Reviewed,
UniProtKB/Swiss-Prot P01138 (NGF_HUMAN)
Last modified
November 25, 2008.
Version 103.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Beta-nerve growth factor Short name=Beta-NGF | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 241 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Involvement in disease | Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. Hereditary sensory and autonomic neuropathies are characterized by loss of pain sensation in combination with other sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable. |
| Sequence similarities | Belongs to the NGF-beta family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Disease | Disease mutation |
| Domain | Signal |
| Molecular function | Growth factor |
| PTM | Cleavage on pair of basic residues Glycoprotein Phosphoprotein |
| Technical term | 3D-structure |
Gene Ontology (GO) | |
| Biological process | Ras protein signal transduction Inferred from Experiment. Source: Reactome nerve growth factor processingInferred from Experiment. Source: Reactome transmembrane receptor protein tyrosine kinase signaling pathwayInferred from Experiment. Source: Reactome |
| Cellular component | Golgi lumen Inferred from Experiment. Source: Reactome endosomeInferred from Experiment. Source: Reactome extracellular regionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW nerve growth factor receptor bindingInferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | Potential | |||||||||||||||||||||||||||||
| Propeptide | 19 – 121 | 103 | PRO_0000019599 | |||||||||||||||||||||||||||||
| Chain | 122 – 241 | 120 | Beta-nerve growth factor | PRO_0000019600 | ||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||
| Modified residue | 84 | 1 | Phosphoserine | |||||||||||||||||||||||||||||
| Glycosylation | 69 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||
| Glycosylation | 114 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||
| Disulfide bond | 136 ↔ 201 | |||||||||||||||||||||||||||||||
| Disulfide bond | 179 ↔ 229 | |||||||||||||||||||||||||||||||
| Disulfide bond | 189 ↔ 231 | |||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||
| Natural variant | 35 | 1 | A → V: dbSNP rs6330. | VAR_013783 | ||||||||||||||||||||||||||||
| Natural variant | 72 | 1 | V → M: dbSNP rs11466110. | VAR_025553 | ||||||||||||||||||||||||||||
| Natural variant | 80 | 1 | R → Q: dbSNP rs11466111. | VAR_025554 | ||||||||||||||||||||||||||||
| Natural variant | 221 | 1 | R → W in HSAN5. dbSNP rs11466112. | VAR_030659 | ||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||
| Sequence conflict | 164 | 1 | N → S in AAL05874. Ref.6 | |||||||||||||||||||||||||||||
| Sequence conflict | 230 | 1 | V → M in AAL05874. Ref.6 | |||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||
| Beta strand | 133 – 136 | 4 | ||||||||||||||||||||||||||||||
| Beta strand | 138 – 143 | 6 | ||||||||||||||||||||||||||||||
| Beta strand | 148 – 151 | 4 | ||||||||||||||||||||||||||||||
| Beta strand | 156 – 159 | 4 | ||||||||||||||||||||||||||||||
| Beta strand | 161 – 167 | 7 | ||||||||||||||||||||||||||||||
| Beta strand | 169 – 171 | 3 | ||||||||||||||||||||||||||||||
| Beta strand | 174 – 179 | 6 | ||||||||||||||||||||||||||||||
| Beta strand | 190 – 192 | 3 | ||||||||||||||||||||||||||||||
| Turn | 194 – 196 | 3 | ||||||||||||||||||||||||||||||
| Beta strand | 197 – 212 | 16 | ||||||||||||||||||||||||||||||
| Beta strand | 215 – 217 | 3 | ||||||||||||||||||||||||||||||
| Beta strand | 219 – 235 | 17 | ||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Human beta-nerve growth factor gene sequence highly homologous to that of mouse." Ullrich A., Gray A., Berman C., Dull T.J. Nature 303:821-825(1983) [PubMed: 6688123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35. |
| [2] | "Sequence homology of human and mouse beta-NGF subunit genes." Ullrich A., Gray A., Berman C., Coussens L., Dull T.J. Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983) [PubMed: 6327169] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35. |
| [3] | "cDNA sequence of human beta-NGF." Borsani G., Pizzuti A., Rugarli E.I., Falini A., Silani V., Sidoli A., Scarlato G., Barelle F.E. Nucleic Acids Res. 18:4020-4020(1990) [PubMed: 2374737] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-35. Tissue: Brain. |
| [4] | "Cloning and sequencing of the gene for premature beta nerve growth factor." Tong Y., Wang H., Chen W. Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997) [PubMed: 10322959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "Silver project." Kitano T., Kobayakawa H., Saitou N. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35. |
| [6] | Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [7] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [8] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [9] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [10] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-35. Tissue: Eye. |
| [11] | "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." Hallboeoek F., Ibanez C.F., Persson H. Neuron 6:845-858(1991) [PubMed: 2025430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 178-219. Tissue: Leukocyte. |
| [12] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, MASS SPECTROMETRY. Tissue: Epithelium. |
| [13] | "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor." Wiesmann C., Ultsch M.H., Bass S.H., de Vos A.M. Nature 401:184-188(1999) [PubMed: 10490030] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 122-241, DISULFIDE BONDS. |
| [14] | "Characterization of single-nucleotide polymorphisms in coding regions of human genes." Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 22:231-238(1999) [PubMed: 10391209] [Abstract] Cited for: VARIANT VAL-35. |
| [15] | Erratum Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S. Nat. Genet. 23:373-373(1999) |
| [16] | "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception." Einarsdottir E., Carlsson A., Minde J., Toolanen G., Svensson O., Solders G., Holmgren G., Holmberg D., Holmberg M. Hum. Mol. Genet. 13:799-805(2004) [PubMed: 14976160] [Abstract] Cited for: VARIANT HSAN5 TRP-221. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| V01511 Genomic DNA. Translation: CAA24755.1. M21062 Genomic DNA. Translation: AAA59931.1. AF150960 Genomic DNA. Translation: AAD55975.1. AB037517 Genomic DNA. Translation: BAA90437.1. AF411526 mRNA. Translation: AAL05874.1. CR541855 mRNA. Translation: CAG46653.1. BT019733 mRNA. Translation: AAV38538.1. AL049825 Genomic DNA. Translation: CAB75625.1. BC032517 mRNA. Translation: AAH32517.2. Different initiation. X52599 mRNA. Translation: CAA36832.1. | |||||||||||||||||||||||||
| PIR | NGHUBM. A01399. | ||||||||||||||||||||||||
| RefSeq | NP_002497.2. | ||||||||||||||||||||||||
| UniGene | Hs.2561 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| |||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| DIP | DIP:5712N. | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSG00000134259. Homo sapiens. [Contig view] | ||||||||||||||||||||||||
| GeneID | 4803. | ||||||||||||||||||||||||
| KEGG | hsa:4803. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| H-InvDB | HIX0028607. | ||||||||||||||||||||||||
| HGNC | HGNC:7808. NGF. | ||||||||||||||||||||||||
| MIM | 162030. gene. 608654. phenotype. | ||||||||||||||||||||||||
| Orphanet | 64752. Neuropathy, sensory and autonomic , hereditary, type 5. | ||||||||||||||||||||||||
| PharmGKB | PA31614. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
| GeneCards | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOGENOM | P01138. | ||||||||||||||||||||||||
| HOVERGEN | P01138. | ||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||
| Reactome | REACT_11061. Signalling by NGF. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P01138. | ||||||||||||||||||||||||
| CleanEx | HS_NGF. | ||||||||||||||||||||||||
| GermOnline | ENSG00000134259. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR002072. NGF. [Graphical view] | ||||||||||||||||||||||||
| PANTHER | PTHR11589. NGF. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00243. NGF. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PIRSF | PIRSF001789. NGF. 1 hit. | ||||||||||||||||||||||||
| PRINTS | PR00268. NGF. | ||||||||||||||||||||||||
| ProDom | PD002052. NGF. 2 hits. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||||||||
| SMART | SM00140. NGF. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||
| DrugBank | DB01407. Clenbuterol. | ||||||||||||||||||||||||
| LinkHub | P01138. | ||||||||||||||||||||||||
| NextBio | 18514. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | NGF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P01138 Secondary accession number(s): Q6FHA0 Q9UKL8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with