P01156 (NEUT_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotensin/neuromedin N

Cleaved into the following 4 chains:

1. Large neuromedin N
   Alternative name(s):
   NmN-125
2. Neuromedin N
   Short name=NN
   Short name=NmN
3. Neurotensin
   Short name=NT
4. Tail peptide

Gene names

Name:

NTS

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Subcellular location	Secreted. Cytoplasmic vesicle › secretory vesicle. Note: Packaged within secretory vesicles.
Tissue specificity	Brain and gut.
Sequence similarities	Belongs to the neurotensin family.
Sequence caution	The sequence AAA30668.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Domain	Signal
Molecular function	Vasoactive
PTM	Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of blood vessel size Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell transport vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 148	125	Large neuromedin N		PRO_0000019513
	Peptide	143 – 148	6	Neuromedin N		PRO_0000019514
	Peptide	151 – 163	13	Neurotensin Ref.4		PRO_0000019515
	Peptide	166 – 170	5	Tail peptide Potential		PRO_0000019516
Amino acid modifications
	Modified residue	151	1	Pyrrolidone carboxylic acid

Sequences

	Sequence		Length	Mass (Da)
	P01156 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: C6ED46ED9A41D468	FASTA	170	19,843
	10 20 30 40 50 60 MMAGMKIQLV CMILLAFSSW SLCSDSEEEM KALETDLLTN MHTSKISKAS VPSWKMSLLN 70 80 90 100 110 120 VCSLINNLNS QAEETGEFHE EELITRRKFP AALDGFSLEA MLTIYQLQKI CHSRAFQHWE 130 140 150 160 170 LIQEDILDAG NDKNEKEEVI KRKIPYILKR QLYENKPRRP YILKRGSYYY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences." Kislauskis E., Bullock B., McNeil S., Dobner P.R. J. Biol. Chem. 263:4963-4968(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Polymorphism identification in the neurotensin gene of cattle." Reddick K.D., Schmutz S.M. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.
[4]	"The amino acid sequence of a hypothalamic peptide, neurotensin." Carraway R., Leeman S.E. J. Biol. Chem. 250:1907-1911(1975) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 151-163. Tissue: Hypothalamus.
[5]	"The synthesis of neurotensin." Carraway R., Leeman S.E. J. Biol. Chem. 250:1912-1918(1975) [PubMed] [Europe PMC] [Abstract] Cited for: SYNTHESIS OF NEUROTENSIN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18621 mRNA. Translation: AAA30668.1. Different initiation. DQ515198 mRNA. Translation: ABF72466.1. BC102381 mRNA. Translation: AAI02382.1.
IPI	IPI00714089.
PIR	UNBO. A01420.
RefSeq	NP_776370.2. NM_173945.4.
UniGene	Bt.440.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000006980.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000006980; ENSBTAP00000006980; ENSBTAG00000005305.
GeneID	280881.
KEGG	bta:280881.
Organism-specific databases
CTD	4922.
Phylogenomic databases
eggNOG	NOG46419.
GeneTree	ENSGT00640000091574.
HOGENOM	HOG000113770.
HOVERGEN	HBG003785.
InParanoid	P01156.
KO	K05235.
OMA	NSQAEET.
OrthoDB	EOG4CVG82.
Family and domain databases
InterPro	IPR008055. NeurotensiN. [Graphical view]
PANTHER	PTHR15356. PTHR15356. 1 hit.
Pfam	PF07421. Pro-NT_NN. 1 hit. [Graphical view]
PRINTS	PR01668. NEUROTENSIN.
ProDom	PD016590. NeurotensiN. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	20805018.

Entry information

Entry name

NEUT_BOVIN

Accession

Primary (citable) accession number: P01156
Secondary accession number(s): Q3ZCG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program