last modified:August 13, 1987 - v1
    Checksum:iB38F03AA066A73EC
    GO

    Sequence cautioni

    The sequence CAA15955.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651E → D in AAA35529. (PubMed:3158606)Curated

    Polymorphismi

    There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321V → M.
    Corresponds to variant rs5063 [ dbSNP | Ensembl ].
    VAR_014579
    Natural varianti152 – 1532Missing in allele 2.
    VAR_000594

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02043 Genomic DNA. Translation: AAB59379.1.
    M30262 mRNA. Translation: AAA35669.1.
    X01470, X02558 Genomic DNA. Translation: CAA25699.1.
    X01471 Genomic DNA. Translation: CAA25700.2.
    M54951, M54947 Genomic DNA. Translation: AAA35529.1.
    AL021155 Genomic DNA. Translation: CAA15955.2. Different initiation.
    AL021155 Genomic DNA. Translation: CAI23398.1.
    EU326308 Genomic DNA. Translation: ACA05916.1.
    BC005893 mRNA. Translation: AAH05893.1.
    K02399 Genomic DNA. Translation: AAA35528.1.
    K02044 mRNA. Translation: AAA51730.1.
    PIRiA22693. AWHU.
    RefSeqiNP_006163.1. NM_006172.3.
    UniGeneiHs.75640.

    Genome annotation databases

    EnsembliENST00000376480; ENSP00000365663; ENSG00000175206.
    GeneIDi4878.
    KEGGihsa:4878.
    UCSCiuc001ati.3. human.

    Polymorphism databases

    DMDMi113864.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Atrial natriuretic peptide entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K02043 Genomic DNA. Translation: AAB59379.1 .
    M30262 mRNA. Translation: AAA35669.1 .
    X01470 , X02558 Genomic DNA. Translation: CAA25699.1 .
    X01471 Genomic DNA. Translation: CAA25700.2 .
    M54951 , M54947 Genomic DNA. Translation: AAA35529.1 .
    AL021155 Genomic DNA. Translation: CAA15955.2 . Different initiation.
    AL021155 Genomic DNA. Translation: CAI23398.1 .
    EU326308 Genomic DNA. Translation: ACA05916.1 .
    BC005893 mRNA. Translation: AAH05893.1 .
    K02399 Genomic DNA. Translation: AAA35528.1 .
    K02044 mRNA. Translation: AAA51730.1 .
    PIRi A22693. AWHU.
    RefSeqi NP_006163.1. NM_006172.3.
    UniGenei Hs.75640.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ANP NMR - A 124-151 [» ]
    1YK0 X-ray 2.40 E 129-149 [» ]
    3N57 X-ray 3.03 C/D 124-151 [» ]
    DisProti DP00747.
    ProteinModelPortali P01160.
    SMRi P01160. Positions 122-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110938. 10 interactions.
    IntActi P01160. 1 interaction.
    MINTi MINT-2861355.
    STRINGi 9606.ENSP00000365663.

    Chemistry

    BindingDBi P01160.
    ChEMBLi CHEMBL1293193.

    PTM databases

    PhosphoSitei P01160.

    Polymorphism databases

    DMDMi 113864.

    Proteomic databases

    PaxDbi P01160.
    PRIDEi P01160.

    Protocols and materials databases

    DNASUi 4878.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376480 ; ENSP00000365663 ; ENSG00000175206 .
    GeneIDi 4878.
    KEGGi hsa:4878.
    UCSCi uc001ati.3. human.

    Organism-specific databases

    CTDi 4878.
    GeneCardsi GC01M011909.
    H-InvDB HIX0199955.
    HGNCi HGNC:7939. NPPA.
    HPAi HPA058269.
    MIMi 108780. gene.
    612201. phenotype.
    neXtProti NX_P01160.
    Orphaneti 334. Familial atrial fibrillation.
    PharmGKBi PA256.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42244.
    HOGENOMi HOG000033937.
    HOVERGENi HBG004227.
    InParanoidi P01160.
    KOi K12334.
    OrthoDBi EOG7K9K4Q.
    PhylomeDBi P01160.
    TreeFami TF106304.

    Enzyme and pathway databases

    Reactomei REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
    REACT_75925. Amyloids.

    Miscellaneous databases

    EvolutionaryTracei P01160.
    GeneWikii Atrial_natriuretic_peptide.
    GenomeRNAii 4878.
    NextBioi 18776.
    PMAP-CutDB Q5JZE1.
    PROi P01160.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01160.
    Bgeei P01160.
    CleanExi HS_NPPA.
    Genevestigatori P01160.

    Family and domain databases

    InterProi IPR000663. Natr_peptide.
    IPR002407. Natriuretic_peptide_atrial.
    [Graphical view ]
    Pfami PF00212. ANP. 1 hit.
    [Graphical view ]
    PRINTSi PR00711. ANATPEPTIDE.
    PR00710. NATPEPTIDES.
    SMARTi SM00183. NAT_PEP. 1 hit.
    [Graphical view ]
    PROSITEi PS00263. NATRIURETIC_PEPTIDE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide."
      Oikawa S., Imai M., Ueno A., Tanaka S., Noguchi T., Nakazato H., Kangawa K., Fukuda A., Matsuo H.
      Nature 309:724-726(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
    2. "mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria."
      Nakayama K., Ohkubo H., Hirose T., Inayama S., Nakanishi S.
      Nature 310:699-701(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE 2).
    3. "Gene structure of human cardiac hormone precursor, pronatriodilatin."
      Nemer M., Chamberland M., Sirois D., Argentin S., Drouin J., Dixon R.A.F., Zivin R.A., Condra J.H.
      Nature 312:654-656(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
    4. "Nucleotide sequence of the gene encoding human atrial natriuretic factor precursor."
      Greenberg B.D., Bencen G.H., Seilhamer J.J., Lewicki J.A., Fiddes J.C.
      Nature 312:656-658(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
    5. "Nucleotide sequences of the human and mouse atrial natriuretic factor genes."
      Seidman C.E., Bloch K.D., Klein K.A., Smith J.A., Seidman J.G.
      Science 226:1206-1209(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
    6. "Molecular studies of the atrial natriuretic factor gene."
      Seidman C.E., Bloch K.D., Zisfein J., Smit J., Haber E., Homcy C., Duby A.D., Choi E., Graham R.M., Seidman J.G.
      Hypertension 7:I31-I34(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
    7. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE 2).
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE 2).
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE 1).
      Tissue: Prostate.
    10. "Cloning of genomic DNA for human atrial natriuretic factor."
      Maki M., Parmentier M., Inagami T.
      Biochem. Biophys. Res. Commun. 125:797-802(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
    11. "Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors."
      Zivin R.A., Condra J.H., Dixon R.A.F., Seidah N.G., Chretien M., Nemer M., Chamberland M., Drouin J.
      Proc. Natl. Acad. Sci. U.S.A. 81:6325-6329(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-153 (ALLELE 1).
    12. "Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)."
      Kangawa K., Matsuo H.
      Biochem. Biophys. Res. Commun. 118:131-139(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 124-151.
    13. "Hydrolysis of intact and Cys-Phe-cleaved human atrial natriuretic peptide in vitro by human tissue kallikrein."
      Vanneste Y., Michel A., Deschodt-Lanckman M.
      Eur. J. Biochem. 196:281-286(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 124-151.
    14. "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
      Bennett B.D., Bennett G.L., Vitangcol R.V., Jewett J.R., Burnier J., Henzel W., Lowe D.G.
      J. Biol. Chem. 266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: RECEPTOR-BINDING.
    15. "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
      Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., Goeddel D.V.
      Science 252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."
      Yan W., Wu F., Morser J., Wu Q.
      Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING, MUTAGENESIS OF ARG-123.
    17. "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."
      Knappe S., Wu F., Masikat M.R., Morser J., Wu Q.
      J. Biol. Chem. 278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    18. "Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor."
      Fairbrother W.J., McDowell R.S., Cunningham B.C.
      Biochemistry 33:8897-8904(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 124-151 MUTANT SELECTIVE FOR NPR-C RECEPTOR.
    19. "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
      He X.-L., Dukkipati A., Garcia K.C.
      J. Mol. Biol. 361:698-714(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 129-149 IN COMPLEX WITH NPR3, DISULFIDE BOND.
    20. Cited for: INVOLVEMENT IN ATFB6.

    Entry informationi

    Entry nameiANF_HUMAN
    AccessioniPrimary (citable) accession number: P01160
    Secondary accession number(s): Q13766, Q5JZE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 160 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3