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Protein

Pro-thyrotropin-releasing hormone

Gene

Trh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.

GO - Molecular functioni

  • thyrotropin-releasing hormone activity Source: RGD

GO - Biological processi

  • adult walking behavior Source: Ensembl
  • eating behavior Source: RGD
  • histamine metabolic process Source: RGD
  • hormone-mediated signaling pathway Source: InterPro
  • negative regulation of feeding behavior Source: RGD
  • negative regulation of glutamate secretion Source: RGD
  • positive regulation of gamma-aminobutyric acid secretion Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • response to cold Source: RGD
  • response to corticosterone Source: RGD
  • response to ethanol Source: RGD
  • response to glucose Source: RGD
  • response to hypoxia Source: RGD
  • response to organic cyclic compound Source: RGD
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-thyrotropin-releasing hormone
Short name:
Pro-TRH
Alternative name(s):
Prothyroliberin
Cleaved into the following chain:
Alternative name(s):
Protirelin
TSH-releasing factor
Thyroliberin
Thyrotropin-releasing factor
Short name:
TRF
Gene namesi
Name:Trh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3903 Trh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000002252225 – 255Pro-thyrotropin-releasing hormoneAdd BLAST231
PeptideiPRO_000002252377 – 79Thyrotropin-releasing hormone3
PeptideiPRO_0000022524109 – 111Thyrotropin-releasing hormone3
PeptideiPRO_0000022525154 – 156Thyrotropin-releasing hormone3
PeptideiPRO_0000022526172 – 174Thyrotropin-releasing hormone3
PeptideiPRO_0000022527202 – 204Thyrotropin-releasing hormone3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79Proline amideBy similarity1
Modified residuei111Proline amideBy similarity1
Modified residuei154Pyrrolidone carboxylic acid1 Publication1
Modified residuei156Proline amideBy similarity1
Modified residuei172Pyrrolidone carboxylic acid1 Publication1
Modified residuei174Proline amideBy similarity1
Modified residuei204Proline amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01150
PRIDEiP01150

Miscellaneous databases

PMAP-CutDBP01150

Expressioni

Gene expression databases

BgeeiENSRNOG00000011824
ExpressionAtlasiP01150 baseline and differential
GenevisibleiP01150 RN

Interactioni

GO - Molecular functioni

  • thyrotropin-releasing hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015944

Chemistry databases

BindingDBiP01150

Family & Domainsi

Sequence similaritiesi

Belongs to the TRH family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IXZK Eukaryota
ENOG4111JXZ LUCA
GeneTreeiENSGT00390000016951
HOGENOMiHOG000054194
HOVERGENiHBG083494
InParanoidiP01150
KOiK05253
OMAiQHPGRRE
OrthoDBiEOG091G0M01
PhylomeDBiP01150
TreeFamiTF332073

Family and domain databases

InterProiView protein in InterPro
IPR008857 TRH
PANTHERiPTHR17530 PTHR17530, 1 hit
PfamiView protein in Pfam
PF05438 TRH, 1 hit
PIRSFiPIRSF001795 TRH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPWLLLAL ALIFTLTGIP ESCALPEAAQ EEGAVTPDLP GLENVQVRPE
60 70 80 90 100
RRFLWKDLQR VRGDLGAALD SWITKRQHPG KREEEEKDIE AEERGDLGEG
110 120 130 140 150
GAWRLHKRQH PGRRANQDKY SWADEEDSDW MPRSWLPDFF LDSWFSDVPQ
160 170 180 190 200
VKRQHPGRRS FPWMESDVTK RQHPGRRFID PELQRSWEEK EGEGVLMPEK
210 220 230 240 250
RQHPGKRALG HPCGPQGTCG QTGLLQLLGD LSRGQETLVK QSPQVEPWDK

EPLEE
Length:255
Mass (Da):29,284
Last modified:July 21, 1986 - v1
Checksum:i440DCCEADC0A22EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12138 mRNA Translation: AAA42275.1
M23632, M23643 Genomic DNA Translation: AAA65750.2
M27465, M27464 Genomic DNA Translation: AAA42239.1
M36317 mRNA Translation: AAA42276.1
PIRiA31773 RHRTT
RefSeqiNP_037178.1, NM_013046.3
XP_006236961.1, XM_006236899.2
UniGeneiRn.22

Genome annotation databases

EnsembliENSRNOT00000015944; ENSRNOP00000015944; ENSRNOG00000011824
GeneIDi25569
KEGGirno:25569

Similar proteinsi

Entry informationi

Entry nameiTRH_RAT
AccessioniPrimary (citable) accession number: P01150
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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