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Protein

Neurotensin/neuromedin N

Gene

NTS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:NTS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 148125Large neuromedin NPRO_0000019513Add
BLAST
Peptidei143 – 1486Neuromedin NPRO_0000019514
Peptidei151 – 16313NeurotensinPRO_0000019515Add
BLAST
Peptidei166 – 1705Tail peptideSequence analysisPRO_0000019516

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Pyrrolidone carboxylic acid

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01156.
PRIDEiP01156.

Expressioni

Tissue specificityi

Brain and gut.

Gene expression databases

BgeeiENSBTAG00000005305.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006980.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP01156.
KOiK05235.
OMAiLTNMYTS.
OrthoDBiEOG091G0PRU.
TreeFamiTF330765.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAGMKIQLV CMILLAFSSW SLCSDSEEEM KALETDLLTN MHTSKISKAS
60 70 80 90 100
VPSWKMSLLN VCSLINNLNS QAEETGEFHE EELITRRKFP AALDGFSLEA
110 120 130 140 150
MLTIYQLQKI CHSRAFQHWE LIQEDILDAG NDKNEKEEVI KRKIPYILKR
160 170
QLYENKPRRP YILKRGSYYY
Length:170
Mass (Da):19,843
Last modified:October 14, 2008 - v3
Checksum:iC6ED46ED9A41D468
GO

Sequence cautioni

The sequence AAA30668 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18621 mRNA. Translation: AAA30668.1. Different initiation.
DQ515198 mRNA. Translation: ABF72466.1.
BC102381 mRNA. Translation: AAI02382.1.
PIRiA01420. UNBO.
RefSeqiNP_776370.2. NM_173945.4.
UniGeneiBt.440.

Genome annotation databases

EnsembliENSBTAT00000006980; ENSBTAP00000006980; ENSBTAG00000005305.
GeneIDi280881.
KEGGibta:280881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18621 mRNA. Translation: AAA30668.1. Different initiation.
DQ515198 mRNA. Translation: ABF72466.1.
BC102381 mRNA. Translation: AAI02382.1.
PIRiA01420. UNBO.
RefSeqiNP_776370.2. NM_173945.4.
UniGeneiBt.440.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006980.

Proteomic databases

PaxDbiP01156.
PRIDEiP01156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006980; ENSBTAP00000006980; ENSBTAG00000005305.
GeneIDi280881.
KEGGibta:280881.

Organism-specific databases

CTDi4922.

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiP01156.
KOiK05235.
OMAiLTNMYTS.
OrthoDBiEOG091G0PRU.
TreeFamiTF330765.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Gene expression databases

BgeeiENSBTAG00000005305.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNEUT_BOVIN
AccessioniPrimary (citable) accession number: P01156
Secondary accession number(s): Q3ZCG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.