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Protein

Corticoliberin

Gene

Crh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland (PubMed:6603620). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity1 Publication

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD

GO - Biological processi

  • adrenal gland development Source: Ensembl
  • associative learning Source: RGD
  • cellular response to cocaine Source: UniProtKB
  • cellular response to dexamethasone stimulus Source: RGD
  • diterpenoid metabolic process Source: RGD
  • female pregnancy Source: Ensembl
  • glucocorticoid biosynthetic process Source: Ensembl
  • hormone-mediated apoptotic signaling pathway Source: RGD
  • hypothalamus development Source: RGD
  • inflammatory response Source: Ensembl
  • ion homeostasis Source: RGD
  • learning or memory Source: RGD
  • locomotory exploration behavior Source: Ensembl
  • long-term synaptic potentiation Source: RGD
  • lung development Source: Ensembl
  • negative regulation of blood pressure Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of epinephrine secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of glucagon secretion Source: RGD
  • negative regulation of luteinizing hormone secretion Source: RGD
  • negative regulation of norepinephrine secretion Source: RGD
  • positive regulation of behavioral fear response Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cAMP biosynthetic process Source: RGD
  • positive regulation of cell death Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of corticosterone secretion Source: RGD
  • positive regulation of corticotropin secretion Source: RGD
  • positive regulation of cortisol secretion Source: Ensembl
  • positive regulation of digestive system process Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: UniProtKB
  • regulation of serotonin secretion Source: RGD
  • response to cocaine Source: RGD
  • response to corticosterone Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to ethanol Source: RGD
  • response to ether Source: RGD
  • response to immobilization stress Source: RGD
  • response to pain Source: RGD
  • steroid metabolic process Source: RGD
  • synaptic transmission, dopaminergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:Crh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620505. Crh.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
  • perikaryon Source: RGD
  • varicosity Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 1441201 PublicationPRO_0000006218Add
BLAST
Peptidei145 – 18541Corticoliberin1 PublicationPRO_0000006219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851Isoleucine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01143.

Expressioni

Tissue specificityi

Produced by the hypothalamus.1 Publication

Gene expression databases

GenevisibleiP01143. RN.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016953.

Chemistry

BindingDBiP01143.

Structurei

3D structure databases

ProteinModelPortaliP01143.
SMRiP01143. Positions 145-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiP01143.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG7NSB43.
PhylomeDBiP01143.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRLLVSAG MLLVALSPCL PCRALLSRGS VSGAPRAPQP LNFLQPEQPQ
60 70 80 90 100
QPQPILIRMG EEYFLRLGNL NRSPAARLSP NSTPLTAGRG SRPSHDQAAA
110 120 130 140 150
NFFRVLLQQL QMPQRPLDSS TELAERGAED ALGGHQGALE RERRSEEPPI
160 170 180
SLDLTFHLLR EVLEMARAEQ LAQQAHSNRK LMEIIGK
Length:187
Mass (Da):20,680
Last modified:January 1, 1988 - v1
Checksum:i911602C82A444CFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03036 mRNA. Translation: CAA26838.1.
M54987 Genomic DNA. Translation: AAA40965.1.
PIRiA40906. RHRTCE.
RefSeqiNP_112281.1. NM_031019.1.
UniGeneiRn.10349.

Genome annotation databases

EnsembliENSRNOT00000016953; ENSRNOP00000016953; ENSRNOG00000012703.
GeneIDi81648.
KEGGirno:81648.
UCSCiRGD:620505. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03036 mRNA. Translation: CAA26838.1.
M54987 Genomic DNA. Translation: AAA40965.1.
PIRiA40906. RHRTCE.
RefSeqiNP_112281.1. NM_031019.1.
UniGeneiRn.10349.

3D structure databases

ProteinModelPortaliP01143.
SMRiP01143. Positions 145-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016953.

Chemistry

BindingDBiP01143.

Proteomic databases

PaxDbiP01143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016953; ENSRNOP00000016953; ENSRNOG00000012703.
GeneIDi81648.
KEGGirno:81648.
UCSCiRGD:620505. rat.

Organism-specific databases

CTDi1392.
RGDi620505. Crh.

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiP01143.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG7NSB43.
PhylomeDBiP01143.
TreeFamiTF332956.

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi615174.
PROiP01143.

Gene expression databases

GenevisibleiP01143. RN.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of cDNA for rat corticotropin-releasing factor precursor."
    Jingami H., Mizuno N., Takahashi H., Shibahara S., Furutani Y., Imura H., Numa S.
    FEBS Lett. 191:63-66(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Rat corticotropin-releasing hormone gene: sequence and tissue-specific expression."
    Thompson R.C., Seasholtz A.F., Herbert E.
    Mol. Endocrinol. 1:363-370(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  3. "Characterization of rat hypothalamic corticotropin-releasing factor."
    Rivier J., Spiess J., Vale W.
    Proc. Natl. Acad. Sci. U.S.A. 80:4851-4855(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 145-185, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCRF_RAT
AccessioniPrimary (citable) accession number: P01143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: November 11, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.