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Protein

Corticoliberin

Gene

Crh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland (PubMed:6603620). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: Ensembl
  • associative learning Source: RGD
  • cellular response to cocaine Source: UniProtKB
  • cellular response to dexamethasone stimulus Source: RGD
  • diterpenoid metabolic process Source: RGD
  • female pregnancy Source: Ensembl
  • glucocorticoid biosynthetic process Source: Ensembl
  • hormone-mediated apoptotic signaling pathway Source: RGD
  • hypothalamus development Source: RGD
  • inflammatory response Source: Ensembl
  • ion homeostasis Source: RGD
  • learning or memory Source: RGD
  • locomotory exploration behavior Source: Ensembl
  • long-term synaptic potentiation Source: RGD
  • lung development Source: Ensembl
  • negative regulation of cell death Source: RGD
  • negative regulation of epinephrine secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of glucagon secretion Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • negative regulation of norepinephrine secretion Source: RGD
  • negative regulation of systemic arterial blood pressure Source: RGD
  • positive regulation of behavioral fear response Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cAMP-mediated signaling Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of corticosterone secretion Source: RGD
  • positive regulation of corticotropin secretion Source: RGD
  • positive regulation of cortisol secretion Source: GO_Central
  • positive regulation of digestive system process Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of NMDA receptor activity Source: UniProtKB
  • regulation of serotonin secretion Source: RGD
  • response to cocaine Source: RGD
  • response to corticosterone Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to ethanol Source: RGD
  • response to ether Source: RGD
  • response to immobilization stress Source: RGD
  • response to pain Source: RGD
  • steroid metabolic process Source: RGD
  • synaptic transmission, dopaminergic Source: UniProtKB

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-373080 Class B/2 (Secretin family receptors)
R-RNO-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:Crh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620505 Crh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000621825 – 1441 PublicationAdd BLAST120
PeptideiPRO_0000006219145 – 185Corticoliberin1 PublicationAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185Isoleucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01143
PRIDEiP01143

Expressioni

Tissue specificityi

Produced by the hypothalamus.1 Publication

Gene expression databases

BgeeiENSRNOG00000012703
GenevisibleiP01143 RN

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016953

Chemistry databases

BindingDBiP01143

Structurei

3D structure databases

ProteinModelPortaliP01143
SMRiP01143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK Eukaryota
ENOG4111ZIN LUCA
GeneTreeiENSGT00510000048573
HOGENOMiHOG000004762
HOVERGENiHBG001951
InParanoidiP01143
KOiK05256
OMAiREMMEMS
OrthoDBiEOG091G0QDI
PhylomeDBiP01143
TreeFamiTF332956

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRLLVSAG MLLVALSPCL PCRALLSRGS VSGAPRAPQP LNFLQPEQPQ
60 70 80 90 100
QPQPILIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA
110 120 130 140 150
NFFRVLLQQL QMPQRPLDSS TELAERGAED ALGGHQGALE RERRSEEPPI
160 170 180
SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK
Length:187
Mass (Da):20,680
Last modified:January 1, 1988 - v1
Checksum:i911602C82A444CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03036 mRNA Translation: CAA26838.1
M54987 Genomic DNA Translation: AAA40965.1
PIRiA40906 RHRTCE
RefSeqiNP_112281.1, NM_031019.1
UniGeneiRn.10349

Genome annotation databases

EnsembliENSRNOT00000016953; ENSRNOP00000016953; ENSRNOG00000012703
GeneIDi81648
KEGGirno:81648
UCSCiRGD:620505 rat

Similar proteinsi

Entry informationi

Entry nameiCRF_RAT
AccessioniPrimary (citable) accession number: P01143
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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