Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sauvagin

Gene
N/A
Organism
Phyllomedusa sauvagei (Sauvage's leaf frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Hypotensive and diuretic peptide.

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Sauvagin
Alternative name(s):
Sauvagine
Short name:
SVG
OrganismiPhyllomedusa sauvagei (Sauvage's leaf frog)
Taxonomic identifieri8395 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 4040SauvaginPRO_0000044693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11Pyrrolidone carboxylic acid1 Publication
Modified residuei40 – 401Isoleucine amide1 Publication

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
QGPPISIDLS LELLRKMIEI EKQEKEKQQA ANNRLLLDTI
Length:40
Mass (Da):4,617
Last modified:July 21, 1986 - v1
Checksum:i1E3CD73D61128C4F
GO

Sequence databases

PIRiA01406. SWFGS.

Cross-referencesi

Sequence databases

PIRiA01406. SWFGS.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of sauvagine, a vasoactive peptide from the skin of a frog."
    Montecucchi P.C., Henschen A., Erspamer V.
    Hoppe-Seyler's Z. Physiol. Chem. 360:1178-1178(1978)
    Cited for: PRELIMINARY PROTEIN SEQUENCE.
    Tissue: Skin secretion.
  2. "Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei."
    Montecucchi P.C., Anastasi A., de Castiglione R., Erspamer V.
    Int. J. Pept. Protein Res. 18:113-120(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Skin secretion.
  3. "Primary structure of sauvagine."
    Montecucchi P.C., Henschen A.
    Int. J. Pept. Protein Res. 19:325-325(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Skin secretion.
  4. "Studies on peptides. CLVII. Synthesis of frog-skin peptide, sauvagine."
    Nomizu M., Akaji K., Fukata J., Imura H., Inoue A., Nakata Y., Segawa T., Fujii N., Yajima H.
    Chem. Pharm. Bull. 36:122-133(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS.
  5. "Secondary structure prediction of sauvagine, a novel biologically active polypeptide from a frog."
    Montecucchi P.C., Gozzini L.
    Int. J. Pept. Protein Res. 20:139-143(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: SECONDARY STRUCTURE PREDICTION.

Entry informationi

Entry nameiSAUV_PHYSA
AccessioniPrimary (citable) accession number: P01144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 1, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.