P01144 (SAUV_PHYSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Sauvagin Alternative name(s): Sauvagine Short name=SVG
Organism	Phyllomedusa sauvagei (Sauvage's leaf frog)
Taxonomic identifier	8395 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Neobatrachia › Hyloidea › Hylidae › Phyllomedusinae › Phyllomedusa

Protein attributes

Sequence length	40 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hypotensive and diuretic peptide.
Subcellular location	Secreted.
Sequence similarities	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Hormone
PTM	Amidation Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 40	40	Sauvagin		PRO_0000044693
Amino acid modifications
	Modified residue	1	1	Pyrrolidone carboxylic acid Ref.2
	Modified residue	40	1	Isoleucine amide Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P01144 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 1E3CD73D61128C4F	FASTA	40	4,617
	10 20 30 40 QGPPISIDLS LELLRKMIEI EKQEKEKQQA ANNRLLLDTI

References

[1]	"Structure of sauvagine, a vasoactive peptide from the skin of a frog." Montecucchi P.C., Henschen A., Erspamer V. Hoppe-Seyler's Z. Physiol. Chem. 360:1178-1178(1979) Cited for: PRELIMINARY PROTEIN SEQUENCE. Tissue: Skin secretion.
[2]	"Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei." Montecucchi P.C., Anastasi A., de Castiglione R., Erspamer V. Int. J. Pept. Protein Res. 18:113-120(1981) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.
[3]	"Primary structure of sauvagine." Montecucchi P.C., Henschen A. Int. J. Pept. Protein Res. 19:325-325(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.
[4]	"Studies on peptides. CLVII. Synthesis of frog-skin peptide, sauvagine." Nomizu M., Akaji K., Fukata J., Imura H., Inoue A., Nakata Y., Segawa T., Fujii N., Yajima H. Chem. Pharm. Bull. 36:122-133(1988) [PubMed] [Europe PMC] [Abstract] Cited for: SYNTHESIS.
[5]	"Secondary structure prediction of sauvagine, a novel biologically active polypeptide from a frog." Montecucchi P.C., Gozzini L. Int. J. Pept. Protein Res. 20:139-143(1982) [PubMed] [Europe PMC] [Abstract] Cited for: SECONDARY STRUCTURE PREDICTION.

Cross-references

Sequence databases
PIR	SWFGS. A01406.
3D structure databases
ProteinModelPortal	P01144.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR018446. Corticotropin-releasing_fac_CS. IPR000187. Corticotropin-releasing_factor. IPR003620. Urocortin_CRF. [Graphical view]
Pfam	PF00473. CRF. 1 hit. [Graphical view]
PRINTS	PR01612. CRFFAMILY.
SMART	SM00039. CRF. 1 hit. [Graphical view]
PROSITE	PS00511. CRF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAUV_PHYSA

Accession

Primary (citable) accession number: P01144

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program