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Protein

Neurotensin/neuromedin N

Gene

NTS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionVasoactive

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:NTS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001951324 – 148Large neuromedin NAdd BLAST125
PeptideiPRO_0000019514143 – 148Neuromedin N6
PeptideiPRO_0000019515151 – 163NeurotensinAdd BLAST13
PeptideiPRO_0000019516166 – 170Tail peptideSequence analysis5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Pyrrolidone carboxylic acidBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01156.
PRIDEiP01156.

Expressioni

Tissue specificityi

Brain and gut.

Gene expression databases

BgeeiENSBTAG00000005305.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006980.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP01156.
KOiK05235.
OMAiLTNMYTS.
OrthoDBiEOG091G0PRU.
TreeFamiTF330765.

Family and domain databases

InterProiView protein in InterPro
IPR008055. NeurotensiN.
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiView protein in Pfam
PF07421. Pro-NT_NN. 1 hit.
PRINTSiPR01668. NEUROTENSIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016590. NeurotensiN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAGMKIQLV CMILLAFSSW SLCSDSEEEM KALETDLLTN MHTSKISKAS
60 70 80 90 100
VPSWKMSLLN VCSLINNLNS QAEETGEFHE EELITRRKFP AALDGFSLEA
110 120 130 140 150
MLTIYQLQKI CHSRAFQHWE LIQEDILDAG NDKNEKEEVI KRKIPYILKR
160 170
QLYENKPRRP YILKRGSYYY
Length:170
Mass (Da):19,843
Last modified:October 14, 2008 - v3
Checksum:iC6ED46ED9A41D468
GO

Sequence cautioni

The sequence AAA30668 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18621 mRNA. Translation: AAA30668.1. Different initiation.
DQ515198 mRNA. Translation: ABF72466.1.
BC102381 mRNA. Translation: AAI02382.1.
PIRiA01420. UNBO.
RefSeqiNP_776370.2. NM_173945.4.
UniGeneiBt.440.

Genome annotation databases

EnsembliENSBTAT00000006980; ENSBTAP00000006980; ENSBTAG00000005305.
GeneIDi280881.
KEGGibta:280881.

Similar proteinsi

Entry informationi

Entry nameiNEUT_BOVIN
AccessioniPrimary (citable) accession number: P01156
Secondary accession number(s): Q3ZCG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 14, 2008
Last modified: August 30, 2017
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families