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P01138 (NGF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 161. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-nerve growth factor

Short name=Beta-NGF
Gene names
Name:NGF
Synonyms:NGFB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

Subunit structure

Homodimer.

Subcellular location

Secreted.

Involvement in disease

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.18 Ref.19

Sequence similarities

Belongs to the NGF-beta family.

Sequence caution

The sequence AAH32517.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
Neuropathy
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRas protein signal transduction

Traceable author statement. Source: Reactome

activation of MAPKK activity

Traceable author statement. Source: Reactome

activation of phospholipase C activity

Traceable author statement. Source: Reactome

adult locomotory behavior

Inferred from electronic annotation. Source: Ensembl

apoptotic signaling pathway

Traceable author statement. Source: Reactome

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway via death domain receptors

Inferred from direct assay PubMed 14985763. Source: BHF-UCL

inflammatory response

Inferred from electronic annotation. Source: Ensembl

memory

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Traceable author statement. Source: Reactome

negative regulation of cell cycle

Traceable author statement. Source: Reactome

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of type B pancreatic cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

nerve growth factor processing

Traceable author statement. Source: Reactome

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuron projection morphogenesis

Inferred from direct assay PubMed 17724343. Source: MGI

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

peripheral nervous system development

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of apoptotic process

Traceable author statement. Source: Reactome

positive regulation of axon extension

Inferred from electronic annotation. Source: Ensembl

positive regulation of axonogenesis

Traceable author statement. Source: Reactome

positive regulation of gene expression

Inferred from mutant phenotype PubMed 16153003. Source: UniProtKB

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neurotrophin TRK receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein autophosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of stem cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of axonogenesis

Traceable author statement. Source: Reactome

regulation of cysteine-type endopeptidase activity involved in apoptotic process

Traceable author statement. Source: Reactome

regulation of neurotransmitter secretion

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to electrical stimulus

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

response to nicotine

Inferred from electronic annotation. Source: Ensembl

response to ozone

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to radiation

Inferred from electronic annotation. Source: Ensembl

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

small GTPase mediated signal transduction

Traceable author statement. Source: Reactome

transmembrane receptor protein tyrosine kinase signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

endosome

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionnerve growth factor receptor binding

Inferred from physical interaction PubMed 14985763. Source: BHF-UCL

receptor signaling protein activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 121103
PRO_0000019599
Chain122 – 241120Beta-nerve growth factor
PRO_0000019600

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Disulfide bond136 ↔ 201 Ref.14
Disulfide bond179 ↔ 229 Ref.14
Disulfide bond189 ↔ 231 Ref.14

Natural variations

Natural variant351A → V. Ref.1 Ref.2 Ref.3 Ref.5 Ref.10 Ref.11 Ref.15
Corresponds to variant rs6330 [ dbSNP | Ensembl ].
VAR_013783
Natural variant721V → M.
Corresponds to variant rs11466110 [ dbSNP | Ensembl ].
VAR_025553
Natural variant801R → Q.
Corresponds to variant rs11466111 [ dbSNP | Ensembl ].
VAR_025554
Natural variant1621E → EGE in HSAN5; uncertain pathological significance.
VAR_068478
Natural variant1871S → N Found in a patient with congenital insensitivity to pain; uncertain pathological significance. Ref.19
VAR_068479
Natural variant2211R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor; may act as a hypomorphic allele. Ref.17 Ref.18
Corresponds to variant rs11466112 [ dbSNP | Ensembl ].
VAR_030659

Experimental info

Sequence conflict1641N → S in AAL05874. Ref.6
Sequence conflict2301V → M in AAL05874. Ref.6

Secondary structure

...................... 241
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01138 [UniParc].

Last modified March 21, 2006. Version 3.
Checksum: 619DFC65EB3BD671

FASTA24126,959
        10         20         30         40         50         60 
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSAPAAAIA 

        70         80         90        100        110        120 
ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT QDLDFEVGGA APFNRTHRSK 

       130        140        150        160        170        180 
RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR 

       190        200        210        220        230        240 
DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR 


A 

« Hide

References

« Hide 'large scale' references
[1]"Human beta-nerve growth factor gene sequence highly homologous to that of mouse."
Ullrich A., Gray A., Berman C., Dull T.J.
Nature 303:821-825(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
[2]"Sequence homology of human and mouse beta-NGF subunit genes."
Ullrich A., Gray A., Berman C., Coussens L., Dull T.J.
Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
[3]"cDNA sequence of human beta-NGF."
Borsani G., Pizzuti A., Rugarli E.I., Falini A., Silani V., Sidoli A., Scarlato G., Barelle F.E.
Nucleic Acids Res. 18:4020-4020(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-35.
Tissue: Brain.
[4]"Cloning and sequencing of the gene for premature beta nerve growth factor."
Tong Y., Wang H., Chen W.
Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Human-specific amino acid changes found in 103 protein-coding genes."
Kitano T., Liu Y.-H., Ueda S., Saitou N.
Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
[6]Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[7]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[9]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-35.
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-35.
Tissue: Eye.
[12]"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
Hallboeoek F., Ibanez C.F., Persson H.
Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 178-219.
Tissue: Leukocyte.
[13]"The trk proto-oncogene encodes a receptor for nerve growth factor."
Klein R., Jing S., Nanduri V., O'Rourke E., Barbacid M.
Cell 65:189-197(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF NTRK1 AS THE HIGH AFFINITY NGF RECEPTOR.
[14]"Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor."
Wiesmann C., Ultsch M.H., Bass S.H., de Vos A.M.
Nature 401:184-188(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 122-241, DISULFIDE BONDS.
[15]"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VAL-35.
[16]Erratum
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.
Nat. Genet. 23:373-373(1999)
[17]"A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception."
Einarsdottir E., Carlsson A., Minde J., Toolanen G., Svensson O., Solders G., Holmgren G., Holmberg D., Holmberg M.
Hum. Mol. Genet. 13:799-805(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HSAN5 TRP-221.
[18]"A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy."
Carvalho O.P., Thornton G.K., Hertecant J., Houlden H., Nicholas A.K., Cox J.J., Rielly M., Al-Gazali L., Woods C.G.
J. Med. Genet. 48:131-135(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANT HSAN5 TRP-221.
[19]"Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort."
Davidson G.L., Murphy S.M., Polke J.M., Laura M., Salih M.A., Muntoni F., Blake J., Brandner S., Davies N., Horvath R., Price S., Donaghy M., Roberts M., Foulds N., Ramdharry G., Soler D., Lunn M.P., Manji H. expand/collapse author list , Davis M.B., Houlden H., Reilly M.M.
J. Neurol. 259:1673-1685(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HSAN5 GLY-GLU-162 INS, VARIANT ASN-187.
+Additional computationally mapped references.

Web resources

Wikipedia

Nerve growth factor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V01511 Genomic DNA. Translation: CAA24755.1.
M21062 Genomic DNA. Translation: AAA59931.1.
AF150960 Genomic DNA. Translation: AAD55975.1.
AB037517 Genomic DNA. Translation: BAA90437.1.
AF411526 mRNA. Translation: AAL05874.1.
CR541855 mRNA. Translation: CAG46653.1.
BT019733 mRNA. Translation: AAV38538.1.
AL049825 Genomic DNA. Translation: CAB75625.1.
CH471122 Genomic DNA. Translation: EAW56629.1.
BC032517 mRNA. Translation: AAH32517.2. Different initiation.
BC126148 mRNA. Translation: AAI26149.1.
BC126150 mRNA. Translation: AAI26151.1.
X52599 mRNA. Translation: CAA36832.1.
CCDSCCDS882.1.
PIRNGHUBM. A01399.
RefSeqNP_002497.2. NM_002506.2.
XP_006710726.1. XM_006710663.1.
XP_006710727.1. XM_006710664.1.
XP_006710728.1. XM_006710665.1.
UniGeneHs.2561.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SG1X-ray2.40A/B122-241[»]
1WWWX-ray2.20V/W122-241[»]
2IFGX-ray3.40E/F122-241[»]
4EDWX-ray2.48V122-241[»]
4EDXX-ray2.50V/W122-241[»]
ProteinModelPortalP01138.
SMRP01138. Positions 129-236.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110869. 6 interactions.
DIPDIP-5712N.
IntActP01138. 2 interactions.
MINTMINT-122414.
STRING9606.ENSP00000358525.

Chemistry

ChEMBLCHEMBL1649058.
DrugBankDB01407. Clenbuterol.

PTM databases

PhosphoSiteP01138.

Proteomic databases

PaxDbP01138.
PRIDEP01138.

Protocols and materials databases

DNASU4803.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369512; ENSP00000358525; ENSG00000134259.
GeneID4803.
KEGGhsa:4803.
UCSCuc001efu.1. human.

Organism-specific databases

CTD4803.
GeneCardsGC01M115828.
HGNCHGNC:7808. NGF.
MIM162030. gene.
608654. phenotype.
neXtProtNX_P01138.
Orphanet64752. Hereditary sensory and autonomic neuropathy type 5.
PharmGKBPA162397475.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44820.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidP01138.
KOK02582.
OMAIFHRGEF.
OrthoDBEOG7RBZ8Z.
PhylomeDBP01138.
TreeFamTF106463.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkP01138.

Gene expression databases

BgeeP01138.
CleanExHS_NGF.
GenevestigatorP01138.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR020425. Nerve_growth_factor_bsu.
IPR020437. Nerve_growth_factor_bsu_mml.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01925. MAMLNGFBETA.
PR00268. NGF.
PR01913. NGFBETA.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01138.
GeneWikiNerve_growth_factor.
GenomeRNAi4803.
NextBio18514.
PMAP-CutDBP01138.
PROP01138.
SOURCESearch...

Entry information

Entry nameNGF_HUMAN
AccessionPrimary (citable) accession number: P01138
Secondary accession number(s): A1A4E5 expand/collapse secondary AC list , Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 161 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM