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P01138

- NGF_HUMAN

UniProt

P01138 - NGF_HUMAN

Protein

Beta-nerve growth factor

Gene

NGF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 163 (01 Oct 2014)
      Sequence version 3 (21 Mar 2006)
      Previous versions | rss
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    Functioni

    Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

    GO - Molecular functioni

    1. nerve growth factor receptor binding Source: BHF-UCL
    2. receptor signaling protein activity Source: Ensembl

    GO - Biological processi

    1. activation of MAPKK activity Source: Reactome
    2. activation of phospholipase C activity Source: Reactome
    3. adult locomotory behavior Source: Ensembl
    4. apoptotic signaling pathway Source: Reactome
    5. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    6. extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    7. inflammatory response Source: Ensembl
    8. memory Source: Ensembl
    9. negative regulation of apoptotic process Source: Reactome
    10. negative regulation of cell cycle Source: Reactome
    11. negative regulation of neuron apoptotic process Source: Ensembl
    12. negative regulation of type B pancreatic cell apoptotic process Source: Ensembl
    13. nerve growth factor processing Source: Reactome
    14. neuron apoptotic process Source: Ensembl
    15. neuron projection morphogenesis Source: MGI
    16. neurotrophin TRK receptor signaling pathway Source: Reactome
    17. peripheral nervous system development Source: Ensembl
    18. phosphatidylinositol-mediated signaling Source: Reactome
    19. positive regulation of apoptotic process Source: Reactome
    20. positive regulation of axon extension Source: Ensembl
    21. positive regulation of axonogenesis Source: Reactome
    22. positive regulation of gene expression Source: UniProtKB
    23. positive regulation of neuron differentiation Source: Ensembl
    24. positive regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
    25. positive regulation of protein autophosphorylation Source: Ensembl
    26. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    27. positive regulation of stem cell proliferation Source: Ensembl
    28. Ras protein signal transduction Source: Reactome
    29. regulation of axonogenesis Source: Reactome
    30. regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
    31. regulation of neurotransmitter secretion Source: Ensembl
    32. response to drug Source: Ensembl
    33. response to electrical stimulus Source: Ensembl
    34. response to glucocorticoid Source: Ensembl
    35. response to lipopolysaccharide Source: Ensembl
    36. response to mechanical stimulus Source: Ensembl
    37. response to nicotine Source: Ensembl
    38. response to ozone Source: Ensembl
    39. response to peptide hormone Source: Ensembl
    40. response to radiation Source: Ensembl
    41. sensory perception of pain Source: Ensembl
    42. small GTPase mediated signal transduction Source: Reactome
    43. transmembrane receptor protein tyrosine kinase signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_11060. TRKA activation by NGF.
    REACT_11062. NGF processing.
    REACT_12002. ARMS-mediated activation.
    REACT_12033. Signalling to RAS.
    REACT_12049. Signalling to STAT3.
    REACT_12076. Frs2-mediated activation.
    REACT_12077. Signalling to p38 via RIT and RIN.
    REACT_12079. PLC-gamma1 signalling.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12464. PI3K/AKT activation.
    REACT_13415. p75NTR recruits signalling complexes.
    REACT_13526. NADE modulates death signalling.
    REACT_13638. NRAGE signals death through JNK.
    REACT_13643. NRIF signals cell death from the nucleus.
    REACT_13695. p75NTR negatively regulates cell cycle via SC1.
    REACT_13696. NF-kB is activated and signals survival.
    REACT_13724. NFG and proNGF binds to p75NTR.
    REACT_13779. Axonal growth stimulation.
    REACT_13806. Ceramide signalling.
    SignaLinkiP01138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-nerve growth factor
    Short name:
    Beta-NGF
    Gene namesi
    Name:NGF
    Synonyms:NGFB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7808. NGF.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: Reactome
    2. extracellular region Source: Reactome
    3. extracellular space Source: Ensembl
    4. Golgi lumen Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti162 – 1621E → EGE in HSAN5; uncertain pathological significance. 1 Publication
    VAR_068478
    Natural varianti221 – 2211R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor; may act as a hypomorphic allele. 1 Publication
    Corresponds to variant rs11466112 [ dbSNP | Ensembl ].
    VAR_030659

    Keywords - Diseasei

    Disease mutation, Neuropathy

    Organism-specific databases

    MIMi608654. phenotype.
    Orphaneti64752. Hereditary sensory and autonomic neuropathy type 5.
    PharmGKBiPA162397475.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 121103PRO_0000019599Add
    BLAST
    Chaini122 – 241120Beta-nerve growth factorPRO_0000019600Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 2011 Publication
    Disulfide bondi179 ↔ 2291 Publication
    Disulfide bondi189 ↔ 2311 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01138.
    PRIDEiP01138.

    PTM databases

    PhosphoSiteiP01138.

    Miscellaneous databases

    PMAP-CutDBP01138.

    Expressioni

    Gene expression databases

    BgeeiP01138.
    CleanExiHS_NGF.
    GenevestigatoriP01138.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    BioGridi110869. 6 interactions.
    DIPiDIP-5712N.
    IntActiP01138. 2 interactions.
    MINTiMINT-122414.
    STRINGi9606.ENSP00000358525.

    Structurei

    Secondary structure

    1
    241
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi127 – 1304
    Beta strandi133 – 1364
    Beta strandi138 – 1436
    Beta strandi148 – 1514
    Beta strandi156 – 1594
    Beta strandi161 – 17111
    Beta strandi174 – 1796
    Beta strandi190 – 1923
    Turni194 – 1963
    Beta strandi197 – 21317
    Beta strandi215 – 23521

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SG1X-ray2.40A/B122-241[»]
    1WWWX-ray2.20V/W122-241[»]
    2IFGX-ray3.40E/F122-241[»]
    4EDWX-ray2.48V122-241[»]
    4EDXX-ray2.50V/W122-241[»]
    ProteinModelPortaliP01138.
    SMRiP01138. Positions 129-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01138.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44820.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiP01138.
    KOiK02582.
    OMAiIFHRGEF.
    OrthoDBiEOG7RBZ8Z.
    PhylomeDBiP01138.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR020425. Nerve_growth_factor_bsu.
    IPR020437. Nerve_growth_factor_bsu_mml.
    IPR019846. Nerve_growth_factor_CS.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01925. MAMLNGFBETA.
    PR00268. NGF.
    PR01913. NGFBETA.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01138-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR    50
    ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT 100
    QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT 150
    DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY 200
    CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A 241
    Length:241
    Mass (Da):26,959
    Last modified:March 21, 2006 - v3
    Checksum:i619DFC65EB3BD671
    GO

    Sequence cautioni

    The sequence AAH32517.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1641N → S in AAL05874. 1 PublicationCurated
    Sequence conflicti230 – 2301V → M in AAL05874. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351A → V.7 Publications
    Corresponds to variant rs6330 [ dbSNP | Ensembl ].
    VAR_013783
    Natural varianti72 – 721V → M.
    Corresponds to variant rs11466110 [ dbSNP | Ensembl ].
    VAR_025553
    Natural varianti80 – 801R → Q.
    Corresponds to variant rs11466111 [ dbSNP | Ensembl ].
    VAR_025554
    Natural varianti162 – 1621E → EGE in HSAN5; uncertain pathological significance. 1 Publication
    VAR_068478
    Natural varianti187 – 1871S → N Found in a patient with congenital insensitivity to pain; uncertain pathological significance. 1 Publication
    VAR_068479
    Natural varianti221 – 2211R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor; may act as a hypomorphic allele. 1 Publication
    Corresponds to variant rs11466112 [ dbSNP | Ensembl ].
    VAR_030659

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01511 Genomic DNA. Translation: CAA24755.1.
    M21062 Genomic DNA. Translation: AAA59931.1.
    AF150960 Genomic DNA. Translation: AAD55975.1.
    AB037517 Genomic DNA. Translation: BAA90437.1.
    AF411526 mRNA. Translation: AAL05874.1.
    CR541855 mRNA. Translation: CAG46653.1.
    BT019733 mRNA. Translation: AAV38538.1.
    AL049825 Genomic DNA. Translation: CAB75625.1.
    CH471122 Genomic DNA. Translation: EAW56629.1.
    BC032517 mRNA. Translation: AAH32517.2. Different initiation.
    BC126148 mRNA. Translation: AAI26149.1.
    BC126150 mRNA. Translation: AAI26151.1.
    X52599 mRNA. Translation: CAA36832.1.
    CCDSiCCDS882.1.
    PIRiA01399. NGHUBM.
    RefSeqiNP_002497.2. NM_002506.2.
    XP_006710726.1. XM_006710663.1.
    XP_006710727.1. XM_006710664.1.
    XP_006710728.1. XM_006710665.1.
    UniGeneiHs.2561.

    Genome annotation databases

    EnsembliENST00000369512; ENSP00000358525; ENSG00000134259.
    GeneIDi4803.
    KEGGihsa:4803.
    UCSCiuc001efu.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Nerve growth factor entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V01511 Genomic DNA. Translation: CAA24755.1 .
    M21062 Genomic DNA. Translation: AAA59931.1 .
    AF150960 Genomic DNA. Translation: AAD55975.1 .
    AB037517 Genomic DNA. Translation: BAA90437.1 .
    AF411526 mRNA. Translation: AAL05874.1 .
    CR541855 mRNA. Translation: CAG46653.1 .
    BT019733 mRNA. Translation: AAV38538.1 .
    AL049825 Genomic DNA. Translation: CAB75625.1 .
    CH471122 Genomic DNA. Translation: EAW56629.1 .
    BC032517 mRNA. Translation: AAH32517.2 . Different initiation.
    BC126148 mRNA. Translation: AAI26149.1 .
    BC126150 mRNA. Translation: AAI26151.1 .
    X52599 mRNA. Translation: CAA36832.1 .
    CCDSi CCDS882.1.
    PIRi A01399. NGHUBM.
    RefSeqi NP_002497.2. NM_002506.2.
    XP_006710726.1. XM_006710663.1.
    XP_006710727.1. XM_006710664.1.
    XP_006710728.1. XM_006710665.1.
    UniGenei Hs.2561.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SG1 X-ray 2.40 A/B 122-241 [» ]
    1WWW X-ray 2.20 V/W 122-241 [» ]
    2IFG X-ray 3.40 E/F 122-241 [» ]
    4EDW X-ray 2.48 V 122-241 [» ]
    4EDX X-ray 2.50 V/W 122-241 [» ]
    ProteinModelPortali P01138.
    SMRi P01138. Positions 129-236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110869. 6 interactions.
    DIPi DIP-5712N.
    IntActi P01138. 2 interactions.
    MINTi MINT-122414.
    STRINGi 9606.ENSP00000358525.

    Chemistry

    ChEMBLi CHEMBL1649058.
    DrugBanki DB01407. Clenbuterol.

    PTM databases

    PhosphoSitei P01138.

    Proteomic databases

    PaxDbi P01138.
    PRIDEi P01138.

    Protocols and materials databases

    DNASUi 4803.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369512 ; ENSP00000358525 ; ENSG00000134259 .
    GeneIDi 4803.
    KEGGi hsa:4803.
    UCSCi uc001efu.1. human.

    Organism-specific databases

    CTDi 4803.
    GeneCardsi GC01M115828.
    HGNCi HGNC:7808. NGF.
    MIMi 162030. gene.
    608654. phenotype.
    neXtProti NX_P01138.
    Orphaneti 64752. Hereditary sensory and autonomic neuropathy type 5.
    PharmGKBi PA162397475.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44820.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi P01138.
    KOi K02582.
    OMAi IFHRGEF.
    OrthoDBi EOG7RBZ8Z.
    PhylomeDBi P01138.
    TreeFami TF106463.

    Enzyme and pathway databases

    Reactomei REACT_11060. TRKA activation by NGF.
    REACT_11062. NGF processing.
    REACT_12002. ARMS-mediated activation.
    REACT_12033. Signalling to RAS.
    REACT_12049. Signalling to STAT3.
    REACT_12076. Frs2-mediated activation.
    REACT_12077. Signalling to p38 via RIT and RIN.
    REACT_12079. PLC-gamma1 signalling.
    REACT_12435. Retrograde neurotrophin signalling.
    REACT_12464. PI3K/AKT activation.
    REACT_13415. p75NTR recruits signalling complexes.
    REACT_13526. NADE modulates death signalling.
    REACT_13638. NRAGE signals death through JNK.
    REACT_13643. NRIF signals cell death from the nucleus.
    REACT_13695. p75NTR negatively regulates cell cycle via SC1.
    REACT_13696. NF-kB is activated and signals survival.
    REACT_13724. NFG and proNGF binds to p75NTR.
    REACT_13779. Axonal growth stimulation.
    REACT_13806. Ceramide signalling.
    SignaLinki P01138.

    Miscellaneous databases

    EvolutionaryTracei P01138.
    GeneWikii Nerve_growth_factor.
    GenomeRNAii 4803.
    NextBioi 18514.
    PMAP-CutDB P01138.
    PROi P01138.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01138.
    CleanExi HS_NGF.
    Genevestigatori P01138.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR020425. Nerve_growth_factor_bsu.
    IPR020437. Nerve_growth_factor_bsu_mml.
    IPR019846. Nerve_growth_factor_CS.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01925. MAMLNGFBETA.
    PR00268. NGF.
    PR01913. NGFBETA.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human beta-nerve growth factor gene sequence highly homologous to that of mouse."
      Ullrich A., Gray A., Berman C., Dull T.J.
      Nature 303:821-825(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
    2. "Sequence homology of human and mouse beta-NGF subunit genes."
      Ullrich A., Gray A., Berman C., Coussens L., Dull T.J.
      Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-35.
      Tissue: Brain.
    4. "Cloning and sequencing of the gene for premature beta nerve growth factor."
      Tong Y., Wang H., Chen W.
      Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T., Liu Y.-H., Ueda S., Saitou N.
      Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
    6. Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-35.
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-35.
      Tissue: Eye.
    12. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
      Hallboeoek F., Ibanez C.F., Persson H.
      Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 178-219.
      Tissue: Leukocyte.
    13. "The trk proto-oncogene encodes a receptor for nerve growth factor."
      Klein R., Jing S., Nanduri V., O'Rourke E., Barbacid M.
      Cell 65:189-197(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF NTRK1 AS THE HIGH AFFINITY NGF RECEPTOR.
    14. "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor."
      Wiesmann C., Ultsch M.H., Bass S.H., de Vos A.M.
      Nature 401:184-188(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 122-241, DISULFIDE BONDS.
    15. Cited for: VARIANT VAL-35.
    16. "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception."
      Einarsdottir E., Carlsson A., Minde J., Toolanen G., Svensson O., Solders G., Holmgren G., Holmberg D., Holmberg M.
      Hum. Mol. Genet. 13:799-805(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HSAN5 TRP-221.
    17. "A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy."
      Carvalho O.P., Thornton G.K., Hertecant J., Houlden H., Nicholas A.K., Cox J.J., Rielly M., Al-Gazali L., Woods C.G.
      J. Med. Genet. 48:131-135(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT HSAN5 TRP-221.
    18. Cited for: VARIANT HSAN5 GLY-GLU-162 INS, VARIANT ASN-187.

    Entry informationi

    Entry nameiNGF_HUMAN
    AccessioniPrimary (citable) accession number: P01138
    Secondary accession number(s): A1A4E5
    , Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: March 21, 2006
    Last modified: October 1, 2014
    This is version 163 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3