##gff-version 3 P01133 UniProtKB Signal peptide 1 22 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Chain 23 1207 . . . ID=PRO_0000007540;Note=Pro-epidermal growth factor P01133 UniProtKB Chain 971 1023 . . . ID=PRO_0000007541;Note=Epidermal growth factor P01133 UniProtKB Topological domain 23 1032 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Transmembrane 1033 1053 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Topological domain 1054 1207 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Repeat 86 127 . . . Note=LDL-receptor class B 1 P01133 UniProtKB Repeat 128 169 . . . Note=LDL-receptor class B 2 P01133 UniProtKB Repeat 170 211 . . . Note=LDL-receptor class B 3 P01133 UniProtKB Repeat 212 258 . . . Note=LDL-receptor class B 4 P01133 UniProtKB Domain 314 355 . . . Note=EGF-like 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 356 396 . . . Note=EGF-like 2%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 397 437 . . . Note=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 435 477 . . . Note=EGF-like 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Repeat 483 523 . . . Note=LDL-receptor class B 5 P01133 UniProtKB Repeat 524 566 . . . Note=LDL-receptor class B 6 P01133 UniProtKB Repeat 567 609 . . . Note=LDL-receptor class B 7 P01133 UniProtKB Repeat 610 653 . . . Note=LDL-receptor class B 8 P01133 UniProtKB Repeat 654 696 . . . Note=LDL-receptor class B 9 P01133 UniProtKB Domain 741 781 . . . Note=EGF-like 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 831 869 . . . Note=EGF-like 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 870 911 . . . Note=EGF-like 7%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 912 952 . . . Note=EGF-like 8%3B calcium-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Domain 972 1013 . . . Note=EGF-like 9;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Region 801 807 . . . Note=O-glycosylated at one site P01133 UniProtKB Region 1067 1093 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P01133 UniProtKB Region 1108 1131 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P01133 UniProtKB Region 1177 1207 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P01133 UniProtKB Compositional bias 1070 1086 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P01133 UniProtKB Glycosylation 38 38 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 104 104 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 117 117 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 148 148 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 324 324 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 404 404 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 596 596 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 815 815 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Glycosylation 926 926 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01133 UniProtKB Disulfide bond 318 330 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 325 339 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 341 354 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 360 371 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 367 380 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 382 395 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 401 412 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 408 421 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 423 436 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 439 451 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 447 461 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 463 476 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 745 756 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 752 765 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 767 780 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 835 846 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 840 855 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 857 868 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 874 888 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 881 897 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 899 910 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 916 929 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 923 938 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 940 951 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076 P01133 UniProtKB Disulfide bond 976 990 . . . . P01133 UniProtKB Disulfide bond 984 1001 . . . . P01133 UniProtKB Disulfide bond 1003 1012 . . . . P01133 UniProtKB Alternative sequence 314 355 . . . ID=VSP_041586;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P01133 UniProtKB Alternative sequence 912 952 . . . ID=VSP_047190;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01133 UniProtKB Natural variant 16 16 . . . ID=VAR_020161;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11568849 P01133 UniProtKB Natural variant 151 151 . . . ID=VAR_033825;Note=H->Y;Dbxref=dbSNP:rs9991664 P01133 UniProtKB Natural variant 257 257 . . . ID=VAR_020968;Note=D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11568911 P01133 UniProtKB Natural variant 292 292 . . . ID=VAR_033826;Note=L->H;Dbxref=dbSNP:rs35191533 P01133 UniProtKB Natural variant 431 431 . . . ID=VAR_020162;Note=R->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11568943 P01133 UniProtKB Natural variant 638 638 . . . ID=VAR_020969;Note=S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11568992 P01133 UniProtKB Natural variant 708 708 . . . ID=VAR_002275;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs2237051 P01133 UniProtKB Natural variant 723 723 . . . ID=VAR_020163;Note=G->R;Dbxref=dbSNP:rs6413481 P01133 UniProtKB Natural variant 784 784 . . . ID=VAR_020164;Note=D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569017 P01133 UniProtKB Natural variant 842 842 . . . ID=VAR_020165;Note=M->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569046 P01133 UniProtKB Natural variant 920 920 . . . ID=VAR_020970;Note=E->V;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|Ref.2;Dbxref=dbSNP:rs4698803,PMID:14702039 P01133 UniProtKB Natural variant 981 981 . . . ID=VAR_020971;Note=D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569086 P01133 UniProtKB Natural variant 1043 1043 . . . ID=VAR_020166;Note=L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569098 P01133 UniProtKB Natural variant 1070 1070 . . . ID=VAR_039474;Note=In HOMG4%3B affects basolateral sorting of pro-EGF preventing the hormone to stimulate EGFR%3B lack of TRPM6 activation. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17671655;Dbxref=dbSNP:rs121434567,PMID:17671655 P01133 UniProtKB Natural variant 1084 1084 . . . ID=VAR_020972;Note=A->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11569111 P01133 UniProtKB Sequence conflict 302 302 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01133 UniProtKB Beta strand 979 981 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JL9 P01133 UniProtKB Beta strand 982 984 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1P9J P01133 UniProtKB Turn 985 987 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JL9 P01133 UniProtKB Beta strand 989 993 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1NQL P01133 UniProtKB Turn 994 997 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1NQL P01133 UniProtKB Beta strand 998 1003 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1NQL P01133 UniProtKB Beta strand 1007 1009 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1NQL P01133 UniProtKB Helix 1017 1019 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7SYE