Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-nerve growth factor

Gene

NGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).1 Publication

GO - Molecular functioni

  1. growth factor activity Source: GO_Central
  2. metalloendopeptidase inhibitor activity Source: UniProtKB
  3. nerve growth factor receptor binding Source: BHF-UCL
  4. receptor signaling protein activity Source: Ensembl

GO - Biological processi

  1. activation of MAPKK activity Source: Reactome
  2. activation of phospholipase C activity Source: Reactome
  3. adult locomotory behavior Source: Ensembl
  4. apoptotic signaling pathway Source: Reactome
  5. cell-cell signaling Source: GO_Central
  6. circadian rhythm Source: Ensembl
  7. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  8. extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
  9. inflammatory response Source: Ensembl
  10. memory Source: Ensembl
  11. negative regulation of apoptotic process Source: Reactome
  12. negative regulation of cell cycle Source: Reactome
  13. negative regulation of endopeptidase activity Source: GOC
  14. negative regulation of neuron apoptotic process Source: GO_Central
  15. negative regulation of type B pancreatic cell apoptotic process Source: Ensembl
  16. nerve growth factor processing Source: Reactome
  17. nerve growth factor signaling pathway Source: Ensembl
  18. neuron apoptotic process Source: Ensembl
  19. neuron projection morphogenesis Source: MGI
  20. neurotrophin TRK receptor signaling pathway Source: Reactome
  21. peripheral nervous system development Source: Ensembl
  22. phosphatidylinositol-mediated signaling Source: Reactome
  23. positive regulation of apoptotic process Source: Reactome
  24. positive regulation of axon extension Source: Ensembl
  25. positive regulation of axonogenesis Source: Reactome
  26. positive regulation of gene expression Source: UniProtKB
  27. positive regulation of neuron maturation Source: Ensembl
  28. positive regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  29. positive regulation of protein autophosphorylation Source: Ensembl
  30. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  31. positive regulation of stem cell proliferation Source: Ensembl
  32. Ras protein signal transduction Source: Reactome
  33. regulation of axonogenesis Source: Reactome
  34. regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
  35. regulation of neuron differentiation Source: GO_Central
  36. regulation of neurotransmitter secretion Source: Ensembl
  37. regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  38. response to drug Source: Ensembl
  39. response to electrical stimulus Source: Ensembl
  40. response to glucocorticoid Source: Ensembl
  41. response to lipopolysaccharide Source: Ensembl
  42. response to mechanical stimulus Source: Ensembl
  43. response to nicotine Source: Ensembl
  44. response to ozone Source: Ensembl
  45. response to peptide hormone Source: Ensembl
  46. response to radiation Source: Ensembl
  47. sensory perception of pain Source: Ensembl
  48. small GTPase mediated signal transduction Source: Reactome
  49. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

ReactomeiREACT_11060. TRKA activation by NGF.
REACT_11062. NGF processing.
REACT_12002. ARMS-mediated activation.
REACT_12033. Signalling to RAS.
REACT_12049. Signalling to STAT3.
REACT_12076. Frs2-mediated activation.
REACT_12077. Signalling to p38 via RIT and RIN.
REACT_12079. PLC-gamma1 signalling.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12464. PI3K/AKT activation.
REACT_13415. p75NTR recruits signalling complexes.
REACT_13526. NADE modulates death signalling.
REACT_13638. NRAGE signals death through JNK.
REACT_13643. NRIF signals cell death from the nucleus.
REACT_13695. p75NTR negatively regulates cell cycle via SC1.
REACT_13696. NF-kB is activated and signals survival.
REACT_13724. NFG and proNGF binds to p75NTR.
REACT_13779. Axonal growth stimulation.
REACT_13806. Ceramide signalling.
SignaLinkiP01138.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-nerve growth factor
Short name:
Beta-NGF
Gene namesi
Name:NGF
Synonyms:NGFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7808. NGF.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: GO_Central
  2. endosome Source: Reactome
  3. extracellular region Source: GO_Central
  4. extracellular space Source: Ensembl
  5. Golgi lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.

See also OMIM:608654
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621E → EGE in HSAN5; uncertain pathological significance. 1 Publication
VAR_068478
Natural varianti221 – 2211R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor. 2 Publications
Corresponds to variant rs11466112 [ dbSNP | Ensembl ].
VAR_030659

Keywords - Diseasei

Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

MIMi608654. phenotype.
Orphaneti64752. Hereditary sensory and autonomic neuropathy type 5.
PharmGKBiPA162397475.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 121103PRO_0000019599Add
BLAST
Chaini122 – 241120Beta-nerve growth factorPRO_0000019600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi136 ↔ 2011 Publication
Disulfide bondi179 ↔ 2291 Publication
Disulfide bondi189 ↔ 2311 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01138.
PRIDEiP01138.

PTM databases

PhosphoSiteiP01138.

Miscellaneous databases

PMAP-CutDBP01138.

Expressioni

Gene expression databases

BgeeiP01138.
CleanExiHS_NGF.
GenevestigatoriP01138.

Interactioni

Subunit structurei

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NGFRP081382EBI-1028250,EBI-1387782
NgfrP071742EBI-1028250,EBI-1038810From a different organism.
NTRK1P046292EBI-1028250,EBI-1028226
SORT1Q995234EBI-1028250,EBI-1057058

Protein-protein interaction databases

BioGridi110869. 6 interactions.
DIPiDIP-5712N.
IntActiP01138. 5 interactions.
MINTiMINT-122414.
STRINGi9606.ENSP00000358525.

Structurei

Secondary structure

1
241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi127 – 1304Combined sources
Beta strandi133 – 1364Combined sources
Beta strandi138 – 1436Combined sources
Beta strandi148 – 1514Combined sources
Beta strandi156 – 1594Combined sources
Beta strandi161 – 17111Combined sources
Beta strandi174 – 1796Combined sources
Beta strandi190 – 1923Combined sources
Turni194 – 1963Combined sources
Beta strandi197 – 21317Combined sources
Beta strandi215 – 23521Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SG1X-ray2.40A/B122-241[»]
1WWWX-ray2.20V/W122-241[»]
2IFGX-ray3.40E/F122-241[»]
4EDWX-ray2.48V122-241[»]
4EDXX-ray2.50V/W122-241[»]
ProteinModelPortaliP01138.
SMRiP01138. Positions 129-236.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01138.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG44820.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP01138.
KOiK02582.
OMAiIFHRGEF.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP01138.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR020425. Nerve_growth_factor_bsu.
IPR020437. Nerve_growth_factor_bsu_mml.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01925. MAMLNGFBETA.
PR00268. NGF.
PR01913. NGFBETA.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01138-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR
60 70 80 90 100
ARSAPAAAIA ARVAGQTRNI TVDPRLFKKR RLRSPRVLFS TQPPREAADT
110 120 130 140 150
QDLDFEVGGA APFNRTHRSK RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT
160 170 180 190 200
DIKGKEVMVL GEVNINNSVF KQYFFETKCR DPNPVDSGCR GIDSKHWNSY
210 220 230 240
CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR A
Length:241
Mass (Da):26,959
Last modified:March 21, 2006 - v3
Checksum:i619DFC65EB3BD671
GO

Sequence cautioni

The sequence AAH32517.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641N → S in AAL05874 (Ref. 6) Curated
Sequence conflicti230 – 2301V → M in AAL05874 (Ref. 6) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351A → V.7 Publications
Corresponds to variant rs6330 [ dbSNP | Ensembl ].
VAR_013783
Natural varianti72 – 721V → M.
Corresponds to variant rs11466110 [ dbSNP | Ensembl ].
VAR_025553
Natural varianti80 – 801R → Q.
Corresponds to variant rs11466111 [ dbSNP | Ensembl ].
VAR_025554
Natural varianti162 – 1621E → EGE in HSAN5; uncertain pathological significance. 1 Publication
VAR_068478
Natural varianti187 – 1871S → N Found in a patient with congenital insensitivity to pain; uncertain pathological significance. 1 Publication
VAR_068479
Natural varianti221 – 2211R → W in HSAN5; the mutant protein is unable to activate the NTRK1 receptor. 2 Publications
Corresponds to variant rs11466112 [ dbSNP | Ensembl ].
VAR_030659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01511 Genomic DNA. Translation: CAA24755.1.
M21062 Genomic DNA. Translation: AAA59931.1.
AF150960 Genomic DNA. Translation: AAD55975.1.
AB037517 Genomic DNA. Translation: BAA90437.1.
AF411526 mRNA. Translation: AAL05874.1.
CR541855 mRNA. Translation: CAG46653.1.
BT019733 mRNA. Translation: AAV38538.1.
AL049825 Genomic DNA. Translation: CAB75625.1.
CH471122 Genomic DNA. Translation: EAW56629.1.
BC032517 mRNA. Translation: AAH32517.2. Different initiation.
BC126148 mRNA. Translation: AAI26149.1.
BC126150 mRNA. Translation: AAI26151.1.
X52599 mRNA. Translation: CAA36832.1.
CCDSiCCDS882.1.
PIRiA01399. NGHUBM.
RefSeqiNP_002497.2. NM_002506.2.
XP_006710726.1. XM_006710663.1.
XP_006710727.1. XM_006710664.1.
XP_006710728.1. XM_006710665.1.
UniGeneiHs.2561.

Genome annotation databases

EnsembliENST00000369512; ENSP00000358525; ENSG00000134259.
GeneIDi4803.
KEGGihsa:4803.
UCSCiuc001efu.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Nerve growth factor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01511 Genomic DNA. Translation: CAA24755.1.
M21062 Genomic DNA. Translation: AAA59931.1.
AF150960 Genomic DNA. Translation: AAD55975.1.
AB037517 Genomic DNA. Translation: BAA90437.1.
AF411526 mRNA. Translation: AAL05874.1.
CR541855 mRNA. Translation: CAG46653.1.
BT019733 mRNA. Translation: AAV38538.1.
AL049825 Genomic DNA. Translation: CAB75625.1.
CH471122 Genomic DNA. Translation: EAW56629.1.
BC032517 mRNA. Translation: AAH32517.2. Different initiation.
BC126148 mRNA. Translation: AAI26149.1.
BC126150 mRNA. Translation: AAI26151.1.
X52599 mRNA. Translation: CAA36832.1.
CCDSiCCDS882.1.
PIRiA01399. NGHUBM.
RefSeqiNP_002497.2. NM_002506.2.
XP_006710726.1. XM_006710663.1.
XP_006710727.1. XM_006710664.1.
XP_006710728.1. XM_006710665.1.
UniGeneiHs.2561.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SG1X-ray2.40A/B122-241[»]
1WWWX-ray2.20V/W122-241[»]
2IFGX-ray3.40E/F122-241[»]
4EDWX-ray2.48V122-241[»]
4EDXX-ray2.50V/W122-241[»]
ProteinModelPortaliP01138.
SMRiP01138. Positions 129-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110869. 6 interactions.
DIPiDIP-5712N.
IntActiP01138. 5 interactions.
MINTiMINT-122414.
STRINGi9606.ENSP00000358525.

Chemistry

BindingDBiP01138.
ChEMBLiCHEMBL1649058.
DrugBankiDB01407. Clenbuterol.

PTM databases

PhosphoSiteiP01138.

Proteomic databases

PaxDbiP01138.
PRIDEiP01138.

Protocols and materials databases

DNASUi4803.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369512; ENSP00000358525; ENSG00000134259.
GeneIDi4803.
KEGGihsa:4803.
UCSCiuc001efu.1. human.

Organism-specific databases

CTDi4803.
GeneCardsiGC01M115828.
HGNCiHGNC:7808. NGF.
MIMi162030. gene.
608654. phenotype.
neXtProtiNX_P01138.
Orphaneti64752. Hereditary sensory and autonomic neuropathy type 5.
PharmGKBiPA162397475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44820.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP01138.
KOiK02582.
OMAiIFHRGEF.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP01138.
TreeFamiTF106463.

Enzyme and pathway databases

ReactomeiREACT_11060. TRKA activation by NGF.
REACT_11062. NGF processing.
REACT_12002. ARMS-mediated activation.
REACT_12033. Signalling to RAS.
REACT_12049. Signalling to STAT3.
REACT_12076. Frs2-mediated activation.
REACT_12077. Signalling to p38 via RIT and RIN.
REACT_12079. PLC-gamma1 signalling.
REACT_12435. Retrograde neurotrophin signalling.
REACT_12464. PI3K/AKT activation.
REACT_13415. p75NTR recruits signalling complexes.
REACT_13526. NADE modulates death signalling.
REACT_13638. NRAGE signals death through JNK.
REACT_13643. NRIF signals cell death from the nucleus.
REACT_13695. p75NTR negatively regulates cell cycle via SC1.
REACT_13696. NF-kB is activated and signals survival.
REACT_13724. NFG and proNGF binds to p75NTR.
REACT_13779. Axonal growth stimulation.
REACT_13806. Ceramide signalling.
SignaLinkiP01138.

Miscellaneous databases

EvolutionaryTraceiP01138.
GeneWikiiNerve_growth_factor.
GenomeRNAii4803.
NextBioi18514.
PMAP-CutDBP01138.
PROiP01138.
SOURCEiSearch...

Gene expression databases

BgeeiP01138.
CleanExiHS_NGF.
GenevestigatoriP01138.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR020425. Nerve_growth_factor_bsu.
IPR020437. Nerve_growth_factor_bsu_mml.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01925. MAMLNGFBETA.
PR00268. NGF.
PR01913. NGFBETA.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human beta-nerve growth factor gene sequence highly homologous to that of mouse."
    Ullrich A., Gray A., Berman C., Dull T.J.
    Nature 303:821-825(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
  2. "Sequence homology of human and mouse beta-NGF subunit genes."
    Ullrich A., Gray A., Berman C., Coussens L., Dull T.J.
    Cold Spring Harb. Symp. Quant. Biol. 48:435-442(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-35.
    Tissue: Brain.
  4. "Cloning and sequencing of the gene for premature beta nerve growth factor."
    Tong Y., Wang H., Chen W.
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 13:316-318(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Human-specific amino acid changes found in 103 protein-coding genes."
    Kitano T., Liu Y.-H., Ueda S., Saitou N.
    Mol. Biol. Evol. 21:936-944(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-35.
  6. Zhang Y., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-35.
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-35.
    Tissue: Eye.
  12. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 178-219.
    Tissue: Leukocyte.
  13. "The trk proto-oncogene encodes a receptor for nerve growth factor."
    Klein R., Jing S., Nanduri V., O'Rourke E., Barbacid M.
    Cell 65:189-197(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF NTRK1 AS THE HIGH AFFINITY NGF RECEPTOR.
  14. "Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI."
    Wijeyewickrema L.C., Gardiner E.E., Gladigau E.L., Berndt M.C., Andrews R.K.
    J. Biol. Chem. 285:11793-11799(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ADAM10.
  15. "Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor."
    Wiesmann C., Ultsch M.H., Bass S.H., de Vos A.M.
    Nature 401:184-188(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 122-241, DISULFIDE BONDS.
  16. Cited for: VARIANT VAL-35.
  17. "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception."
    Einarsdottir E., Carlsson A., Minde J., Toolanen G., Svensson O., Solders G., Holmgren G., Holmberg D., Holmberg M.
    Hum. Mol. Genet. 13:799-805(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HSAN5 TRP-221.
  18. "A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy."
    Carvalho O.P., Thornton G.K., Hertecant J., Houlden H., Nicholas A.K., Cox J.J., Rielly M., Al-Gazali L., Woods C.G.
    J. Med. Genet. 48:131-135(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANT HSAN5 TRP-221.
  19. Cited for: VARIANT HSAN5 GLY-GLU-162 INS, VARIANT ASN-187.

Entry informationi

Entry nameiNGF_HUMAN
AccessioniPrimary (citable) accession number: P01138
Secondary accession number(s): A1A4E5
, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 21, 2006
Last modified: April 1, 2015
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.