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P01144 (SAUV_PHYSA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sauvagin
Alternative name(s):
Sauvagine
Short name=SVG
OrganismPhyllomedusa sauvagei (Sauvage's leaf frog)
Taxonomic identifier8395 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

Protein attributes

Sequence length40 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hypotensive and diuretic peptide.

Subcellular location

Secreted.

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionHormone
   PTMAmidation
Pyrrolidone carboxylic acid
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 4040Sauvagin
PRO_0000044693

Amino acid modifications

Modified residue11Pyrrolidone carboxylic acid Ref.2
Modified residue401Isoleucine amide Ref.2

Sequences

Sequence LengthMass (Da)Tools
P01144 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 1E3CD73D61128C4F

FASTA404,617
        10         20         30         40 
QGPPISIDLS LELLRKMIEI EKQEKEKQQA ANNRLLLDTI 

« Hide

References

[1]"Structure of sauvagine, a vasoactive peptide from the skin of a frog."
Montecucchi P.C., Henschen A., Erspamer V.
Hoppe-Seyler's Z. Physiol. Chem. 360:1178-1178(1979)
Cited for: PRELIMINARY PROTEIN SEQUENCE.
Tissue: Skin secretion.
[2]"Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei."
Montecucchi P.C., Anastasi A., de Castiglione R., Erspamer V.
Int. J. Pept. Protein Res. 18:113-120(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Skin secretion.
[3]"Primary structure of sauvagine."
Montecucchi P.C., Henschen A.
Int. J. Pept. Protein Res. 19:325-325(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Skin secretion.
[4]"Studies on peptides. CLVII. Synthesis of frog-skin peptide, sauvagine."
Nomizu M., Akaji K., Fukata J., Imura H., Inoue A., Nakata Y., Segawa T., Fujii N., Yajima H.
Chem. Pharm. Bull. 36:122-133(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: SYNTHESIS.
[5]"Secondary structure prediction of sauvagine, a novel biologically active polypeptide from a frog."
Montecucchi P.C., Gozzini L.
Int. J. Pept. Protein Res. 20:139-143(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: SECONDARY STRUCTURE PREDICTION.

Cross-references

Sequence databases

PIRSWFGS. A01406.

3D structure databases

ProteinModelPortalP01144.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PfamPF00473. CRF. 1 hit.
[Graphical view]
PRINTSPR01612. CRFFAMILY.
SMARTSM00039. CRF. 1 hit.
[Graphical view]
PROSITEPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAUV_PHYSA
AccessionPrimary (citable) accession number: P01144
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families