P01140 (NGFV_NAJNA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom nerve growth factor Short name=v-NGF Short name=vNGF
Organism	Naja naja (Indian cobra)
Taxonomic identifier	35670 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Elapidae › Elapinae › Naja

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. It probably participates directly or indirectly in the toxic activity.
Subunit structure	Homodimer.
Subcellular location	Secreted Ref.2.
Tissue specificity	Expressed by the venom gland. Ref.2
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Growth factor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Venom nerve growth factor		PRO_0000159607
Amino acid modifications
	Disulfide bond	14 ↔ 78		By similarity
	Disulfide bond	56 ↔ 106		By similarity
	Disulfide bond	66 ↔ 108		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01140 [UniParc]. Last modified May 1, 1991. Version 2. Checksum: DAB346B1093E7E06	FASTA	116	13,023
	10 20 30 40 50 60 EDHPVHNLGE HSVCDSVSAW VTKTTATDIK GNTVTVMENV NLDNKVYKEY FFETKCKNPN 70 80 90 100 110 PEPSGCRGID SSHWNSYCTE TDTFIKALTM EGNQASWRFI RIDTACVCVI TKKTGN

References

[1]	"Amino acid sequences of nerve growth factors derived from cobra venoms." Inoue S., Oda T., Koyama J., Ikeda K., Hayashi K. FEBS Lett. 279:38-40(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.
[2]	"Molecular diversity in venom proteins of the Russell's viper (Daboia russellii russellii) and the Indian cobra (Naja naja) in Sri Lanka." Suzuki M., Itoh T., Bandaranayake B.M.A.I.K., Ranasinghe J.G., Athauda S.B., Moriyama A. Biomed. Res. 31:71-81(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-26, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Venom.
[3]	"Purification, characterization, and partial amino acid sequence of nerve growth factor from cobra venom." Hogue-Angeletti R.A., Frazier W.A., Jacobs J.W., Niall H.D., Bradshaw R.A. Biochemistry 15:26-34(1976) [PubMed] [Europe PMC] [Abstract] Cited for: PRELIMINARY PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	NGNJXI. S13927.
3D structure databases
ProteinModelPortal	P01140.
SMR	P01140. Positions 3-113.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006494.
Family and domain databases
InterPro	IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR020425. Nerve_growth_factor_bsu. IPR019846. Nerve_growth_factor_CS. [Graphical view]
PANTHER	PTHR11589. PTHR11589. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PRINTS	PR00268. NGF. PR01913. NGFBETA.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NGFV_NAJNA

Accession

Primary (citable) accession number: P01140

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	May 1, 1991
Last modified:	April 3, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program

Annotation program

Chordata Protein Annotation Program